Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

A role for mitochondria in nlrp3 inflammasome activation

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Type 2 diabetes as an inflammatory disease

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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The Inflammasomes: Guardians of the Body

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GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

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Inflammasomes in health and disease

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The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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RA and ω-3 PUFA co-treatment activates autophagy in cancer cells

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Adherence to Mediterranean Diet Pattern among Spanish Adults Attending a Medical Centre: Nondiabetic Subjects and Type 1 and 2 Diabetic Patients

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Impact of Dietary Fatty Acids on Macrophage Lipid Metabolism, Signaling and Function

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Dietary Fatty Acids at the Crossroad between Obesity and Colorectal Cancer: Fine Regulators of Adipose Tissue Homeostasis and Immune Response

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Dietary omega-3 polyunsaturated fatty acid and alpha-linolenic acid are associated with physical capacity measure but not muscle mass in older women 65–72 years

Isanejad, M., Tajik, B., McArdle, A., Tuppurainen, M. T., Sirola, J. P., Kröger, H., Rikkonen, T., & Erkkilä, A. T. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02773-z · Cited by 25

GPR40 Agonism Modulates Inflammatory Reactions in Vascular Endothelial Cells

Kim, J. W., Roh, E., Choi, K. M., Yoo, H. J., Hwang, H., & Baik, S. H. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2021.0092 · Cited by 22

Neuroinflammation and COVID-19 Ischemic Stroke Recovery—Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1–7)/Mas Receptor Axis and NLRP3 Inflammasome

Nassir, C. M. N. C. M., Zolkefley, M. K. I., Ramli, M. D. C., Norman, H. H., Hamid, H. A., & Mustapha, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063085 · Cited by 22

α-Linolenic acid regulates macrophages via GPR120-NLRP3 inflammasome pathway to ameliorate diabetic rats

Liu, Y., Guo, M., Li, Y., Wang, T., Yi, R., Wang, R., Jiang, X., Zhang, X., Tian, J., & Wang, H. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105348 · Cited by 22

Butyrate ameliorates inflammation of alcoholic liver disease by suppressing the LPS-TLR4-NF-κB/NLRP3 axis via binding GPR43-β-arrestin2

Ren, Y., Wang, R., Yu, J., Bao, T., Liu, Y., Bai, Z., Wang, T., Li, Y., Zhang, X., Wang, H., et al. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105351 · Cited by 24

Lauric acid-mediated gelatin/hyaluronic acid composite hydrogel with effective antibacterial and immune regulation for accelerating MRSA-infected diabetic wound healing

Yang, J. G., Wang, D., Yu, H., Wang, L., Wang, Y., Liu, X., Huang, Y., Ouyang, C., Hong, Y., Ren, S., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138792 · Cited by 23

Requisite Omega-3 HUFA Biomarker Thresholds for Preventing Murine Lupus Flaring

Wierenga, K. A., Strakovsky, R. S., Benninghoff, A. D., Rajasinghe, L. D., Lock, A. L., Harkema, J. R., & Pestka, J. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01796 · Cited by 21

Nutraceuticals and probiotics in the management of psychiatric and neurological disorders: A focus on microbiota-gut-brain-immune axis

Tong, J., Satyanarayanan, S. K., & Su, H. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.08.027 · Cited by 24

Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome

Wang, W., Li, J., Cui, S., Li, J., Ye, X., Wang, Z., Zhang, T., Jiang, X. J., Kong, Y., Chen, X., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj7813 · Cited by 22

Nervonic acid triggered ovarian inflammation by inducing mitochondrial oxidative stress to activate NLRP3/ IL-1β pathway

Zeng, X., Fan, X., Yu, H., Cai, S., Zhou, L., Wu, H., Zhang, Z., Quan, S., Li, S., Wang, X., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.08.028 · Cited by 23

Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole

Martinez, C. S., Zheng, A., & Xiao, Q. (2024) · Antioxidants · doi:10.3390/antiox13111330 · Cited by 26

EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors

Lamantia, V., Bissonnette, S., Beaudry, M., Cyr, Y., Rosiers, C. D., Baass, A. W., & Faraj, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-73672-6 · Cited by 24

Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals

Paradee, N., Koonyosying, P., Kusirisin, W., Janthip, R., Kanjanapothi, D., Pattanapanyasat, K., & Srichairatanakool, S. (2021) · Bioscience Reports · doi:10.1042/bsr20203166 · Cited by 21

Activation of NLRP3 Inflammasome by Palmitic Acid in Human Sebocytes

Jung, Y.-R., Shin, J., Kim, C.-H., Kim, S., Kim, C. D., Seo, Y., Lee, J., Im, M., Lee, Y., & Lee, Y. (2021) · Annals of Dermatology · doi:10.5021/ad.2021.33.6.541 · Cited by 21

Omega-3 pleiad: The multipoint anti-inflammatory strategy

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Inflammasomes: Cause or consequence of obesity‐associated comorbidities in humans

Herrera-Martínez, A. D., Herrero‐Aguayo, V., Pérez‐Gómez, J. M., Gahete, M. D., & Luque, R. M. (2022) · Obesity · doi:10.1002/oby.23581 · Cited by 22

Metabolic Composition and Quality Traits of Polygonatum cyrtonema Hua from Different Germplasms and Age Sections Based on Widely Targeted Metabolomics Analysis

Wang, Q., Ban, J., Cai, R., Zhang, X., Lai, C., Chen, Y., Li, X., Chen, C., Chen, Y., Zhang, Z., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076077 · Cited by 21

n-3 Fatty acids modulate the mRNA expression of theNlrp3inflammasome andMtorin the liver of rats fed with high-fat or high-fat/fructose diets

Garay-Lugo, N., Domínguez‐López, A., Miliar-García, Á., Barrera, E. S. A., Gómez‐López, M., Alcalá, A. G., Martínez–Godínez, M. D. L. Á., & Lara‐Padilla, E. (2016) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2016.1208221 · Cited by 21

Fatty Acids, Gut Bacteria, and Immune Cell Function

Xiang, M. S. W., Tan, J. K., & Macia, L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811297-7.00011-1 · Cited by 20

Anti-atherosclerotic action of GW9508 – Free fatty acid receptors activator – In apoE-knockout mice

Suski, M., Kiepura, A., Wiśniewska, A., Kuś, K., Skałkowska, A., Stachyra, K., Stachowicz, A., Gajda, M., Korbut, R., & Olszanecki, R. (2019) · Pharmacological Reports · doi:10.1016/j.pharep.2019.02.014 · Cited by 20

A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome

Wang, Y., Li, Y., Wang, J.-N., Zhao, Q.-X., Wen, S., Wang, S.-C., & Sun, T. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03050-x · Cited by 20

Potential Therapeutic Exploitation of G Protein-Coupled Receptor 120 (GPR120/FFAR4) Signaling in Obesity-Related Metabolic Disorders

Szukiewicz, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062501 · Cited by 23

Phospholipid metabolism in innate immunity and inflammation: from basic to clinic

Liu, J., Chen, Y., & O'Neill, L. A. J. (2025) · Immunity & Inflammation · doi:10.1007/s44466-025-00001-5 · Cited by 23

Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) for Immunomodulation in COVID-19 Related Acute Respiratory Distress Syndrome (ARDS)

Velotti, F., Costantini, L., & Merendino, N. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010304 · Cited by 21

Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and orthodontic tooth movement through GPR120

Ma, J., Kitaura, H., Ogawa, S., Ohori, F., Noguchi, T., Marahleh, A., Nara, Y., Pramusita, A., Kinjo, R., Kanou, K., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.929690 · Cited by 21

Nod-like receptors in inflammatory arthritis

Madahar, S. S., Gideon, A. R., & Sater, A. A. A. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100655 · Cited by 25

Effects of omega-3, omega-6, and total dietary polyunsaturated fatty acid supplementation in patients with atherosclerotic cardiovascular disease: a systematic review and meta-analysis

Luo, S., Hou, H., Wang, Y., Li, Y., Zhang, L., Zhang, H., Jin, Q., Wu, G., & Wang, X. (2023) · Food & Function · doi:10.1039/d3fo02522e · Cited by 22

Role of NLRP3 Inflammasome in Stroke Pathobiology: Current Therapeutic Avenues and Future Perspective

Panbhare, K., Pandey, R., Chauhan, C., Sinha, A., Shukla, R., & Kaundal, R. K. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00536 · Cited by 21

Nutraceutical Compounds Targeting Inflammasomes in Human Diseases

Castejón‐Vega, B., Giampieri, F., & Álvarez-Suárez, J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144829 · Cited by 22

GPR120 Ameliorates Apoptosis and Inhibits the Production of Inflammatory Cytokines in Renal Tubular Epithelial Cells

Zhi, D., Zhang, M., Lin, J., Liu, P., & Duan, M. (2020) · Inflammation · doi:10.1007/s10753-020-01346-2 · Cited by 20

Docosahexaenoic acid ameliorates autoimmune inflammation by activating GPR120 signaling pathway in dendritic cells

Feng, C., Li, L., Li, Q., Switzer, K. C., Liu, M., Han, S., & Zheng, B. Q. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107698 · Cited by 20

Complementary and Integrative Medicines as Prophylactic Agents for Pediatric Migraine: A Narrative Literature Review

Yamanaka, G., Kanou, K., Takamatsu, T., Takeshita, M., Morıchı, S., Suzuki, S., Ishida, Y., Watanabe, Y., Go, S., Oana, S., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10010138 · Cited by 19

Regulation of crystal induced inflammation: current understandings and clinical implications

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Biomimetic Integrated Nanozyme for Flare and Recurrence of Gouty Arthritis

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Dietary Fish Oil Inhibits Pro-Inflammatory and ER Stress Signalling Pathways in the Liver of Sows during Lactation

Geßner, D. K., Gröne, B., Couturier, A., Rosenbaum, S., Hillen, S., Becker, S., Erhardt, G., Reiner, G., Ringseis, R., & Eder, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137684 · Cited by 19

GPR120, a potential therapeutic target for experimental colitis in IL-10 deficient mice

Zhao, J., Wang, H., Shi, P., Wang, W., & Sun, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.14210 · Cited by 19

Lupus, Silica, and Dietary Omega-3 Fatty Acid Interventions

Wierenga, K. A., Harkema, J. R., & Pestka, J. J. (2019) · Toxicologic Pathology · doi:10.1177/0192623319878398 · Cited by 20

DHA Sensor GPR120 in Host Defense Exhibits the Dual Characteristics of Regulating Dendritic Cell Function and Skewing the Balance of Th17/Tregs

Zhao, C., Zhou, J., Meng, Y., Shi, N., Wang, X., Zhou, M., Li, G., & Yang, Y. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.39551 · Cited by 19

Dietary omega-3 alleviates copper-induced nephrotoxicity via suppression of NLRP3-mediated pyroptosis and lipid metabolism disorder in chickens

Zhang, X., Zhang, Y., Lu, H., Zhen, H., Zhang, Y., Wang, Q., Wang, R., Liu, M., & Xing, M. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110086 · Cited by 18

Teuvincenone F Suppresses LPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination

Zhao, X., Pu, D.-B., Zhao, Z., Zhu, H., Li, H., Shen, Y., Zhang, X., Zhang, R., Shen, J., Xiao, W., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00565 · Cited by 18

Regulation of Free Fatty Acid Receptor 4 on Inflammatory Gene Induced by LPS in Large Yellow Croaker (Larimichthys crocea)

Wu, M., Li, Q., Mai, K., & Ai, Q. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.703914 · Cited by 18

Differential effects of EPA and DHA on PPARγ-mediated sympathetic innervation in infarcted rat hearts by GPR120-dependent and -independent mechanisms

Wang, C.-P., Lee, C.-C., Wu, D., Chen, S.-Y., & Lee, T. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108950 · Cited by 19

Exogenous alpha-linolenic acid and Vibrio parahaemolyticus induce EPA and DHA levels mediated by delta-6 desaturase to enhance shrimp immunity

Chen, Z., Kong, Y., Huang, Z., Zheng, X., Zheng, Z., Yao, D., Yang, S., Zhang, Y., & Aweya, J. J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128583 · Cited by 18

Metabolic Disorder in Chronic Obstructive Pulmonary Disease (COPD) Patients: Towards a Personalized Approach Using Marine Drug Derivatives

Lamonaca, P., Prinzi, G., Kisialiou, A., Cardaci, V., Fini, M., & Russo, P. (2017) · Marine Drugs · doi:10.3390/md15030081 · Cited by 18

Transcriptome analysis and the effects of polyunsaturated fatty acids on the immune responses of the critically endangered angtze sturgeon (Acipenser dabryanus)

Chen, H., Wang, B., Yu, N., Qi, J., Tang, N., Wang, S., Tian, Z., Wang, M., Xu, S., Zhou, B., et al. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.09.012 · Cited by 18

The relationship between different fatty acids intake and frequency of migraine attacks

Askari, G., Sadeghi, O., Maghsoudi, Z., Khorvash, F., & Ghiasvand, R. (2015) · Iranian Journal of Nursing and Midwifery Research · doi:10.4103/1735-9066.157831 · Cited by 18

Functionalized nanomaterials targeting NLRP3 inflammasome driven immunomodulation: Friend or Foe

Kanika, & Khan, R. (2023) · Nanoscale · doi:10.1039/d3nr03857b · Cited by 18

α-linolenic acid mitigates microglia-mediated neuroinflammation of schizophrenia in mice by suppressing the NF-κB/NLRP3 pathway via binding GPR120-β-arrestin 2

Wang, T., Liu, S., Shen, W., Li, J., Liu, Y., Li, Y., Zhang, F., Li, T., Zhang, X., Tian, W., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113047 · Cited by 17

Flaxseed (Linum Usitatissimum L.) Supplementation in Patients Undergoing Lipoprotein Apheresis for Severe Hyperlipidemia—A Pilot Study

Kanikowska, D., Korybalska, K., Mickiewicz, A., Rutkowski, R., Kuchta, A., Sato, M., Kreft, E., Fijałkowski, M., Gruchała, M., Jankowski, M., et al. (2020) · Nutrients · doi:10.3390/nu12041137 · Cited by 17

Metabolic regulators of enigmatic inflammasomes in autoimmune diseases and crosstalk with innate immune receptors

Jimenez‐Duran, G., & Triantafilou, M. (2021) · Immunology · doi:10.1111/imm.13326 · Cited by 17

Multi-Omic Profiling of Macrophages Treated with Phospholipids Containing Omega-3 and Omega-6 Fatty Acids Reveals Complex Immunomodulatory Adaptations at Protein, Lipid and Metabolic Levels

Maurício, T., Aveiro, S. S., Guedes, S. D. M., Lopes, D., Melo, T., Neves, B. M., Domingues, M. R., & Domingues, P. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042139 · Cited by 17

Oral administration of the selective GPR 120/ FFA 4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases

Wannick, M., Bezdek, S., Guillen, N., Thieme, M., Meshrkey, F., Mousavi, S., Seeling, M., Nimmerjahn, F., Mócsai, A., Zillikens, D., et al. (2018) · Pharmacology Research & Perspectives · doi:10.1002/prp2.438 · Cited by 17

Effect of icosapent ethyl on susceptibility to ventricular arrhythmias in postinfarcted rat hearts: Role of GPR120‐mediated connexin43 phosphorylation

Chen, W., Chen, S., Wu, D., Lee, C., & Lee, T. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15575 · Cited by 17

Gut microbiota CLA and IL-35 induction in macrophages through Gαq/11-mediated STAT1/4 pathway: an animal-based study

Su, L., Yang, Y., Gao, Y., Wang, J., Yang, H., Zhang, Y., & Yang, R. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2437253 · Cited by 17

Molecular mechanisms of aberrant fatty acids metabolism in driving cardiovascular diseases: key regulatory targets and dietary interventions

Yang, R., Pang, J., Zhong, X. Y., Pang, S., Hu, X., Wei, C., Yan, W., Chen, X., Zhao, R., Xu, B., et al. (2025) · Food & Function · doi:10.1039/d5fo01237f · Cited by 18

Omega-3 polyunsaturated fatty acids ameliorated inflammatory response of mammary epithelial cells and mammary gland induced by lipopolysaccharide

Feng, J., Wang, Q., Yang, W., Liu, J., & Gao, M. (2021) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmab100 · Cited by 16

Targeting the inflammasome in rheumatic diseases

McCoy, S. S., Stannard, J. N., & Kahlenberg, J. M. (2015) · Translational research · doi:10.1016/j.trsl.2015.06.006 · Cited by 16

Nutrients and Immunometabolism: Role of Macrophage NLRP3

Larson, K., Alvine, T., Wu, D., Kalupahana, N. S., Moustaïd‐Moussa, N., & Roemmich, J. N. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa085 · Cited by 16

Regulation of glucose and glycerol for production of docosahexaenoic acid in Schizochytrium limacinum SR21 with metabolomics analysis

Li, Z., Meng, T., Hang, W., Cao, X., Ni, H., Shi, Y., Li, Q., Xiong, Y., & He, N. (2021) · Algal Research · doi:10.1016/j.algal.2021.102415 · Cited by 15

Effects of omega-3 and omega-6 fatty acids on human placental cytokine production

Melody, S. M., Vincent, R. K., Mori, T. A., Mas, E., Barden, A. E., Waddell, B. J., & Keelan, J. A. (2014) · Placenta · doi:10.1016/j.placenta.2014.10.013 · Cited by 16

Fish Oil-Derived Long-Chain n-3 Polyunsaturated Fatty Acids Reduce Expression of M1-Associated Macrophage Markers in an ex vivo Adipose Tissue Culture Model, in Part through Adiponectin

Boer, A. A. D., Monk, J. M., Liddle, D. M., Power, K. A., David, W. L., & Robinson, L. E. (2015) · Frontiers in Nutrition · doi:10.3389/fnut.2015.00031 · Cited by 17

Inflammasomes as the molecular hub of cardiovascular-metabolic-immune comorbidity networks

Qian, X., Sun, J. M., Li, F., Li, X., Hu, X., Dong, N., & Li, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1690443 · Cited by 18

Factors Affecting Gut Microbiota of Puppies from Birth to Weaning

Balouei, F., Stefanon, B., Sgorlon, S., & Sandri, M. (2023) · Animals · doi:10.3390/ani13040578 · Cited by 18

Omega-3 Polyunsaturated Fatty Acids and Their Anti-Oxidant, Anti-Inflammatory and Neuroprotective Effects in Diabetic Retinopathy: A Narrative Review

Fathima, S., Prokopiou, E., & Georgiou, T. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2807153 · Cited by 15

The role for ω-3 polyunsaturated and short chain fatty acids in hypertension: An updated view on the interaction with gut microbiota

Brosolo, G., Porto, A. D., Marcante, S., Capilupi, F., Bertin, N., Vivarelli, C., Bulfone, L., Vacca, A., Catena, C., & Sechi, L. A. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177107 · Cited by 16

Increased Omega-3 Fatty Acid Intake is Inversely Associated with Sarcopenic Obesity in Women but not in Men, Based on the 2014–2018 Korean National Health and Nutrition Examination Survey

Yang, W., Lee, J., Kim, Y., Lee, J. H., & Kang, H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123856 · Cited by 16

Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling

Sakaguchi, M., OKAGAWA, S., Okubo, Y., Otsuka, Y., Fukuda, K., Igata, M., Kondo, T., Sato, Y., Yoshizawa, T., Fukuda, T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33842-4 · Cited by 15

Practical approaches to the nutritional management of nonalcoholic fatty liver disease

Freidoony, L., & Kong, I. D. (2014) · Integrative Medicine Research · doi:10.1016/j.imr.2014.09.003 · Cited by 18

Effects of RAMEA-complexed polyunsaturated fatty acids on the response of human dendritic cells to inflammatory signals

Rajnavölgyi, É., Laczik, R., Kun, V., Szente, L., & Fenyvesi, É. (2014) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.10.332 · Cited by 15

Omega-3 Polyunsaturated Fatty Acids for the Treatment of IgA Nephropathy

Hirahashi, J. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6070070 · Cited by 15

AIE-enabled transfection-free identification and isolation of viable cell subpopulations differing in the level of autophagy

Zhang, W., Wei, P., Liu, L., Ding, T., Yang, Y., Jin, P., Zhang, L., Zhao, Z., Wang, M., Hu, B., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2235197 · Cited by 14

ω-3 polyunsaturated fatty acid alleviates systemic lupus erythematosus by suppressing autoimmunity in a murine model

Liu, A., Li, Z., Peng, Y., Peng, Y., Wang, S., Bi, X., Zhao, Z., Zhou, S., Zhao, A. Z., Mu, Y., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111299 · Cited by 14

Linoleic acid‐derived diol 12,13‐ DiHOME enhances NLRP3 inflammasome activation in macrophages

y Valencia, R. H., Kranrod, J. W., Fang, L., Soliman, A. M., Azer, B., Clemente‐Casares, X., & Seubert, J. M. (2024) · The FASEB Journal · doi:10.1096/fj.202301640rr · Cited by 15

New insights into the function of the NLRP3 inflammasome in sarcopenia: mechanism and therapeutic strategies

Zou, Y., Tang, X., Yang, S., Chen, Z., Liu, B., 周作琼, Peng, X., & Tang, C. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155972 · Cited by 14

Exploring the potential of omega‐3 fatty acids in acne patients: A prospective intervention study

Guertler, A., Neu, K., Lill, D., Clanner-Engelshofen, B. M., French, L. E., & Reinholz, M. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16434 · Cited by 22

GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson’s disease animal models

Ha, T.-Y., Kim, J.-B., Kim, Y., Park, S. M., & Chang, K. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107432 · Cited by 14

Role of dietary α- and γ-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine model

Tapia, G., Silva, D., Romero, N., Pettinelli, P., Dossi, C. G., de Miguel, M., & Gonzalez‐Mañán, D. (2018) · Nutrition · doi:10.1016/j.nut.2018.01.012 · Cited by 14

Influence of different lipid emulsions on specific immune cell functions in head and neck cancer patients receiving supplemental parenteral nutrition: An exploratory analysis

Candiloro, F., Borioli, V., Borsellino, G., Picozza, M., Pellini, R., Cereda, E., Gargano, F., Caraccia, M., Nardi, M. T., Bellu, L., et al. (2021) · Nutrition · doi:10.1016/j.nut.2021.111178 · Cited by 14

NLRP3 as a sensor of metabolism gone awry

Neuwirt, E., Gorka, O., Saller, B. S., Groß, C. J., Madl, T., & Groß, O. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.03.009 · Cited by 13

Fish oil–based lipid emulsion alleviates parenteral nutrition–associated liver diseases and intestinal injury in piglets

Chen, S., Xiao, Y., Liu, Y., Tian, X., Wang, W., Jiang, L., Wu, W., Zhang, T., Cai, W., & Wang, Y. (2021) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2229 · Cited by 14

Fasting Induces IL-1 Resistance and Free-Fatty Acid-Mediated Up-Regulation of IL-1R2 and IL-1RA

Joesting, J. J., Moon, M. L., Gainey, S. J., Tisza, B. L., Blevins, N. A., & Freund, G. G. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00315 · Cited by 14

Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120)

Hansen, S. V. F., & Ulven, T. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_60 · Cited by 14

Transcriptome analysis of the effect of polyunsaturated fatty acids against Vibrio vulnificus infection in Oreochromis niloticus

Pan, C., Liu, Y., Gong, H., & Chen, J. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.01.018 · Cited by 14

Aggressive Crosstalk Between Fatty Acids and Inflammation in Macrophages and Their Influence on Metabolic Homeostasis

Nishiyama, K., Fujimoto, Y., Takeuchi, T., & Azuma, Y. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2269-x · Cited by 14

Combined administration of docosahexaenoic acid and thyroid hormone synergistically enhances rat liver levels of resolvins RvD1 and RvD2

Videla, L. A., Vargas, R., Valenzuela, R., Muñoz, P., Corbari, A., & Hernández‐Rodas, M. C. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.11.013 · Cited by 14

A Selectivity Study of FFAR4/FFAR1 Agonists by Molecular Modeling

Zhang, X., Sun, H., Wen, X., & Yuan, H. (2019) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.9b00735 · Cited by 14

Mitogen-Activated Protein Kinase and Nuclear Hormone Receptor Crosstalk in Cancer Immunotherapy

Burgermeister, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713661 · Cited by 13

Free fatty acid receptor 4 (FFA4) activation attenuates obese asthma by suppressing adiposity and resolving metaflammation

Son, S., Koh, J., & Im, D. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116509 · Cited by 13

Exploring Anti-Inflammatory Treatment as Upstream Therapy in the Management of Atrial Fibrillation

Zheng, E., Warchoł, I., Mejza, M., Możdżan, M., Strzemińska, M., Bajer, A., Madura, P., Żak, J., & Plewka, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14030882 · Cited by 17

GPR40 agonist inhibits NLRP3 inflammasome activation via modulation of nuclear factor-κB and sarco/endoplasmic reticulum Ca2+-ATPase

Park, J., Lee, M., Seo, Y., Kang, B., Lim, S., & Kang, K. W. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120127 · Cited by 13

Vincamine as an agonist of G protein-coupled receptor 40 effectively ameliorates pulmonary fibrosis in mice

Zhao, T., Zhou, Z., Zhao, S., Wan, H., Li, H., Hou, J., Wang, J., Qian, M., & Shen, X. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154919 · Cited by 13

Editorial: Can GPR43 Sensing of Short‐Chain Fatty Acids Unchain Inflammasome‐Driven Arthritis?

Haslberger, A. G., & Terkeltaub, R. A. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39102 · Cited by 13

N-homocysteinylation of β-arrestins biases GPCR signaling and promotes platelet activation

Zhang, L., Che, C.-X., Du, Y., Han, L., Wang, J., Zhang, C.-Y., Huang, S.-M., Zheng, Z., He, Q., Yang, Z., et al. (2025) · Blood · doi:10.1182/blood.2024025593 · Cited by 12

Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile

Tognocchi, M., Conte, M., Testai, L., Martucci, M., Serra, A., Salvioli, S., Calderone, V., Mele, M. L., & Conte, G. (2022) · Foods · doi:10.3390/foods11030398 · Cited by 12

Design of nanoformulation of specialized pro-resolving mediators to facilitate inflammation resolution and disease treatment

Li, J., Xiang, Q., Xia, T., Meng, H., & Liu, X. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101978 · Cited by 14

Fish Oil Cools the Inflammasome

Polage, C. R. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006920

(De-) Oiling Inflammasomes

Marty-Roix, R., & Lien, E. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.006 · Cited by 8

Dietary fatty acid composition is sensed by the NLRP3 inflammasome: omega-3 fatty acid (DHA) prevents NLRP3 activation in human macrophages

Martínez-Micaelo, N., González‐Abuín, N., Pinent, M., Ardèvol, A., & Blay, M. (2016) · Food & Function · doi:10.1039/c6fo00477f · Cited by 48

Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

Williams-Bey, Y., Boularan, C., Vural, A., Huang, N.-N., Hwang, I.-Y., Shan-Shi, C., & Kehrl, J. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097957 · Cited by 215

Fishing for anti-inflammatory mechanisms

Minton, K. (2013) · Nature reviews. Immunology · doi:10.1038/nri3498 · Cited by 2