Local silencing controls the oxidative stress response and the multidrug resistance in C andida glabrata
Abstract
Summary: In C andida glabrata , the sirtuins Sir 2 and Hst 1 control the expression of a wide number of genes including adhesins required for host colonization and niacin transporters needed for growth. Given that these sirtuins can be inactivated during infection, we asked if their inhibition could modify the response of C . glabrata to other stressful conditions. Here, we found that deletion of HST1 decreases susceptibility of C . glabrata to fluconazole and hydrogen peroxide. The transcription factor Pdr1 and the ABC transporter Cdr 1 mediated the fluconazole resistance phenotype of the hst1 Δ cells, whereas the transcriptional activator Msn4 and the catalase Cta 1 are necessary to provide oxidative stress resistance. We show that the transcription factor Sum1 interacts with Hst1 and participate in the regulation of these genes. Interestingly, even though C . glabrata and S accharomyces cerevisiae are closely related phylogenetically, deletion of HST1 decreased susceptibility to fluconazole and hydrogen peroxide only in C . glabrata but not in S . cerevisiae , indicating a different transcriptional control by two similar sirtuins. Our findings suggest that Hst 1 acts as a regulator of stress resistance associated‐genes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lack of the histone deacetylase CgHst1 led to high expression of CgCTA1 and elevated resistance to oxidative stress, which was dependent upon CgMsn4.
“Additionally, lack of the histone deacetylase CgHst1 led to high expression of CgCTA1 and elevated resistance to oxidative stress, which was dependent upon CgMsn4 [87].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [87]
Hst1 acts as a regulator of stress resistance associated-genes.
“The findings state that Hst1 acts as a regulator of stress resistance associated-genes [206].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [206]
Pdr1 and CDR1 mediated the fluconazole resistance phenotype of Δhst1 cells, while the transcriptional activator Msn4 and the catalase Cta1 were required to provide oxidative stress resistance.
“Pdr1 and CDR1 mediated the fluconazole resistance phenotype of the Δ hst1 cells, while the transcriptional activator Msn4 and the catalase Cta1 were required to provide oxidative stress resistance.”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [206]
Deletion of HST1 reduced the susceptibility of C. glabrata to fluconazole and hydrogen peroxide.
“The results showed that a deletion of HST1 reduced the susceptibility of C. glabrata to fluconazole and hydrogen peroxide.”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [206]
The transcription factor Sum1 interacts with Hst1 and participates in the regulation of these genes.
“Also, the authors showed that the transcription factor Sum1 interacts with Hst1 and participates in the regulation of these genes.”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [206]
Orta-Zavalza et al. proved that inhibition of sirtuins could change the response of C. glabrata to other stressful conditions.
“With the knowledge that these sirtuins can be inactivated during infection, Orta-Zavalza et al. [206] proved that their inhibition could change the response of C. glabrata to other stressful conditions.”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [206]
Cites
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696 · see citing works
Brachmann, C. B., Davies, A., Cost, G. J., Caputo, E. M., Li, J., Hieter, P., & Boeke, J. D. (1998) · Yeast · doi:10.1002/(sici)1097-0061(19980130)14:2 · Cited by 3,411 · see citing works
Recent progress in the biology and physiology of sirtuins
Finkel, T., Deng, C., & Mostoslavsky, R. (2009) · Nature · doi:10.1038/nature08197 · Cited by 1,484 · see citing works
A simple and efficient method for direct gene deletion inSaccharomyces cerevisiae
Baudin‐Baillieu, A., Ozier-Kalogéropoulos, O., DENOUEL, A., Lacroute, F., & Cullin, C. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.14.3329 · Cited by 1,268 · see citing works
Dynamics of cell wall structure in Saccharomyces cerevisiae
Klis, F. M., Mol, P. C., Hellingwerf, K. J., & Brul, S. (2002) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2002.tb00613.x · Cited by 1,007 · see citing works
Bitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M., & Sinclair, D. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205670200 · Cited by 1,002 · see citing works
Epidemiology of Invasive Mycoses in North America
Pfaller, M. A., & Diekema, D. J. (2010) · Critical Reviews in Microbiology · doi:10.3109/10408410903241444 · Cited by 901 · see citing works
Sauve, A. A., Wolberger, C., Schramm, V. L., & Boeke, J. D. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133500 · Cited by 763 · see citing works
Pfaller, M. A., Diekema, D. J., Gibbs, D. L., Newell, V. A., Ellis, D., Tullio, V., Rodloff, A., Fu, W., & Ling, T. A. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.02117-09 · Cited by 718 · see citing works
Efflux-Mediated Antifungal Drug Resistance
Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., & Monk, B. C. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-08 · Cited by 608 · see citing works
Changing epidemiology of systemic fungal infections
Richardson, M., & Lass-Flörl, C. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2008.01978.x · Cited by 524 · see citing works
An Enzymatic Activity in the Yeast Sir2 Protein that Is Essential for Gene Silencing
Tanny, J. C., Dowd, G. J., Huang, J., Hilz, H., & Moazed, D. (1999) · Cell · doi:10.1016/s0092-8674(00)81671-2 · Cited by 391 · see citing works
Cormack, B. P., Ghori, N., & Falkow, S. (1999) · Science · doi:10.1126/science.285.5427.578 · Cited by 383 · see citing works
Sanglard, D., Ischer, F., Calabrese, D., Majcherczyk, P. A., & Bille, J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.11.2753 · Cited by 337 · see citing works
Sanguinetti, M., Posteraro, B., Fiori, B., Ranno, S., Torelli, R., & Fadda, G. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.668-679.2005 · Cited by 319 · see citing works
Ferrari, S., Ischer, F., Calabrese, D., Posteraro, B., Sanguinetti, M., Fadda, G., Rohde, B., Bauser, C., Bader, O., & Sanglard, D. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000268 · Cited by 295 · see citing works
Vermitsky, J.-P., & Edlind, T. D. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.10.3773-3781.2004 · Cited by 285 · see citing works
Kaur, R., Ma, B., & Cormack, B. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611195104 · Cited by 284 · see citing works
De Las Peñas, A., Pan, S.-J., Castaño, I., Alder, J., Cregg, R., & Cormack, B. P. (2003) · Genes & Development · doi:10.1101/gad.1121003 · Cited by 268 · see citing works
Self-citationMesquita, A., Weinberger, M., Silva, A., Sampaio‐Marques, B., Almeida, B., Leão, C., Costa, V., Rodrigues, F. J. S., Burhans, W. C., & Ludovico, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004432107 · Cited by 268 · see citing works
Nicotinic Acid Limitation Regulates Silencing of <i>Candida</i> Adhesins During UTI
Domergue, R., Castaño, I., De Las Peñas, A., Zupancic, M., Lockatell, V., Hebel, J. R., Johnson, D., & Cormack, B. P. (2005) · Science · doi:10.1126/science.1108640 · Cited by 249 · see citing works
Self-citationSeider, K., Brunke, S., Schild, L., Jablonowski, N., Wilson, D., Majer, O., Barz, D., Haas, A., Kuchler, K., Schaller, M., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003730 · Cited by 220 · see citing works
Mechanism of Increased Fluconazole Resistance in <i>Candida glabrata</i> during Prophylaxis
Bennett, J. E., Izumikawa, K., & Marr, K. A. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.5.1773-1777.2004 · Cited by 217 · see citing works
Xie, J., Pierce, M. M., Gailus-Durner, V., Wagner, M., Winter, E., & Vershon, A. K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6448 · Cited by 209 · see citing works
Moazed, D., Kistler, A. L., Axelrod, A., Rine, J., & Johnson, A. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2186 · Cited by 208 · see citing works
Sirtuin/Sir2 Phylogeny, Evolutionary Considerations and Structural Conservation
Greiss, S., & Gartner, A. (2009) · Molecules and Cells · doi:10.1007/s10059-009-0169-x · Cited by 207 · see citing works
Formation of new chromosomes as a virulence mechanism in yeast <i>Candida glabrata</i>
Poláková, S., Blume, C., Zárate, J. Á., Mentel, M., Jørck-Ramberg, D., Stenderup, J., & Piškur, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809793106 · Cited by 206 · see citing works
Cuéllar-Cruz, M., Briones-Martin-del-Campo, M., Cañas-Villamar, I., Montalvo-Arredondo, J., Riego-Ruiz, L., Castaño, I., & De Las Peñas, A. (2008) · Eukaryotic Cell · doi:10.1128/ec.00011-08 · Cited by 190 · see citing works
Self-citationCastaño, I., Pan, S., Zupancic, M., Hennequin, C., Dujon, B., & Cormack, B. P. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04465.x · Cited by 188 · see citing works
Self-citationCormack, B. P., & Falkow, S. (1999) · Genetics · doi:10.1093/genetics/151.3.979 · Cited by 180 · see citing works
Kaur, R., Castaño, I., & Cormack, B. P. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.5.1600-1613.2004 · Cited by 167 · cited 2× · see citing works
“…transporters engage genetic modifications, such as the acquisition of gain of function mutations in Pdr1(Ferrari et al., 2009), loss of mitochondrial function (Kaur et al., 2004; Ferrari et al., 2011) and increased gene dosage of transporters by chromosomal rearrangements (Polakova et al., 2009).”
BackgroundSelf-citationMechanisms of Azole Resistance in Petite Mutants of <i>Candida glabrata</i>
Brun, S., Bergès, T., Poupard, P., Vauzelle-Moreau, C., Renier, G., Chabasse, D., & Bouchara, J.-P. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.5.1788-1796.2004 · Cited by 151 · see citing works
Ferrari, S., Sanguinetti, M., De Bernardis, F., Torelli, R., Posteraro, B., Vandeputte, P., & Sanglard, D. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01271-10 · Cited by 144 · cited 2× · see citing works
“…transporters engage genetic modifications, such as the acquisition of gain of function mutations in Pdr1(Ferrari et al., 2009), loss of mitochondrial function (Kaur et al., 2004; Ferrari et al., 2011) and increased gene dosage of transporters by chromosomal rearrangements (Polakova et al., 2009).”
BackgroundAutophagy supports<i>Candida glabrata</i>survival during phagocytosis
Roetzer, A., Gratz, N., Kovarik, P., & Schüller, C. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01391.x · Cited by 142 · see citing works
Bedalov, A., Hirao, M., Posakony, J., Nelson, M., & Simon, J. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.19.7044-7054.2003 · Cited by 136 · see citing works
Rai, M. N., Balusu, S., Gorityala, N., Dandu, L., & Kaur, R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002863 · Cited by 117 · see citing works
The conserved role of sirtuins in chromatin regulation
Vaquero, A. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082675av · Cited by 116 · see citing works
Borst, A., Raimer, M. T., Warnock, D. W., Morrison, C. J., & Arthington, B. A. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.783-787.2005 · Cited by 107 · see citing works
Nevitt, T., & Thiele, D. J. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001322 · Cited by 95 · cited 1× · see citing works
“…response (OSR), autophagy, shift in metabolism and chromatin remodelling are required for the survival of C. glabrata inside phagocytes (Kaur et al., 2007; Cuellar-Cruz et al., 2008; Roetzer et al., 2010; 2011; Nevitt and Thiele, 2011; Seider et al., 2011; Rai et al., 2012; Fukuda et al., 2013).”
BackgroundThe Conserved Core of a HumanSIR2Homologue Functions in Yeast Silencing
Sherman, J. M., Stone, E. M., Freeman-Cook, L. L., Brachmann, C. B., Boeke, J. D., & Pillus, L. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.9.3045 · Cited by 94 · see citing works
Regulation of <i>Candida glabrata</i> oxidative stress resistance is adapted to host environment
Roetzer, A., Klopf, E., Gratz, N., Marcet-Houben, M., Hiller, E., Rupp, S., Gabaldón, T., Kovarik, P., & Schüller, C. (2011) · FEBS Letters · doi:10.1016/j.febslet.2010.12.006 · Cited by 90 · see citing works
A Murine Model of Candida glabrata Vaginitis
Fidel, P. L., Cutright, J. L., Tait, L. R., & Sobel, J. D. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/173.2.425 · Cited by 84 · see citing works
McCord, R., Pierce, M. M., Xie, J., Wonkatal, S., Mickel, C., & Vershon, A. K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.6.2009-2016.2003 · Cited by 82 · see citing works
Tn 7 -Based Genome-Wide Random Insertional Mutagenesis of Candida glabrataPreprint
Castaño, I., Kaur, R., Pan, S., Cregg, R. C., Peñas, A. D. L., Guo, N., Biery, M. C., Craig, N. L., & Cormack, B. P. (2003) · Genome Research · doi:10.1101/gr.848203 · Cited by 76 · see citing works
Self-citationHirao, M., Posakony, J., Nelson, M., Hruby, H., Jung, M., Simon, J. A., & Bedalov, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308966200 · Cited by 73 · see citing works
The Glutaredoxin -C-P-Y-C- Motif: Influence of Peripheral Residues
Foloppe, N., & Nilsson, L. (2004) · Structure · doi:10.1016/j.str.2004.01.009 · Cited by 69 · see citing works
Function of <i>Candida glabrata</i> ABC transporter gene, <i>PDH1</i>
Izumikawa, K., Kakeya, H., Tsai, H., Grimberg, B., & Bennett, J. E. (2003) · Yeast · doi:10.1002/yea.962 · Cited by 67 · see citing works
Skn7p is involved in oxidative stress response and virulence of Candida glabrata
Saijo, T., Miyazaki, T., Izumikawa, K., Mihara, T., Takazono, T., Kosai, K., Imamura, Y., Seki, M., Kakeya, H., Yamamoto, Y., et al. (2010) · Mycopathologia · doi:10.1007/s11046-009-9233-5 · Cited by 59 · see citing works
Assimilation of NAD + precursors in Candida glabrata
Ma, B., Pan, S., Zupancic, M. L., & Cormack, B. P. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05886.x · Cited by 54 · see citing works
yKu70/yKu80 and Rif1 Regulate Silencing Differentially at Telomeres in Candida glabrata
Rosas-Hernández, L. L., Juárez‐Reyes, A., Arroyo-Helguera, O. E., Peñas, A. D. L., Pan, S., Cormack, B. P., & Castaño, I. (2008) · Eukaryotic Cell · doi:10.1128/ec.00228-08 · Cited by 46 · see citing works
Self-citationFukuda, Y., Tsai, H.-F., Myers, T. G., & Bennett, J. E. (2013) · Infection and Immunity · doi:10.1128/iai.00851-12 · Cited by 41 · see citing works
Cuéllar‐Cruz, M., Castaño, I., Arroyo-Helguera, O. E., & Peñas, A. D. L. (2009) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762009000400020 · Cited by 41 · see citing works
Self-citationSTB5 Is a Negative Regulator of Azole Resistance in Candida glabrata
Noble, J. A., Tsai, H., Suffis, S. D., Su, Q., Myers, T. G., & Bennett, J. E. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01278-12 · Cited by 40 · see citing works
Ma, B., Pan, S., Domergue, R., Rigby, T., Whiteway, M. S., Johnson, D., & Cormack, B. P. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01461-08 · Cited by 29 · see citing works
Froyd, C. A., & Rusché, L. N. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05175-11 · Cited by 27 · see citing works
Mead, J., McCord, R., Youngster, L. K. G., Sharma, M., Gartenberg, M. R., & Vershon, A. K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01641-06 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Antifungal Drug Resistance: Molecular Mechanisms in <i>Candida albicans</i> and Beyond
Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801 · see citing works
Candida glabrata Biofilms: How Far Have We Come?
Rodrigues, C., Rodrigues, M., Silva, S., & Henriques, M. (2017) · Journal of Fungi · doi:10.3390/jof3010011 · Cited by 129 · see citing works
Candida glabrata: A Lot More Than Meets the Eye
Kumar, K., Askari, F., Sahu, M. S., & Kaur, R. (2019) · Microorganisms · doi:10.3390/microorganisms7020039 · Cited by 128 · see citing works
Drug resistance in Giardia duodenalis
Ansell, B. R. E., McConville, M. J., Ma’ayeh, S. Y., Dagley, M. J., Gasser, R. B., Svärd, S. G., & Jex, A. R. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.04.009 · Cited by 119 · see citing works
Azole Resistance in Candida glabrata
Whaley, S. G., & Rogers, P. D. (2016) · Current Infectious Disease Reports · doi:10.1007/s11908-016-0554-5 · Cited by 85 · see citing works
Histone Deacetylases and Their Inhibition in Candida Species
Garnaud, C., Champleboux, M., Maubon, D., Cornet, M., & Govin, J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01238 · Cited by 85 · see citing works
Tipping the balance both ways: drug resistance and virulence in Candida glabrata
Vale-Silva, L. A., & Sanglard, D. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov025 · Cited by 68 · see citing works
Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases
Pan, Z., Dong, H., Huang, N., & Fang, J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.953078 · Cited by 65 · see citing works
Genome structure and dynamics of the yeast pathogen Candida glabrata
Ahmad, K. M., Kokošar, J., Guo, X., Gu, Z., Ishchuk, O. P., & Piškur, J. (2014) · FEMS Yeast Research · doi:10.1111/1567-1364.12145 · Cited by 57 · see citing works
Gale, A. N., Sakhawala, R. M., Levitan, A., Sharan, R., Berman, J., Timp, W., & Cunningham, K. W. (2020) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.120.401595 · Cited by 56 · see citing works
Recent gene selection and drug resistance underscore clinical adaptation across Candida species
Schikora-Tamarit, M. À., & Gabaldón, T. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01547-z · Cited by 54 · see citing works
Pais, P., Costa, C., Pires, C. M. B. F., Shimizu, K., Chibana, H., & Teixeira, M. C. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.045344 · Cited by 46 · see citing works
Epigenetic Regulation of Antifungal Drug Resistance
Patra, S., Raney, M., Pareek, A., & Kaur, R. (2022) · Journal of Fungi · doi:10.3390/jof8080875 · Cited by 33 · see citing works
Baker, K. M., Hoda, S., Saha, D., Gregor, J. B., Georgescu, L., Serratore, N. D., Zhang, Y., Cheng, L., Lanman, N. A., & Briggs, S. D. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02250-21 · Cited by 30 · see citing works
Briones-Martin-del-Campo, M., Orta-Zavalza, E., Cañas-Villamar, I., Gutiérrez-Escobedo, G., Juárez-Cepeda, J., Robledo-Márquez, K., Arroyo-Helguera, O., Castaño, I., & De Las Peñas, A. (2015) · Microbiology · doi:10.1099/mic.0.000006 · Cited by 29 · see citing works
Self-citationGutiérrez‐Escobedo, G., Hernández-Carreón, O., Morales-Rojano, B., Revuelta-Rodríguez, B., Vázquez-Franco, N., Castaño, I., & Peñas, A. D. L. (2019) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2019.103287 · Cited by 29 · see citing works
Self-citationGale, A. N., Pavesic, M. W., Nickels, T. J., Xu, Z., Cormack, B. P., & Cunningham, K. W. (2023) · mSphere · doi:10.1128/msphere.00254-23 · Cited by 27 · see citing works
Yáñez-Carrillo, P., Orta‐Zavalza, E., Gutiérrez‐Escobedo, G., Patrón‐Soberano, A., Peñas, A. D. L., & Castaño, I. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.04.020 · Cited by 26 · see citing works
Self-citationThe Microevolution of Antifungal Drug Resistance in Pathogenic Fungi
Boyce, K. J. (2023) · Microorganisms · doi:10.3390/microorganisms11112757 · Cited by 25 · see citing works
Genetic Analysis of Sirtuin Deacetylases in Hyphal Growth of Candida albicans
Zhao, G., & Rusché, L. N. (2021) · mSphere · doi:10.1128/msphere.00053-21 · Cited by 25 · see citing works
Antivirulence and avirulence genes in human pathogenic fungi
Siscar-Lewin, S., Hube, B., & Brunke, S. (2019) · Virulence · doi:10.1080/21505594.2019.1688753 · Cited by 25 · see citing works
Peñas, A. D. L., Juárez‐Cepeda, J., López-Fuentes, E., Briones-Martín-del-Campo, M., Gutiérrez‐Escobedo, G., & Castaño, I. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov056 · Cited by 25 · see citing works
Self-citationCalcineurin-dependent contributions to fitness in the opportunistic pathogen <i>Candida glabrata</i>
Pavesic, M. W., Gale, A. N., Nickels, T. J., Harrington, A. A., Bussey, M., & Cunningham, K. W. (2024) · mSphere · doi:10.1128/msphere.00554-23 · Cited by 22 · see citing works
Ren, Z., Dong, X., Guan, L., Yang, L., Liu, C., Cai, X., Hu, H., Lv, Z., Liu, H., Zheng, L., et al. (2024) · New Phytologist · doi:10.1111/nph.19683 · Cited by 21 · see citing works
Moirangthem, R., Kumar, K., & Kaur, R. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02415-20 · Cited by 20 · see citing works
Sirtuins in Epigenetic Silencing and Control of Gene Expression in Model and Pathogenic Fungi
Zhao, G., & Rusché, L. N. (2022) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041020-100926 · Cited by 20 · see citing works
Martins, D., Nguyen, D. M., & English, A. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-45070-w · Cited by 19 · see citing works
Chromatin Structure and Drug Resistance in Candida spp.
O’Kane, C. J., Weild, R., & Hyland, E. M. (2020) · Journal of Fungi · doi:10.3390/jof6030121 · Cited by 19 · see citing works
A fungal sirtuin modulates development and virulence in the insect pathogen, Beauveria bassiana
Cai, Q., Li, T., Xiè, J., Huang, Q., Feng, M., & Keyhani, N. O. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15497 · Cited by 19 · see citing works
The challenges of the genome-based identification of antifungal resistance in the clinical routine
Alastruey‐Izquierdo, A., & Martín-Galiano, A. J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1134755 · Cited by 18 · see citing works
Qasim, M. N., Arevalo, A. V., Nobile, C. J., & Hernday, A. D. (2021) · Journal of Fungi · doi:10.3390/jof7010037 · Cited by 17 · see citing works
Huang, M., & Kao, K. C. (2018) · Yeast · doi:10.1002/yea.3352 · Cited by 16 · see citing works
Genome-Wide Response to Drugs and Stress in the Pathogenic Yeast Candida glabrata
Pais, P., Galocha, M., & Teixeira, M. C. (2019) · Progress in molecular and subcellular biology · doi:10.1007/978-3-030-13035-0_7 · Cited by 16 · see citing works
Telomeric and Sub-Telomeric Structure and Implications in Fungal Opportunistic Pathogens
Diotti, R., Esposito, M. M., & Shen, C. H. (2021) · Microorganisms · doi:10.3390/microorganisms9071405 · Cited by 15 · see citing works
López-Fuentes, E., Hernández-Hernández, G., Castanedo, L., Gutiérrez‐Escobedo, G., Oktaba, K., Peñas, A. D. L., & Castaño, I. (2018) · Genetics · doi:10.1534/genetics.118.301202 · Cited by 12 · see citing works
Self-citationHumphrey, K. M., Zhu, L., Hickman, M. A., Hasan, S., Maria, H., Liu, T., & Rusché, L. N. (2020) · Genetics · doi:10.1534/genetics.120.303087 · Cited by 12 · see citing works
Naskar, S., Prajapati, A., & Kaur, R. (2025) · FEMS Yeast Research · doi:10.1093/femsyr/foaf025 · Cited by 11 · see citing works
Paul, S. K., McDonald, W. H., & Moye-Rowley, S. (2018) · Molecular Microbiology · doi:10.1111/mmi.14109 · Cited by 11 · see citing works
Bhakt, P., Shivarathri, R., Choudhary, D. K., Borah, S., & Kaur, R. (2018) · Molecular Microbiology · doi:10.1111/mmi.14110 · Cited by 11 · see citing works
Leiva-Peláez, O., Gutiérrez-Escobedo, G., López-Fuentes, E., Cruz-Mora, J., De Las Peñas, A., & Castaño, I. (2018) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2018.05.005 · Cited by 10 · see citing works
Self-citationNickels, T. J., Gale, A. N., Harrington, A. A., Timp, W., & Cunningham, K. W. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae173 · Cited by 10 · see citing works
Santos, F. J. P.-D. L., García-Ortega, L. F., Robledo-Márquez, K., Guzmán-Moreno, J., & Riego‐Ruiz, L. R. (2021) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2012.12034 · Cited by 10 · see citing works
Spectrum of activity and mechanisms of azole–bisphosphonate synergy in pathogenic Candida
Kane, A., Dinh, H., Campbell, L. T., Cain, A. K., Hibbs, D. E., & Carter, D. A. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00121-24 · Cited by 9 · see citing works
Robledo-Márquez, K., Gutiérrez‐Escobedo, G., Yáñez-Carrillo, P., Vidal-Aguiar, Y., Briones-Martín-del-Campo, M., Orta‐Zavalza, E., Peñas, A. D. L., & Castaño, I. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow082 · Cited by 9 · see citing works
Self-citationNickels, T. J., & Cunningham, K. W. (2025) · mSphere · doi:10.1128/msphere.00270-25 · Cited by 8 · see citing works
Rupert, C. B., & Rusché, L. N. (2022) · mSphere · doi:10.1128/msphere.00029-22 · Cited by 8 · see citing works
Rupert, C. B., Heltzel, J. M. H., Taylor, D. J., & Rusché, L. N. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.033845 · Cited by 8 · see citing works
Lin, C.-J., Yang, S.-Y., Hsu, L.-H., Yu, S.-J., & Chen, Y.-L. (2023) · Medical Mycology · doi:10.1093/mmy/myad004 · Cited by 7 · see citing works
Microevolution of Candida glabrata (Nakaseomyces glabrata) during an infection
López-Marmolejo, A. L., Hernández-Chávez, M. J., Gutiérrez‐Escobedo, G., Herrera-Basurto, M. S., Mora-Montes, H. M., Peñas, A. D. L., & Castaño, I. (2024) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2024.103891 · Cited by 6 · see citing works
Self-citationCuan, R., Liu, S., Zhou, C., Wang, S., Zheng, Y., & Yuan, Y. (2024) · Microorganisms · doi:10.3390/microorganisms12050888 · Cited by 5 · see citing works
Natural trait variation across Saccharomycotina species
Wang, J.-T. J., Steenwyk, J. L., & Brem, R. B. (2024) · FEMS Yeast Research · doi:10.1093/femsyr/foae002 · Cited by 4 · see citing works
Sierra‐Campos, E., Valdez-Solana, M. A., Ruiz‐Baca, E., Ventura-García, E. K., Avitia-Domínguez, C. I., Aguilera-Ortíz, M., & Téllez‐Valencia, A. (2022) · Scientia Pharmaceutica · doi:10.3390/scipharm90040070 · Cited by 2 · see citing works
Candida glabrata Hst1-Rfm1-Sum1 complex evolved to control virulence-related genes
Vázquez-Franco, N., Gutiérrez‐Escobedo, G., Juárez‐Reyes, A., Orta‐Zavalza, E., Castaño, I., & Peñas, A. D. L. (2021) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2021.103656 · Cited by 2 · see citing works
Self-citationLee, Y.-H., Hsu, L.-H., Yu, Z.-H., Leong, K.-Q., Chiang, H.-S., & Chen, Y. (2025) · Journal of Infection · doi:10.1016/j.jinf.2025.106595 · Cited by 1 · see citing works
González-Ruiz, R., Montalvo-Arredondo, J. I., Gómez‐Hernández, N., Mancilla-Montelongo, G., Contreras-Bravo, Y., López-Ramos, J. E., Gutiérrez‐Escobedo, G., Castaño, I., & Peñas, A. D. L. (2026) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2026.104106 · Cited by 1 · see citing works
Self-citationGenome dynamics and virulence in the human pathogen Candida glabrata
Ahmad, K. M. (2014) · Lund University Publications (Lund University)
Acharjee, M., Humphrey, K. M., Lactaoen, V., Karageorgiou, C., Liu, B., Gökçümen, Ö., & Rusché, L. N. (2026) · Genetics · doi:10.1093/genetics/iyag025
Etude fonctionnelle et inhibition de la protéine Bdf1 chez Candida albicans
Champleboux, M. (2016) · theses.fr (ABES) · doi:10.70675/07079ce8z25e3z45dfz98e6ze8e3ccbc6182
Caracciolo, M., Caracciolo, S. A., Stagno, M. F., Papola, C., Pellicano, S., Nicolò, G. M., D’Aleo, F., Ripepi, A., Scopelliti, C., Principe, L., et al. (2026) · Journal of Fungi · doi:10.3390/jof12110802
- Authors
- Orta‐Zavalza, E., Guerrero‐Serrano, G., Gutiérrez‐Escobedo, G., Cañas‐Villamar, I., Juárez‐Cepeda, J., Castaño, I., & De Las Peñas, A.
- Affiliations
- Institute for Scientific and Technological Research (MX)
- IPICYT División de Biología Molecular Instituto Potosino de Investigación Científica y Tecnológica Camino a la Presa San José 2055 Lomas 4<sup>a</sup> sección San Luis Potosí 78216 México
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2013-05-16
- Volume
- 88
- Issue
- 6
- Pages
- 1135-1148
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W1547006808
- Semantic Scholar
- 5979ac2bcc6880a6d093932192f56d947dcac5ab
- Cited by
- 61
- References
- 56
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 3
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- Candida glabrata, oxidative stress response, multidrug resistance, fluconazole resistance, hydrogen peroxide resistance, transcriptional regulation, Saccharomyces cerevisiae comparison, antifungal susceptibility
- MeSH terms
- Antifungal Agents, Fungal Proteins, Hydrogen Peroxide, Stress, Physiological, Transcription Factors, Fluconazole, Gene Expression Regulation, Fungal, Gene Deletion, Oxidative Stress, Protein Interaction Mapping, Drug Resistance, Multiple, Fungal, Sirtuins, Candida glabrata
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
