Cited by 90Fungal and yeast genetics researchAntifungal resistance and susceptibilityRedox biology and oxidative stress

Regulation of Candida glabrata oxidative stress resistance is adapted to host environment

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Roetzer, Andreas, Klopf, Eva, Gratz, Nina, Marcet-Houben, Marina, Hiller, Ekkehard, Rupp, Steffen, Gabaldón, Toni, Kovarik, Pavel +1 more·2011·FEBS Letters

Abstract

The human fungal pathogen Candida glabrata is related to Saccharomyces cerevisiae but has developed high resistance against reactive oxygen species. We find that induction of conserved genes encoding antioxidant functions is dependent on the transcription factors CgYap1 and CgSkn7 which cooperate for promoter recognition. Superoxide stress resistance of C. glabrata is provided by superoxide dismutase CgSod1, which is not dependent on CgYap1/Skn7. Only double mutants lacking both CgSod1 and CgYap1 were efficiently killed by primary mouse macrophages. Our results suggest that in C. glabrata the regulation of key genes providing stress protection is adopted to meet a host-pathogen situation.

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Crossref · 10.1016/j.febslet.2010.12.006

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  • CgCTA1 expression is regulated by several stress response transcriptional regulators including CgYap1, CgMsn2, CgMsn4 and CgSkn7.

    “CgCTA1 expression is regulated by several stress response transcriptional regulators including CgYap1, CgMsn2, CgMsn4 and CgSkn7 [80,84,85,86].”

    From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [85]

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Authors
Roetzer, A., Klopf, E., Gratz, N., Marcet-Houben, M., Hiller, E., Rupp, S., Gabaldón, T., Kovarik, P., & Schüller, C.
Affiliations
  • University of Vienna (AT)
  • Fraunhofer Institute for Interfacial Engineering and Biotechnology (DE)
  • Centre for Genomic Regulation (ES)
Corresponding author
Schüller, Christoph
Venue
FEBS Letters
Publisher
Wiley
Published
2010-12-13
Volume
585
Issue
2
Pages
319-327
ISSN
0014-5793 (ISSN-L)
OpenAlex
W2134035883
Cited by
90
References
49
Citations by year
2026: 6 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 12 · 2012: 4
FWCI
2.21
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
Funders
  • Herzfelder Foundation
  • Austrian Research Foundation (FWF) (P16726-B14, I27-B03, SFB F28)
  • University of Vienna (I031-B)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
Candida glabrata, oxidative stress resistance, superoxide dismutase, host-pathogen interaction, macrophage killing, reactive oxygen species, fungal pathogenesis
MeSH terms
Adaptation, Physiological, Animals, Fungal Proteins, Macrophages, Superoxide Dismutase, Transcription Factors, Gene Expression Regulation, Fungal, Oxidative Stress, Candida glabrata, Mice

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