Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer

Angiogenesis in cancer, vascular, rheumatoid and other disease

Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627

Death Receptors: Signaling and Modulation

Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866

The biochemistry of apoptosis

Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779

Mammalian MAP kinase signalling cascades

Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118

AP-1 as a regulator of cell life and death

Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824

Journal of Food Science and Technology

(2013) · Journal of Food Science and Technology · doi:10.1007/13197.0975-8402 · Cited by 2,456

International Journal of Molecular Medicine

(2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm · Cited by 2,247

Bioactive compounds in seaweed: functional food applications and legislation

Holdt, S. L., & Kraan, S. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9632-5 · Cited by 2,135

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

Kaufmann, S. H., Desnoyers, S., Ottaviano, Y. L., Davidson, N. E., & Poirier, G. G. (1993) · PubMed · Cited by 1,889

Present and emerging pharmacotherapies for non-alcoholic steatohepatitis in adults

Ogawa, Y., Yoneda, M., Kobayashi, T., Honda, Y., Kessoku, T., Imajo, K., Saito, S., & Nakajima, A. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1543403 · Cited by 18

Sulfated polysaccharides as multi target molecules to fight COVID 19 and comorbidities

Barriga, E. J. C., & Fields, R. D. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13797 · Cited by 17

Characterization of Unfractionated Polysaccharides in Brown Seaweed by Methylation-GC-MS-Based Linkage Analysis

Bajwa, B., Xing, X., Serin, S. C., Hayes, M., Terry, S. A., Gruninger, R. J., & Abbott, D. W. (2024) · Marine Drugs · doi:10.3390/md22100464 · Cited by 18

Characterization and gelling properties of a bioactive extract from Ascophyllum nodosum obtained using a chemical-free approach

Gómez‐Mascaraque, L. G., Martínez‐Sanz, M., Martínez-López, R., Martínez‐Abad, A., Panikuttira, B., López‐Rubio, A., Tuohy, M. G., Hogan, S. A., & Brodkorb, A. (2021) · Current Research in Food Science · doi:10.1016/j.crfs.2021.05.005 · Cited by 17

Effectiveness of Fucoidan on Supplemental Therapy in Cancer Patients: A Systematic Review

Wu, C., Yeh, T., Wang, Y., Hu, H.-F., Tsay, S., & Liu, L. (2022) · Healthcare · doi:10.3390/healthcare10050923 · Cited by 17

In vitro cytotoxicity assay of Fucoidan extracted from Turbinaria conoides against cancer cell lines MCF7, A549, and normal cell line L929

Santhanam, R. C., Yacoob, S. A. M., & Venkatraman, A. (2022) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902022e19542 · Cited by 16

Chemical characterization, antiproliferative activity and molecular docking of bioactive compounds from brown algae Fucus spiralis

Boutjagualt, I., Benbacer, L., Hmimid, F., Guenaou, I., Errami, A., Bouothmany, K., Mohamed, E. M., Samira, E., & Benba, J. (2022) · Algal Research · doi:10.1016/j.algal.2022.102887 · Cited by 17

The regulatory effects of fucoidan and laminarin on functional dyspepsia mice induced by loperamide

Liu, T., Zhang, M., Asif, I. M., Wu, Y., Li, B., & Wang, L. (2023) · Food & Function · doi:10.1039/d3fo00936j · Cited by 15

Quantitative determination of fucoidan using polyion-sensitive membrane electrodes

Kim, J. M., Nguyen, L., Barr, M. F., Morabito, M., Stringer, D. N., Fitton, J. H., & Mowery, K. A. (2015) · Analytica Chimica Acta · doi:10.1016/j.aca.2015.04.020 · Cited by 15

Antioxidant and antimitotic activities of sulfated polysaccharide from marine brown algae Padina tetrastromatica

Jose, G. M., Radhakrishnan, A., & Kurup, G. M. (2015) · The Journal of Phytology · doi:10.19071/jp.2015.v7.2921 · Cited by 15

The Sulfated Polysaccharides of Brown Algae and Products of Their Enzymatic Transformation as Potential Vaccine Adjuvants

Kuznetsova, T. A., Persiyanova, E. V., Ermakova, S. P., Khotimchenko, M., & Besednova, N. N. (2018) · Natural Product Communications · doi:10.1177/1934578x1801300837 · Cited by 15

Functional and Nutraceutical Ingredients From Marine Resources

Binsi, P. K., & Zynudheen, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816687-1.00004-7 · Cited by 15

Fucoidan based hydrogel biomaterials for tissue engineering

Prova, O. S., Afrin, S., Tabish, T. A., & Rizwan, M. (2025) · Biomaterials Science · doi:10.1039/d5bm00676g · Cited by 16

Seaweeds: Valuable Ingredients for the Pharmaceutical Industries

Siahaan, E. A., Pangestuti, R., & Kim, S. (2018) · Grand challenges in biology and biotechnology · doi:10.1007/978-3-319-69075-9_2 · Cited by 17

Roles and mechanisms of fucoidan against dermatitis: A review

Jiang, Y., Yin, Z., Liu, Z., Fang, J. K., Lai, K. P., & Li, R. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135268 · Cited by 14

Drug loaded marine polysaccharides-based hydrogel dressings for treating skin burns

Zhai, G., Wang, Y., Han, P., Xiao, T., You, J., Guo, C., & Wu, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135779 · Cited by 13

Seaweeds and Cancer Prevention

Jiang, J., & Shi, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813312-5.00014-5 · Cited by 13

Evaluation of the immunomodulatory effects of a South African commercial traditional immune booster in human peripheral blood mononuclear cells

Ngcobo, M., & Gqaleni, N. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1294-7 · Cited by 13

The Properties of Brown Marine Algae Sargassum turbinarioides and Sargassum ilicifolium Collected From Yogyakarta, Indonesia

Artemisia, R., Nugroho, A. K., Setyowati, E. P., & Martien, R. (2019) · INDONESIAN JOURNAL OF PHARMACY · doi:10.14499/indonesianjpharm30iss1pp43 · Cited by 14

The effect of polydisperse fucoidans from Fucus vesiculosus on Hep G2 and Chang liver cells

Zhurishkina, E. V., Stepanov, S. I., Ayrapetyan, O. N., Skorik, Y. А., Vlasova, E. N., Kruchina-Bogdanov, I. V., Лебедев, Д. В., Kulminskaya, A. A., & Lapina, I. M. (2019) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2019.100209 · Cited by 13

Interactions of fibroblast growth factors with sulfated galactofucan from Saccharina japonica

Jin, W., Jiang, D., Zhang, W., Wang, C., Xia, K., Zhang, F., & Linhardt, R. J. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.05.183 · Cited by 13

Seaweeds as emerging functional foods and therapeutics for colorectal cancer management

Gengatharan, A., Mohamad, N.-V., Zahari, C. N. M. C., & Vijayakumar, R. (2025) · Discover Food · doi:10.1007/s44187-025-00383-w · Cited by 14

Gracilaria foliifera (Forssk.) Børgesen ethanolic extract triggers apoptosis via activation of p53 expression in HepG2 cells

Ezhilarasan, D., Shebi, S., Thomas, J., Chandrasekaran, N., & Mukherjee, A. (2019) · Pharmacognosy Magazine · doi:10.4103/pm.pm_379_18 · Cited by 21

Isolation, structural characterization, and antiviral activity of a sulfated polysaccharide (LJP-1) from Laminaria japonica

Deng, L.-M., Zhou, P., Yi, Y., Li, Y., Zheng, H., Wu, X., Cai, C., Zhou, L., Luo, Z., Wu, K., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143943 · Cited by 11

Effects of fucoidan on cell morphology and migration in osteoblasts

Kim, H., Lee, A., Jung, W., & Jeon, T. J. (2015) · Food Science and Biotechnology · doi:10.1007/s10068-015-0091-2 · Cited by 12

Fucoidan Induces Cell Aggregation and Apoptosis in Osteosarcoma MG-63 Cells

Kim, H., & Jeon, T. J. (2016) · Animal Cells and Systems · doi:10.1080/19768354.2016.1215349 · Cited by 11

A comparison of the effect of fucoidan from alga Fucus vesiculosus and its fractions obtained by anion-exchange chromatography on HeLa G-63, Hep G2, and Chang liver cells

Zhurishkina, E. V., Stepanov, S. I., Shvetsova, S. V., Kulminskaya, A. A., & Lapina, I. M. (2017) · Cell and Tissue Biology · doi:10.1134/s1990519x17030117 · Cited by 11

Proteomic analyses for profiling regulated proteins/enzymes by Fucus vesiculosus fucoidan in B16 melanoma cells: A combination of enzyme kinetics functional study

Wang, Z., Li, Z., Yang, J., Kang, Y., & Park, Y. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.02.011 · Cited by 11

Algae and Their Extracts in Medical Treatment

Korzeniowska, K., Górka, B., Lipok, J., & Wieczorek, P. P. (2018) · Springer eBooks · doi:10.1007/978-3-319-74703-3_7 · Cited by 12

Branched architecture of fucoidan characterized by dynamic and static light scattering

Gasilova, E. R., Lapina, I. M., Kulminskaya, A. A., & Skorik, Y. А. (2020) · Colloid & Polymer Science · doi:10.1007/s00396-020-04706-4 · Cited by 11

Marine Macroalgal Polysaccharides in Nanomedicine: Blue Biotechnology Contributions in Advanced Therapeutics

Bai, R. G., Sudheer, S. M., Premarathna, A. D., & Tuvikene, R. (2026) · Molecules · doi:10.3390/molecules31010175 · Cited by 10

Oligosaccharides from Sargassum thunbergii inhibit osteoclast differentiation via regulation of IRF-8 signaling

Jin, W., Chen, F., Fang, Q., Mao, G., & Bao, Y. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.112057 · Cited by 10

Extract of Saccharina japonica Induces Apoptosis companied by Cell Cycle Arrest and Endoplasmic Reticulum Stress in SK-Hep1 Human Hepatocellular Carcinoma Cells

Jung, H. I., Jo, M. J., Kim, H.-R., Choi, Y. H., & Kim, G. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.7.2993 · Cited by 10

Antitumor activity of doxorubicine-loaded nanoemulsion against Ehrlich ascites carcinoma-bearing mice

Alkhatib, M. H., Alkreathy, H. M., Balamash, K. S., & Abdu, F. (2016) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v15i5.6 · Cited by 10

BROWN SEAWEEDS AMELIORATE RENAL ALTERATIONS IN MICE TREATED WITH THE CARCINOGEN AZOXYMETHANE

Mahmoud, A. M., El-Derby, A. M., Elsayed, K. N. M., & Abdella, E. M. (2014) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 10

A fucan of a brown seaweed and its antitumoral property on HT-29 and immunomodulatory activity in murine RAW 264.7 macrophage cell line

Pinheiro, T. D. S., Santos, M. D. S. N., Castro, L. S. E. P. W., Paiva, A. A. D. O., Alves, L. G., da Cruz, A. K. M., Nobre, L. T. D. B., Alves, M. G. D. C. F., & Leite, E. L. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1075-9 · Cited by 10

L-Fucose-Rich Sulfated Glycans from Edible Brown Seaweed: A Promising Functional Food for Obesity and Energy Expenditure Improvement

Hyun, J., Lee, H.-G., Je, J.-G., Choi, Y., Song, K., Kim, T., Ryu, B., Kang, M., & Jeon, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179738 · Cited by 9

Fucoidan Stimulates Glucose Uptake via the PI3K/AMPK Pathway and Increases Insulin Sensitivity in 3T3-L1 Adipocytes

Lee, J. H., Park, J. E., & Han, J.-S. (2021) · JoLS Journal of Life Sciences · doi:10.5352/jls.2021.31.1.1 · Cited by 9

Phytovesicular Nanoconstructs for Advanced Delivery of Medicinal Metabolites: An In-Depth Review

Pandey, V., Rathee, S., Sen, D., Jain, S., & Patil, U. K. (2024) · Current Drug Targets · doi:10.2174/0113894501310832240815071618 · Cited by 8

Mechanical Properties and Microstructure of Decellularized Brown Seaweed Scaffold for Tissue Engineering

Kristinsdottir, S., Rolfsson, Ó., Sigurjónsson, Ó. E., Brynjólfsson, S., & Karlsdóttir, S. N. (2025) · Bioengineering · doi:10.3390/bioengineering12090943 · Cited by 8

Structural diversity, biosynthesis, and extraction of brown algae fucoidan and its bio-stimulant applications in crop improvement

Punjamgod, D., Anjana, K., Muthusamy, A., Rathinam, R., & Arunkumar, K. (2026) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2025.2582742 · Cited by 9

Experimental Determination and Association Model for the Solubility of Laminarin in Supercritical Carbon Dioxide

Zhan, S., Miao, H., Zhao, Y., Wang, J., & Li, Z. (2020) · Journal of Chemical & Engineering Data · doi:10.1021/acs.jced.9b01084 · Cited by 8

The role of biopolymers as therapeutic agents: A review

Widhiantara, I. G., Permatasari, A. A. A. P., Rosiana, I. W., Sari, N. K. Y., Sandhika, I. M. G. S., Wiradana, P. A., & Jawi, I. M. (2022) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2023.130104-1 · Cited by 8

Nutritional Benefits of Fucoidan and Its Applications (A Review)

Bulya, E. T., Alqubelat, R. S., & Rao, A. R. (2024) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162024060335 · Cited by 8

Ekstraksi Polisakarida Sulfat dari Sargassum polycystum dengan Metode Microwave Assisted Extraction dan Uji Toksisitasnya

Panjaitan, R. S., & Natalia, L. (2021) · Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan · doi:10.15578/jpbkp.v16i1.692 · Cited by 7

Potential of Fucoidan From Brown Seaweeds (Sargassum sp.) as Innovation Therapy on Breast Cancer

Satyarsa, A. B. S. (2019) · Journal Of Medicine & Health · doi:10.28932/jmh.v2i3.1235 · Cited by 7

Marine-Derived Polysaccharides: Prospects for Future Pharmaceuticals and Drug Delivery Systems

Sharifian, S., & Homaei, A. A. (2022) · Springer eBooks · doi:10.1007/978-981-16-4787-1_12 · Cited by 8

Algae Extract as a Potential Feed Additive

Korczyński, M., Witkowska, Z., Opaliński, S., Świniarska, M., & Dobrzański, Z. (2015) · doi:10.1002/9783527679577.ch34 · Cited by 7

Secret heroes of the sea: brown macroalgae and their bioactive powers—a narrative review

Başak, C. A. N., & Şanlıer, N. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1766041 · Cited by 6

Current Prospects and Clinical Status of Microalgae Derived Chemotherapeutics

Joshi, V., & Bharadvaja, N. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00384-9 · Cited by 6

Algae Biomass in Animal Production

Konkol, D., Górniak, W., Świniarska, M., & Korczyński, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-74703-3_11 · Cited by 6

Constructing ethanol-derived bioactive extracts using the brown seaweed Zonaria tournefortii (J.V.Lamouroux) Montagne performed with Timatic extractor by means of response surface methodology (RSM)

Nunes, N., Valente, S., Ferraz, S., Barreto, M. D. C., & de Carvalho, M. Â. A. P. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-019-01973-9 · Cited by 6

Fucoidan from Sargassum hemiphyllum (Turner) C. Agardh inhibits human hepatoma cell (HepG2) through cell cycle arrest and apoptotic induction

Chen, Y., Liu, X., Chen, J., Luo, B., Zhu, F., Li, R., Wang, Z., Cheong, K., & Zhong, S. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105051 · Cited by 6

Immunomodulatory and Therapeutic Potential of Marine Flora Products in the Treatment of Cancer

Singh, A., & Krishna, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-7607-8_7 · Cited by 6

Impact of various surfactants on the properties of fucoidan-based biopolymer films extracted from brown seaweed (Padina boergesenii) for active food packaging

Khan, T. S., Shah, Y. A., Al‐Harrasi, A., Dawery, S. K. A., Harharah, H. N., Harharah, R. H., Ahmad, M. W., Al-Kharusi, L., & Bhatia, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146919 · Cited by 5

Plant-Based Biomaterials as Bio-Instructive Immunomodulators: Design Principles, Mechanisms, and Translational Challenges

Lamponi, S. (2026) · Life · doi:10.3390/life16040538 · Cited by 6

Seaweed- A Sustainable Food Source in the Food Industry

Sharma, U. K., Jadaun, S., Khapudang, R., & Siddiqui, S. (2023) · World sustainability series · doi:10.1007/978-3-031-46046-3_10 · Cited by 5

New perspective of ceria nanodots for precise tumor therapy via oxidative stress pathway

Wang, H., Wang, Q., Dong, J., Jiang, W., Kong, L., Zhang, Q., & Liu, H. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e10370 · Cited by 5

Extracting activity patterns: Exploratory data analysis on a fucoidan extract data set with mixed variables

Ptak, S. H., Errico, M., & Christensen, K. V. (2021) · Algal Research · doi:10.1016/j.algal.2021.102220 · Cited by 5

In vitro antibacterial activity of biosynthesized silver nanoparticles against gram negative bacteria

Dhas, T. S., Sowmiya, P., Parthasarathy, K., Natarajan, A., Narendrakumar, G., Kumar, R., Samrot, A. V., Riyaz, S. U. M., Kumar, V. G., Karthick, V., et al. (2022) · Inorganic and Nano-Metal Chemistry · doi:10.1080/24701556.2022.2034014 · Cited by 5

Analysis of Volatile Constituent by Hydrodistillation and Solid‐Phase Microextraction Techniques and Antimicrobial and Scolicidal Activities of Essential Oil and Soxhlet Extracts of Ulva rigida grown in Turkey

YÜCEL, T. B., Korkmaz, B., Cebeci, T., Karaman, Ü., Arıcı, Y. K., Fandaklı, S., & Gül, T. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202300965 · Cited by 5

Fucoidan Modulated Oxidative Stress and Caspase-3 mRNA Expression Induced by Sulfoxaflor in the Brain of Mice

Benli, P. P., Kaya, M., & Coşkun, Ç. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00415-0 · Cited by 5

Seaweed-derived green hydrogels: advances, biomedical applications, and future perspectives-a review

Vijayakumar, D. (2026) · Polymer Bulletin · doi:10.1007/s00289-026-06378-6 · Cited by 4

Therapeutic potential of fucoidan in atherosclerosis: a review

Feng, Q., Ma, J., Jiang, X., Wei, W., Xu, D., Cao, Y. C., & Pei, H. (2025) · Food & Function · doi:10.1039/d4fo05388e · Cited by 4

Nutraceutical benefits of seaweeds and their phytocompounds: a functional approach to disease prevention and management

Kahwa, I., Omara, T., Ayesiga, I., Shah, K., Ambe, G. N. N. N., Panwala, Z. J., Mbabazi, R., Iqbal, S., Kyarimpa, C. M., Nagawa, C. B., et al. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.14287 · Cited by 7

Investigation of Biological, Scolicidal and Antimicrobial Activities of the Solvent Extracts Components of Cystoseria barbata Seen off Sinop Province

Karaman, Ü., YÜCEL, T. B., Cebeci, T., Arıcı, Y. K., Yücel, M., & Korkmaz, B. (2022) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.56.2s.102 · Cited by 4

Assessing the impact of arsenite and arsenate on Sarcodia suae: a tale of two toxicities

Tzean, Y., Wang, K.-T., Lee, P.-Y., & Wu, T. (2024) · Ecotoxicology · doi:10.1007/s10646-024-02793-5 · Cited by 4

Homology modeling of chemokine CCR7, molecular docking, and in vitro studies evidenced plausible immunotherapeutic anticancer natural compounds

Singh, P., Singh, R. S., Rani, A., & Bast, F. (2016) · Medicinal Chemistry Research · doi:10.1007/s00044-016-1647-2 · Cited by 4

Potential of L-fucose isolated from Brown Seaweeds as Promising Natural Emulsifier compare to Carboxymethyl Cellulose (CMC)

Al–Baarri, A. N., Legowo, A. M., Widayat, W., Abduh, S. B. M., Lestari, F. P., Desnasari, D., & Santoso, I. P. M. (2018) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/116/1/012005 · Cited by 4

The reducibility of heLa cell viability by Sargassum polycystum extracts

Firdaus, M., Setijawati, D., Islam, I., Nursyam, H., Kartikaningsih, H., Yufidasari, H. S., Prihanto, A. A., Nurdiani, R., & Jaziri, A. A. (2018) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/137/1/012064 · Cited by 4

Sulfated Seaweed Polysaccharides

Inácio, A. R., Carvalho, A., Oliveira, C., Reys, L. L., Silva, S. S., Neves, N. M., Martins, A. M., Reis, R. L., & Silva, T. H. (2022) · Springer eBooks · doi:10.1007/978-3-030-42215-8_17 · Cited by 5

The Cytotoxic Activity Chara elegans on Growth of same Cell Lines

Mohammed, I. H., Abed, A. K., Nsaif, Q. H., & Taha, Z. (2018) · Diyala Journal of Medicine · doi:10.26505/djm.14023450612 · Cited by 4

Marine Algal Products and Algal Nanoparticle Synthesis Against Cancer

Ramu, A. K., & Ahmed, A. B. A. (2021) · Nanotechnology in the life sciences · doi:10.1007/978-3-030-81557-8_11 · Cited by 4

EVALUATION OF ANTHELMINTIC ACTIVITY USING SOLVENT EXTRACT OF PADINA TETRASTROMATICA IN INDIAN EARTHWORM (PHERETIMA POSTHUMA)

Selvi, B. C. G., & Santhanam, A. (2016) · International Journal of Therapeutic Applications · doi:10.20530/ijta_32_77-80 · Cited by 4

Current Designs and Developments of Fucoidan-based Formulations for Cancer Therapy

Tran, P. H. L., & Tran, T. T. D. (2019) · Current Drug Metabolism · doi:10.2174/1389200220666191007154723 · Cited by 4

Phytochemical profiling, toxicity, and pharmacological investigations of the brown seaweed Sargassum vulgare collected from the Red Sea coast combined with molecular docking analysis and SwissADMET prediction

al-hashdy, D. F., El-Shaibany, A. M., Abdelkhalek, A. S., Raweh, S. M., Elaasser, M. M., & Raslan, A. E. (2025) · South African Journal of Botany · doi:10.1016/j.sajb.2025.05.006 · Cited by 3

Supplementation of Seaweeds Extracts Suppresses Azoxymethane-induced Aberrant DNA Methylation in Colon and Liver of ICR Mice

Bu, S. Y., Kwon, H., & Sung, M. (2014) · Journal of Cancer Prevention · doi:10.15430/jcp.2014.19.3.216 · Cited by 3

Microwave-Assisted Extraction of Fucoidan from Brown Seaweeds of Nizimuddinia zanardini and Assessment of the Chemical and Antioxidant Properties of the Extracted Compound

Torabi, P., Hamdami, N., & Keramat, J. (2021) · Iranian Journal of Nutrition Sciences & Food Technology · doi:10.52547/nsft.16.1.61 · Cited by 3

Isolation, characterisation and in vitro screening of anticataract potential of Fucoidan from Sargassum wightii Greville

Ramu, S., Mahendra, S. A., Kunchakuri, K., Karadi, P. P., Swetha, K., & Radhakrishnan, G. (2018) · Journal of Herbmed Pharmacology · doi:10.15171/jhp.2018.37 · Cited by 3

Anticancer and Apoptosis Inducing Effect of Methanolic Extract of Leaves and Rhizomes of Curcuma amada Roxb in Breast Cancer Cell Lines

Sivaprabha, J. (2014) · Shodhganga · Cited by 3

Normalization of Immune Response via Chondroitin Sulfate and Fucoidan Targeting N-Acetylgalactosaminidase

Zima, J., Nováková, E., Špaglová, M., & Šupolíková, M. (2025) · Scientia Pharmaceutica · doi:10.3390/scipharm93040047 · Cited by 2

Role of deep eutectic solvents for the extraction of polysaccharides from seaweed for food applications

Jerome, R. E., Sivapragasam, N., Gupta, V. K., Tiwari, B. K., & Rajauria, G. (2026) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2026.125575 · Cited by 3

Insight into the relationships of structure and anti-tumor effects of Glucuronomannan oligosaccharides (Gx) and its derivatives on the A549 lung adenocarcinoma cells

He, X., Wang, S., Cai, M., Qiao, P., Mao, G., Jin, W., & Zhong, W. (2023) · Algal Research · doi:10.1016/j.algal.2023.102979 · Cited by 2

Cosmetic and Dermatological Application of Seaweed: Skincare Therapy-Cosmeceuticals

Gökbulut, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-65529-6_11 · Cited by 3

Biological clock and carcinogenesis: role of Lobophora variegata extract on liver cancer

Adaikkalam, A., Sankaran, S., Rajan, S. S., & Subramanian, P. (2018) · Biological Rhythm Research · doi:10.1080/09291016.2018.1525141 · Cited by 2

Valuable bioproducts from seaweeds obtained by green extraction technologies: Potential health benefits and applications in pharmacological industries

Pangestuti, R., Ridwanudin, A., Putra, Y., Pratama, I. S., Rahmadi, P., Siahaan, E. A., & Kim, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824270-4.00005-5 · Cited by 2

Anticancer activity of natural compounds from marine plants

Banik, B. K., & Das, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99710-2.00003-2 · Cited by 3

Marine Polysaccharides and Their Importance for Human Health

Laurienzo, P. (2018) · Blue Biotechnology · doi:10.1002/9783527801718.ch15 · Cited by 2

Main Marine Biopolymers for Food Packaging Film Applications

Rodríguez‐Núñez, J. R., Montoya-Anaya, D. G., Fortiz‐Hernández, J., Freile‐Pelegrín, Y., & Madera-Santana, T. J. (2023) · doi:10.1002/9783527837304.ch10 · Cited by 2

Strategies for Quality Control of Polysaccharides in Chinese Medicines

Li, S., Zhao, J., & Ip, C. (2024) · Springer eBooks · doi:10.1007/978-981-99-9871-5_2 · Cited by 1

The Storage and Production of Bioenergy Using Macroalgae Biomass—Part I: Ensiling

Ditchfield, A. K., Kerrison, P. D., Mair, A., Hurst, G., Green, D. H., Stanley, M. S., Fedenko, J. R., & Hughes, A. D. (2024) · Sustainability · doi:10.3390/su162411094 · Cited by 1

Brown Seaweed Biomass as Potential Raw Material for Biorefinery

Sharma, A. A. K., & Baghel, R. S. (2025) · Springer eBooks · doi:10.1007/978-981-96-0519-4_12 · Cited by 2

Innovations in Ulva lactuca Valorisation: A Comprehensive Review and Bibliometric Analysis for Food Science

Putra, N. R., Rizkiyah, D. N., Mukhaimin, I., Mamat, H., Aziz, A. H. A., & Airlangga, B. (2025) · Journal of Aquatic Food Product Technology · doi:10.1080/10498850.2025.2504909 · Cited by 1

Review of Sargassum thunbergii (Fucales, Phaeophyta): phycology, chemistry, bioactivity, and application

Wang, X., Xiao, D., Yeo, I., Wang, L., Li, Y., Fu, J. R., Fu, Y., Cho, S., Jeon, Y., & Yang, F. (2025) · ALGAE · doi:10.4490/algae.2025.40.12.7 · Cited by 1

Marine Polysaccharide Nanocarriers: New Strategies for Targeted Cancer Therapy

Das, S., Murty, U. S., & Banerjee, S. (2026) · BioNanoScience · doi:10.1007/s12668-026-02610-9 · Cited by 1

Fucoidan-Mediated Biogenic Gold Nanoparticles from Padina tetrastromatica: In Vitro and In Silico Evaluation of Multifunctional Biological Activities

Newehy, A. S. E., Elshobary, M. E., al., M. M. I. E., Alrebaish, A. S., Sulaiman, A. A. A., Aldisi, D. A., Abulmeaty, M. M. A., & Gheda, S. F. (2026) · Pharmaceuticals · doi:10.3390/ph19070976 · Cited by 1

From oceanic depths to oncology frontlines: Fucoidan as a marine-forged bioactive agent targeting non-small cell lung cancer

Devi, A., Phatale, V., Shukla, S., Shetty, P., Srivastava, A., Chaure, P., Khairnar, P., & Srivastava, S. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109461 · Cited by 1

Produtos marinhos como fonte promissora de fármacos: um foco para ação cardiovascular

Moreira, B. D. S., & Silva, D. F. (2015) · Revista de Ciências Médicas e Biológicas · doi:10.9771/cmbio.v13i3.12944 · Cited by 1

Review of Associated Health Benefits of Algal Supplementation in Cattle with Reference to Bovine Respiratory Disease Complex in Feedlot Systems

Willett, M., Campbell, M., Schoenfeld, E., & Callcott, E. T. (2022) · Animals · doi:10.3390/ani12151943 · Cited by 1

Induction of apoptosis using the mixture of fucoidan and Crepidiastrum denticulatum extract in HepG2 liver cancer cells

Park, S., Choi, D., Oh, K., Kim, H., Park, H., & Kim, K. (2024) · Food Science and Preservation · doi:10.11002/fsp.2024.31.2.276 · Cited by 1

Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic Target for Cancer

Kalimuthu, S., & Kim, S. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_7 · Cited by 26

In vitro anticancer activity of fucoidan extracted from Sargassum cinereum against Caco-2 cells

Narayani, S. S., Saravanan, S., Jaganathan, R., Ramasamy, M. S., & Chitra, J. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.07.127 · Cited by 108

Fucoidan, a major component of brown seaweed, prohibits the growth of human cancer cell lines in vitro

Fukahori, S., Yano, H., Akiba, J., Ogasawara, S., Momosaki, S., Sanada, S., Kuratomi, K., Ishizaki, Y., Moriya, F., Yagi, M., et al. (2008) · Molecular Medicine Reports · doi:10.3892/mmr.1.4.537 · Cited by 67

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

Atashrazm, F., Lowenthal, R. M., Woods, G. M., Holloway, A. F., & Dickinson, J. L. (2015) · Marine Drugs · doi:10.3390/md13042327 · Cited by 367

98P Seaweed extract and fucoidan on breast cancer cell proliferation

Chavoshi, S. H., & Chavoshi, M. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw575.037