Cited by 176FOXO transcription factor regulationMetabolism, Diabetes, and CancerFibroblast Growth Factor Research

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The FoxO transcription factors and metabolic regulation

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Nakae, Jun, Oki, Miyo, Cao, Yongheng·2008·FEBS Letters

DOI 10.1016/j.febslet.2007.11.025

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Abstract

Forkhead transcription factors FoxOs are conserved beyond species and regulated by insulin signaling pathway. FoxOs have diverse functions on differentiation, proliferation and cell survival. In calorie restriction (CR) or starvation, FoxOs are in nucleus, active transcriptionally, and increase hepatic glucose production, decrease insulin secretion, increase food intake and cause degradation of skeletal muscle for supplying substrates for glucose production. However, even in insulin resistance due to excessive calorie intake, FoxOs are active and causes type 2 diabetes and hyperlipidemia. The understanding of molecular mechanism how FoxOs affect glucose or lipid metabolism will shed light on the novel therapy of type 2 diabetes and the metabolic syndrome.

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Authors: Nakae, J., Oki, M., & Cao, Y.
Affiliations: Kobe University (JP)
Corresponding author: Nakae, Jun
Venue: FEBS Letters
Publisher: Wiley
Published: 2007-11-20
Volume: 582
Issue: 1
Pages: 54-67
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2007.11.025
OpenAlex: W2085299577
Cited by: 176
References: 135
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 13 · 2017: 7 · 2016: 13 · 2015: 17 · 2014: 10 · 2013: 9 · 2012: 11
FWCI: 0.79
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Keywords: FOXO transcription factors, forkhead transcription factor, insulin signaling, caloric restriction, starvation, hepatic glucose production, insulin secretion, dietary intake, insulin resistance, type 2 diabetes, hyperlipidemia, metabolic syndrome, glucose metabolism, lipid metabolism
MeSH terms: Animals, Humans, Insulin, Metabolism, Transcription Factors, Signal Transduction, Mice, Knockout, Mice

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