The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mitochondria-associated ER membranes and Alzheimer disease
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“While impairment or perturbation of MAM function has been implicated in several neurodegenerative disease conditions [13–20, 76], the contributing underlying mechanism(s) remain unknown.”
From The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs (2020) · cites this paper as [76]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442
Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
Holtzman, D. M., Herz, J., & Bu, G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006312 · Cited by 782
Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease
Area‐Gomez, E., del Carmen Lara Castillo, M., Tambini, M. D., Guardia‐Laguarta, C., de Groof, A. J. C., Madra, M., Ikenouchi, J., Umeda, M., Bird, T. D., Sturley, S. L., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.202 · Cited by 638
Self-citationAssociation of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes
Vetrivel, K. S., Cheng, H., Lin, W., Sakurai, T., Li, T., Nukina, N., Wong, P. C., Xu, H., & Thinakaran, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407986200 · Cited by 413
Nicastrin, Presenilin, APH-1, and PEN-2 Form Active γ-Secretase Complexes in Mitochondria
Hansson, C. A., Frykman, S., Farmery, M. R., Tjernberg, L. O., Nilsberth, C., Pursglove, S. E., Ito, A., Winblad, B., Cowburn, R. F., Thyberg, J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404500200 · Cited by 256
Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation
Heeren, J., Grewal, T., Laatsch, A., Becker, N., Rinninger, F., Rye, K.-A., & Beisiegel, U. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409324200 · Cited by 139
Research works printed but not linked: 65
- Armstrong, 2008, What determines the molecular composition of abnormal protein aggregates in neurodegenerative disease?, Neuropathology, 28, 351, 10.1111/j.1440-1789.2008.00916.x · DOI
- Atwood, 2002, Senile plaque composition and posttranslational modification of amyloid-β peptide and associated proteins, Peptides, 23, 1343, 10.1016/S0196-9781(02)00070-0 · DOI
- Selkoe, 2011, Alzheimer's disease, Cold Spring Harb Perspect Biol, 3, a004457, 10.1101/cshperspect.a004457 · DOI
- Huang, 2010, Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease, Trends Mol Med, 16, 287, 10.1016/j.molmed.2010.04.004 · DOI · Paper page
- Hardy, 1992, Alzheimer's disease: the amyloid cascade hypothesis, Science, 256, 184, 10.1126/science.1566067 · DOI · Paper page
- Schon, 2010, Is Alzheimer's disease a disorder of mitochondria-associated membranes?, J Alzheimers Dis, 20, S281, 10.3233/JAD-2010-100495 · DOI
- Schon, 2013, Mitochondria-associated E.R. membranes in Alzheimer disease, Mol Cell Neurosci, 55, 26, 10.1016/j.mcn.2012.07.011 · DOI · Paper page
- Stefani, 2009, Cholesterol in Alzheimer's disease: unresolved questions, Curr Alzheimer Res, 6, 15, 10.2174/156720509787313899 · DOI
- Fraser, 2010, Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease, Neurochem Res, 35, 503, 10.1007/s11064-009-0087-5 · DOI
- Hoyer, 1988, Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?, J Neurol, 235, 143, 10.1007/BF00314304 · DOI
- Liu, 2009, Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease, Brain, 132, 1820, 10.1093/brain/awp099 · DOI · Paper page
- Pettegrew, 2001, Brain membrane phospholipid alterations in Alzheimer's disease, Neurochem Res, 26, 771, 10.1023/A:1011603916962 · DOI
- Bezprozvanny, 2008, Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease, Trends Neurosci, 31, 454, 10.1016/j.tins.2008.06.005 · DOI · Paper page
- Wang, 2009, The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease, J Neurochem, 109, 153, 10.1111/j.1471-4159.2009.05867.x · DOI
- Area-Gomez, 2014, Mitochondrial genetics and disease, J Child Neurol, 29, 1208, 10.1177/0883073814539561 · DOI
- Csordas, 2006, Structural and functional features and significance of the physical linkage between ER and mitochondria, J Cell Biol, 174, 915, 10.1083/jcb.200604016 · DOI
- Hayashi, 2009, MAM: more than just a housekeeper, Trends Cell Biol, 19, 81, 10.1016/j.tcb.2008.12.002 · DOI · Paper page
- Raturi, 2013, Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM), Biochim Biophys Acta, 1833, 213, 10.1016/j.bbamcr.2012.04.013 · DOI
- Rusinol, 1994, A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins, J Biol Chem, 269, 27494, 10.1016/S0021-9258(18)47012-3 · DOI
- Vance, 1997, Phosphatidylethanolamine N-methyltransferase from liver, Biochim Biophys Acta, 1348, 142, 10.1016/S0005-2760(97)00108-2 · DOI
- Stone, 2000, Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes, J Biol Chem, 275, 34534, 10.1074/jbc.M002865200 · DOI
- Prasad, 2015, Mitochondria-associated endoplasmic reticulum membrane (MAM) regulates steroidogenic activity via steroidogenic acute regulatory protein (StAR)-voltage-dependent anion channel 2 (VDAC2) interaction, J Biol Chem, 290, 2604, 10.1074/jbc.M114.605808 · DOI · Paper page
- Mendes, 2005, The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria, J Biol Chem, 280, 40892, 10.1074/jbc.M506623200 · DOI
- Szabadkai, 2006, Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels, J Cell Biol, 175, 901, 10.1083/jcb.200608073 · DOI · Paper page
- Jia, 2007, Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts, J Biol Chem, 282, 20573, 10.1074/jbc.M700568200 · DOI
- Friedman, 2011, ER tubules mark sites of mitochondrial division, Science, 334, 358, 10.1126/science.1207385 · DOI · Paper page
- Simmen, 2005, PACS-2 controls endoplasmic reticulum–mitochondria communication and Bid-mediated apoptosis, EMBO J, 24, 717, 10.1038/sj.emboj.7600559 · DOI
- Area-Gomez, 2009, Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria, Am J Pathol, 175, 1810, 10.2353/ajpath.2009.090219 · DOI · Paper page
- Newman, 2014, Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease, Hum Mol Genet, 23, 602, 10.1093/hmg/ddt448 · DOI
- Schreiner, 2015, Amyloid-β peptides are generated in mitochondria-associated endoplasmic reticulum membranes, J Alzheimers Dis, 43, 369, 10.3233/JAD-132543 · DOI
- Du, 2008, Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease, Nat Med, 14, 1097, 10.1038/nm.1868 · DOI
- Hayashi, 2010, Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum–mitochondria junction, Mol Pharmacol, 77, 517, 10.1124/mol.109.062539 · DOI
- Marambaud, 2002, A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions, EMBO J, 21, 1948, 10.1093/emboj/21.8.1948 · DOI
- Csordas, 2010, Imaging interorganelle contacts and local calcium dynamics at the ER–mitochondrial interface, Mol Cell, 39, 121, 10.1016/j.molcel.2010.06.029 · DOI · Paper page
- Patergnani, 2011, Calcium signaling around mitochondria associated membranes (MAMs), Cell Commun Signal, 9, 19, 10.1186/1478-811X-9-19 · DOI
- Liang, 2015, Ca2+ dysregulation in the endoplasmic reticulum related to Alzheimer's disease: a review on experimental progress and computational modeling, Biosystems, 134, 1, 10.1016/j.biosystems.2015.05.003 · DOI
- Mattson, 2010, ER calcium and Alzheimer's disease: in a state of flux, Sci Signal, 3, pe10, 10.1126/scisignal.3114pe10 · DOI
- Supnet, 2010, Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease, J Alzheimers Dis, 20, S487, 10.3233/JAD-2010-100306 · DOI
- Gibson, 1997, Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation, Neurobiol Aging, 18, 573, 10.1016/S0197-4580(97)00149-8 · DOI
- Peterson, 1986, Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors, Proc Natl Acad Sci U S A, 83, 2758, 10.1073/pnas.83.8.2758 · DOI
- Sims, 1987, Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease, Ann Neurol, 21, 451, 10.1002/ana.410210507 · DOI
- Sun, 2014, Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice, Neuron, 82, 79, 10.1016/j.neuron.2014.02.019 · DOI
- Cho, 2009, S-nitrosylation of Drp1 mediates β-amyloid-related mitochondrial fission and neuronal injury, Science, 324, 102, 10.1126/science.1171091 · DOI · Paper page
- Ferrer, 2009, Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease, J Bioenerg Biomembr, 41, 425, 10.1007/s10863-009-9243-5 · DOI
- Gibson, 2004, Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases, J Bioenerg Biomembr, 36, 335, 10.1023/B:JOBB.0000041764.45552.f3 · DOI
- Riemer, 2013, Axonal transport and mitochondrial dysfunction in Alzheimer's disease, Neurodegener Dis, 12, 111, 10.1159/000342020 · DOI
- Stokin, 2005, Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease, Science, 307, 1282, 10.1126/science.1105681 · DOI · Paper page
- Wang, 2008, Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins, Proc Natl Acad Sci U S A, 105, 19318, 10.1073/pnas.0804871105 · DOI · Paper page
- Young-Collier, 2012, The dying of the light: mitochondrial failure in Alzheimer's disease, J Alzheimers Dis, 28, 771, 10.3233/JAD-2011-111487 · DOI
- Flis, 2013, Lipid transport between the endoplasmic reticulum and mitochondria, Cold Spring Harb Perspect Biol, 5, a013235, 10.1101/cshperspect.a013235 · DOI
- Voelker, 2005, Bridging gaps in phospholipid transport, Trends Biochem Sci, 30, 396, 10.1016/j.tibs.2005.05.008 · DOI
- Puglielli, 2001, Acyl-coenzyme A:cholesterol acyltransferase modulates the generation of the amyloid β-peptide, Nat Cell Biol, 3, 905, 10.1038/ncb1001-905 · DOI · Paper page
- Feng, 2003, The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages, Nat Cell Biol, 5, 781, 10.1038/ncb1035 · DOI
- Gómez-Ramos, 2007, Ultrastructural localization of intraneuronal Aβ-peptide in Alzheimer disease brains, J Alzheimers Dis, 11, 53, 10.3233/JAD-2007-11109 · DOI · Paper page
- Pani, 2009, Altered cholesterol ester cycle in skin fibroblasts from patients with Alzheimer's disease, J Alzheimers Dis, 18, 829, 10.3233/JAD-2009-1193 · DOI · Paper page
- Puglielli, 2004, Role of acyl-coenzyme A:cholesterol acyltransferase activity in the processing of the amyloid precursor protein, J Mol Neurosci, 24, 93, 10.1385/JMN:24:1:093 · DOI
- Tambini, 2016, ApoE4 upregulates the activity of mitochondria-associated ER membranes, EMBO Rep, 17, 27, 10.15252/embr.201540614 · DOI · Paper page
- Heeren, 2003, Recycling of apoprotein E is associated with cholesterol efflux and high density lipoprotein internalization, J Biol Chem, 278, 14370, 10.1074/jbc.M209006200 · DOI · Paper page
- Ikonen, 2008, Cellular cholesterol trafficking and compartmentalization, Nat Rev Mol Cell Biol, 9, 125, 10.1038/nrm2336 · DOI
- Wollmer, 2010, Cholesterol-related genes in Alzheimer's disease, Biochim Biophys Acta, 1801, 762, 10.1016/j.bbalip.2010.05.009 · DOI
- Steinberg, 2015, Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease, Nat Genet, 47, 445, 10.1038/ng.3246 · DOI · Paper page
- Abe-Dohmae, 2004, Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein, J Biol Chem, 279, 604, 10.1074/jbc.M309888200 · DOI
- Winkler, 2012, Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness, J Biol Chem, 287, 21326, 10.1074/jbc.M112.356659 · DOI
- Perl, 2010, Neuropathology of Alzheimer's disease, Mt Sinai J Med, 77, 32, 10.1002/msj.20157 · DOI · Paper page
- Yoshikane, 1986, Three-dimensional observation of intracellular membranous structures in dog heart muscle cells by scanning electron microscopy, J Submicrosc Cytol, 18, 629
Cited by
Sorted by citations
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives
Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., et al. (2022) · Cells · doi:10.3390/cells11030552 · Cited by 915
Redox proteomics and amyloid β-peptide: Insights into Alzheimer disease
Butterfield, D. A., & Boyd‐Kimball, D. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14589 · Cited by 105
Orr, A. L., Kim, C., Jimenez-Morales, D., Newton, B. W., Johnson, J. R., Krogan, N. J., Swaney, D. L., & Mahley, R. W. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-181184 · Cited by 103
Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease
McDaid, J., Mustaly-Kalimi, S., & Stutzmann, G. E. (2020) · Cells · doi:10.3390/cells9122655 · Cited by 73
Wang, W.-X., Prajapati, P., Nelson, P. T., & Springer, J. E. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01937-y · Cited by 49
Metadata
- Authors
- Area-Gomez, E., & Schon, E. A.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 38
- Pages
- 90-96
- ISSN
- 0959-437X
- PMC
- PMC5390896
- Cited by
- 124
- References
- 7
- Language
- en
- Licence
- Funders
- U.S. National Institutes of Health (K01 AG045335)
- U.S. Department of Defense (W911F-15-1-0169)
- J. Willard and Alice S. Marriott Foundation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review