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The WNT system: background and its role in bone

Lerner, U. H., Ohlsson, C.·2015·Journal of Internal Medicine
DOI 10.1111/joim.12368
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Abstract

WNT s are extracellular proteins that activate different cell surface receptors linked to canonical and noncanonical WNT signalling pathways. The Wnt genes were originally discovered as important for embryonic development of fruit flies and malignant transformation of mouse mammary cancers. More recently, WNT s have been implicated in a wide spectrum of biological phenomena and diseases. During the last decade, several lines of clinical and preclinical evidence have indicated that WNT signalling is critical for trabecular and cortical bone mass, and this pathway is currently an attractive target for drug development. Based on detailed knowledge of the different WNT signalling pathways, it appears that it might be possible to develop drugs that specifically target cortical and trabecular bone. Neutralization of a bone‐specific WNT inhibitor is now being evaluated as a promising anabolic treatment for patients with osteoporosis. Here, we provide the historical background to the discoveries of WNT s, describe the different WNT signalling pathways and summarize the current understanding of how these proteins regulate bone mass by affecting bone formation and resorption.

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Metadata

Authors
Lerner, U. H., & Ohlsson, C.
Affiliations
Centre for Bone and Arthritis Research Institute for Medicine Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2015-05-25
Volume
277
Issue
6
Pages
630-649
ISSN
  • 0954-6820
  • 1365-2796
DOI
10.1111/joim.12368
Cited by
228
References
10
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • Swedish Research Council
  • the Swedish Foundation for Strategic Research
  • COMBINE
  • the ALF/LUA research grant in Gothenburg
  • the Lundberg Foundation
  • the Torsten and Ragnar Söderberg′s Foundation
  • the Swedish Rheumatism Association
  • the Royal 80 Year Fund of King Gustav V
  • the Novo Nordisk Foundation

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