Regulation of Candida glabrata oxidative stress resistance is adapted to host environment
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The human fungal pathogen Candida glabrata is related to Saccharomyces cerevisiae but has developed high resistance against reactive oxygen species. We find that induction of conserved genes encoding antioxidant functions is dependent on the transcription factors CgYap1 and CgSkn7 which cooperate for promoter recognition. Superoxide stress resistance of C. glabrata is provided by superoxide dismutase CgSod1, which is not dependent on CgYap1/Skn7. Only double mutants lacking both CgSod1 and CgYap1 were efficiently killed by primary mouse macrophages. Our results suggest that in C. glabrata the regulation of key genes providing stress protection is adopted to meet a host-pathogen situation.
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CgCTA1 expression is regulated by several stress response transcriptional regulators including CgYap1, CgMsn2, CgMsn4 and CgSkn7.
“CgCTA1 expression is regulated by several stress response transcriptional regulators including CgYap1, CgMsn2, CgMsn4 and CgSkn7 [80,84,85,86].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [85]
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- Authors
- Roetzer, A., Klopf, E., Gratz, N., Marcet-Houben, M., Hiller, E., Rupp, S., Gabaldón, T., Kovarik, P., & Schüller, C.
- Affiliations
- University of Vienna (AT)
- Fraunhofer Institute for Interfacial Engineering and Biotechnology (DE)
- Centre for Genomic Regulation (ES)
- Corresponding author
- Schüller, Christoph
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2010-12-13
- Volume
- 585
- Issue
- 2
- Pages
- 319-327
- ISSN
- 0014-5793 (ISSN-L)
- PMC
- PMC3022126
- OpenAlex
- W2134035883
- Cited by
- 90
- References
- 49
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 12 · 2012: 4
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- FEBS Letters (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Funders
- Herzfelder Foundation
- Austrian Research Foundation (FWF) (P16726-B14, I27-B03, SFB F28)
- University of Vienna (I031-B)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- Candida glabrata, oxidative stress resistance, superoxide dismutase, host-pathogen interaction, macrophage killing, reactive oxygen species, fungal pathogenesis
- MeSH terms
- Adaptation, Physiological, Animals, Fungal Proteins, Macrophages, Superoxide Dismutase, Transcription Factors, Gene Expression Regulation, Fungal, Oxidative Stress, Candida glabrata, Mice
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