Cited by 355Diabetes Management and EducationCardiac Health and Mental HealthMental Health Treatment and Access

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Depression and risk of mortality in individuals with diabetes: a meta-analysis and systematic review

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Park, Mijung, Katon, Wayne J., Wolf, Fredric M.·2013·General Hospital Psychiatry

DOI 10.1016/j.genhosppsych.2013.01.006PMC PMC3644308

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Abstract

OBJECTIVES: To estimate risk of comorbid depression on all-cause mortality over time among individuals with diabetes. METHODS: The Medline, Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, Embase and Science Direct databases were searched through September 30, 2012. We limited our search to longitudinal or prospective studies reporting all-cause mortality among those having depression and diabetes, compared with those having diabetes alone that used hazard ratios (HRs) as the main outcome. Two reviewers independently extracted primary data and evaluated the quality of studies using predetermined criteria. The pooled random effects adjusted HRs were estimated using meta-analysis. The impact of moderator variables on study effect size was examined with meta-regression. RESULTS: A total of 42,363 respondents from 10 studies were included in the analysis. Depression was significantly associated with risk of mortality (pooled HR=1.50, 95% confidence interval=1.35-1.66). Little evidence for heterogeneity was found across the studies (Cochran Q=13.52, P=.20, I(2)=26.03). No significant possibility of publication bias was detected (Egger's regression intercept=0.98, P=.23). CONCLUSION: Depression significantly increases the risk of mortality among individuals with diabetes. Early detection and treatment of depression may improve health outcomes in this population.

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Authors: Park, M., Katon, W. J., & Wolf, F. M.
Affiliations: University of Pittsburgh (US)
University of Washington (US)
Corresponding author: Park, Mijung
ORCID: Park, Mijung
Venue: General Hospital Psychiatry
Publisher: Elsevier BV
Published: 2013-05
Volume: 35
Issue: 3
Pages: 217-225
ISSN: 0163-8343 (ISSN-L)
DOI: 10.1016/j.genhosppsych.2013.01.006
PMC: PMC3644308
OpenAlex: W2109708655
Cited by: 355
References: 69
Citations by year: 2026: 13 · 2025: 17 · 2024: 25 · 2023: 28 · 2022: 37 · 2021: 20 · 2020: 32 · 2019: 27 · 2018: 26 · 2017: 27 · 2016: 38 · 2015: 21 · 2014: 30 · 2013: 14
FWCI: 5.11
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/3.0/ (vor, 76 d)
Locations: General Hospital Psychiatry (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: University of Washington
National Institute of Mental Health (MH069471, K24MH069471, NIMH K24, T32MH073553, 2 T32 MH 37553-6)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: depression, diabetes mellitus, all-cause mortality, comorbidities, depression screening, depression treatment, cardiovascular risk
MeSH terms: Depressive Disorder, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Risk Factors, Comorbidity

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Depression and risk of mortality in individuals with diabetes: a meta-analysis and systematic review

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