New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity
Abstract
Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals. One of these studies performed under the responsibility of Monsanto Company with a transgenic corn MON863 has been subjected to questions from regulatory reviewers in Europe, where it was finally approved in 2005. This necessitated a new assessment of kidney pathological findings, and the results remained controversial. An Appeal Court action in Germany (Münster) allowed public access in June 2005 to all the crude data from this 90-day rat-feeding study. We independently re-analyzed these data. Appropriate statistics were added, such as a multivariate analysis of the growth curves, and for biochemical parameters comparisons between GMO-treated rats and the controls fed with an equivalent normal diet, and separately with six reference diets with different compositions. We observed that after the consumption of MON863, rats showed slight but dose-related significant variations in growth for both sexes, resulting in 3.3% decrease in weight for males and 3.7% increase for females. Chemistry measurements reveal signs of hepatorenal toxicity, marked also by differential sensitivities in males and females. Triglycerides increased by 24-40% in females (either at week 14, dose 11% or at week 5, dose 33%, respectively); urine phosphorus and sodium excretions diminished in males by 31-35% (week 14, dose 33%) for the most important results significantly linked to the treatment in comparison to seven diets tested. Longer experiments are essential in order to indicate the real nature and extent of the possible pathology; with the present data it cannot be concluded that GM corn MON863 is a safe product.
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Detailed analyses have revealed alterations in kidney and liver functions that may be signs of early chronic diet intoxication, possibly explained at least in part by pesticide residues in GM feed.
“Detailed analyses have revealed alterations in kidney and liver functions that may be the signs of early chronic diet intoxication, possibly explained at least in part by pesticide residues in the GM feed (Séralini et al., 2007;Spiroux de Vendômois et al., 2009).”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Séralini et al., 2007
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- Authors
- Séralini, G.-E., Cellier, D., & de Vendomois, J. S.
- Affiliations
- Laboratoire d'Informatique, du Traitement de l'Information et des Systèmes (FR)
- Venue
- Archives of Environmental Contamination and Toxicology
- Published
- 2007-03-13
- Volume
- 52
- Issue
- 4
- Pages
- 596-602
- ISSN
- 0090-4341 (ISSN-L)
- 1432-0703
- OpenAlex
- W2128203876
- Cited by
- 222
- References
- 21
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 18 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 3 · 2015: 20 · 2014: 16 · 2013: 22 · 2012: 25
- FWCI
- 19.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Environmental Contamination and Toxicology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- transgenic maize, MON863, rat feeding study, hepatorenal toxicity, kidney pathology, growth retardation, sex differences, triglycerides, urinary sodium, health risk assessment, data reanalysis
- MeSH terms
- Animals, Body Weight, Zea mays, Diet, Female, Kidney, Liver, Male, Sex Factors, Rats, Sprague-Dawley, Plants, Genetically Modified, Rats
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