The DOI matches its Crossref record; 197 of the 198 references it cites were found in a registry or an index.
A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals
Abstract
Phenolic phytochemicals have been of particular interests in food and pharmaceutical fields because they have potential to reduce the incidences of coronary heart disease, diabetes, cancers, and other chronic diseases. However, extremely low absorption rate of phenolic phytochemicals restricts their bioactivity in vivo. Such low absorption and bioavailability are due to their low water solubility, poor stability, passive diffusion, and active efflux in the gastrointestinal tract. Nanoparticle delivery system has been widely applied in pharmaceutical field to enhance absorption of bioactive compounds. This review explains absorption barriers of phenolic phytochemicals in the gastrointestinal tract. Nanoparticles delivery systems are emphasized regarding fabrication methods and their potential benefits on phenolic phytochemical absorption. Particularly, absorption mechanisms of nanoparticles by epithelial cells and biodistribution of nanoparticles after absorption are mainly discussed. Moreover, the potential challenges of nanoparticles as delivery system for phenolic phytochemicals in the gastrointestinal tract are also discussed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The higher antimicrobial activity of the nanoparticles or nanoemulsion of phytochemicals is related to the size of the nanoparticles or nanoemulsion droplets, which is in the subcellular size range.”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [266]
In the citing paper
“This allows the penetration of the nanoparticles or nanoemulsion droplets to the microbial cells leading to enhanced activity (265, 266).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [266]
Citations
Cites
1 retracted
Anand, P., Nair, H. B. B., Sung, B., Kunnumakkara, A. B., Yadav, V. R., TEKMAL, R. R., & Aggarwal, B. B. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.003 · Cited by 575
RetractedBinnig, G. K., Quate, C. F., & Gerber, C. (1986) · Physical Review Letters · doi:10.1103/physrevlett.56.930 · Cited by 14,795
Whitesides, G. M., & Grzybowski, B. A. (2002) · Science · doi:10.1126/science.1070821 · Cited by 7,550
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Antioxidant properties of phenolic compounds
Rice-Evans, C. A., Miller, N., & Paganga, G. (1997) · Trends in Plant Science · doi:10.1016/s1360-1385(97)01018-2 · Cited by 4,491
Transmission Electron Microscopy
Williams, D. B., & Carter, C. B. (2009) · Springer eBooks · doi:10.1007/978-0-387-76501-3 · Cited by 4,146
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Antioxidant activity of plant extracts containing phenolic compounds
Kähkönen, M. P., Hopia, A. I., Vuorela, H. J., Rauha, J.-P., Pihlaja, K., Kujala, T. S., & Heinonen, M. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990146l · Cited by 3,854
Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art
Müller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,836
Rejman, J., Oberle, V., Zuhorn, I. S., & Hoekstra, D. (2004) · Biochemical Journal · doi:10.1042/bj20031253 · Cited by 2,872
Cited by
Sorted by citations
Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases
Zhang, Y.-J., Gan, R.-Y., Li, S., Zhou, Y., Li, A.-N., Xu, D.-P., & Li, H.-B. (2015) · Molecules · doi:10.3390/molecules201219753 · Cited by 1,369
Role of the Encapsulation in Bioavailability of Phenolic Compounds
Grgić, J., Šelo, G., Planinić, M., Tišma, M., & Bucić‐Kojić, A. (2020) · Antioxidants · doi:10.3390/antiox9100923 · Cited by 446
Improving the bioavailability of phenolic compounds by loading them within lipid-based nanocarriers
Esfanjani, A. F., Assadpour, E., & Jafari, S. M. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.04.002 · Cited by 406
A Brief Overview on Antioxidant Activity Determination of Silver Nanoparticles
Bedlovičová, Z., Strapáč, I., Baláž, M., & Salayová, A. (2020) · Molecules · doi:10.3390/molecules25143191 · Cited by 388
Functionality of Food Components and Emerging Technologies
Galanakis, C. M. (2021) · Foods · doi:10.3390/foods10010128 · Cited by 415
Metadata
- Authors
- Li, Z., Jiang, H., Xu, C., & Gu, L.
- Affiliations
- University of Florida (US)
- University of Louisville (US)
- Corresponding author
- Li, Zheng
- Venue
- Food Hydrocolloids
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 43
- Pages
- 153-164
- ISSN
- 0268-005X (ISSN-L)
- OpenAlex
- W2042232868
- Cited by
- 376
- References
- 198
- Citations by year
- 2026: 13 · 2025: 40 · 2024: 32 · 2023: 39 · 2022: 38 · 2021: 42 · 2020: 39 · 2019: 41 · 2018: 26 · 2017: 25 · 2016: 20 · 2015: 18
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Hydrocolloids (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- phenolic phytochemicals, nanoparticles, nanoparticle delivery systems, bioavailability, gastrointestinal absorption, tissue distribution, dietary bioactive compounds, chronic disease prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
