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A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals
Abstract
Phenolic phytochemicals have been of particular interests in food and pharmaceutical fields because they have potential to reduce the incidences of coronary heart disease, diabetes, cancers, and other chronic diseases. However, extremely low absorption rate of phenolic phytochemicals restricts their bioactivity in vivo. Such low absorption and bioavailability are due to their low water solubility, poor stability, passive diffusion, and active efflux in the gastrointestinal tract. Nanoparticle delivery system has been widely applied in pharmaceutical field to enhance absorption of bioactive compounds. This review explains absorption barriers of phenolic phytochemicals in the gastrointestinal tract. Nanoparticles delivery systems are emphasized regarding fabrication methods and their potential benefits on phenolic phytochemical absorption. Particularly, absorption mechanisms of nanoparticles by epithelial cells and biodistribution of nanoparticles after absorption are mainly discussed. Moreover, the potential challenges of nanoparticles as delivery system for phenolic phytochemicals in the gastrointestinal tract are also discussed.
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“The higher antimicrobial activity of the nanoparticles or nanoemulsion of phytochemicals is related to the size of the nanoparticles or nanoemulsion droplets, which is in the subcellular size range.”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [266]
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“This allows the penetration of the nanoparticles or nanoemulsion droplets to the microbial cells leading to enhanced activity (265, 266).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [266]
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Metadata
- Authors
- Li, Z., Jiang, H., Xu, C., & Gu, L.
- Affiliations
- University of Florida (US)
- University of Louisville (US)
- Corresponding author
- Li, Zheng
- Venue
- Food Hydrocolloids
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 43
- Pages
- 153-164
- ISSN
- 0268-005X (ISSN-L)
- OpenAlex
- W2042232868
- Cited by
- 376
- References
- 198
- Citations by year
- 2026: 13 · 2025: 40 · 2024: 32 · 2023: 39 · 2022: 38 · 2021: 42 · 2020: 39 · 2019: 41 · 2018: 26 · 2017: 25 · 2016: 20 · 2015: 18
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Hydrocolloids (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- phenolic phytochemicals, nanoparticles, nanoparticle delivery systems, bioavailability, gastrointestinal absorption, tissue distribution, dietary bioactive compounds, chronic disease prevention
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