Results of a 90-day safety assurance study with rats fed grain from corn rootworm-protected corn
Abstract
The results of a 90-day rat feeding study with YieldGard (YieldGard Rootworm Corn is a registered trademark of Monsanto Technology, LLC.) Rootworm corn (MON 863) grain that is protected against feeding damage caused by corn rootworm larvae are presented. Corn rootworm-protection was accomplished through the introduction of a cry3Bb1 coding sequence into the corn genome for in planta production of a modified Cry3Bb1 protein from Bacillus thuringiensis. Grain from MON 863 and its near isogenic control were separately formulated into rodent diets at levels of 11% and 33% (w/w) by Purina Mills, Inc. Additionally, six groups of rats were fed diets containing grain from different conventional (non-biotechnology-derived) reference varieties. The responses of rats fed diets containing MON 863 were compared to those of rats fed grain from conventional corn varieties. All diets were nutritionally balanced and conformed to Purina Mills, Inc. specifications for Certified LabDiet 5002. There were a total of 400 rats in the study divided into 10 groups of 20 rats/sex/group. Overall health, body weight gain, food consumption, clinical pathology parameters (hematology, blood chemistry, urinalysis), organ weights, gross and microscopic appearance of tissues were comparable between groups fed diets containing MON 863 and conventional corn varieties. This study complements extensive agronomic, compositional and farm animal feeding studies with MON 863 grain, confirming that it is as safe and nutritious as existing conventional corn varieties.
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A detailed analysis of the data in the subchronic toxicity studies has revealed statistically significant alterations in kidney and liver function that may constitute signs of the early onset of chronic toxicity.
“A detailed analysis of the data in the subchronic toxicity studies [2–5] has revealed statistically significant alterations in kidney and liver function that may constitute signs of the early onset of chronic toxicity.”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [4]
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BackgroundInfluentialHow subchronic and chronic health effects can be neglected for GMOs, pesticides or chemicals
Séralini, G.-E., de Vendômois, J. S., Cellier, D., Sultan, C., Buiatti, M., Gallagher, L., Antoniou, M., & Dronamraju, K. R. (2009) · International Journal of Biological Sciences · doi:10.7150/ijbs.5.438 · Cited by 57 · see citing works
- Authors
- Hammond, B., Lemen, J., Dudek, R., Ward, D., Jiang, C., Nemeth, M., & Burns, J.
- Affiliations
- Covance (United States) (US)
- Corresponding author
- Hammond, B.
- ORCID
- Jiang, C.
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 44
- Issue
- 2
- Pages
- 147-160
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2142608883
- Cited by
- 128
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 12 · 2013: 7 · 2012: 15
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
- Keywords
- Bt maize, Bacillus thuringiensis, transgenic maize, safety assurance, 90-day feeding study, rat toxicity, food safety, nutritional safety
- MeSH terms
- Animals, Behavior, Animal, Blood Cell Count, Blood Chemical Analysis, Body Weight, Zea mays, Diet, Eating, Female, Insect Control, Male, Organ Size, Plant Diseases, Urine, Rats, Sprague-Dawley, Food, Genetically Modified, Rats
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