Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

A role for mitochondria in nlrp3 inflammasome activation

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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The Inflammasomes: Guardians of the Body

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GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

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Inflammasomes in health and disease

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The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

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Modifiable risk factors linked to the development of rheumatoid arthritis: evidence, immunological mechanisms and prevention

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Regulation of Nlrp3 inflammasome by dietary metabolites

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Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response

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Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function

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Fish Oil Derived Omega 3 Fatty Acids Suppress Adipose NLRP3 Inflammasome Signaling in Human Obesity

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Bioactive Compounds as Therapeutic Alternatives

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Molecular Mechanisms of Healthy Aging: The Role of Caloric Restriction, Intermittent Fasting, Mediterranean Diet, and Ketogenic Diet—A Scoping Review

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N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2

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The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis

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Beneficial Effects of Omega-3 Fatty Acids on Obesity and Related Metabolic and Chronic Inflammatory Diseases

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Caspases and inflammasomes in metabolic inflammation

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Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation

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Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts

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The Inhibitory Effects of Purple Sweet Potato Color on Hepatic Inflammation Is Associated with Restoration of NAD+ Levels and Attenuation of NLRP3 Inflammasome Activation in High-Fat-Diet-Treated Mice

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Activation of GPR120 by TUG891 ameliorated cisplatin-induced acute kidney injury via repressing ER stress and apoptosis

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Taking the fuel out of the fire: Evidence for the use of anti-inflammatory agents in the treatment of bipolar disorders

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Proinflammatory effects of arachidonic acid in a lipopolysaccharide-induced inflammatory microenvironment in 3T3-L1 adipocytes in vitro

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FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids

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Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials

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Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment

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Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis

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Disentangling the Molecular Mechanisms of the Antidepressant Activity of Omega-3 Polyunsaturated Fatty Acid: A Comprehensive Review of the Literature

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Docosahexaenoic acid modulates brain-derived neurotrophic factor via GPR40 in the brain and alleviates diabesity-associated learning and memory deficits in mice

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NLRP inflammasome as a key role player in the pathogenesis of environmental toxicants

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Effect of n -3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome

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Interleukin-1 and Systemic Sclerosis: Getting to the Heart of Cardiac Involvement

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Amelioration of PM2.5-induced lung toxicity in rats by nutritional supplementation with fish oil and Vitamin E

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Dietary Influence on Pain via the Immune System

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Cardiovascular, electrophysiologic, and hematologic effects of omega-3 fatty acids beyond reducing hypertriglyceridemia: as it pertains to the recently published REDUCE-IT trial

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Engineered Biomimetic Nanovesicles Based on Neutrophils for Hierarchical Targeting Therapy of Acute Respiratory Distress Syndrome

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Fish-oil-derived n-3 polyunsaturated fatty acids reduce NLRP3 inflammasome activity and obesity-related inflammatory cross-talk between adipocytes and CD11b+ macrophages

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Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-α Production in Macrophages and Directly Inhibiting Osteoclast Formation

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Altered Lipidome Composition Is Related to Markers of Monocyte and Immune Activation in Antiretroviral Therapy Treated Human Immunodeficiency Virus (HIV) Infection and in Uninfected Persons

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Microbial sensing in the intestine

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Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-κB/iNOS/NO Signaling Pathway Activation in H9C2 Cardiac Cells

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Blood Circulation-Prolonging Peptides for Engineered Nanoparticles Identified via Phage Display

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Effect of Dietary and Supplemental Omega‐3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares

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Metabolic Inflammation in Obesity—At the Crossroads between Fatty Acid and Cholesterol Metabolism

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NLRP3 Inflammasome and Its Critical Role in Gynecological Disorders and Obstetrical Complications

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ω3 Polyunsaturated Fatty Acids as Immunomodulators in Colorectal Cancer: New Potential Role in Adjuvant Therapies

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Role of mitochondrial dysfunction on rheumatic diseases

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Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases

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GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure

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Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35

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Effects of obesity/fatty acids on the expression of GPR120

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A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid

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Fish-Oil–Derived n–3 PUFAs Reduce Inflammatory and Chemotactic Adipokine-Mediated Cross-talk between Co-cultured Murine Splenic CD8+ T Cells and Adipocytes

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Integrated Immunomodulatory Mechanisms through which Long-Chain n-3 Polyunsaturated Fatty Acids Attenuate Obese Adipose Tissue Dysfunction

Liddle, D. M., Hutchinson, A. L., Wellings, H. R., Power, K. A., Robinson, L. E., & Monk, J. M. (2017) · Nutrients · doi:10.3390/nu9121289 · Cited by 47

Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach

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Emerging roles of metabolites of ω3 and ω6 essential fatty acids in the control of intestinal inflammation

Nagatake, T., & Kunisawa, J. (2019) · International Immunology · doi:10.1093/intimm/dxy086 · Cited by 44

Dietary chia seeds (Salvia hispanica) improve acute dyslipidemia and steatohepatitis in rats

Fernández‐Martínez, E., Lira‐Islas, I. G., Cariño‐Cortés, R., Soria-Jasso, L. E., Pérez‐Hernández, E., & Pérez‐Hernández, N. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.12986 · Cited by 45

Omega-3 Polyunsaturated Fatty Acids: Versatile Roles in Blood Pressure Regulation

Wang, H., Li, Q., Zhu, Y., & Zhang, X. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8108 · Cited by 44

Dietary EPA‐Enriched Phospholipids Alleviate Chronic Stress and LPS‐Induced Depression‐ and Anxiety‐Like Behavior by Regulating Immunity and Neuroinflammation

Wang, C., Du, L., Shi, H., Ding, L., Yanagita, T., Xue, C., Wang, Y., & Zhang, T. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100009 · Cited by 46

Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon

Cheshmehkani, A., Senatorov, I. S., Kandi, P., Singh, M., Britt, A., Hayslett, R. L., & Moniri, N. H. (2015) · Inflammation Research · doi:10.1007/s00011-015-0864-3 · Cited by 43

Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes

Kien, C. L., Bunn, J. Y., Fukagawa, N. K., Anathy, V., Matthews, D. E., Crain, K. I., Ebenstein, D. B., Tarleton, E. K., Pratley, R. E., & Poynter, M. E. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.07.014 · Cited by 44

EPA’s pleiotropic mechanisms of action: a narrative review

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Plasma lipid profiling for the prognosis of 90-day mortality, in-hospital mortality, ICU admission, and severity in bacterial community-acquired pneumonia (CAP)

Banoei, M. M., Vogel, H. J., Weljie, A. M., Yende, S. P., Angus, D. C., & Winston, B. W. (2020) · Critical Care · doi:10.1186/s13054-020-03147-3 · Cited by 41

Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice

Rajasinghe, L. D., Li, Q., Zhu, C., Yan, M., Chauhan, P., Wierenga, K. A., Bates, M. A., Harkema, J. R., Benninghoff, A. D., & Pestka, J. J. (2020) · Autoimmunity · doi:10.1080/08916934.2020.1801651 · Cited by 42

Tissue-specific mechanisms of fat metabolism that focus on insulin actions

Wu, S., Tan, J., Zhang, H., Hou, D., & He, J. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.12.009 · Cited by 44

Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome

Zheng, X., Hou, Y., He, H., Chen, Y., Zhou, R., Wang, X., Gong, T., & Jiang, W. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00545-z · Cited by 43

Mechanisms underlying the pathophysiology of heart failure with preserved ejection fraction: the tip of the iceberg

Miranda‐Silva, D., Lima, T., Rodrigues, P., Leite-Moreira, A. F., & Falcão‐Pires, I. (2021) · Heart Failure Reviews · doi:10.1007/s10741-020-10042-0 · Cited by 45

Antioxidant and Anti-Inflammatory Properties of Walnut Constituents: Focus on Personalized Cancer Prevention and the Microbiome

Fan, N., Fusco, J. L., & Rosenberg, D. W. (2023) · Antioxidants · doi:10.3390/antiox12050982 · Cited by 44

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

Spano, M., Matteo, G. D., Ingallina, C., Ambroselli, D., Carradori, S., Gallorini, M., Giusti, A. M., Salvo, A., Grosso, M., & Mannina, L. (2022) · Nutrients · doi:10.3390/nu14030490 · Cited by 44

Lipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome

Pizzuto, M., Pelegrín, P., & Ruysschaert, J. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101182 · Cited by 44

Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring

Segovia, S. A., Vickers, M. H., Zhang, X. D., Gray, C. L., & Reynolds, C. M. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.07.013 · Cited by 44

FFA4 receptor (GPR120): A hot target for the development of anti-diabetic therapies

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The Role of NLRP3 Inflammasome in Diabetic Cardiomyopathy and Its Therapeutic Implications

Ding, K., Song, C., Hu, H.-J., Yin, K., Huang, H., & Tang, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3790721 · Cited by 43

A Lipid Perspective on Regulated Pyroptosis

Qiu, Y., Shi, Y., Zhu, N., Zhang, S., Zhang, C., Gu, J. L., He, P., Dai, A., & Li, Q. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.81017 · Cited by 44

Vitamin D and Marine n‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double‐Blind , Placebo‐Controlled Trial

Costenbader, K. H., Cook, N. R., Lee, I.-M. M., Hahn, J., Walter, J. N., Bubes, V. Y., Kotler, G., Yang, N., Friedman, S., Alexander, E. K., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42811 · Cited by 43

G Protein‐Coupled Receptor 120 Signaling Negatively Regulates Osteoclast Differentiation, Survival, and Function

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GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathway

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Free Fatty Acid Receptors and Cancer: From Nutrition to Pharmacology

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Function of Pro-Resolving Lipid Mediator Resolvin E1 in Type 2 Diabetes

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NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy

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N-3 essential fatty acids in Nile tilapia, Oreochromis niloticus : Effects of linolenic acid on non-specific immunity and anti-inflammatory responses in juvenile fish

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Astrocytes Release Polyunsaturated Fatty Acids by Lipopolysaccharide Stimuli

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Eicosapentaenoic Acid-Enriched Phosphatidylcholine Mitigated Aβ1-42-Induced Neurotoxicity via Autophagy-Inflammasome Pathway

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A Higher Proportion of Eicosapentaenoic Acid (EPA) When Combined with Docosahexaenoic Acid (DHA) in Omega-3 Dietary Supplements Provides Higher Antioxidant Effects in Human Retinal Cells

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Functional differences between primary monocyte-derived and THP-1 macrophages and their response to LCPUFAs

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Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4

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EPA and DHA differentially improve insulin resistance by reducing adipose tissue inflammation—targeting GPR120/PPARγ pathway

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A Comprehensive View of the β-Arrestinome

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Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms

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The interplay between regulatory T cells and metabolism in immune regulation

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Immunoregulation in cancer-associated cachexia

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Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads

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Gout and NLRP3 Inflammasome Biology

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Rosa Mosqueta Oil Prevents Oxidative Stress and Inflammation through the Upregulation of PPAR-α and NRF2 in C57BL/6J Mice Fed a High-Fat Diet

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An Overview of Dietary Interventions and Strategies to Optimize the Management of Non-Alcoholic Fatty Liver Disease

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Dietary fatty acids and susceptibility to multiple sclerosis

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Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection

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Potential neuroprotective and anti-inflammatory effects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells

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Association between polyunsaturated fatty acids and inflammatory markers in patients in secondary prevention of cardiovascular disease

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Common NLRP3 inflammasome inhibitors and Covid-19: Divide and conquer

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Mediterranean diet affects the metabolic outcome of metabolic dysfunction-associated fatty liver disease

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Doliroside A attenuates monosodium urate crystals-induced inflammation by targeting NLRP3 inflammasome

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Protectin DX prevents H2O2-mediated oxidative stress in vascular endothelial cells via an AMPK-dependent mechanism

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The Use of Intact Fish Skin as a Novel Treatment Method for Deep Dermal Burns Following Enzymatic Debridement: A Retrospective Case-Control Study

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Fish Oil Cools the Inflammasome

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(De-) Oiling Inflammasomes

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Dietary fatty acid composition is sensed by the NLRP3 inflammasome: omega-3 fatty acid (DHA) prevents NLRP3 activation in human macrophages

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Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

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Fishing for anti-inflammatory mechanisms

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