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Cited by 340Seaweed-derived Bioactive CompoundsEchinoderm biology and ecologyMarine and coastal plant biology

The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.

Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer

Senthilkumar, Kalimuthu, Manivasagan, Panchanathan, Venkatesan, Jayachandran, Kim, Se-Kwon·2013·International Journal of Biological Macromolecules
DOI 10.1016/j.ijbiomac.2013.06.030
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Abstract

Seaweeds, being abundant sources of bioactive components have much interest in recent times. The complex polysaccharides from the brown, red and green seaweeds possess broad spectrum therapeutic properties. The sulfated polysaccharides are routinely used in biomedical research and have known biological activities. Fucoidan, a fucose-rich polysaccharide extracted from brown seaweed has various biological functions including anticancer effects. Cellular damage induces growth arrest and tumor suppression by inducing apoptosis, the mechanism of cell death depends on the magnitude of DNA damage following exposure to anticancer agents. Apoptosis is mainly regulated by cell growth signaling molecules. Number of research studies evidenced that fucoidan shown to induce cytotoxicity of various cancer cells, induces apoptosis, and inhibits invasion, metastasis and angiogenesis of cancer cells. There are few articles discussing on fucoidan biological activity but no specific review on cancer and its signaling mechanism. Hence, this review discusses the brown seaweed fucoidan structure and some biological function and role in apoptosis, invasion, metastasis, angiogenesis and growth signal mechanism on cancer.

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Crossref · 10.1016/j.ijbiomac.2013.06.030

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Citations

Cites

Show all 123 references

Research works printed but not linked: 8

  1. Riou, 1996, Anticancer Research, 16, 1213
  2. Yamamoto, 1984, Japanese Journal of Experimental Medicine, 54, 143
  3. Itoh, 1995, Anticancer Research, 15, 1937
  4. Makarenkova, 2010, Voprosy Virusologii, 55, 41
  5. Semenov, 1998, Voprosy medit sinskoĭ khimii, 44, 135
  6. Hayakawa, 2009, Anticancer Research, 29, 1211
  7. Kaufmann, 1993, Cancer Research, 53, 3976
  8. Rodriguez, 1999, Science Signaling, 13, 3179

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Metadata

Authors
Senthilkumar, K., Manivasagan, P., Venkatesan, J., & Kim, S.-K.
Affiliations
Pukyong National University (KR)
Corresponding author
Kim, Se-Kwon
ORCID
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2013-09
Volume
60
Pages
366-374
ISSN
0141-8130 (ISSN-L)
DOI
10.1016/j.ijbiomac.2013.06.030
OpenAlex
W2018692723
Cited by
340
References
123
Citations by year
2026: 20 · 2025: 21 · 2024: 26 · 2023: 18 · 2022: 28 · 2021: 32 · 2020: 24 · 2019: 40 · 2018: 33 · 2017: 25 · 2016: 26 · 2015: 22 · 2014: 20 · 2013: 4
FWCI
3.82
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Oceans and Fisheries, Republic of Korea
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
  • Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Keywords
fucoidan, brown algae, sulfated polysaccharides, apoptosis, tumor suppression, metastasis suppression, angiogenesis inhibition, cytotoxicity, DNA damage, anticancer activity
MeSH terms
Animals, Antineoplastic Agents, Phytogenic, Cell Cycle, Humans, Molecular Weight, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Polysaccharides, Seaweed, Signal Transduction, Apoptosis

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