Evaluation of elevated urinary enolase I levels in patients with endometriosis
Open accessAbstract
OBJECTIVE: The aim of this study is to validate and investigate the clinical value of urinary enolase I in patients with endometriosis. METHODS: Urine samples of 39 patients with histologically confirmed endometriosis and 20 patients without endometriosis were collected. Western blot analysis and enzyme-linked immunosorbent assay were used to detect the increase of enolase I in patients' urine. RESULTS: Urinary enolase I expression corrected for creatinine ratio (non neuronal enolase (NNE)-Cr) was significantly greater in patients with endometriosis (p = 0.026). When the diagnostic performance of NNE-Cr was evaluated with serum CA-125 combination, the area under the curve was 0.821 (95% confidence interval 0.713-0.928) with sensitivity and specificity of 76.9% and 85.0%, respectively. CONCLUSION: Elevated urinary enolase I, in conjunction with serum CA-125, may be used as a potential biomarker for endometriosis.
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Enolase-1 lacked sufficient diagnostic power as an individual analyte (sensitivity 56% and specificity 72%) in a separate study.
“Despite elevation in women with endometriosis, enolase-1 lacked sufficient diagnostic power as an individual analyte (sensitivity 56% and specificity 72%) in a separate study [108].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [108]
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- Authors
- Yun, B. H., Lee, Y. S., Chon, S. J., Jung, Y. S., Yim, S. Y., Kim, H. Y., Park, J. H., Seo, S. K., Cho, S., Choi, Y. S., & Lee, B. S.
- Affiliations
- Yonsei University (KR)
- Corresponding author
- Cho, SiHyun
- ORCID
- Venue
- Biomarkers
- Publisher
- Informa UK Limited
- Published
- 2013-11-28
- Volume
- 19
- Issue
- 1
- Pages
- 16-21
- ISSN
- 1354-750X (ISSN-L)
- 1366-5804
- OpenAlex
- W2050558848
- Cited by
- 17
- References
- 41
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2018: 2 · 2016: 2 · 2015: 2 · 2014: 1
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- Locations
- Biomarkers (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Keywords
- endometriosis, CA125, diagnostic accuracy, serum biomarkers, urinary biomarkers
- MeSH terms
- Adult, Creatinine, DNA-Binding Proteins, Endometriosis, Female, Humans, Phosphopyruvate Hydratase, ROC Curve, Biomarkers, Tumor, Biomarkers, Case-Control Studies, CA-125 Antigen, Tumor Suppressor Proteins
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