The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
The FoxO transcription factors and metabolic regulation
Open accessAbstract
Forkhead transcription factors FoxOs are conserved beyond species and regulated by insulin signaling pathway. FoxOs have diverse functions on differentiation, proliferation and cell survival. In calorie restriction (CR) or starvation, FoxOs are in nucleus, active transcriptionally, and increase hepatic glucose production, decrease insulin secretion, increase food intake and cause degradation of skeletal muscle for supplying substrates for glucose production. However, even in insulin resistance due to excessive calorie intake, FoxOs are active and causes type 2 diabetes and hyperlipidemia. The understanding of molecular mechanism how FoxOs affect glucose or lipid metabolism will shed light on the novel therapy of type 2 diabetes and the metabolic syndrome.
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“Several training interventions have not produced changes in basal IL-6 or CRP concentrations (213 -218) , while significant reductions in inflammatory markers have been observed following training without changes in BMI or body fat in elderly participants (219,220) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [219]
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Metadata
- Authors
- Nakae, J., Oki, M., & Cao, Y.
- Affiliations
- Kobe University (JP)
- Corresponding author
- Nakae, Jun
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-11-20
- Volume
- 582
- Issue
- 1
- Pages
- 54-67
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2085299577
- Cited by
- 176
- References
- 135
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 13 · 2017: 7 · 2016: 13 · 2015: 17 · 2014: 10 · 2013: 9 · 2012: 11
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Keywords
- FOXO transcription factors, forkhead transcription factor, insulin signaling, caloric restriction, starvation, hepatic glucose production, insulin secretion, dietary intake, insulin resistance, type 2 diabetes, hyperlipidemia, metabolic syndrome, glucose metabolism, lipid metabolism
- MeSH terms
- Animals, Humans, Insulin, Metabolism, Transcription Factors, Signal Transduction, Mice, Knockout, Mice
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