Cited by 4,197Immune cells in cancerPhagocytosis and Immune RegulationT-cell and B-cell Immunology

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Alternative Activation of Macrophages: Mechanism and Functions

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Gordon, Siamon, Martinez, Fernando O.·2010·Immunity

DOI 10.1016/j.immuni.2010.05.007

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Abstract

The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.

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Authors: Gordon, S., & Martinez, F. O.
Affiliations: University of Oxford (GB)
Corresponding author: Gordon, Siamon
ORCID: Gordon, Siamon
Venue: Immunity
Publisher: Elsevier BV
Published: 2010-05
Volume: 32
Issue: 5
Pages: 593-604
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2010.05.007
OpenAlex: W2065210647
Cited by: 4,197
References: 118
Citations by year: 2026: 193 · 2025: 255 · 2024: 262 · 2023: 292 · 2022: 319 · 2021: 318 · 2020: 292 · 2019: 251 · 2018: 249 · 2017: 271 · 2016: 244 · 2015: 289 · 2014: 283 · 2013: 277 · 2012: 226
FWCI: 17.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1209 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Open Research (University of Surrey) (submittedVersion)
Funders: British Heart Foundation
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: alternative macrophage activation, M2 macrophages, Th2 cytokines, IL-4, IL-13, macrophage polarization, macrophage homeostasis
MeSH terms: Animals, Humans, Macrophage Activation, Macrophages, Models, Biological, Neoplasms, Signal Transduction, Cytokines, Receptors, Interleukin

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Alternative Activation of Macrophages: Mechanism and Functions

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