The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets
Open accessAbstract
Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown. Here, we present a unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, revealing tissue-intrinsic compartmentalization of naive, effector, and memory subsets conserved between diverse individuals. Effector memory CD4(+) T cells producing IL-2 predominated in mucosal tissues and accumulated as central memory subsets in lymphoid tissue, whereas CD8(+) T cells were maintained as naive subsets in lymphoid tissues and IFN-γ-producing effector memory CD8(+) T cells in mucosal sites. The T cell activation marker CD69 was constitutively expressed by memory T cells in all tissues, distinguishing them from circulating subsets, with mucosal memory T cells exhibiting additional distinct phenotypic and functional properties. Our results provide an assessment of human T cell compartmentalization as a new baseline for understanding human adaptive immunity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“The preferred collagenase used by multiple research groups is collagenase IV [253, 256, 257, 267].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [253]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Trm do not express other putative activation markers, such as CD25, CD137, CD38, or HLA-DR [244, 253, 258, 264].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [253]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Both CD8+ and CD4+ Trm have been identified in the human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes [241, 244, 246, 253-259].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [253]
Experimental — accuracy not yet measuredIn the citing paper
“Seeding into tissues occurs in childhood, and the resident population persists throughout adulthood”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Sathaliyawala et al., 2013
In the citing paper
“Resident memory T cells in lungs, skin, and submucosal sites account for a large fraction of memory cells numbering more than 5 × 1010 cells in an individual.”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Sathaliyawala et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 1×
“The low proportion of CD8 Tcm cells compared to CD4 Tcm cells was not predicted from analysis of peripheral blood (Gattinoni et al., 2011; Sallusto et al., 1999) and is most striking when comparing whole body subset delineation as accomplished here.”
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974 · cited 1×
“The low proportion of CD8 Tcm cells compared to CD4 Tcm cells was not predicted from analysis of peripheral blood (Gattinoni et al., 2011; Sallusto et al., 1999) and is most striking when comparing whole body subset delineation as accomplished here.”
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · cited 1×
“CD45RO memory T cells are subdivided into two subsets: CCR7 ‘‘central memory’’ (Tcm) cells, which migrate to lymphoid tissue, and CCR7 ‘‘effector memory’’ (Tem) cells, which circulate to nonlymphoid sites (Masopust et al., 2001; Sallusto et al., 1999, 2004).”
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · cited 1×
“CD69 memory T cells in lymphoid and mucosal sites were largely IL-7R (Figure 4B), indicative of a resting memory T cell phenotype, as IL-7R is downregulated on activated effector T cells (Dooms et al., 2007; Kaech et al., 2003; Paiardini et al., 2005; Seddiki et al., 2006).”
Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770
Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060468 · Cited by 1,512 · cited 1×
“CD69 memory T cells in lymphoid and mucosal sites were largely IL-7R (Figure 4B), indicative of a resting memory T cell phenotype, as IL-7R is downregulated on activated effector T cells (Dooms et al., 2007; Kaech et al., 2003; Paiardini et al., 2005; Seddiki et al., 2006).”
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193
Flagged first, then by citations
Cited by
Sorted by citations
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Peterson, L. W., & Artis, D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3608 · Cited by 3,367
Regional specialization within the intestinal immune system
Mowat, A. M., & Agace, W. W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3738 · Cited by 1,882
Human T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257
Kumar, B. V., Ma, W., Miron, M., Granot, T., Guyer, R. S., Carpenter, D. J., Senda, T., Sun, X., Ho, S.-H., Lerner, H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.078 · Cited by 1,068
Self-citationTissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
“In this regard, it will be crucial to determine whether the total number of Trm cells established within NLTs is tightly regulated, as it appears to be for Tcm cells within LNs, or whether it is flexible, as shown for Tem cells (Vezys et al., 2009).”
BackgroundInfluentialTissue-resident memory T cells: local specialists in immune defence
Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 1,007
Fuchs, A. G., Vermi, W., Lee, J. S., Lonardi, S., Gilfillan, S., Newberry, R. D., Cella, M., & Colonna, M. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.010 · Cited by 904
Human memory T cells: generation, compartmentalization and homeostasis
Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897
Self-citationThe who's who of T ‐cell differentiation: Human memory T ‐cell subsets
Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817
Szabo, P. A., Levitin, H. M., Miron, M., Snyder, M. E., Senda, T., Yuan, J., Cheng, Y. L., Bush, E. C., Dogra, P., Thapa, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12464-3 · Cited by 756
The multifaceted role of CD4+ T cells in CD8+ T cell memory
Laidlaw, B. J., Craft, J. E., & Kaech, S. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.10 · Cited by 657
Location, location, location: Tissue resident memory T cells in mice and humans
Szabo, P. A., Miron, M., & Farber, D. L. (2019) · Science Immunology · doi:10.1126/sciimmunol.aas9673 · Cited by 651
The integration of T cell migration, differentiation and function
Masopust, D., & Schenkel, J. M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3442 · Cited by 657
Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens
Netea, M. G., Schlitzer, A., Placek, K., Joosten, L. A. B., & Schultze, J. L. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2018.12.006 · Cited by 644
Mackay, L. K., Wynne-Jones, E., Freestone, D., Pellicci, D. G., Mielke, L. A., Newman, D. M., Braun, A., Masson, F., Kallies, A., Belz, G. T., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.008 · Cited by 625
Spatial map of human T cell compartmentalization and maintenance over decades of life
Thome, J. J. C., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y., & Farber, D. L. (2014) · Cell · doi:10.1016/j.cell.2014.10.026 · Cited by 587
Self-citationMolecular regulation of effector and memory T cell differentiation
Chang, J. T., Wherry, E. J., & Goldrath, A. W. (2014) · Nature Immunology · doi:10.1038/ni.3031 · Cited by 604
Watanabe, R., Gehad, A., Yang, C., Scott, L. L., Teague, J. E., Schlapbach, C., Elco, C. P., Huang, V., Matos, T. R., Kupper, T. S., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010302 · Cited by 569
Machado-Santos, J., Saji, E., Tröscher, A. R., Paunovic, M., Liblau, R., Gabriely, G., Bien, C. G., Bauer, J., & Lassmann, H. (2018) · Brain · doi:10.1093/brain/awy151 · Cited by 548
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Understanding subset diversity in T cell memory
Jameson, S. C., & Masopust, D. (2018) · Immunity · doi:10.1016/j.immuni.2018.02.010 · Cited by 523
Ganesan, A.-P., Clarke, J., Wood, O., Garrido-Martin, E. M., Chee, S. J., Mellows, T., Samaniego-Castruita, D., Singh, D., Seumois, G., Alzetani, A., et al. (2017) · Nature Immunology · doi:10.1038/ni.3775 · Cited by 528
The emerging role of resident memory T cells in protective immunity and inflammatory disease
Park, C. O., & Kupper, T. S. (2015) · Nature Medicine · doi:10.1038/nm.3883 · Cited by 537
Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
Gubser, P. M., Bantug, G. R., Razik, L., Fischer, M., Dimeloe, S., Höenger, G., Müller-Durovic, B., Jauch, A., & Hess, C. (2013) · Nature Immunology · doi:10.1038/ni.2687 · Cited by 500
Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells
Hombrink, P., Helbig, C., Backer, R. A., Piet, B., Oja, A. E., Stark, R., Brasser, G., Jongejan, A., Jonkers, R. E., Nota, B., et al. (2016) · Nature Immunology · doi:10.1038/ni.3589 · Cited by 455
Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial
Vermeire, S., O’Byrne, S., Keir, M. E., Williams, M. B., Lu, T. T., Mansfield, J. C., Lamb, C. A., Feagan, B. G., Panés, J., Salas, A., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60661-9 · Cited by 452
Emerging insights into natural killer cells in human peripheral tissues
Björkström, N. K., Ljunggren, H., & Michaëlsson, J. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.34 · Cited by 466
Resident memory T cells in human health and disease
Clark, R. A. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010641 · Cited by 456
Martin, M. D., & Badovinac, V. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02692 · Cited by 464
Edwards, J. J., Wilmott, J. S., Madore, J., Gide, T. N., Quek, C. Y. J., Tasker, A. T., Ferguson, A. L., Chen, J., Hewavisenti, R., Hersey, P., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2257 · Cited by 448
Zens, K. D., Chen, J. K., & Färber, D. L. (2016) · JCI Insight · doi:10.1172/jci.insight.85832 · Cited by 427
Tissue-resident memory T cells populate the human brain
Smolders, J., Heutinck, K. M., Fransen, N. L., Remmerswaal, E. B. M., Hombrink, P., ten Berge, I. J. M., van Lier, R. A. W., Huitinga, I., & Hamann, J. (2018) · Nature Communications · doi:10.1038/s41467-018-07053-9 · Cited by 406
Lung niches for the generation and maintenance of tissue-resident memory T cells
Turner, D., Bickham, K. L., Thome, J. J. C., Kim, C. Y., D’Ovidio, F., Wherry, E. J., & Färber, D. L. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.67 · Cited by 406
Self-citationDutzan, N., Kajikawa, T., Abusleme, L., Greenwell-Wild, T., Zuazo, C. E., Ikeuchi, T., Brenchley, L., Abe, T., Hurabielle, C., Martin, D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0797 · Cited by 382
β 2 -adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses
Moriyama, S., Brestoff, J. R., Flamar, A.-L., Moeller, J. B., Klose, C. S. N., Rankin, L. C., Yudanin, N. A., Monticelli, L. A., Putzel, G., Rodewald, H.-R., et al. (2018) · Science · doi:10.1126/science.aan4829 · Cited by 379
Self-citationSzabo, P. A., Dogra, P., Gray, J. I., Wells, S. B., Connors, T. J., Weisberg, S. P., Krupska, I., Matsumoto, R., Poon, M. M. L., Idzikowski, E., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.03.005 · Cited by 378
Laidlaw, B. J., Zhang, N., Marshall, H. D., Staron, M. M., Guan, T., Hu, Y., Cauley, L. S., Craft, J. E., & Kaech, S. M. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.007 · Cited by 382
Successful and Maladaptive T Cell Aging
Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362
From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality
Larbi, A., & Fulop, T. (2014) · Cytometry Part A · doi:10.1002/cyto.a.22351 · Cited by 359
IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection
Pallett, L. J., Davies, J., Colbeck, E. J., Robertson, F., Hansi, N., Easom, N. J. W., Burton, A. R., Stegmann, K. A., Schurich, A., Swadling, L., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162115 · Cited by 347
Künzli, M., & Masopust, D. (2023) · Nature Immunology · doi:10.1038/s41590-023-01510-4 · Cited by 338
Pathophysiology of Crohn’s disease inflammation and recurrence
Petagna, L., Antonelli, A., Ganini, C., Bellato, V., Campanelli, M., Divizia, A., Efrati, C., Franceschilli, M., Guida, A. M., Ingallinella, S., et al. (2020) · Biology Direct · doi:10.1186/s13062-020-00280-5 · Cited by 324
Park, S. L., Zaid, A., Hor, J. L., Christo, S. N., Prier, J. E., Davies, B., Alexandre, Y. O., Gregory, J. L., Russell, T., Gebhardt, T., et al. (2018) · Nature Immunology · doi:10.1038/s41590-017-0027-5 · Cited by 332
Integrative Physiology of Pneumonia
Quinton, L. J., Walkey, A. J., & Mizgerd, J. P. (2018) · Physiological Reviews · doi:10.1152/physrev.00032.2017 · Cited by 330
Thome, J. J. C., Bickham, K. L., Ohmura, Y., Kubota, M., Matsuoka, N., Gordon, C., Granot, T., Griesemer, A., Lerner, H., Kato, T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4008 · Cited by 305
Self-citationCharacterization of the human immune cell network at the gingival barrier
Dutzan, N., Konkel, J. E., Greenwell-Wild, T., & Moutsopoulos, N. M. (2016) · Mucosal Immunology · doi:10.1038/mi.2015.136 · Cited by 305
Plasticity of Human CD4 T Cell Subsets
Geginat, J., Paroni, M., Maglie, S., Alfen, J. S., Kastirr, I., Gruarin, P., Simone, M. C. D., Pagani, M., & Abrignani, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00630 · Cited by 313
Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life
Granot, T., Senda, T., Carpenter, D. J., Matsuoka, N., Weiner, J. I., Gordon, C. L., Miron, M., Kumar, B. V., Griesemer, A. D., Ho, S., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.019 · Cited by 284
Self-citationGeneration and persistence of human tissue-resident memory T cells in lung transplantation
Snyder, M. E., Finlayson, M. O., Connors, T. J., Dogra, P., Senda, T., Bush, E. C., Carpenter, D. J., Marboe, C. C., Benvenuto, L. J., Shah, L., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav5581 · Cited by 285
Self-citationUnique aspects of the perinatal immune system
Zhang, X., Zhivaki, D., & Lo-Man, R. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.54 · Cited by 276
Chen, Z., Wang, H., D’Souza, C., Sun, S., Kostenko, L., Eckle, S. B. G., Meehan, B. S., Jackson, D. C., Strugnell, R. A., Cao, H., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.39 · Cited by 279
T cell responses in the central nervous system
Korn, T., & Kallies, A. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.144 · Cited by 268
Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA
Tian, Y., Babor, M., Lane, J., Schulten, V. M. J., Patil, V. S., Seumois, G., Rosales, S. L., Fu, Z., Picarda, G. G. A., Burel, J. G., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01728-5 · Cited by 284
T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells
Beura, L. K., Wijeyesinghe, S., Thompson, E. A., Macchietto, M. G., Rosato, P. C., Pierson, M. J., Schenkel, J. M., Mitchell, J. S., Vezys, V., Fife, B. T., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.015 · Cited by 271
Lung Homeostasis: Influence of Age, Microbes, and the Immune System
Lloyd, C. M., & Marsland, B. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.005 · Cited by 263
The germinal centre B cell response to SARS-CoV-2
Laidlaw, B. J., & Ellebedy, A. H. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00657-1 · Cited by 268
Hudspeth, K., Donadon, M., Cimino, M., Pontarini, E., Tentorio, P., Preti, M., Hong, M., Bertoletti, A., Bicciato, S., Invernizzi, P., et al. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.08.011 · Cited by 246
Wong, M. T., Ong, D. E. H., Lim, F. S. H., Teng, K. W. W., McGovern, N. N., Narayanan, S., Ho, W. Q., Cerny, D., Tan, H. K. K., Anicete, R., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.007 · Cited by 252
T cells and the skin: from protective immunity to inflammatory skin disorders
Ho, A. W., & Kupper, T. S. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0162-3 · Cited by 241
Human CD8+ T cell cross-reactivity across influenza A, B and C viruses
Koutsakos, M., Illing, P. T., Nguyen, T. H. O., Mifsud, N. A., Crawford, J. C., Rizzetto, S., Eltahla, A. A., Clemens, E. B., Sant, S. A., Chua, B. Y. L., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0320-6 · Cited by 239
Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human
Zhao, J., Zhang, S., Liu, Y., He, X., Qu, M., Xu, G., Wang, H., Huang, M., Pan, J., Liu, Z., et al. (2020) · Cell Discovery · doi:10.1038/s41421-020-0157-z · Cited by 243
CXCR6 marks a novel subset of T-betloEomeshi natural killer cells residing in human liver
Stegmann, K. A., Robertson, F., Hansi, N., Gill, U., Pallant, C., Christophides, T., Pallett, L. J., Peppa, D., Dunn, C., Fusai, G., et al. (2016) · Scientific Reports · doi:10.1038/srep26157 · Cited by 235
The Influence of Lung Microbiota on Lung Carcinogenesis, Immunity, and Immunotherapy
Ramírez-Labrada, A., Isla, D., Artal, A., Arias, M. A., Rezusta, A., Pardo, J., & Gálvez, E. M. (2020) · Trends in cancer · doi:10.1016/j.trecan.2019.12.007 · Cited by 236
Memory CD4+ T Cells in Immunity and Autoimmune Diseases
Raphael, I., Robinson, R. R., & Forsthuber, T. G. (2020) · Cells · doi:10.3390/cells9030531 · Cited by 241
White, K. D., Chung, W., Chung, W., Mallal, S. A., & Phillips, E. J. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.050 · Cited by 229
Chimeric Antigen Receptor T Cell Therapy: Challenges to Bench-to-Bedside Efficacy
Srivastava, S., & Riddell, S. R. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701155 · Cited by 222
Memory CD8+ T cell responses to cancer
Han, J., Khatwani, N., Searles, T. G., Turk, M. J., & Angeles, C. V. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101435 · Cited by 236
A guide to adaptive immune memory
Lam, N., Lee, Y. S., & Färber, D. L. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01040-6 · Cited by 236
Cutting Edge: Resident Memory CD8 T Cells Occupy Frontline Niches in Secondary Lymphoid Organs
Schenkel, J. M., Fraser, K. A., & Masopust, D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400003 · Cited by 216
Damouche, A., Lazure, T., Avettand-Fènoël, V., Huot, N., Dejucq‐Rainsford, N., Satié, A.-P., Mélard, A., David, L., Gommet, C., Ghosn, J., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005153 · Cited by 228
SARS-CoV-2 infection generates tissue-localized immunological memory in humans
Poon, M. M. L., Rybkina, K., Kato, Y., Kubota, M., Matsumoto, R., Bloom, N. I., Zhang, Z., Hastie, K. M., Grifoni, A., Weiskopf, D., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abl9105 · Cited by 220
Self-citationTissue‐resident memory T cells
Shin, H., & Iwasaki, A. (2013) · Immunological Reviews · doi:10.1111/imr.12087 · Cited by 215
Tissue‐resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance
Gebhardt, T., Palendira, U., Tscharke, D. C., & Bedoui, S. (2018) · Immunological Reviews · doi:10.1111/imr.12650 · Cited by 208
Mucosal Resident Memory CD4 T Cells in Protection and Immunopathology
Turner, D., & Färber, D. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00331 · Cited by 204
Self-citationDurek, P., Nordström, K. J. V., Gasparoni, G., Salhab, A., Kressler, C., de Almeida, M., Bassler, K. E., Ulas, T., Schmidt, F., Xiong, J., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.022 · Cited by 200
Transcriptional Regulation of Tissue-Resident Lymphocytes
Mackay, L. K., & Kallies, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.11.004 · Cited by 202
CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses
Beura, L. K., Fares-Frederickson, N. J., Steinert, E. M., Scott, M. C., Thompson, E. A., Fraser, K. A., Schenkel, J. M., Vezys, V., & Masopust, D. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20181365 · Cited by 190
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
Tu, W., & Rao, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02111 · Cited by 192
Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory
Okhrimenko, A., Grün, J. R., Westendorf, K., Fang, Z., Reinke, S., von Roth, P., Wassilew, G., Kühl, A. A., Kudernatsch, R., Demski, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318731111 · Cited by 188
Tissue-Resident Memory CD8+ T Cells: From Phenotype to Function
Topham, D. J., & Reilly, E. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00515 · Cited by 197
Ritzel, R. M., Crapser, J. D., Patel, A. R., Verma, R., Grenier, J. M., Chauhan, A., Jellison, E. R., & McCullough, L. D. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502021 · Cited by 187
The function and dysfunction of memory CD 8+ T cells in tumor immunity
Reading, J. L., Gálvez‐Cancino, F., Swanton, C., Lladser, Á., Peggs, K. S., & Quezada, S. A. (2018) · Immunological Reviews · doi:10.1111/imr.12657 · Cited by 186
Tissue-resident immune cells in humans
Gray, J. I., & Farber, D. L. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-112809 · Cited by 181
Pizzolla, A., Nguyen, T. H. O., Sant, S. A., Jaffar, J., Loudovaris, T., Mannering, S. I., Thomas, P. G., Westall, G. P., Kedzierska, K., & Wakim, L. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96957 · Cited by 181
Wu, Q., Wang, Q., Mao, G., Dowling, C. A., Lundy, S. K., & Mao‐Draayer, Y. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601532 · Cited by 179
Herndler‐Brandstetter, D., Shan, L., Yao, Y., Stecher, C., Plajer, V., Lietzenmayer, M., Strowig, T., de Zoete, M. R., Palm, N. W., Chen, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705301114 · Cited by 180
Mass Cytometry Imaging for the Study of Human Diseases—Applications and Data Analysis Strategies
Baharlou, H., Canete, N. P., Cunningham, A. L., Harman, A. N., & Patrick, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02657 · Cited by 180
Phenotypic signatures of immune selection in HIV-1 reservoir cells
Sun, W., Gao, C., Hartana, C. A., Osborn, M. R., Einkauf, K. B., Lian, X., Bone, B., Bonheur, N., Chun, T., Rosenberg, E. S., et al. (2023) · Nature · doi:10.1038/s41586-022-05538-8 · Cited by 181
An atlas of B-cell clonal distribution in the human body
Meng, W., Zhang, B., Schwartz, G. W., Rosenfeld, A. M., Ren, D., Thome, J. J. C., Carpenter, D. J., Matsuoka, N., Lerner, H., Friedman, A. L., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3942 · Cited by 172
Self-citationExit Strategies: S1P Signaling and T Cell Migration
Baeyens, A., Fang, V., Chen, C., & Schwab, S. R. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.10.005 · Cited by 174
Wang, B., Wu, S., Zeng, H., Liu, Z., Dong, W., He, W., Chen, X., Dong, X., Zheng, L., Lin, T., et al. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.02.2941 · Cited by 166
Antigen Presentation by Vascular Cells
Pober, J. S., Merola, J., Liu, R., & Manes, T. D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01907 · Cited by 165
Vesely, M. C. A., Pallis, P., Bielecki, P., Low, J. S., Zhao, J., Harman, C. C. D., Kroehling, L., Jackson, R. P., Bailis, W., Licona-Limón, P., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.032 · Cited by 166
Long-term maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites
Thome, J. J. C., Grinshpun, B., Kumar, B. V., Kubota, M., Ohmura, Y., Lerner, H., Sempowski, G. D., Shen, Y., & Farber, D. L. (2016) · Science Immunology · doi:10.1126/sciimmunol.aah6506 · Cited by 162
Self-citationBuggert, M., Nguyen, S., de Oca, G. S. M., Bengsch, B., Darko, S. W., Ransier, A., Roberts, E. R., Alcazar, D. D., Brody, I. B., Vella, L. A., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar4526 · Cited by 165
Trigger-happy resident memory CD4+ T cells inhabit the human lungs
Oja, A. E., Piet, B., Helbig, C., Stark, R., van der Zwan, D., Blaauwgeers, H., Remmerswaal, E. B. M., Amsen, D., Jonkers, R. E., Moerland, P. D., et al. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.94 · Cited by 160
PET of Adoptively Transferred Chimeric Antigen Receptor T Cells with 89 Zr-Oxine
Weist, M. R., Starr, R., Aguilar, B., Chea, J., Miles, J. K., Poku, E. K., Gerdts, E. A., Yang, X., Priceman, S. J., Forman, S. J., et al. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.206714 · Cited by 159
IL-17 in the immunopathogenesis of spondyloarthritis
Taams, L. S., Steel, K. J. A., Srenathan, U., Burns, L. A., & Kirkham, B. W. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0044-2 · Cited by 164
Tissue adaptation and clonal segregation of human memory T cells in barrier sites
Poon, M. M. L., Caron, D. P., Wang, Z., Wells, S. B., Chen, D., Meng, W., Szabo, P. A., Lam, N., Kubota, M., Matsumoto, R., et al. (2023) · Nature Immunology · doi:10.1038/s41590-022-01395-9 · Cited by 158
Self-citation
Metadata
- Authors
- Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J. J. C., Bickham, K. L., Lerner, H., Goldstein, M., Sykes, M., Kato, T., & Farber, D. L.
- Affiliations
- Columbia University Irving Medical Center (US)
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 38
- Issue
- 1
- Pages
- 187-197
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3557604
- OpenAlex
- W2082595913
- Cited by
- 848
- References
- 41
- Citations by year
- 2026: 33 · 2025: 39 · 2024: 50 · 2023: 54 · 2022: 74 · 2021: 77 · 2020: 78 · 2019: 96 · 2018: 95 · 2017: 75 · 2016: 69 · 2015: 47 · 2014: 40 · 2013: 20
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (RC1AI086164)
- National Center for Research Resources (S10RR027050)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- memory T cells, T cell compartmentalization, mucosal immunity, lymphoid tissue, effector memory T cells, central memory T cells, naive T cells, CD4+ T cells, CD8+ T cells, interleukin-2, interferon-gamma, CD69, T cell activation, tissue-resident T cells
- MeSH terms
- CD69 Antigens, Adolescent, Adult, Age Factors, Antigens, Differentiation, T-Lymphocyte, Female, Humans, Immunologic Memory, Male, Middle Aged, Mucous Membrane, Organ Specificity, Tissue Donors, CD4-Positive T-Lymphocytes, Antigens, CD, Immunophenotyping, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Lectins, C-Type, Integrin alpha Chains, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
