The DOI matches its Crossref record; 121 of the 132 references it cites were found in a registry or an index; 3 of the 73 sources its claims cite were checked for support.
Biomarkers in endometriosis: challenges and opportunities
Open accessAbstract
Endometriosis is a debilitating gynecologic disease affecting millions of women across the world, with symptoms including dysmenorrhea, chronic pelvic pain, and infertility. Theorized to stem from the phenomenon of retrograde menstruation, the diagnosis of endometriosis is typically delayed by 8-10 years owing to misinterpretation of symptoms as common menstrual cramps in adolescent girls and young women. With increased incidence of endometriosis in young girls correlated with earlier menarche, the development of diagnostic biomarkers is imperative for diagnosing and treating women afflicted with endometriosis as early as we can. In the past few years, multiple reviews highlighted the list of potential diagnostic candidates in peritoneal fluid, blood, urine, and endometrial biopsies from endometriosis patients in different stages of disease and menstrual cycle. In this review, we explore the opportunities and challenges facing the field of diagnostic biomarkers for endometriosis. We highlight the importance of eutopic endometrium as a source of potential diagnostic biomarkers by looking at the expression levels of noncoding RNA in tissue as well as in blood. Finally, we discuss some of the challenges that hinder our efforts in validating candidate diagnostic biomarkers for endometriosis.
Overview
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Written from the paper’s full text.
TL;DR
This review argues that noninvasive diagnostic biomarkers for endometriosis are urgently needed because diagnosis is typically delayed by 8–10 years, but disease heterogeneity, comorbidities, and nonstandardized sample collection hinder validation. It highlights eutopic endometrium and circulating/tissue noncoding RNAs as promising candidates, while cautioning that inflammatory cytokines and endometrial DNA methylome have not proven sufficiently specific.
Key findings
- Diagnostic delay is substantial: adolescent girls delay seeking medical attention by 4.6 years, and it takes another 4.7 years until diagnosis; overall diagnosis is typically delayed by 8–10 years.
- Endometriosis symptoms are more common than in women without endometriosis: nonmenstrual pelvic pain 38.7% vs. 14.3%, dyspareunia 29.5% vs. 13.4%, and infertility 11.6% vs. 3.4%; economic burden is $1.8 billion in Canada and $18–22 billion in the United States.
- Candidate noncoding RNA biomarkers show diagnostic potential: plasma brain-derived neurotropic factor for stage I–II disease had 91.7% sensitivity and 69.4% specificity; circulating let-7b had 83.3% sensitivity and 100% specificity; miR-17-5p, miR-20a, and miR-22 discriminated severe endometriosis with an AUC of 0.90; a five-lncRNA combination had 89.7% sensitivity and 73.2% specificity.
- Cytokine panels have been tested but are limited: one six-marker panel showed 60%–71% specificity and 87%–92% sensitivity, and a 28-biomarker panel showed 63%–81% specificity and 81%–90% sensitivity, but control selection and nonendometriotic pelvic inflammation can confound results.
Methods
- Design: narrative review of diagnostic biomarkers for endometriosis, focused on opportunities and challenges in validation.
- Data/sample: literature on candidate biomarkers from peritoneal fluid, blood, urine, endometrial biopsies, eutopic endometrium, and epigenetic markers, including miRNA and lncRNA; no primary cohort or new experimental data are reported.
- Main analysis: synthesizes prior reviews, meta-analyses, and selected studies to evaluate biomarker specificity/sensitivity and discuss barriers to clinical validation; evident from the text that this is not a systematic review or meta-analysis.
Limitations
- The paper states that endometriosis is heterogeneous in phenotype and symptoms, with endopelvic and extrapelvic manifestations, and that comorbidities such as autoimmune disorders, migraines, gastrointestinal problems, and adenomyosis can mask or confound biomarker signals.
- The paper states that biomarker studies are limited by unstandardized sample collection, storage, and phenotyping; small sample sizes; lack of representation across all disease stages and menstrual stages; and discrepancies between tissue and blood miRNA expression.
- Evident from the text: as a narrative review, it does not provide a systematic search strategy, quantitative synthesis, or primary validation data, so its conclusions depend on selected published literature.
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Claims the paper makes
52 Not checked yet · 14 Own interpretation · 3 Supported · 2 No basis given
Every source the paper cites for this claim was checked and supports it.
In the paper
“MicroRNA expression in normal endometrium exhibits dynamic changes across the menstrual cycle (105), where their involvement in nonpathologic mechanisms can be used to understand physiologic systems that have derailed into pathologic phenotypes.”
§ Biomarkers in endometriosis: challenges and opportunities > MicroRNA and Long Noncoding RNA
What the sources say
- Supportedcites [105] Rekker, 2013, Circulating microRNA profile throughout the menstrual cycle, PLoS One source
The Introduction reports that several studies found fluctuations in endometrial miRNA profiles across the menstrual cycle. The Discussion likewise describes differential expression in receptive and non-receptive endometrium. The paper’s finding of no significant change concerns circulating plasma miRNAs, not endometrial tissue. (LLM, conf=0.93)
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“In addition, Wang et al. (2016) showed that a combination of five lncRNAs can differentiate patients from disease-free control subjects with 89.7% sensitivity and 73.2% specificity, further demonstrating the potential of circulating lncRNA as a noninvasive diagnostic biomarker for endometriosis (112).”
§ Biomarkers in endometriosis: challenges and opportunities > Ahn. Biomarkers in endometriosis. Fertil Steril 2017.
What the sources say
- Supportedcites [112] Wang, 2016, Genome-wide long noncoding RNA analysis identified circulating lncRNAs as novel noninvasive diagnostic biomarkers for gynecological disease, Sci Rep source
The Results section, “Investigation of circulating lncRNAs for use in the diagnosis of endometriosis,” reports 89.66% sensitivity and 73.17% specificity for the five-lncRNA combination, matching the citing sentence after rounding. The Discussion identifies those circulating lncRNAs as potential non-invasive biomarkers for endometriosis. (LLM, conf=0.95)
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Supported
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In the paper
“They further identified 1,557 lncRNAs specific to the serum and 1,310 lncRNAs specific to the endometriotic tissues of endometriosis patients (112), demonstrating that the function of lncRNAs in serum may be different from that of lncRNAs found in tissue, echoing a similar pattern found in miRNA expression patterns in serum and tissue.”
§ Biomarkers in endometriosis: challenges and opportunities > Ahn. Biomarkers in endometriosis. Fertil Steril 2017.
What the sources say
- Supportedcites [112] Wang, 2016, Genome-wide long noncoding RNA analysis identified circulating lncRNAs as novel noninvasive diagnostic biomarkers for gynecological disease, Sci Rep source
The Results section on differential expression between tissue and serum explicitly says that the expression pattern and function of serum lncRNAs may differ from those in tissue. The same section reports 1,557 lncRNAs present only in the serum set and 1,310 present only in the endometriosis tissue set. (LLM, conf=0.95)
hedgedconditional- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“For decades, both basic and clinical research have been much focused on elucidating the pathogenesis of endometriosis, but they have lumped different phenotypes of the disease, including ovarian, peritoneal, and deep infiltrating endometriosis, as one entity.”
§ Biomarkers in endometriosis: challenges and opportunities > Heterogeneous Nature of Endometriosis and Endometriosis-Associated Symptoms
plain- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“which have demonstrated that the endometrium of endometriosis patients displays aberrant molecular expression patterns that give it the ability to implant, invade, and develop into endometriotic foci (27)(28)(29)(30).”
§ Biomarkers in endometriosis: challenges and opportunities > E
What the sources say
- Not checked yetcites [27] Burney, 2007, Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis, Endocrinology source
- Not checked yetcites [28] Bulun, 2006, Progesterone resistance in endometriosis: link to failure to metabolize estradiol, Mol Cell Endocrinol source
- Not checked yetcites [29] Mehasseb, 2011, Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis, Fertil Steril source
boosteddirect- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
In the paper
“For example, Naqvi et al. (26) observed five hypermethylated (MGMT, DUSP22, CDCA2, ID2, and RBBP7) and five hypomethylated (TNFRSF1B, MBPR1B, ZNF681, IGSF21, and TP73) genes in eutopic endometrium of patients compared with endometriosis-free control subjects.”
§ Biomarkers in endometriosis: challenges and opportunities > Assessing the Usefulness of Endometrial Biopsies
What the sources say
- Not checked yetcites [26] Naqvi, 2014, Altered genome-wide methylation in endometriosis, Reprod Sci source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Such heterogeneity of disease phenotype also increases the potential of false-negative laparoscopic surgery in symptomatic women, wherein a ''clean'' pelvic cavity might not necessarily indicate the absence of endometriosis in other areas of the body (Table 1).”
§ Biomarkers in endometriosis: challenges and opportunities > Heterogeneous Nature of Endometriosis and Endometriosis-Associated Symptoms
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Unless accompanied by explorative laparoscopic surgery for complete diagnosis, accurate differential diagnosis in potential endometriosis patients based on symptoms proves to be a difficult challenge.”
§ Biomarkers in endometriosis: challenges and opportunities > Heterogeneous Nature of Endometriosis and Endometriosis-Associated Symptoms
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The concentration of peripheral markers in blood and peritoneal fluid may be diluted with factors that are driving the development of conditions other than endometriosis in patients.”
§ Biomarkers in endometriosis: challenges and opportunities > Comorbidities
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“Case studies have shown that symptoms of pelvic pain are not a useful diagnostic parameter to differentiate women with or without endometriosis (54), owing to the similarity of symptoms with other pelvic pain pathologies, such as irritable bowel disease.”
§ Biomarkers in endometriosis: challenges and opportunities > Heterogeneous Nature of Endometriosis and Endometriosis-Associated Symptoms
What the sources say
- Not checked yetcites [54] Ballard, 2010, Can specific pain symptoms help in the diagnosis of endometriosis? A cohort study of women with chronic pelvic pain, Fertil Steril source
plain- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
- It may state two separate claims as one. 8
- Probably not a substantial claim. 2
In the paper
“Owing to the common misinterpretation of endometriosis-induced pain as menstrualrelated abdominal pain, the diagnosis of endometriosis is typically delayed by 8-10 years: Adolescent girls who suffer from the symptoms of endome-triosis delay seeking medical attention by 4.6 years, and by the time they seek medical attention, it takes another 4.7 years until diagnosis (11).”
§ Biomarkers in endometriosis: challenges and opportunities > E
What the sources say
- Not checked yetcites [11] Greene, 2009, Diagnostic experience among 4,334 women reporting surgically diagnosed endometriosis, Fertil Steril source
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
In the paper
“Furthermore, As-Sanie et al. demonstrated that increased concentration of glutamine and glutamate within the anterior insula and greater neuronal connectivity from the anterior insula to the medial prefrontal cortex positively correlated with not only pain intensity, but also clinical anxiety and depression in patients (60).”
§ Biomarkers in endometriosis: challenges and opportunities > Heterogeneous Nature of Endometriosis and Endometriosis-Associated Symptoms
What the sources say
- Not checked yetcites [60] As-Sanie, 2016, Functional connectivity is associated with altered brain chemistry in women with endometriosis-associated chronic pelvic pain, J Pain source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Endometriosis is a complex disease with variable phenotypic and symptomatic presentation in women (14,15).”
§ Biomarkers in endometriosis: challenges and opportunities > E
What the sources say
- Not checked yetcites [14] Vercellini, 2007, Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients, Hum Reprod source
- Not checked yetcites [15] Acién, 2013, Endometriosis: a disease that remains enigmatic, Int Sch Res Not Obstet Gynecol
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Furthermore, basic scientific research on the pathogenesis of extrapelvic endometriosis is limited.”
§ Biomarkers in endometriosis: challenges and opportunities > Heterogeneous Nature of Endometriosis and Endometriosis-Associated Symptoms
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“The method of obtaining endometrial sample by either pipelle or curette is minimally invasive; however, aside from minimal discomfort for the patient, biopsy can prove to be a useful not only to test endometrial receptivity in infertile women with or without endometriosis (81), but also as a diagnostic tool for endometriosis in an outpatient setting (82).”
§ Biomarkers in endometriosis: challenges and opportunities > Assessing the Usefulness of Endometrial Biopsies
What the sources say
- Not checked yetcites [81] Garcia-Velasco, 2015, Is endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study, Reprod Biomed Online source
- Not checked yetcites [82] Saare, 2016, The influence of menstrual cycle and endometriosis on endometrial methylome, Clin Epigenetics source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Because endometriosis can be found in asymptomatic women, however, the biochemical pathway of nerve stimulation by the release of damage-associated molecular patterns and pathogen-associated molecular patterns by the menstrual debris (58) does not apply to the asymptomatic women, suggesting that the inflammation caused by ''menstruating'' ectopic foci and menstrual debris may not be the sole cause”
§ Biomarkers in endometriosis: challenges and opportunities > Heterogeneous Nature of Endometriosis and Endometriosis-Associated Symptoms
What the sources say
- Not checked yetcites [58] Laux-Biehlmann, 2015, Menstruation pulls the trigger for inflammation and pain in endometriosis, Trends Pharmacol Sci source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Even though GWASs have identified numerous SNPs associated with endometriosis risk across multiple populations, the strengths of the studies are affected by unstandardized methods of biologic sample collection, storage, and phenotyping of samples across studies, which may invariably lead to heterogeneous interpretations and findings (24).”
§ Biomarkers in endometriosis: challenges and opportunities > In Search of Molecular Patterns Unique to Endometriosis
What the sources say
- Not checked yetcites [24] Rahmioglu, 2014, Genetic variants underlying risk of endometriosis: Insights from meta-analysis of eight genome-wide association and replication datasets, Hum Reprod Update source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The studies showed that a panel of cytokines, rather than a single biomarker, improve sensitivity and specificity values, with some panels showing the ability to discriminate between different stages of disease.”
§ Biomarkers in endometriosis: challenges and opportunities > Biomarkers That Were Not So Useful: Inflammatory Cytokines
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: The physiologic process of menstruation is an inflammatory event.
None of the sources cited for this claim have been checked yet.
In the paper
“However, one limiting factor hindering the exploration of miRNA as biomarkers in clinical trials is the small sample sizes of patients and lack of representation of all stages of endometriosis, which are also stratified by menstrual stage (85, 109, 110).”
§ Biomarkers in endometriosis: challenges and opportunities > Ahn. Biomarkers in endometriosis. Fertil Steril 2017.
What the sources say
- Not checked yetcites [85] Burney, 2009, MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis, Mol Hum Reprod source
- Not checked yetcites [109] Cho, 2015, Circulating microRNAs as potential biomarkers for endometriosis, Fertil Steril source
- Not checked yetcites [110] Jia, 2013, Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis, Hum Reprod source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, miRNA profiling of eutopic endometrium in endometriosis patients would provide pathophysiologic molecular fingerprints that we can use to further understand disease pathogenesis and as potential noninvasive biomarkers for endometriosis.”
§ Biomarkers in endometriosis: challenges and opportunities > MicroRNA and Long Noncoding RNA
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper relies on this without support.
Laparoscopic surgery remains the current criterion-standard diagnostic tool for endometriosis.
“Laparoscopic surgery remains the current criterion-standard diagnostic tool; however, it is unlikely that women of reproductive age would subject themselves to such an invasive surgery when they can opt to temporarily diminish pain symptoms by means of other therapeutic mechanisms.”
The paper relies on this without support.
Women of reproductive age would be unlikely to subject themselves to laparoscopic surgery when they can opt to temporarily diminish pain symptoms by other therapeutic mechanisms.
“Laparoscopic surgery remains the current criterion-standard diagnostic tool; however, it is unlikely that women of reproductive age would subject themselves to such an invasive surgery when they can opt to temporarily diminish pain symptoms by means of other therapeutic mechanisms.”
The paper relies on this without support.
Only 10% of women develop endometriosis.
“This is critical to elucidate why only 10% of women develop endometriosis although the phenomenon of retrograde menstruation occurs in 76%-90% of reproductive-age women (94)(95)(96).”
The paper relies on this without support.
The physiologic process of menstruation is an inflammatory event.
“The physiologic process of menstruation is an inflammatory event, as is the pathophysiologic process of endometriosis.”
The paper relies on this without support.
There is a need for a diagnostic biomarker for endometriosis.
“Along with the need to better understand the pathophysiology of endometriosis, the need for a diagnostic biomarker for endometriosis has been equally recognized.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The time from the appearance of the first symptoms of the disease to the diagnosis is up to 8 to 10 years [38].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Biomarkers in endometriosis: challenges and opportunities > Heterogeneous Nature of Endometriosis and Endometriosis-Associated Symptoms
“Endometriosis is often described as occurring in three areas in the pelvis-in the peritoneum, on the ovary, and in the rectovaginal pouch-which are referred to as peritoneal implants, ovarian endometrioma, and deep infiltrating endometriosis, respectively.”
§ Biomarkers in endometriosis: challenges and opportunities > Heterogeneous Nature of Endometriosis and Endometriosis-Associated Symptoms
“The extrapelvic manifestations include the typical peritoneal or abdominal wall endometriosis, including endometriosis found on surgical scars on the peritoneum (44,45), the urinary and gastrointestinal tract, the thorax, and the nasal mucosa (42).”
Citations
Cites
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
ESHRE guideline: management of women with endometriosis
Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D'Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., et al. (2014) · Human Reproduction · doi:10.1093/humrep/det457 · Cited by 2,211
Endometriosis: pathogenesis and treatment
Vercellini, P., Viganò, P., Somigliana, E., & Fedele, L. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.255 · Cited by 1,940
Giudice, L. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1000274 · Cited by 1,924
Pathogenesis and pathophysiology of endometriosis
Burney, R. O., & Giudice, L. C. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.06.029 · Cited by 1,590
Nisolle, M., & Donnez, J. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00191-x · Cited by 1,279
(1927) · PubMed Central · Cited by 1,008
(1984) · PubMed · Cited by 997
Sources of estrogen and their importance
Simpson, E. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00360-1 · Cited by 936
Estrogen production and action
Nelson, L. R., & Bulun, S. E. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.117432 · Cited by 834
Research works printed but not linked: 3
- Liu, 2015, Urinary biomarkers for the noninvasive diagnosis of endometriosis, Cochrane Database Syst Rev, CD012019
- Nisenblat, 2016, Imaging modalities for the noninvasive diagnosis of endometriosis, Cochrane Database Syst Rev, CD009591
- Nisenblat, 2016, Combination of the noninvasive tests for the diagnosis of endometriosis, Cochrane Database Syst Rev, CD012281
Cited by
Sorted by citations
Pathophysiology, diagnosis, and management of endometriosis
Horne, A. W., & Missmer, S. A. (2022) · BMJ · doi:10.1136/bmj-2022-070750 · Cited by 661
“87 However, the extent to which this inflammation is a cause or an effect of endometriosis remains unclear.”
BackgroundClinical Management of Endometriosis
Falcone, T., & Flyckt, R. L. (2018) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002469 · Cited by 582
The Immunopathophysiology of Endometriosis
Symons, L. K., Miller, J. E., Kay, V. R., Marks, R. M., Liblik, K., Koti, M., & Tayade, C. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.07.004 · Cited by 601
“There is a real need to establish sensitivity, specificity, and clinical utility of several biomarkers that have been identified in recent years [92].”
BackgroundSelf-citationSmolarz, B., Szyłło, K., & Romanowicz, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910554 · Cited by 560
The Main Theories on the Pathogenesis of Endometriosis
Lamceva, J., Uljanovs, R., & Strumfa, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054254 · Cited by 324
“Usually it takes up to 8 to 10 years to reach the diagnosis of this disease [4].”
BackgroundBiomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives
Anastasiu, C. V., Moga, M., Neculau, A. E., Bălan, A., Scârneciu, I., Dragomir, R. M., Dull, A.-M., & Chicea, L.-M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051750 · Cited by 202
“The increased incidence of this pathology in women with early menarche compels the development of novel noninvasive diagnostic biomarkers for faster diagnosis, appropriate treatment, and for triaging potential patients for surgery [9,10].”
BackgroundAnti-inflammatory cytokines in endometriosis
Zhou, W., Yang, H., Shao, J., Mei, J., Chang, K., Zhu, R., & Li, M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03056-x · Cited by 198
Cyclooxygenase-2 in Endometriosis
Lai, Z., Yang, H., Ha, S., Chang, K., Mei, J., Zhou, W.-J., Qiu, X., Wang, X.-Q., Zhu, R., Li, D., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.35128 · Cited by 176
“In the past few years, the field of diagnostic biomarkers for EMS has gained increasing attention [10].”
BackgroundThe management of menopause in women with a history of endometriosis: A systematic review
Gemmell, L. C., Webster, K. E., Kirtley, S., Vincent, K., Zondervan, K. T., & Becker, C. M. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx011 · Cited by 154
“However, due to a lack of reliable diagnostic tools and the non-specific nature of the symptoms, there exists a widely recognized delay in diagnosis of 8–10 years (Ahn et al., 2017).”
BackgroundMicroRNAs in endometriosis: biological function and emerging biomarker candidates†
Bjorkman, S. H., & Taylor, H. S. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz014 · Cited by 131
“Several recent review articles have addressed the current challenges in pursuit of noninvasive diagnostic markers for endometriosis (see [129, 130] and [131]).”
BackgroundmiR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo
Liang, Z., Chen, Y., Zhao, Y., Xu, C., Zhang, A., Zhang, Q., Wang, D., He, J., Hua, W., & Duan, P. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0706-z · Cited by 119
“Recent studies have revealed that lncRNAs have crucial roles in endometriosis [9].”
Gut Microbiota Exceeds Cervical Microbiota for Early Diagnosis of Endometriosis
Huang, L., Liu, B., Liu, Z., Feng, W.-Q., Liu, M., Wang, Y., Peng, D., Fu, X., Zhu, H., Cui, Z., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.788836 · Cited by 118
“A solid diagnosis of endometriosis requires surgical visualization with histological verification (Rösner and Böger, 1979); however, it is unrealistic for all women with suspected endometriosis to receive an invasive surgery while the recurrence rate is high and the surgery could possibly damage the reproductive syste…”
Nanoparticles in pregnancy: the next frontier in reproductive therapeutics
Pritchard, N., Kaitu’u‐Lino, T. J., Harris, L. K., Tong, S., & Hannan, N. J. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa049 · Cited by 101
“To date, although circulating biomarkers have been linked to endometriosis, none have the sensitivity or specificity to be incorporated into routine clinical care (May et al., 2010; Ahn et al., 2017).”
BackgroundMáté, G., Bernstein, L. R., & Török, Á. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00725 · Cited by 93
Endometrial microbiota is more diverse in people with endometriosis than symptomatic controls
Wessels, J. M., Domínguez, M. A., Leyland, N. A., Agarwal, S. K., & Foster, W. G. (2021) · Scientific Reports · doi:10.1038/s41598-021-98380-3 · Cited by 88
Mariadas, H., Chen, J.-H., & Chen, K.-H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062458 · Cited by 107
MicroRNAs in the Regulation of Endometrial Receptivity for Embryo Implantation
Shekibi, M., Heng, S., & Nie, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116210 · Cited by 74
New biomarkers in endometriosis
(2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2018.12.002 · Cited by 72
Morelli, M. A. C., Iuliano, A., Schettini, S. C. A., Petruzzi, D., Ferri, A., Colucci, P., Viggiani, L., Cuviello, F., & Ostuni, A. (2019) · Metabolomics · doi:10.1007/s11306-019-1481-x · Cited by 70
Li, J., Gao, Y., Guan, L., Zhang, H., Sun, J., Gong, X., Li, D., Chen, P., Ma, Z., Liang, X., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00014 · Cited by 68
“Instead of peripheral blood or urine, endometrium might contain various information to indicate the presence of endometriosis, using the direct source of the disease is perhaps logical to identify biomarkers for endometriosis (Ahn et al., 2017).”
BackgroundMoga, M., Bălan, A., Dimienescu, O. G., Burtea, V., Dragomir, R. M., & Anastasiu, C. V. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050735 · Cited by 67
“The diagnosis is delayed by 8–10 years due to the misinterpretation of endometriosis symptoms as common menstrual cramps [2].”
BackgroundJiang, J., Jiang, Z., & Xue, M. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1554034 · Cited by 66
“the serum and PF levels of these specific cytokines is useful for the diagnosis of endometriosis [13].”
BackgroundOvarian endometrioma – a possible finding in adolescent girls and young women: a mini-review
Gałczyński, K., Jóźwik, M., Lewkowicz, D., Semczuk‐Sikora, A., & Semczuk, A. (2019) · Journal of Ovarian Research · doi:10.1186/s13048-019-0582-5 · Cited by 74
Nanomedicines for Endometriosis: Lessons Learned from Cancer Research
Moses, A. S., Demessie, A. A., Taratula, O. R., Korzun, T., Slayden, O. D., & Taratula, O. (2021) · Small · doi:10.1002/smll.202004975 · Cited by 67
Li, J., Guan, L., Zhang, H., Gao, Y., Sun, J., Gong, X., Li, D., Chen, P., Liang, X., Huang, M., et al. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0360-z · Cited by 65
“In the past few years, several studies identified a list of potential diagnostic candidates in peritoneal fluid, blood and urine from endometriosis patients at different stages of disease and menstrual cycle [9, 10].”
BackgroundPeritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes
Zhou, J., Chern, B. S. M., Barton‐Smith, P., Phoon, J. W. L., Tan, T. Y., Viardot-Foucault, V., Ku, C. W., Tan, H. H., Chan, J. K. Y., & Lee, Y. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103515 · Cited by 64
McKillop, M. M., Mamykina, L., & Elhadad, N. (2018) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3173574.3174139 · Cited by 61
“There are no known biomarkers to help diagnose or monitor the progression of the disease [3].”
BackgroundAssisted reproduction in endometriosis
de Ziegler, D., Pirtea, P., Carbonnel, M., Poulain, M., Cicinelli, E., Bulletti, C., Kostaras, K., Kontopoulos, G., Keefe, D. L., & Ayoubi, J. M. (2018) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2018.10.001 · Cited by 56
O, D. F., Flores, I., Waelkens, E., & D’Hooghe, T. M. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.04.001 · Cited by 55
“This diagnostic delay can be attributed to the need for laparoscopy for diagnosis, the variability of disease symptoms and the overlap in symptoms with other diseases [1,3].”
BackgroundApoptotic functions of microRNAs in pathogenesis, diagnosis, and treatment of endometriosis
Taghavipour, M., Sadoughi, F., Mirzaei, H., Yousefi, B., Moazzami, B., Chaichian, S., Mansournia, M. A., & Asemi, Z. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-0381-0 · Cited by 54
Kimber-Trojnar, Ż., Pilszyk, A., Niebrzydowska-Tatus, M., Pilszyk, Z., Ruszała, M., & Leszczyńska‐Gorzelak, B. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132762 · Cited by 54
Freitag, N., Pour, S. J., Fehm, T. N., Tóth, B., Markert, U. R., Weber, M., Togawa, R., Krüssel, J.-S., Baston-Büst, D. M., & Bielfeld, A. P. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05679-z · Cited by 50
Endocrinology Meets Metabolomics: Achievements, Pitfalls, and Challenges
Tokarz, J., Haid, M., Cecil, A., Prehn, C. P., Artati, A., Möller, G., & Adamski, J. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.07.001 · Cited by 44
Current biomarkers for the detection of endometriosis
Tian, Z., Chang, X., Zhao, Y. P., & Zhu, H. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001063 · Cited by 45
“Therefore, symptomatic endometriosis may be deduced or diagnosed by endometrial biopsy or intrauterine fluid component estimation.([54]) One Cochrane review evaluated the diagnostic accuracy of biomarkers obtained from endometrial tissue.”
BackgroundLiu, Y., Zhang, Z., Yang, F., Wang, H., Liang, S., Wang, H., Yang, J., & Lin, J. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa011 · Cited by 45
Margatho, D., Carvalho, N. M., & Bahamondes, L. G. (2020) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/13625187.2020.1725461 · Cited by 41
“This finding is in agreement with the results of previous studies, reiterating that ovarian function may play a role in b-cell-mediated humoral response [8,13,15].”
BackgroundResultMaignien, C., Santulli, P., Kateb, F., Caradeuc, C., Marcellin, L., Pocate-Cheriet, K., Bourdon, M., Chouzenoux, S., Batteux, F., Bertho, G., et al. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.06.019 · Cited by 39
“Indeed, the currently available blood tests and imaging techniques have moderate diagnostic values (Ahn et al., 2017), thus making the development of new noninvasive diagnostic methods a high-priority objective in the field of endometriosis research (Thubert et al.”
BackgroundGaia‐Oltean, A. I., Braicu, C., Gulei, D., Ciortea, R., Mihu, D., Roman, H., Irimie, A., & Berindan‐Neagoe, I. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9674 · Cited by 40
“The early detection of the possible malignant lesions in females with endometriosis and the differentiation between women at risk of EAOC and those who will continue to present a benign disease is important in order to improve the preventive and diagnostic methods, as managing the situation after cancer has developed…”
BackgroundThe Diagnostic Accuracy of Combined Enolase/Cr, CA125, and CA19‐9 in the Detection of Endometriosis
Rokhgireh, S., Mehdizadehkashi, A., Chaichian, S., Delbandi, A., Allahqoli, L., Ahmadi-Pishkuhi, M., Khodaverdi, S., & Alkatout, İ. (2020) · BioMed Research International · doi:10.1155/2020/5208279 · Cited by 36
“As endometriosis is linked with a number of potentially confounding factors, the development of a noninvasive biomarker has been a challenging issue [13].”
BackgroundExtracellular vesicle-derived long non-coding RNA as circulating biomarkers for endometriosis
Shan, S., Yang, Y., Jiang, J., Yang, B. X., Yang, Y., Sun, F., Zhang, J., Lin, Y., & Xu, H. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.11.019 · Cited by 38
Cao, Y., Liu, X., & Guo, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45785-w · Cited by 36
Oncological markers CA-125, CA 19-9 and endometriosis
Fiala, L., Bob, P., & Raboch, J. (2018) · Medicine · doi:10.1097/md.0000000000013759 · Cited by 32
“Mainly because diagnosis of endometriosis is generally delayed by 8 to 10 years due to misinterpretation of symptoms in juveniles and young women.([10]) This research needs to be replicated in a larger group of patients which might represent a limitation of this study and interpretation of the results.”
ResultGajbhiye, R., McKinnon, B. D., Mortlock, S., Mueller, M. D., & Montgomery, G. W. (2018) · Reproductive Sciences · doi:10.1177/1933719118768688 · Cited by 31
Herranz‐Blanco, B., Daoud, E., Viganò, P., García-Velasco, J. A., & Colli, E. (2023) · Biomolecules · doi:10.3390/biom13071052 · Cited by 36
“Developing a non-invasive diagnostic tool is essential for faster diagnosis, selection of appropriate treatment, and triaging potential surgical patients [13,14].”
BackgroundFeider, C. L., Woody, S., Ledet, S., Zhang, J., Sebastian, K., Breen, M., & Eberlin, L. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-51853-y · Cited by 29
Interactions between miRNAs and the Wnt/β-catenin signaling pathway in endometriosis
Zhang, Y., Sun, X., Li, Z., Han, X., Wang, W., Xu, P., Liu, Y., Xue, Y., Wang, Z., Xu, S., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116182 · Cited by 29
Chen, X., Liu, H., Sun, W., Guo, Z., & Lang, J. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2019.103398 · Cited by 30
Knific, T., Fishman, D., Vogler, A., Gstoettner, M., Wenzl, R. J., Peterson, H., & Rižner, T. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-52899-8 · Cited by 30
Identification and analysis of novel endometriosis biomarkers via integrative bioinformatics
Bae, S., Jo, Y., Cho, M. K., Jin, J.-S., Kim, J., Shim, J., Kim, Y. H., Park, J.-K., Ryu, D., Lee, H. J., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.942368 · Cited by 28
Nirgianakis, K., Vaineau, C., Agliati, L., McKinnon, B. D., Gasparri, M. L., & Mueller, M. D. (2020) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13969 · Cited by 29
Advances in the diagnosis and management of endometriosis: A comprehensive review
Chen, Y., Waseem, S., & Luo, L. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.155813 · Cited by 34
Sabeh, M. E., Afrin, S., Singh, B., Miyashita‐Ishiwata, M., & Borahay, M. A. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10075-w · Cited by 26
miRNAs and lncRNAs: Potential Non-Invasive Biomarkers for Endometriosis
Maier, I. M., & Maier, A. C. (2021) · Biomedicines · doi:10.3390/biomedicines9111662 · Cited by 27
Endometriosis biomarkers of the disease: an update
Soto, D. E., Rassier, S. L. C., Green, I. C., Burnett, T. L., Khan, Z., & Cope, A. G. (2022) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000798 · Cited by 29
Wang, H., Ni, C., Xiao, W. L., et al. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-6810 · Cited by 26
“Many studies have found that long non-coding RNAs (lncRNAs) cause a variety of biologic behaviors in EMs, which may be a key factor in the diagnosis or treatment of EMs (6,7).”
BackgroundA Practical Guide to the Clinical Evaluation of Endometriosis-Associated Pelvic Pain
Vilasagar, S., Bougie, O., & Singh, S. S. (2019) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2019.10.012 · Cited by 25
“This effort is challenged by the heterogenous nature of both the clinical presentation, as well as the pathological phenotype of the condition [63].”
BackgroundCreed, J. M., Maggrah, A., Reguly, B., & Harbottle, A. (2019) · Biomarkers in Medicine · doi:10.2217/bmm-2018-0419 · Cited by 25
A critical appraisal of the circulating levels of differentially expressed microRNA in endometriosis
Leonova, A., Turpin, V., Agarwal, S. K., Leonardi, M., & Foster, W. G. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab134 · Cited by 29
“In recent years, exosomes and their cargo [16], tissue concentrations of circular RNA [17], and long noncoding RNA [18] as well as circulating concentrations of microRNAs (miRNA) [19– 21] have been documented in women with endometriosis compared with control populations and thus are thought to have potential value as…”
BackgroundElevated serum interleukin‐32 levels in patients with endometriosis: A cross‐sectional study
Choi, Y. S., Kim, S., Oh, Y. S., Cho, S., & Kim, S. H. (2019) · American Journal of Reproductive Immunology · doi:10.1111/aji.13149 · Cited by 24
Alnafakh, R., Choi, F., Bradfield, A., Adishesh, M., Saretzki, G. C., & Hapangama, D. K. (2020) · Biomedicines · doi:10.3390/biomedicines8120588 · Cited by 23
“Eutopic endometrium of women with endometriosis appears to be different to that of women without endometriosis and the aberration in the endometrial functionalis layer in these women have been proposed to play a role in the pathogenesis of endometriosis [7,9,14,15,42,43].”
BackgroundGleason, J. L., Thoma, M. E., Willinger, N. Z., & Shenassa, E. D. (2021) · Journal of Women s Health · doi:10.1089/jwh.2021.0044 · Cited by 23
“These results reflect the well-documented inflammatory nature of this condition, 12,13 and may highlight potential shared pathways linking endo-metriosis to higher risk for chronic disease later in life and other morbidities typically occurring with older age.”
AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis
Ek, M., Roth, B., Engström, G., & Ohlsson, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010189 · Cited by 23
“The role of non-coding RNAs has been discussed in relation to endometriosis, and circulating microRNAs have been proposed as potential biomarkers for the disease [31,32].”
BackgroundYe, C., Chen, P., Xu, B., Jin, Y., Pan, Y., Wu, T., Du, Y., Mao, J., & Wu, R. (2023) · European journal of medical research · doi:10.1186/s40001-023-01180-w · Cited by 23
“Besides, chronic inflammation induced by ectopic cysts contributes to epigenetic alternations in eutopic endometrium [41, 42].”
BackgroundLiu, Y., Huang, X., Lu, D., et al. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110887 · Cited by 21
Medical and Behavioral Aspects of Adolescent Endometriosis: A Review of the Literature
Liakopoulou, M.-K., Tsarna, E., Eleftheriades, A., Arapaki, A., Toutoudaki, K., & Christopoulos, P. (2022) · Children · doi:10.3390/children9030384 · Cited by 22
“A systematic review, published in 2013, concluded that endometriosis is present in 62% of adolescents that undergo laparoscopy [12,18].”
BackgroundElevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis
Matson, B. C., Quinn, K. E., Lessey, B. A., Young, S. L., & Caron, K. M. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.02.004 · Cited by 19
“These diagnostic and therapeutic challenges have fueled interest in identifying biomarkers and signaling pathways associated with endometriosis (7).”
BackgroundEndometriosis in adolescence: Early manifestation of the traditional disease or a unique variant?
Tsonis, O., Barmpalia, Z., Gkrozou, F., Chandraharan, E., Pandey, S., Siafaka, V., & Paschopoulos, M. E. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.01.045 · Cited by 19
Braga, D. P. A. F., Montani, D. A., Setti, A. S., Turco, E. G. L., Oliveira‐Silva, D., & Borges, E. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23221 · Cited by 21
Exploring the Potential Key IncRNAs with Endometriosis by Construction of a ceRNA Network
Gu, C., Meng, Y., Meng, Q., Fan, W., Ye, M., Zhang, Q., Zhang, N., & Li, L. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s321648 · Cited by 17
Szczepańska, M., Wirstlein, P. K., Zawadzka, M., Wender-Ożegowska, E., & Jagodziński, P. P. (2018) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1490403 · Cited by 18
“Endometriosis is a complex gynecological disorder that affects approximately 10% of women of reproductive age [1].”
BackgroundIdentification and Analysis of Potential Immune-Related Biomarkers in Endometriosis
He, Y., Li, J., Qu, Y., Sun, L., Zhao, X., Wu, H., & Zhang, G. (2023) · Journal of Immunology Research · doi:10.1155/2023/2975581 · Cited by 18
“have focused on bioinformatics analysis, which can also serve as the basis for molecular biology experiments of endometriosis [22].”
BackgroundFeng, X., Qi, L., Xu, X., Feng, Y., Gong, X., Aili, A., Chen, Y., Xue, Z., Xue, J., & Tong, X. (2021) · PeerJ · doi:10.7717/peerj.11045 · Cited by 17
Endometriosis and the Temporomandibular Joint—Preliminary Observations
Wójcik, M., Goździewicz, T., Hudáková, Z., & Siatkowski, I. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082862 · Cited by 18
Clinical Management of Chronic Pelvic Pain in Endometriosis Unresponsive to Conventional Therapy
Pereira, A., Trujillano, M. H., Argüello, G. V., Fuentes, L., González, S., Mendiola, A., & Pérez‐Medina, T. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12010101 · Cited by 17
“Due to the difficulty of making an accurate differential diagnosis of this disease through symptoms [1], it might be difficult to establish a precise assessment of the disease’s prevalence and incidence.”
BackgroundDietary Inflammatory Index score and risk of developing endometriosis: A case–control study
da Silva, C. V. D., Felipe, V. A. D. A., Shivappa, N., Hébert, J. R., Perini, J. A., de Brito, P. D., Cardoso, J. V., Ferrari, R., & Filho, G. L. D. A. (2020) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/2284026520967599 · Cited by 17
Wang, D., Cui, L., Yang, Q., & Wang, J. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110145 · Cited by 16
Margatho, D., Carvalho, N. M., Eloy, L., & Bahamondes, L. G. (2018) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/13625187.2018.1531117 · Cited by 17
“Due to the fact that surgery is an invasive diagnostic tool, several biomarkers have recently been proposed as non-invasive diagnostic tools for endometriosis [2,4,5]; however, none of the biomarkers proposed, thus far, have a high enough sensitivity and specificity to properly diagnose the disease [6].”
BackgroundA short anogenital distance on MRI is a marker of endometriosis
Crestani, A., Abdel Wahab, C., Arfi, A., Ploteau, S., Kolanska, K., Breban, M., Bendifallah, S., Ferrier, C., & Darai, E. (2021) · Human Reproduction Open · doi:10.1093/hropen/hoab003 · Cited by 15
Amanda, C. R., Asmarinah, A., Hestiantoro, A., Tulandi, T., & Febriyeni (2024) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2024.07.061 · Cited by 14
Luo, X., Wen, S., Zeng, J.-L., Liu, J., Ye, W., Wu, J., Huang, S., Xie, W., Wen, H., Sun, Y., et al. (2024) · Reproductive Biology · doi:10.1016/j.repbio.2024.100950 · Cited by 15
Circular Rna As A Potential Diagnostic And/Or Therapeutic Target for Endometriosis
Dana, P. M., Taghavipour, M., Mirzaei, H., Yousefi, B., Moazzami, B., Chaichian, S., & Asemi, Z. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2020-0167 · Cited by 14
Liu, D., Liu, M., Yu, P., & Li, H. (2023) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2023.07.003 · Cited by 15
Nati, I. D., Malutan, A. M., Ciortea, R., Oancea, M. D., Bucuri, C. E., Román, M. T. Á., Ormindean, C. M., Milon, A. G., & Mihu, D. (2024) · Diagnostics · doi:10.3390/diagnostics14161822 · Cited by 26
“Current efforts are aimed at assessing prognosis based on serum or tissue levels of certain biomarkers [27,30,35,37,42,43].”
BackgroundCirculating Serum Micro-RNA as Non-Invasive Diagnostic Biomarkers of Endometriosis
Ravaggi, A., Bergamaschi, C., Galbiati, C., Zanotti, L., Fabricio, A. S. C., Gion, M., Cappelletto, E., Leon, A. E., Gennarelli, M., Romagnolo, C., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12102393 · Cited by 18
“MiRNAs are present in all tissues, but they can also be released into circulation, where they may play a role in communication between the eutopic endometrium and ectopic endometrial lesions, causing dysregulation of gene expression [14,17].”
BackgroundInfluentialPediatric and Adolescent Gynecology: Treatment Perspectives in Minimally Invasive Surgery
Pelizzo, G., Nakib, G., & Calcaterra, V. (2019) · Pediatric Reports · doi:10.4081/pr.2019.8029 · Cited by 14
Wang, Z., Mao, Y., Wang, Z., Li, S., Hong, Z., Zhou, R., Xu, S., Xiong, Y., & Zhang, Y. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00493.2024 · Cited by 14
Effect of psychosocial trauma and stress on sexual dysfunction in women with endometriosis
Fiala, L., Lenz, J., & Bob, P. (2021) · Medicine · doi:10.1097/md.0000000000026836 · Cited by 15
“young women.([8,19]) In this context, these results may initiate new psychosomatic research on endometriosis and a discussion of the relationship between neuroendocrine changes in endometriosis and psychosocial stress/trauma symptoms.”
BackgroundMaddern, J., Grundy, L., Harrington, A. M., Schober, G., Castro, J., & Brierley, S. M. (2021) · Pain · doi:10.1097/j.pain.0000000000002552 · Cited by 13
Kaspute, G., Bareikiene, E., Prentice, U., Uzielienè, I., Ramašauskaitė, D., & Ivaškienė, T. (2024) · Medicina · doi:10.3390/medicina60111866 · Cited by 15
Clark, D. A., Dmetrichuk, J. M., Dhesy‐Thind, S., Crowther, M. A., & Arredondo, J. L. (2018) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2018.05.006 · Cited by 13
Yuan, D., Zhu, D., Yin, B., Ge, H., Zhao, Y., Huang, A., Wang, X., Cao, X., Xia, N. L., & Qian, H. (2022) · Genes & Genomics · doi:10.1007/s13258-021-01184-y · Cited by 12
“1 3 the condition leading to 50% infertility in patients (Ahn et al. 2017).”
BackgroundTejada, M. A., Santos-Llamas, A. I., Escrivá, L., Tarín, J. J., Cano, A., Fernández-Ramírez, M. J., Nuñez‐Badinez, P., Leo, B. D., Saunders, P. T. K., Vidal, V., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10020501 · Cited by 14
Rossi, M., Seidita, I., Vannuccini, S., Prisinzano, M., Donati, C., & Petraglia, F. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2023.01.007 · Cited by 16
Xu, A., Jiang, M., Li, S., & Fei, Q. (2020) · Gene · doi:10.1016/j.gene.2020.144926 · Cited by 13
Taşkın, M. İ., Güney, G., Adalı, E., Hişmioğulları, A. A., Dodurga, Y., & Elmas, L. (2020) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2019.1697220 · Cited by 12
“Today, this is one of the widely accepted explanations for the mechanism underlying endometriosis (Ahn et al. 2017).”
BackgroundMitochondrial dynamics: Molecular mechanism and implications in endometriosis
Marino, Y., Inferrera, F., Genovese, T., Cuzzocrea, S., Fusco, R., & Paola, R. D. (2025) · Biochimie · doi:10.1016/j.biochi.2025.01.012 · Cited by 15
ATR‐IR Spectroscopy Application to Diagnostic Screening of Advanced Endometriosis
Kokot, I., Mazurek, S., Piwowar, A., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4777434 · Cited by 12
“The disease ’ s development appears directly related to in fl ammatory processes, and since there is no speci fi c biomarker [35], only a combination of commonly determined blood biochemical markers may allow endometriosis to be distinguished from other in fl ammatory conditions and, in the future,…”
Sinai, D., Avni, C., & Toren, P. (2024) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2024.111809 · Cited by 11
Diagnostic Value of Circulating MicroRNAs for Endometriosis: a Meta-analysis
Zhou, L., Chen, Y., Gao, J., Shankar, S., & Zhang, G. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00024-5 · Cited by 10
Mitranovici, M.-I., Costăchescu, D., Voidăzan, S. T., Munteanu, M. S., Buicu, C.-F., Oală, I. E., Ivan, V. M., Apostol, A., Melinte, I. M., Crișan, A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312749 · Cited by 10
“Endometriosis is an economic and healthcare burden [17], which is why there is a constant concern related to this pathology.”
Influential
Metadata
- Authors
- Ahn, S. H., Singh, V., & Tayade, C.
- Affiliations
- Queen's University (CA)
- Corresponding author
- Tayade, Chandrakant
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 107
- Issue
- 3
- Pages
- 523-532
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2586274172
- Cited by
- 242
- References
- 132
- Citations by year
- 2026: 20 · 2025: 32 · 2024: 35 · 2023: 21 · 2022: 18 · 2021: 29 · 2020: 33 · 2019: 27 · 2018: 23 · 2017: 3
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (394924)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, diagnostic biomarkers, eutopic endometrium, non-coding RNA, peritoneal fluid, blood biomarkers, urinary biomarkers, endometrial biopsy, biomarker validation, delayed diagnosis, retrograde menstruation, infertility, dysmenorrhea, chronic pelvic pain
- MeSH terms
- Biopsy, Endometriosis, Endometrium, Female, Genetic Markers, Humans, Menstrual Cycle, Predictive Value of Tests, Prognosis, Reproducibility of Results, Biomarkers, Comorbidity, Cytokines, Inflammation Mediators, MicroRNAs, RNA, Long Noncoding
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