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Alternative Activation of Macrophages: Mechanism and Functions
Open accessAbstract
The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.
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“The sebum lipids linoleic and oleic acid were detected to be potent inducers of the so-called alternative macrophage activation, which is the characteristic activation pathway for macrophages involved in tissue homeostasis and repair functions.64”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [64]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“These cells are inherently heterogeneous and display remarkable functional plasticity, categorizing into two major phenotypes: M1 and M2 [3, 4].”
From miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1 (2024) · cites this paper as [3]
Experimental — accuracy not yet measuredIn the citing paper
“A pro-wound healing phenotype of macrophage correlates with up regulation in expression of Dendritic Cell Immune Receptor (Dcir), Stabilin 1 (Stab1), chemokine (C-C motif) ligand 22 (CCL22), Chitinase-like 3 (YM1), and Arginase 1 (Arg1)44, 45, 46.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [46]
In the citing paper
“A pro-inflammatory macrophage phenotype correlates with elevated expression of Tumor Necrosis Factor α (TNF α), Interleukin 1 (IL1), and Interferon Regulatory Factor 5 (IRF5)44, 45, 46.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [46]
In the citing paper
“Meanwhile, a regulatory macrophage phenotype has been characterized to correlate with elevated expression of Interleukin 10 (IL10), TNF superfamily member 14 (Light), and Sphingosine Kinase 1 (Sphk1)44, 45, 46.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [46]
In the citing paper
“In general, M1s or classically activated MΦs are pro-inflammatory and microbicidal, whereas M2s or alternatively activated MΦs are immunomodulatory, reparative, and poorly microbicidal [7–12].”
From Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds (2013) · cites this paper as [9]
In the citing paper
“Stimulation of macrophages using IL-4 or IL-10 results in alternative activation, or M2 type polarization, characterized by the release of anti-inflammatory and tissue repair molecules (41).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [41]
In the citing paper
“previous studies have shown that phosphorylation of STAT6 is a key step downstream in the IL-4 cascade that leads to Arg1 expression (49–51).”
From Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions (2020) · cites this paper as [51]
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Cites
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317
Microenvironmental regulation of metastasis
Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Self-citationMartínez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,399
Self-citationNuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M. G., Langford, T. K. A., Bucks, C. M., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 2,079
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Items 201–300 of 1,016
Allen, J. E., & Sutherland, T. E. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.06.003 · Cited by 279
Creatine metabolism: energy homeostasis, immunity and cancer biology
Kazak, L., & Cohen, P. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0365-5 · Cited by 267
Immune defence to invasive fungal infections: A comprehensive review
Pathakumari, B., Liang, G., & Liu, W. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110550 · Cited by 278
The porcine innate immune system: an update
Mair, K. H., Sedlak, C., Käser, T., Pasternak, A., Levast, B., Gerner, W., Saalmüller, A., Summerfield, A., Gerdts, V., Wilson, H. L., et al. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.03.022 · Cited by 264
Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis
Wu, M.-Y., & Lu, J. (2019) · Cells · doi:10.3390/cells9010070 · Cited by 274
Kamerkar, S., Leng, C., Burenkova, O. V., Jang, S. C., McCoy, C., Zhang, K. X., Dooley, K., Kasera, S., Zi, T., Sisó, S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abj7002 · Cited by 266
Macrophage polarization in diabetic wound healing
Wu, X., He, W., Mu, X., Liu, Y., Deng, J., Liu, Y., & Nie, X. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac051 · Cited by 272
Oxidative Stress in Pulmonary Fibrosis
Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190017 · Cited by 312
Matrix metalloproteinases as regulators of inflammatory processes
Fingleton, B. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.05.010 · Cited by 263
Regulatory immune cells in regulation of intestinal inflammatory response to microbiota
Sun, M., He, C. H., Cong, Y., & Liu, Z. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.49 · Cited by 263
Probiotic helminth administration in relapsing–remitting multiple sclerosis: a phase 1 study
Fleming, J. O., Isaak, A., Lee, J., Luzzio, C. C., Carrithers, M. D., Cook, T., Field, A. S., Boland, J., & Fábry, Z. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511398054 · Cited by 257
Louvet, A., Teixeira-Clerc, F., Chobert, M.-N., Deveaux, V., Pavoine, C., Zimmer, A., Pecker, F., Mallat, A., & Lotersztajn, S. (2011) · Hepatology · doi:10.1002/hep.24524 · Cited by 259
Ley, K. F. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701135 · Cited by 257
Cellular and Molecular Mediators of Neuroinflammation in the Pathogenesis of Parkinson’s Disease
More, S. V., Kumar, H., Kim, I. S., Song, S.-Y., & Choi, D.-K. (2013) · Mediators of Inflammation · doi:10.1155/2013/952375 · Cited by 264
Schmall, A., Al-tamari, H. M., Herold, S., Kampschulte, M., Weigert, A., Wietelmann, A., Vipotnik, N., Grimminger, F., Seeger, W., Pullamsetti, S. S., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201406-1137oc · Cited by 257
Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy
Lechner, A. J., Driver, I. H., Lee, J., Conroy, C., Nagle, A., Locksley, R. M., & Rock, J. R. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.03.024 · Cited by 261
Molecular Mechanism for Adiponectin-dependent M2 Macrophage Polarization
Mandal, P., Pratt, B. T., Barnes, M. A., McMullen, M. R., & Nagy, L. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204644 · Cited by 260
Phenotypic Polarization of Macrophages in Atherosclerosis
Leitinger, N., & Schulman, I. G. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300173 · Cited by 259
Unraveling macrophage contributions to bone repair
Wu, A. C., Raggatt, L. J., Alexander, K. A., & Pettit, A. R. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.107 · Cited by 256
Inflammation activation and resolution in human tendon disease
Dakin, S. G., Martínez, F. O., Yapp, C., Wells, G., Oppermann, U. C. T., Dean, B. J. F., Smith, R. D. J., Wheway, K., Watkins, B., Roche, L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac4269 · Cited by 263
First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment
Saluzzo, S., Gorki, A.-D., Rana, B. M. J., Martins, R., Scanlon, S. T., Starkl, P. M., Lakovits, K., Hladik, A., Korosec, A., Sharif, O., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.071 · Cited by 256
Differentiation and gene expression profile of tumor-associated macrophages
Schmieder, A., Michel, J., Schönhaar, K., Goerdt, S., & Schledzewski, K. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.02.002 · Cited by 263
Su, S., Zhao, Q., He, C., Huang, D., Liu, J., Chen, F., Chen, J., Liao, J.-Y., Cui, X., Zeng, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms9523 · Cited by 257
Su, N., Gao, P.-L., Wang, K., Wang, J.-Y., Zhong, Y., & Luo, Y. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.028 · Cited by 254
Czimmerer, Z., Dániel, B., Horváth, A., Rückerl, D., Nagy, G., Kiss, M., Peloquin, M., Budai, M. M., Cuaranta‐Monroy, I., Simándi, Z., et al. (2018) · Immunity · doi:10.1016/j.immuni.2017.12.010 · Cited by 252
Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes
Ren, W., Xia, Y., Chen, S., Wu, G., Bazer, F. W., Zhou, B., Tan, B., Zhu, G., Deng, J., & Yin, Y. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy084 · Cited by 261
Prognostic significance of tumor-associated macrophages in ovarian cancer: A meta-analysis
Yuan, X., Zhang, J., Li, D., Ye, M., Mo, F., Du, W., & Ma, X. (2017) · Gynecologic Oncology · doi:10.1016/j.ygyno.2017.07.007 · Cited by 252
Gu, W., Liu, S., Chen, L., Liu, Y., Gu, C., Ren, H., & Wu, B. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b06386 · Cited by 255
Aging and cancer: The role of macrophages and neutrophils
Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.008 · Cited by 251
Amino acid auxotrophy as a system of immunological control nodes
Murray, P. J. (2016) · Nature Immunology · doi:10.1038/ni.3323 · Cited by 254
D’Alessio, S., Correale, C., Tacconi, C., Gandelli, A., Pietrogrande, G., Vetrano, S., Genua, M., Arena, V., Spinelli, A., Peyrin‐Biroulet, L., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72189 · Cited by 247
Local Arginase 1 Activity Is Required for Cutaneous Wound Healing
Campbell, L., Saville, C. R., Murray, P. J., Cruickshank, S. M., & Hardman, M. J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.164 · Cited by 254
Defining macrophage phenotype and function in adipose tissue
Dalmas, É., Clément, K., & Guerre-Millo, M. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.008 · Cited by 267
MacKenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y. A., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202462 · Cited by 252
Ni, C., Zhou, J., Kong, N., Bian, T., Zhang, Y., Huang, X., Xiao, Y., Yang, W. R., & Yan, F. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.03.039 · Cited by 252
Metabolic reprogramming in triple-negative breast cancer
Sun, X., Wang, M., Wang, M., Yu, X., Guo, J., Sun, T., Li, X., Yao, L., Dong, H., & Xu, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00428 · Cited by 243
Bhattacharjee, A., Shukla, M., Yakubenko, V. P., Mulya, A., Kundu, S., & Cathcart, M. K. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.553 · Cited by 237
Fu, X.-L., Duan, W., Su, C.-Y., Mao, F.-Y., Lv, Y.-P., Teng, Y.-S., Yu, P.-W., Zhuang, Y., & Zhao, Y.-L. (2017) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-017-2052-5 · Cited by 242
Review: the Role and Mechanisms of Macrophage Autophagy in Sepsis
Qiu, P., Liu, Y., & Zhang, J. (2018) · Inflammation · doi:10.1007/s10753-018-0890-8 · Cited by 246
Ji, L., Zhao, X., Zhang, B., Kang, L., Song, W., Zhao, B., Xie, W., Chen, L., & Hu, X. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.007 · Cited by 242
Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13
Gao, S., Zhou, J., Liu, N., Wang, L., Gao, Q., Wu, Y. R., Zhao, Q., Liu, P. N., Wang, S., Liu, Y., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.025 · Cited by 247
Liu, N., Luo, J., Kuang, D., Xu, S., Duan, Y., Xia, Y., Wei, Z., Xie, X., Yin, B., Chen, F., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci123027 · Cited by 251
You, D. G., Lim, G. T., Kwon, S., Um, W., Oh, B. H., Song, S. H., Lee, J., Jo, D., Cho, Y. W., & Park, J. H. (2021) · Science Advances · doi:10.1126/sciadv.abe0083 · Cited by 243
Immune response following traumatic spinal cord injury: Pathophysiology and therapies
Sterner, R. C., & Sterner, R. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1084101 · Cited by 258
Yao, Y., Wang, Y., Zhang, Z., He, L., Zhu, J., Zhang, M., He, X., Cheng, Z., Ao, Q., Cao, Y., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.36 · Cited by 237
The role of airway epithelial cells and innate immune cells in chronic respiratory disease
Holtzman, M. J., Byers, D. E., Alexander‐Brett, J. M., & Wang, X. (2014) · Nature reviews. Immunology · doi:10.1038/nri3739 · Cited by 246
Hu, G., Guo, M., Xu, J., Wu, F., Fan, J., Huang, Q., Yang, G., Lv, Z., Wang, X., & Jin, Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01998 · Cited by 241
12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance
Uderhardt, S., i, M. H., Oskolkova, O., Aschermann, S., Bicker, W., Ipseiz, N., Sarter, K., Frey, B., Rothe, T., Voll, R. E., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.010 · Cited by 246
Protein bio-corona: critical issue in immune nanotoxicology
Neagu, M. T., Piperigkou, Z., Καραμάνου, Κ., Engin, A. B., Docea, A. O., Constantin, C., Negrei, C., Nikitovic, D., & Tsatsakis, A. M. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1797-5 · Cited by 244
Heymann, M.-F., Lézot, F., & Heymann, D. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2017.10.011 · Cited by 233
Xiao, H. P., Guo, Y., Li, B., Li, M., Wang, Y., Han, S., Cheng, D., & Shuai, X. (2020) · ACS Central Science · doi:10.1021/acscentsci.9b01235 · Cited by 234
Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization
Lu, G., Zhang, R., Geng, S., Peng, L., Jayaraman, P., Chen, C., Xu, F., Yang, J., Li, Q., Zheng, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms7676 · Cited by 230
Yang, Y., Salayandia, V. M., Thompson, J. F., Yang, L. Y., Estrada, E. Y., & Yang, Y. R. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0245-4 · Cited by 234
Role of Adaptive and Innate Immunity in Type 2 Diabetes Mellitus
Zhou, T., Hu, Z., Yang, S., Sun, L., Yu, Z., & Wang, G. (2018) · Journal of Diabetes Research · doi:10.1155/2018/7457269 · Cited by 243
Ageing and the immune system: focus on macrophages
Linehan, E., & Fitzgerald, D. (2015) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi-d-14-00035 · Cited by 234
Abdominal Aortic Aneurysm: Roles of Inflammatory Cells
Yuan, Z., Lü, Y., Wei, J., Wu, J., Yang, J., & Cai, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.609161 · Cited by 232
Shechter, R., & Schwartz, M. (2012) · The Journal of Pathology · doi:10.1002/path.4106 · Cited by 237
PCSK9 induces a pro-inflammatory response in macrophages
Ricci, C., Ruscica, M., Camera, M., Rossetti, L., Macchi, C., Colciago, A., Zanotti, I., Lupo, M. G., Adorni, M. P., Cicero, A. F. G., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20425-x · Cited by 234
Macrophage Polarization in Leishmaniasis: Broadening Horizons
Tomiotto‐Pellissier, F., Bortoleti, B. T. D. S., Assolini, J. P., Gonçalves, M. D., Carloto, A. C. M., Miranda-Sapla, M. M., Costa, I. C., Bordignon, J., & Pavanelli, W. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02529 · Cited by 239
Wu, J., Yu, Y., Cheng, Y., Cheng, C., Zhang, Y., Jiang, B., Zhao, X., Miao, L., & Wei, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202010714 · Cited by 227
Eisele, N. A., Ruby, T., Jacobson, A. R., Manzanillo, P. S., Cox, J. S., Lam, L. H., Mukundan, L., Chawla, A., & Monack, D. M. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.010 · Cited by 226
McMahan, R. H., Wang, X. X., Cheng, L. L., Krisko, T., Smith, M., El Kasmi, K., Pruzanski, M., Adorini, L., Golden-Mason, L., Levi, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.446575 · Cited by 225
Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis
Linton, M. F., Babaev, V. R., Huang, J., Linton, E. F., Tao, H., & Yancey, P. G. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0924 · Cited by 235
Pro-Resolving Effect of Ginsenosides as an Anti-Inflammatory Mechanism of Panax ginseng
Im, D. (2020) · Biomolecules · doi:10.3390/biom10030444 · Cited by 225
Disclosure of the culprits: macrophages-versatile regulators of wound healing.
Sindrilaru, A., & Scharffetter-Kochanek, K. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0407 · Cited by 223
Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype
Leal, E. C., Carvalho, E., Tellechea, A., Kafanas, A., Tecilazich, F., Kearney, C., Kuchibhotla, S., Auster, M. E., Kokkotou, E., Mooney, D. J., et al. (2015) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.02.011 · Cited by 223
Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review
Maspi, N., Abdoli, A., & Ghaffarifar, F. (2016) · Pathogens and Global Health · doi:10.1080/20477724.2016.1232042 · Cited by 231
Recruitment of monocytes/macrophages in different tumor microenvironments
Lee, H., Choi, H.-J., Ha, S., Lee, K.-T., & Kwon, Y. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.12.007 · Cited by 233
Ji, Y., Sun, S., Xu, A., Bhargava, P., Yang, L., Lam, K. S. L., Gao, B., Lee, C., Kersten, S., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.350066 · Cited by 221
Feng, Z., Su, Q., Zhang, C., Huang, P., Song, H., Dong, A., Kong, D., & Wang, W. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202006454 · Cited by 221
Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity
Hoves, S., Ooi, C.-H., Wolter, C., Sade, H., Bissinger, S., Schmittnaegel, M., Ast, O., Giusti, A. M., Wartha, K., Runza, V., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171440 · Cited by 224
Patera, A. C., Drewry, A. M., Chang, K. C., Beiter, E. R., Osborne, D., & Hotchkiss, R. S. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4hi0616-255r · Cited by 224
Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
Gupta, S., Roy, A., & Dwarakanath, B. S. R. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00068 · Cited by 225
Zarruk, J. G., Fernández‐López, D., García‐Yébenes, I., García‐Gutiérrez, M. S., Vivancos, J., Nombela, F., Torres, M., Burguete, M. C., Manzanares, J., Lizasoaín, I., et al. (2011) · Stroke · doi:10.1161/strokeaha.111.631044 · Cited by 217
Whyte, C. S., Bishop, E., Rückerl, D., Gaspar-Pereira, S., Barker, R. N., Allen, J. E., Rees, A. J., & Wilson, H. M. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1110644 · Cited by 226
Role of microglial m1/m2 polarization in relapse and remission of psychiatric disorders and diseases
Nakagawa, Y., & Chiba, K. (2014) · Pharmaceuticals · doi:10.3390/ph7121028 · Cited by 215
Liu, W., Taso, O., Wang, R., Bayram, S., Graham, A. C., Garcia-Reitboeck, P., Mallach, A., Andrews, W. D., Piers, T. M., Botia, J. A., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa209 · Cited by 214
“The phosphorylation of the transcription factor STAT6 is a key step downstream in the IL4 cascade that leads to Arg1 expression (Gordon and Martinez 2010; Luzina et al. 2012; Nelms et al. 1999).”
BackgroundSystemic inflammation and fracture healing
Bastian, O. W., Pillay, J., Alblas, J., Leenen, L. P. H., Koenderman, L., & Blokhuis, T. J. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0810446 · Cited by 214
Niu, Y., Wang, Z., Shi, Y., Dong, L., & Wang, C. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.08.012 · Cited by 213
Kumar, A., Barrett, J. P., Alvarez-Croda, D.-M., Stoica, B. A., Faden, A. I., & Loane, D. J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.158 · Cited by 213
Hsiao, H.-M., Sapinoro, R., Thatcher, T. H., Croasdell, A., Levy, E. P., Fulton, R. A., Olsen, K. C., Pollock, S. J., Serhan, C. N., Phipps, R. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058258 · Cited by 212
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Piccolo, V., Curina, A., Genua, M., Ghisletti, S., Simonatto, M., Sabò, A., Amati, B. B., Ostuni, R., & Natoli, G. (2017) · Nature Immunology · doi:10.1038/ni.3710 · Cited by 216
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Mège, J., Mehraj, V., & Capo, C. (2011) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e328344b73e · Cited by 207
Francos-Quijorna, I., Amo‐Aparicio, J., Martínez‐Muriana, A., & López‐Vales, R. (2016) · Glia · doi:10.1002/glia.23041 · Cited by 213
Monocytes and Macrophages in Cancer: Development and Functions
Richards, D. M., Hettinger, J., & Feuerer, M. (2012) · Cancer Microenvironment · doi:10.1007/s12307-012-0123-x · Cited by 215
Zhou, Y., Zhang, T., Wang, X., Wei, X., Chen, Y., Guo, L., Zhang, J., & Wang, C. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430126 · Cited by 209
Ziółkowska, S., Binienda, A., Jabłkowski, M., Szemraj, J., & Czarny, P. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011128 · Cited by 219
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Nakagawa, Y., & Chiba, K. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.010 · Cited by 208
Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis
Ding, N.-H., Li, J. J., & Sun, L.-Q. (2013) · Current Drug Targets · doi:10.2174/13894501113149990198 · Cited by 214
Gautier, E. L., Ivanov, S., Williams, J. W., Huang, S. C., Marcelin, G., Fairfax, K. C., Wang, P. L., Francis, J. S., Leone, P., Wilson, D. B., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140570 · Cited by 210
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice
Barrow, A. D., Raynal, N., Andersen, T. L., Slatter, D. A., Bihan, D. G., Pugh, N., Cella, M., Kim, T. S., Rho, J., Negishi‐Koga, T., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45913 · Cited by 207
The interplay between macrophages and angiogenesis in development, tissue injury and regeneration
Nucera, S., Biziato, D., & Palma, M. D. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.103227sn · Cited by 211
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Paoli, F. D., Staels, B., & Chinetti, G. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0621 · Cited by 214
Lin, X., Wang, S., Sun, M., Zhang, C., Chen, W., Yang, C., Dou, R., Liu, Q., & Xiong, B. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0708-7 · Cited by 208
RetractedMacrophage polarization in inflammatory bowel disease
Zhang, K., Guo, J., Yan, W., & Xu, L. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01386-9 · Cited by 228
Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and Regression
Peled, M., & Fisher, E. A. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00579 · Cited by 212
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Squadrito, M. L., Pucci, F., Magri, L., Moi, D., Gilfillan, G. D., Ranghetti, A., Casazza, A., Mazzone, M., Lyle, R., Naldini, L., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2011.12.005 · Cited by 208
Macrophage responses to implants: prospects for personalized medicine
Kzhyshkowska, J. G., Gudima, A., Riabov, V., Dollinger, C., Lavall�e, P., & Vrana, N. E. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.5vmr0415-166r · Cited by 208
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Pettersen, J. S., Fuentes‐Duculan, J., Suárez‐Fariñas, M., Pierson, K. C., Pitts-Kiefer, A., Fan, L., Belkin, D. A., Wang, C. Q. F., Bhuvanendran, S., Johnson-Huang, L. M., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.9 · Cited by 207
CAFs Interacting With TAMs in Tumor Microenvironment to Enhance Tumorigenesis and Immune Evasion
Günaydın, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.668349 · Cited by 211
Metadata
- Authors
- Gordon, S., & Martinez, F. O.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Gordon, Siamon
- ORCID
- Gordon, Siamon
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 32
- Issue
- 5
- Pages
- 593-604
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2065210647
- Cited by
- 4,197
- References
- 118
- Citations by year
- 2026: 193 · 2025: 255 · 2024: 262 · 2023: 292 · 2022: 319 · 2021: 318 · 2020: 292 · 2019: 251 · 2018: 249 · 2017: 271 · 2016: 244 · 2015: 289 · 2014: 283 · 2013: 277 · 2012: 226
- FWCI
- 17.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1209 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Funders
- British Heart Foundation
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- alternative macrophage activation, M2 macrophages, Th2 cytokines, IL-4, IL-13, macrophage polarization, macrophage homeostasis
- MeSH terms
- Animals, Humans, Macrophage Activation, Macrophages, Models, Biological, Neoplasms, Signal Transduction, Cytokines, Receptors, Interleukin
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