How subchronic and chronic health effects can be neglected for GMOs, pesticides or chemicals
Open accessAbstract
Chronic health effects are increasing in the world such as cancers, hormonal, reproductive, nervous, or immune diseases, even in young people. During regulatory toxicological subchronic tests to prevent these on mammalian health, prior commercialization of chemicals, including pesticides and drugs, or GMOs, some statistically significant findings may be revealed. This discussion is about the need to investigate the relevant criteria to consider those as biologically significant. The sex differences and the non linear dose or time related effects should be considered in contrast to the claims of a Monsanto-supported expert panel about a GMO, the MON 863 Bt maize, but also for pesticides or drugs, in particular to reveal hormone-dependent diseases and first signs of toxicities.
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Significant disturbances have been found in GMO subchronic toxicity studies and may be interpreted differently.
“significant disturbances have been found and may be interpreted differently (Séralini et al., 2009;Spiroux de Vendômois et al., 2010)”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Séralini et al., 2009
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Séralini, G.-E., Clair, E., Mesnage, R., Gress, S., Defarge, N., Malatesta, M., Hennequin, D., & de Vendômois, J. S. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.08.005 · Cited by 397 · see citing works
“, 2004, 2006a,b), significant disturbances have been found and may be interpreted differently (Séralini et al., 2009; Spiroux de Vendômois et al., 2010).”
BackgroundSelf-citationRetractedA literature review on the safety assessment of genetically modified plants
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A comparison of the effects of three GM corn varieties on mammalian health
de Vendômois, J. S., Roullier, F., Cellier, D., & Séralini, G.-E. (2009) · International Journal of Biological Sciences · doi:10.7150/ijbs.5.706 · Cited by 160 · see citing works
Self-citationGenetically modified crops safety assessments: present limits and possible improvements
Séralini, G.-E., Mesnage, R., Clair, E., Gress, S., de Vendômois, J. S., & Cellier, D. (2011) · Environmental Sciences Europe · doi:10.1186/2190-4715-23-10 · Cited by 82 · see citing works
Self-citationDebate on GMOs health risks after statistical findings in regulatory tests
de Vendômois, J. S., Cellier, D., Vélot, C., Clair, E., Mesnage, R., & Séralini, G.-E. (2010) · International Journal of Biological Sciences · doi:10.7150/ijbs.6.590 · Cited by 64 · see citing works
Self-citationBartholomaeus, A., Parrott, W., Bondy, G., Walker, K., & on behalf of the ILSI International Food Biotechnology Committee Task Force on the Use of Mammalian Toxicology Studies in the Safety Assessment of GM Foods (2013) · Critical Reviews in Toxicology · doi:10.3109/10408444.2013.842955 · Cited by 59 · see citing works
“Three notable examples are the re-analyses of rat feeding studies with MON863, MON810, and NK603 corn (de Vendômois et al., 2009; Séralini et al., 2007, 2009), a chronic rodent feeding study on NK603 corn (Séralini et al., 2012), and a series of reproduction and development studies on maize…”
Background
- Authors
- Séralini, G.-E., de Vendômois, J. S., Cellier, D., Sultan, C., Buiatti, M., Gallagher, L., Antoniou, M., & Dronamraju, K. R.
- Affiliations
- Laboratoire d'Informatique, du Traitement de l'Information et des Systèmes (FR)
- Centre National de la Recherche Scientifique (FR)
- New Zealand Institute for Public Health and Forensic Science (NZ)
- Guy's Hospital (GB)
- ORCID
- Antoniou, Michael
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2009
- Volume
- 5
- Issue
- 5
- Pages
- 438-443
- ISSN
- 1449-2288 (ISSN-L)
- PMC
- PMC2706426
- OpenAlex
- W2138322647
- Cited by
- 57
- References
- 32
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 9
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- International Journal of Biological Sciences (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Florence Research (University of Florence) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- long-term health effects, subchronic toxicity, genetically modified organisms, pesticides, chemical toxicity, regulatory toxicology, sex differences, nonlinear dose-response relationship, reproductive toxicity, early detection of toxicity
- MeSH terms
- Animals, Humans, Pesticides, Sex Characteristics, Hazardous Substances, Organisms, Genetically Modified, Toxicity Tests, Chronic
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