Cited by 754RNA Research and SplicingRNA regulation and diseaseCancer-related molecular mechanisms research

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Function of alternative splicing

Kelemen, Olga, Convertini, Paolo, Zhang, Zhaiyi, Wen, Yuan, Shen, Manli, Falaleeva, Marina, Stamm, Stefan·2013·Gene

DOI 10.1016/j.gene.2012.07.083

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Abstract

Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review the functions of alternative splicing events that have been experimentally determined. The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has profound functional effects. Experimental analysis of these protein isoforms showed that alternative splicing regulates binding between proteins, between proteins and nucleic acids as well as between proteins and membranes. Alternative splicing regulates the localization of proteins, their enzymatic properties and their interaction with ligands. In most cases, changes caused by individual splicing isoforms are small. However, cells typically coordinate numerous changes in 'splicing programs', which can have strong effects on cell proliferation, cell survival and properties of the nervous system. Due to its widespread usage and molecular versatility, alternative splicing emerges as a central element in gene regulation that interferes with almost every biological function analyzed.

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Zmijewski, 2009, Modulation of corticotropin releasing factor (CRF) signaling through receptor splicing in mouse pituitary cell line AtT-20—emerging role of soluble isoforms, J. Physiol. Pharmacol., 60, 39

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Authors: Kelemen, O., Convertini, P., Zhang, Z., Wen, Y., Shen, M., Falaleeva, M., & Stamm, S.
Affiliations: University of Kentucky (US)
Corresponding author: Stamm, Stefan
ORCID: Convertini, Paolo
Zhang, Zhaiyi
Wen, Yuan
Shen, Manli
Falaleeva, Marina
Stamm, Stefan
Venue: Gene
Publisher: Elsevier BV
Published: 2013-02
Volume: 514
Issue: 1
Pages: 1-30
ISSN: 0378-1119 (ISSN-L)
DOI: 10.1016/j.gene.2012.07.083
OpenAlex: W3042475334
Cited by: 743
References: 559
Citations by year: 2026: 29 · 2025: 49 · 2024: 57 · 2023: 55 · 2022: 73 · 2021: 82 · 2020: 77 · 2019: 64 · 2018: 52 · 2017: 56 · 2016: 46 · 2015: 38 · 2014: 40 · 2013: 25
FWCI: 3.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gene (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM083187)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: alternative splicing, protein isoforms, protein-protein interaction, protein-nucleic acid interactions, protein-membrane binding, protein localization, ligand binding, gene expression regulation, cell proliferation, cell survival, nervous system

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Function of alternative splicing

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