The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Update on Wnt signaling in bone cell biology and bone disease
Open accessAbstract
For more than a decade, Wnt signaling pathways have been the focus of intense research activity in bone biology laboratories because of their importance in skeletal development, bone mass maintenance, and therapeutic potential for regenerative medicine. It is evident that even subtle alterations in the intensity, amplitude, location, and duration of Wnt signaling pathways affects skeletal development, as well as bone remodeling, regeneration, and repair during a lifespan. Here we review recent advances and discrepancies in how Wnt/Lrp5 signaling regulates osteoblasts and osteocytes, introduce new players in Wnt signaling pathways that have important roles in bone development, discuss emerging areas such as the role of Wnt signaling in osteoclastogenesis, and summarize progress made in translating basic studies to clinical therapeutics and diagnostics centered around inhibiting Wnt pathway antagonists, such as sclerostin, Dkk1 and Sfrp1. Emphasis is placed on the plethora of genetic studies in mouse models and genome wide association studies that reveal the requirement for and crucial roles of Wnt pathway components during skeletal development and disease.
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Cites
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Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease
Jia, L., Piña-Crespo, J., & Li, Y. (2019) · Molecular Brain · doi:10.1186/s13041-019-0525-5 · Cited by 288
Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development
Li, H., Xiao, Z., Quarles, L. D., & Li, W. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867327666200330142432 · Cited by 226
The WNT system: background and its role in bone
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Metadata
- Authors
- Monroe, D. G., McGee-Lawrence, M. E., Oursler, M. J., & Westendorf, J. J.
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 492
- Issue
- 1
- Pages
- 1-18
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W1964059429
- Cited by
- 392
- References
- 23
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Monroe, D. G., McGee-Lawrence, M. E., Oursler, M. J., & Westendorf, J. J. (2012). Update on Wnt signaling in bone cell biology and bone disease. Gene. https://doi.org/10.1016/j.gene.2011.10.044
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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