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Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets
Open accessAbstract
Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown. Here, we present a unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, revealing tissue-intrinsic compartmentalization of naive, effector, and memory subsets conserved between diverse individuals. Effector memory CD4(+) T cells producing IL-2 predominated in mucosal tissues and accumulated as central memory subsets in lymphoid tissue, whereas CD8(+) T cells were maintained as naive subsets in lymphoid tissues and IFN-γ-producing effector memory CD8(+) T cells in mucosal sites. The T cell activation marker CD69 was constitutively expressed by memory T cells in all tissues, distinguishing them from circulating subsets, with mucosal memory T cells exhibiting additional distinct phenotypic and functional properties. Our results provide an assessment of human T cell compartmentalization as a new baseline for understanding human adaptive immunity.
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“The preferred collagenase used by multiple research groups is collagenase IV [253, 256, 257, 267].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [253]
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“Trm do not express other putative activation markers, such as CD25, CD137, CD38, or HLA-DR [244, 253, 258, 264].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [253]
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In the citing paper
“Both CD8+ and CD4+ Trm have been identified in the human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes [241, 244, 246, 253-259].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [253]
Experimental — accuracy not yet measuredIn the citing paper
“Seeding into tissues occurs in childhood, and the resident population persists throughout adulthood”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Sathaliyawala et al., 2013
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“Resident memory T cells in lungs, skin, and submucosal sites account for a large fraction of memory cells numbering more than 5 × 1010 cells in an individual.”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Sathaliyawala et al., 2013
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 1×
“The low proportion of CD8 Tcm cells compared to CD4 Tcm cells was not predicted from analysis of peripheral blood (Gattinoni et al., 2011; Sallusto et al., 1999) and is most striking when comparing whole body subset delineation as accomplished here.”
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974 · cited 1×
“The low proportion of CD8 Tcm cells compared to CD4 Tcm cells was not predicted from analysis of peripheral blood (Gattinoni et al., 2011; Sallusto et al., 1999) and is most striking when comparing whole body subset delineation as accomplished here.”
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · cited 1×
“CD45RO memory T cells are subdivided into two subsets: CCR7 ‘‘central memory’’ (Tcm) cells, which migrate to lymphoid tissue, and CCR7 ‘‘effector memory’’ (Tem) cells, which circulate to nonlymphoid sites (Masopust et al., 2001; Sallusto et al., 1999, 2004).”
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · cited 1×
“CD69 memory T cells in lymphoid and mucosal sites were largely IL-7R (Figure 4B), indicative of a resting memory T cell phenotype, as IL-7R is downregulated on activated effector T cells (Dooms et al., 2007; Kaech et al., 2003; Paiardini et al., 2005; Seddiki et al., 2006).”
Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770
Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060468 · Cited by 1,512 · cited 1×
“CD69 memory T cells in lymphoid and mucosal sites were largely IL-7R (Figure 4B), indicative of a resting memory T cell phenotype, as IL-7R is downregulated on activated effector T cells (Dooms et al., 2007; Kaech et al., 2003; Paiardini et al., 2005; Seddiki et al., 2006).”
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193
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Gordon, C. L., Miron, M., Thome, J. J. C., Matsuoka, N., Weiner, J. I., Rak, M. A., Igarashi, S., Granot, T., Lerner, H., Goodrum, F. D., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160758 · Cited by 158
Self-citationRamwadhdoebé, T. H., van Baarsen, L. G. M., Boumans, M. J. H., Bruijnen, S. T. G., Safy‐Khan, M., Berger, F. H., Semmelink, J. F., van der Laken, C. J., Gerlag, D. M., Thurlings, R. M., et al. (2018) · Rheumatology · doi:10.1093/rheumatology/key428 · Cited by 155
Design and implementation of adoptive therapy with chimeric antigen receptor‐modified T cells
Jensen, M. C., & Riddell, S. R. (2013) · Immunological Reviews · doi:10.1111/imr.12139 · Cited by 156
T Cell Trafficking through Lymphatic Vessels
Hunter, M. C., Teijeira, Á., & Halin, C. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00613 · Cited by 162
Tew, G. W., Hackney, J. A., Gibbons, D. L., Lamb, C. A., Luca, D., Egen, J. G., Diehl, L. J., Anderson, J. E., Vermeire, S., Mansfield, J. C., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.10.041 · Cited by 154
Paradoxical changes in innate immunity in aging: recent progress and new directions
Montgomery, R. R., & Shaw, A. C. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.5mr0315-104r · Cited by 147
Boddupalli, C. S., Bar, N., Kadaveru, K., Krauthammer, M. O., Pornputtapong, N., Mai, Z., Ariyan, S., Narayan, D., Kluger, H. M., Deng, Y., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88955 · Cited by 154
Fenton, T. M., Jørgensen, P. B., Niss, K., Rubin, S. J. S., Mörbe, U. M., Riis, L. B., Da Silva, C., Plumb, A., Vandamme, J., Jakobsen, H. L., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.001 · Cited by 145
Liu, J., Chang, H.-W., Huang, Z., Nakamura, M., Sekhon, S., Ahn, R. S., Muñoz-Sandoval, P., Bhattarai, S., Beck, K. M., Sanchez, I. M., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.11.028 · Cited by 147
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Youssef, G. B., Tourret, M., Salou, M., Ghazarian, L., Houdouin, V., Mondot, S., Mburu, Y. K., Lambert, M., Azarnoush, S., Diana, J., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171739 · Cited by 142
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Ichikawa, T., Hirahara, K., Kokubo, K., Kiuchi, M., Aoki, A., Morimoto, Y., Kumagai, J., Onodera, A., Mato, N., Tumes, D. J., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0494-y · Cited by 133
Oja, A. E., Piet, B., van der Zwan, D., Blaauwgeers, H., Mensink, M., de Kivit, S., Borst, J., Nolte, M. A., van Lier, R. A. W., Stark, R., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02654 · Cited by 130
Zuber, J., Shonts, B. A., Lau, S. P., Obradović, A., Fu, J., Yang, S., Lambert, M., Coley, S. M., Weiner, J. I., Thome, J., et al. (2016) · Science Immunology · doi:10.1126/sciimmunol.aah3732 · Cited by 130
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Fergusson, J. R., Hühn, M. H., Swadling, L., Walker, L. J., Kurioka, A., Llibre, A., Bertoletti, A., Holländer, G. A., Newell, E. W., Davis, M. M., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.69 · Cited by 130
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Sobkowiak, M. J., Davanian, H., Heymann, R., Gibbs, A., Emgård, J., Dias, J., Aleman, S., Krüger‐Weiner, C., Moll, M., Tjernlund, A., et al. (2018) · European Journal of Immunology · doi:10.1002/eji.201847759 · Cited by 127
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Sercan-Alp, Ö., Durlanik, S., Schulz, D., McGrath, M., Grün, J. R., Bardua, M., Ikuta, K., Sgouroudis, E., Riedel, R., Zehentmeier, S., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201445295 · Cited by 122
Ogongo, P., Tezera, L. B., Ardain, A., Nhamoyebonde, S., Ramsuran, D., Singh, A., Ngoepe, A., Karim, F., Naidoo, T., Khan, K., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142014 · Cited by 120
Bolte, F. J., Bolte, A. C., Webb, L. M., Serti, E., Rivera, E., Liang, T. J., Ghany, M. G., & Rehermann, B. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.043 · Cited by 119
Tong, P. L., Roediger, B., Kolesnikoff, N., Biro, M., Tay, S. S., Jain, R., Shaw, L. E., Grimbaldeston, M. A., & Weninger, W. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.289 · Cited by 122
Senda, T., Dogra, P., Granot, T., Furuhashi, K., Snyder, M. E., Carpenter, D. J., Szabo, P. A., Thapa, P., Miron, M., & Farber, D. L. (2019) · Mucosal Immunology · doi:10.1038/s41385-018-0110-8 · Cited by 114
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Smolders, J., Remmerswaal, E. B. M., Schuurman, K. G., Melief, J., van Eden, C. G., van Lier, R. A. W., Huitinga, I., & Hamann, J. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1155-0 · Cited by 114
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Immunological memories of the bone marrow
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Smith, N. M. S., Wasserman, G. A., Coleman, F. T., Hilliard, K. L., Yamamoto, K., Lipsitz, E., Malley, R., Dooms, H., Jones, M. R., Quinton, L. J., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.43 · Cited by 109
Leyre, L., Kroon, E. D. M. B., Vandergeeten, C., Sacdalan, C., Colby, D. J., Buranapraditkun, S., Schuetz, A., Chomchey, N., de Souza, M. S., Bakeman, W., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aav3491 · Cited by 112
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Breden, F. J., Prak, E. T. L., Peters, B., Rubelt, F., Schramm, C. A., Busse, C. E., Heiden, J. A. V., Christley, S., Bukhari, S. A. C., Thorogood, A., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01418 · Cited by 107
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Connors, T. J., Matsumoto, R., Verma, S., Szabo, P. A., Guyer, R. S., Gray, J. I., Wang, Z., Thapa, P., Dogra, P., Poon, M. M. L., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.008 · Cited by 104
Self-citationClarke, E. V., Weist, B. M., Walsh, C. M., & Tenner, A. J. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0614-278r · Cited by 105
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Wagar, L. E., DiFazio, R. M., & Davis, M. M. (2018) · Genome Medicine · doi:10.1186/s13073-018-0584-8 · Cited by 104
Precision mouse models with expanded tropism for human pathogens
Wahl, A. R., De, C., Abad-Fernández, M., Lenarcic, E. M., Xu, Y., Cockrell, A. S., Cleary, R. A., Johnson, C. E., Schramm, N. J., Rank, L., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0225-9 · Cited by 102
Weisberg, S. P., Carpenter, D. J., Chait, M., Dogra, P., Gartrell, R. D., Chen, A., Campbell, S., Liu, W., Saraf, P., Snyder, M. E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.056 · Cited by 104
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Buggert, M., Vella, L. A., Nguyen, S., Wu, V. H., Chen, Z., Sekine, T., Perez‐Potti, A., Maldini, C. R., Manne, S., Darko, S. W., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.019 · Cited by 105
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Barker, K. A., Etesami, N. S., Shenoy, A. T., Arafa, E. I., Ana, C. L. D., Smith, N. M. S., Martin, I. M. C., Goltry, W. N., Barron, A., Browning, J. L., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci141810 · Cited by 106
The CD4-centered universe of human T cell subsets
Geginat, J., Paroni, M., Facciotti, F., Gruarin, P., Kastirr, I., Caprioli, F., Pagani, M., & Abrignani, S. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.012 · Cited by 112
Central memory CD8+ T lymphocytes mediate lung allograft acceptance
Krupnick, A. S., Lin, X., Li, W., Higashikubo, R., Zinselmeyer, B. H., Hartzler, H., Toth, K. A., Ritter, J. H., Berezin, M. Y., Wang, S. T., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71359 · Cited by 106
Human lung tissue resident memory T cells in health and disease
Snyder, M. E., & Färber, D. L. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.05.011 · Cited by 102
CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin
McCully, M. L., Ladell, K., Andrews, R., Jones, R. E., Miners, K. L., Roger, L., Baird, D. M., Cameron, M. J., Jessop, Z. M., Whitaker, I. S., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701377 · Cited by 103
Chen, Y., Yan, Y., Liu, H., Qiu, F., Liang, C.-L., Zhang, Q., Huang, R., Han, L., Lu, C., & Dai, Z. (2020) · Theranostics · doi:10.7150/thno.45211 · Cited by 98
Woon, H. G., Braun, A., Li, J., Smith, C., Edwards, J., Sierro, F., Feng, C. G., Khanna, R., Elliot, M., Bell, A., et al. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005799 · Cited by 97
HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?
Kulpa, D. A., & Chomont, N. (2015) · Journal of Virus Eradication · doi:10.1016/s2055-6640(20)30490-8 · Cited by 109
CD8+ T cells in human autoimmune arthritis: the unusual suspects
Petrelli, A., & van Wijk, F. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.74 · Cited by 97
IL-15 supports the generation of protective lung-resident memory CD4 T cells
Strutt, T. M., Dhume, K., Finn, C. M., Hwang, J. H., Castonguay, C. H., Swain, S. L., & McKinstry, K. K. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.101 · Cited by 97
Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective
Rivière, I., & Sadelain, M. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.034 · Cited by 96
Pao, W. J., Ooi, C.-H., Birzele, F., Ruefli-Brasse, A. A., Cannarile, M. A., Reis, B., Scharf, S. H., Schubert, D. A., Hatje, K., Pelletier, N., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1320 · Cited by 96
Memory CD4 T Cells in Influenza
Zens, K. D., & Färber, D. L. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_401 · Cited by 95
Blimp‐1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 T cells
Kragten, N. A. M., Behr, F. M., Vieira Braga, F. A., Remmerswaal, E. B. M., Wesselink, T. H., Oja, A. E., Hombrink, P., Kallies, A., van Lier, R. A. W., Stark, R., et al. (2018) · European Journal of Immunology · doi:10.1002/eji.201847771 · Cited by 91
Dotan, I., Allez, M., Danese, S., Keir, M. E., Tole, S., & McBride, J. (2019) · Medicinal Research Reviews · doi:10.1002/med.21601 · Cited by 91
Utilizing population variation, vaccination, and systems biology to study human immunology
Tsang, J. S. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.06.005 · Cited by 94
Specific Biological Features of Adipose Tissue, and Their Impact on HIV Persistence
Bourgeois, C., Gorwood, J., Barrail‐Tran, A., Lagathu, C., Capeau, J., Desjardins, D., Grand, R. L., Damouche, A., Béréziat, V., & Lambotte, O. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02837 · Cited by 93
Zimmer, C. L., von Seth, E., Buggert, M., Strauss, O., Hertwig, L., Nguyen, S., Wong, A. Y. W., Zotter, C., Berglin, L., Michaëlsson, J., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb3107 · Cited by 90
Tissue-Resident Lymphocytes in the Kidney
Turner, J., Becker, M., Mittrücker, H., & Panzer, U. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017060599 · Cited by 89
Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse?
Steinbach, K., Vincenti, I., & Merkler, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02827 · Cited by 90
Maintenance of the human memory T cell repertoire by subset and tissue site
Miron, M., Meng, W., Rosenfeld, A. M., Dvorkin, S., Poon, M. M. L., Lam, N., Kumar, B. V., Louzoun, Y., Prak, E. T. L., & Färber, D. L. (2021) · Genome Medicine · doi:10.1186/s13073-021-00918-7 · Cited by 85
Understanding memory CD8 + T cells
Samji, T., & Khanna, K. M. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.02.012 · Cited by 91
Gut-Selective Integrin-Targeted Therapies for Inflammatory Bowel Disease
Lamb, C. A., O’Byrne, S., Keir, M. E., & Butcher, E. C. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy060 · Cited by 88
Systems Immunology: Learning the Rules of the Immune System
Villani, A., Sarkizova, S., & Hacohen, N. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053035 · Cited by 89
Bone Marrow T Cells and the Integrated Functions of Recirculating and Tissue-Resident Memory T Cells
Rosa, F. D., & Gebhardt, T. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00051 · Cited by 88
Divito, S. J., Aasebo, A. T., Matos, T. R., Hsieh, P., Collin, M. P., Elco, C. P., O’Malley, J. T., Bækkevold, E. S., Reims, H. M., Gedde‐Dahl, T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci129965 · Cited by 86
Henriksen, E. K. K., Jørgensen, K. K., Kaveh, F., Holm, K., Hamm, D. E., Olweus, J., Melum, E., Chung, B. K., Eide, T. J., Lundin, K. E. A., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.09.002 · Cited by 81
Prognostic and therapeutic TILs of cervical cancer—Current advances and future perspectives
Tang, Y. C., Zhang, A. X. J., Chen, G., Wu, Y., & Gu, W. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.07.006 · Cited by 81
Weeden, C. E., Gayevskiy, V., Marceaux, C., Batey, D., Tan, T., Yokote, K., Ribera, N. T., Clatch, A., Christo, S. N., Teh, C. E., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.03.019 · Cited by 83
CD4+ Memory T Cells at Home in the Tissue: Mechanisms for Health and Disease
Schreiner, D., & King, C. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02394 · Cited by 84
Kuric, E., Seiron, P., Krogvold, L., Edwin, B., Buanes, T., Hanssen, K. F., Skog, O., Dahl-Jørgensen, K., & Korsgren, O. (2017) · The American Journal of Pathology · doi:10.1016/j.ajpath.2016.11.002 · Cited by 80
Tissue patrol by resident memory CD8+ T cells in human skin
Dijkgraaf, F. E., Matos, T. R., Hoogenboezem, M., Toebes, M., Vredevoogd, D. W., Mertz, M., van den Broek, B., Song, J., Teunissen, M. B. M., Luiten, R. M., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0404-3 · Cited by 83
Identification of a unique subset of tissue-resident memory CD4 + T cells in Crohn’s disease
Yokoi, T., Murakami, M., Kihara, T., Seno, S., Arase, M., Wing, J. B., Søndergaard, J. N., Kuwahara, R., Minagawa, T., Oguro-Igashira, E., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204269120 · Cited by 82
Miron, M., Kumar, B. V., Meng, W., Granot, T., Carpenter, D. J., Senda, T., Chen, D., Rosenfeld, A. M., Zhang, B., Lerner, H., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800716 · Cited by 78
Self-citation
Metadata
- Authors
- Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J. J. C., Bickham, K. L., Lerner, H., Goldstein, M., Sykes, M., Kato, T., & Farber, D. L.
- Affiliations
- Columbia University Irving Medical Center (US)
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 38
- Issue
- 1
- Pages
- 187-197
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3557604
- OpenAlex
- W2082595913
- Cited by
- 848
- References
- 41
- Citations by year
- 2026: 33 · 2025: 39 · 2024: 50 · 2023: 54 · 2022: 74 · 2021: 77 · 2020: 78 · 2019: 96 · 2018: 95 · 2017: 75 · 2016: 69 · 2015: 47 · 2014: 40 · 2013: 20
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (RC1AI086164)
- National Center for Research Resources (S10RR027050)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- memory T cells, T cell compartmentalization, mucosal immunity, lymphoid tissue, effector memory T cells, central memory T cells, naive T cells, CD4+ T cells, CD8+ T cells, interleukin-2, interferon-gamma, CD69, T cell activation, tissue-resident T cells
- MeSH terms
- CD69 Antigens, Adolescent, Adult, Age Factors, Antigens, Differentiation, T-Lymphocyte, Female, Humans, Immunologic Memory, Male, Middle Aged, Mucous Membrane, Organ Specificity, Tissue Donors, CD4-Positive T-Lymphocytes, Antigens, CD, Immunophenotyping, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Lectins, C-Type, Integrin alpha Chains, Young Adult
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