Cited by 376Drug Solubulity and Delivery SystemsProteins in Food SystemsPhytochemicals and Antioxidant Activities

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A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals

Li, Zheng, Jiang, Hong, Xu, Changmou, Gu, Liwei·2015·Food Hydrocolloids

DOI 10.1016/j.foodhyd.2014.05.010

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Abstract

Phenolic phytochemicals have been of particular interests in food and pharmaceutical fields because they have potential to reduce the incidences of coronary heart disease, diabetes, cancers, and other chronic diseases. However, extremely low absorption rate of phenolic phytochemicals restricts their bioactivity in vivo. Such low absorption and bioavailability are due to their low water solubility, poor stability, passive diffusion, and active efflux in the gastrointestinal tract. Nanoparticle delivery system has been widely applied in pharmaceutical field to enhance absorption of bioactive compounds. This review explains absorption barriers of phenolic phytochemicals in the gastrointestinal tract. Nanoparticles delivery systems are emphasized regarding fabrication methods and their potential benefits on phenolic phytochemical absorption. Particularly, absorption mechanisms of nanoparticles by epithelial cells and biodistribution of nanoparticles after absorption are mainly discussed. Moreover, the potential challenges of nanoparticles as delivery system for phenolic phytochemicals in the gastrointestinal tract are also discussed.

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Authors: Li, Z., Jiang, H., Xu, C., & Gu, L.
Affiliations: University of Florida (US)
University of Louisville (US)
Corresponding author: Li, Zheng
ORCID: Li, Zheng
Jiang, Hong
Xu, Changmou
Gu, Liwei
Venue: Food Hydrocolloids
Publisher: Elsevier BV
Published: 2015-01
Volume: 43
Pages: 153-164
ISSN: 0268-005X (ISSN-L)
DOI: 10.1016/j.foodhyd.2014.05.010
OpenAlex: W2042232868
Cited by: 376
References: 198
Citations by year: 2026: 13 · 2025: 40 · 2024: 32 · 2023: 39 · 2022: 38 · 2021: 42 · 2020: 39 · 2019: 41 · 2018: 26 · 2017: 25 · 2016: 20 · 2015: 18
FWCI: 12.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Food Hydrocolloids (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: phenolic phytochemicals, nanoparticles, nanoparticle delivery systems, bioavailability, gastrointestinal absorption, tissue distribution, dietary bioactive compounds, chronic disease prevention

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A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals

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