The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida
Abstract
Hydrolyzed fucoidans, from sporophyll of Undaria pinnatifida, were used to determine the effects of molecular weight (Mw) and hydrolysis conditions on cancer cell growth. Native fucoidans showed anticancer activity of 37.6%. When hydrolyzed in boiling water with HCl for 5 min, fucoidans (Mw = 490 kDa) significantly increased anticancer activity to 75.9%. However, fucoidans hydrolyzed in a microwave oven showed little improvement of anticancer activity and even exhibited the inhibition activity below 30% when treated more than 90s. This suggests that anticancer activity of fucoidans could be significantly enhanced by lowering their Mw only when they are depolymerized by mild condition.
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“The anticancer activity of fucoidans could be increased by lowering their molecular weight whereby they are depolymerized by mild hydrolysis without a considerable amount of desulfation [53].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [53]
Citations
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Yu, Y., Shen, M., Song, Q., & Xie, J. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.12.009 · Cited by 1,447
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Metadata
- Authors
- Yang, C., Chung, D., Shin, I.-S., Lee, H., Kim, J., Lee, Y., & You, S.
- Corresponding author
- You, SangGuan
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 43
- Issue
- 5
- Pages
- 433-437
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2003669320
- Cited by
- 254
- References
- 24
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 13 · 2023: 18 · 2022: 14 · 2021: 15 · 2020: 23 · 2019: 25 · 2018: 22 · 2017: 23 · 2016: 10 · 2015: 14 · 2014: 21 · 2013: 15 · 2012: 8
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Knowledge Economy
- Ministry of Education and Human Resources Development
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, Undaria pinnatifida, sporophylls, molecular weight, hydrolysis conditions, anticancer activity, tumor cell growth inhibition, acid hydrolysis, microwave hydrolysis, depolymerization, brown seaweed polysaccharides
- MeSH terms
- Antineoplastic Agents, Chromatography, Gel, Dose-Response Relationship, Drug, Humans, Hydrolysis, Lung Neoplasms, Molecular Weight, Polysaccharides, Undaria, Cell Line, Tumor
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