Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

A role for mitochondria in nlrp3 inflammasome activation

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Type 2 diabetes as an inflammatory disease

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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The Inflammasomes: Guardians of the Body

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GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

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Inflammasomes in health and disease

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The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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Accelerated wound healing of enzymatically debrided deep dermal burn wounds after the use of fish skin (Kerecis Omega3 Wound®) in comparison to Suprathel®

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Biomimetic Liposomes for G-Protein-Coupled Receptor 120 Exo/Endogenous Coactivation to Reprogram Lipid Metabolism in Obesity-Associated Osteoarthritis

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Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models

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The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults

Lamantia, V., Bissonnette, S., Provost, V., Devaux, M., Cyr, Y., Daneault, C., Rosiers, C. D., & Faraj, M. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy238 · Cited by 13

Combined docosahexaenoic acid and thyroid hormone supplementation as a protocol supporting energy supply to precondition and afford protection against metabolic stress situations

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Effects of fish oil during hemodialysis on nutritional status and quality of life: a randomized double-blinded trial

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DHA‐Enriched Phospholipids Exhibit Anti‐Depressant Effects by Immune and Neuroendocrine Regulation in Mice: A Study on Dose‐ and Structure‐Activity Relationship

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Microalgae and Thraustochytrids are Sustainable Sources of Vegan EPA and DHA with Commercial Feasibility

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Protectin Conjugates in Tissue Regeneration 1 Inhibits Macrophage Pyroptosis by Restricting NLRP3 Inflammasome Assembly to Mitigate Sepsis via the cAMP-PKA Pathway

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High n-3 fatty acids counteract hyperglycemia-induced insulin resistance in fat-1 mice via pre-adipocyte NLRP3 inflammasome inhibition

Yu, Q., Wang, T., Wang, F., Yang, Y., He, C., Yang, W., Zhang, J., & Zou, Z. (2020) · Food & Function · doi:10.1039/d0fo02092c · Cited by 11

Rosuvastatin, lycopene and omega-3 fatty acids: A potential treatment for systemic inflammation in COPD; a pilot study

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Icosabutate: targeting metabolic and inflammatory pathways for the treatment of NASH

Fraser, D. A., Harrison, S. A., & Schuppan, D. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2159804 · Cited by 11

Recent Advance in Regulatory Effect of GRP120 on Bone Metabolism

Wang, Y., Liu, H., & Zhang, Z. (2023) · Aging and Disease · doi:10.14336/ad.2023.0216 · Cited by 10

Omega-3 polyunsaturated fatty acids alleviate hyperuricemic nephropathy by inhibiting renal pyroptosis through GPR120

Yang, Z. H., Li, H., Wu, H., Zhou, Y., Du, J., & Hu, Z. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116575 · Cited by 10

Effects of Prickly Ash Seed Dietary Supplementation on Meat Quality, Antioxidative Capability, and Metabolite Characteristics of Hu Lambs

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Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

Ye, Z., Li, Y., Yang, X., Li, C., Yu, R., Zheng, G., & Su, Z. (2025) · Cell Proliferation · doi:10.1111/cpr.70012 · Cited by 10

Dietary Polyunsaturated Fatty Acid and the Risk of Rheumatoid Arthritis: Insights From Genetic Predisposition and Proteomics

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Mitochondria, Oxidative Stress, and Psychiatric Disorders: An Integrative Perspective on Brain Bioenergetics

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Lipid nutrition: “In silico” studies and undeveloped experiments

Lands, B. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101142 · Cited by 10

Cichorium intybus: A Comprehensive Review on Its Pharmacological Activity and Phytochemistry

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Inflammation macrophages contribute to cardiac homeostasis

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Association between rosacea severity and relative muscle mass: A cross‐sectional study

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Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways

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Tetrahydropalmatine Alleviates Hyperlipidemia by Regulating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammasome Activation by Inhibiting the TLR4-NF-κB Pathway

Ding, K., Chen, L., He, J., Wang, J., Yu, C., & Wang, H. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6614985 · Cited by 10

NLRP3 inflammasome: activation, regulation, and role in diseases

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Regulating against the dysregulation: new treatment options in autoinflammation

Kallinich, T. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0501-9 · Cited by 10

Exploring the structures and molecular mechanisms of bioactive compounds from marine foods for hyperuricemia prevention: a systematic review

Meng, W., Zhang, J., Hou, H., Yu, L., & Dong, P. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2464700 · Cited by 9

Secreted phospholipase A2 regulates intercellular communications by coordinating extracellular phospholipid metabolism

Murakami, M. (2025) · International Immunology · doi:10.1093/intimm/dxaf027 · Cited by 11

Adipose tissue NLRP3 inflammasome: a therapeutic target in obesity and type 2 diabetes mellitus

Nnolum-Orji, N. F., Kumar, P., Ngema, L. M., & Choonara, Y. E. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104456 · Cited by 13

NLRP3 inflammasome activation in PCOS: A novel target for managing insulin resistance and metabolic dysregulation

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Effects of seafood consumption and toenail mercury and selenium levels on cognitive function among American adults: 25 y of follow up

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Dietary and pharmacological energy restriction and exercise for healthspan extension

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Omega-3 Polyunsaturated Fatty Acids in Blood Pressure Control and Essential Hypertension

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Intake of Marine-Derived Omega-3 Polyunsaturated Fatty Acids and Mortality in Renal Transplant Recipients

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The Association of Dietary Fatty Acids and Gut Microbiota Alterations in the Development of Neuropsychiatric Diseases: A Systematic Review

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Innate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Population

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Macrophage polarization by potential nutraceutical compounds: A strategic approach to counteract inflammation in atherosclerosis

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Effectiveness of Osthole on Uric Acid Crystal-induced Acute Gouty Arthritis Through the Inhibition of NLRP3 Inflammasome

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Relationship between Metal Exposures, Dietary Macronutrient Intake, and Blood Glucose Levels of Informal Electronic Waste Recyclers in Ghana

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Long-chain fatty acids - The turning point between ‘mild’ and ‘severe’ acute pancreatitis

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Molecular Mechanisms and Clinical Implications of Complex Prehabilitation in Colorectal Cancer Surgery: A Comprehensive Review

Włodarczyk, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157242 · Cited by 12

Marine ω-3 PUFA Supplementation Enhances FFAR4 Activation and Reduces Inflammatory Markers in PBMC of Subjects with Obesity: A Randomized Controlled Trial (EPICO)

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Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target

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(De-) Oiling Inflammasomes

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Metabolic Regulation of Immune Response and Tissue Remodeling in Gouty Arthritis (Review)

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Dietary polyunsaturated fatty acids intake is negatively associated with hyperuricemia: The National Health and Nutrition Examination Survey 2003–2015

Chen, H., Yang, G., Chen, L., Zhao, Y., Yao, P., Li, Y., Tang, Y., & Li, D. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.05.026 · Cited by 8

Transcription factor ETV4 plays a critical role in the development of non-alcoholic fatty liver disease

Gadiraju, B., Magisetty, J., & Kondreddy, V. K. R. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137235 · Cited by 8

The Role of NLRP3 Inflammasome in Cardiovascular Diseases

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Metabolic Flexibility Assists Reprograming of Central and Peripheral Innate Immunity During Neurodevelopment

Cruz-Carrillo, G., & Camacho‐Morales, A. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02154-3 · Cited by 7

Dietary ω-3 polyunsaturated fatty acids modulate CD4+ T-cell subset markers, adipocyte antigen-presentation potential, and NLRP3 inflammasome activity in a coculture model of obese adipose tissue

Liddle, D. M., Hutchinson, A. L., Monk, J. M., Power, K. A., & Robinson, L. E. (2021) · Nutrition · doi:10.1016/j.nut.2021.111388 · Cited by 8

Dopaminergic Receptors as Neuroimmune Mediators in Experimental Autoimmune Encephalomyelitis

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Omega-3 mechanism of action in inflammation and endoplasmic reticulum stress in mononuclear cells from overweight non-alcoholic fatty liver disease participants: study protocol for the “Brazilian Omega Study” (BROS)—a randomized controlled trial

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Inflammaging

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Effect of nanocapsules containing docosahexaenoic acid in mice with chronic inflammation

Leão, M. D. C., Piazza, I., Caria, S. J., Broering, M. F., Farsky, S. H. P., Uchiyama, M. K., Araki, K., Bonjour, K., Cogliati, B., Pohlmann, A. R., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115474 · Cited by 8

Inflammation and Oxidative Stress in Adipose Tissue

Martínez‐Fernández, L., Fernández‐Galilea, M., Félix‐Soriano, E., Escoté, X., González‐Muniesa, P., & Moreno-Aliaga, M. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812504-5.00004-0 · Cited by 9

NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance

Tian, Q., Guo, H., Zhang, M., Jiang, K., Hu, F., Xu, Y., Wan, L., Zhou, X., Pan, Y., Liu, W., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02181-4 · Cited by 7

GPR43 alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome activation via β-arrestin 2

Wang, C., Zhang, W., Guo, Y., Liao, Y., Li, N., Zhang, Y., Bo, L., Bian, J., & Wang, J.-F. (2026) · Biology Direct · doi:10.1186/s13062-025-00725-9 · Cited by 7

The interplay between NLRP3 inflammasome and metabolic signals in gouty arthritis

Cao, D., Pu, H.-Y., Yuan, X., Li, Z., Yu, X., & Shi, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1761121 · Cited by 8

Targeting PI3K by Natural Products: A Potential Therapeutic Strategy for Attention-deficit Hyperactivity Disorder

Noori, T., Sahebgharani, M., Sureda, A., Sobarzo-Sanchez, E., Fakhri, S., & Shirooie, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220119125040 · Cited by 7

Association of Mediterranean diet pattern with disease activity in the patients with rheumatoid arthritis: A cross-sectional study on Iranian patients

Mostafai, R., Elahi, N., Moludi, J., Moradi, F., Solouki, L., Nachvak, S. M., & Behrooz, M. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.01.012 · Cited by 9

The Role of Alpha Linolenic Acid on Neuroinflammation: A Systemic Review

Wijaya, D. C., & Linawati, N. M. (2024) · Jurnal Penelitian Pendidikan IPA · doi:10.29303/jppipa.v10i7.6173 · Cited by 7

Functional expression of the free fatty acids receptor-1 and -4 (FFA1/GPR40 and FFA4/GPR120) in bovine endometrial cells

Valenzuela, P., Teuber, S., Manosalva, C., Alarcón, P., Figueroa, C. D., Ratto, M. H., Burgos, R. A., & Hidalgo, M. A. (2019) · Veterinary Research Communications · doi:10.1007/s11259-019-09758-8 · Cited by 9

Fluorescent Ligand-Based Discovery of Small-Molecule Sulfonamide Agonists for GPR120

Ma, S., Li, Z., Yang, Y., Zhang, L., Li, M., & Du, L. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.816014 · Cited by 7

Effects of Crude Rice Bran Oil and a Flaxseed Oil Blend in Young Horses Engaged in a Training Program

Mowry, K. C., Thomson, T., Morales, C., Fikes, K. K., Stutts, K. J., Leatherwood, J. L., Anderson, M. J., Smith, R. X., & Suagee-Bedore, J. K. (2022) · Animals · doi:10.3390/ani12213006 · Cited by 7

Mechanisms of BK Channel Activation by Docosahexaenoic Acid in Rat Coronary Arterial Smooth Muscle Cells

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Glaucoma and dietary links: insights from high-salt intake, the Mediterranean diet, and specific nutrients

Yang, Y., Zhou, H., & Zhang, H. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1461748 · Cited by 7

Deciphering the NLRP3 inflammasome in diabetic encephalopathy: Molecular insights and emerging therapeutic targets

Zeng, X., Yuan, Y., Li, Y., Hu, Z., & Hu, S. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115304 · Cited by 8

In silico Target Class Prediction and Probabilities for Plant Derived Omega 3 Fatty Acid from Ethyl Acetate Fraction of Moringa oleifera Leaf Extract

Murugan, M., Krishnaveni, K., Sabitha, M., Kandeepan, C., Senthilkumar, N., Loganathan, T., Pushpalatha, G. G. L., Pandiarajan, G., Ramya, S., & Jayakumararaj, R. (2022) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v12i3.5352 · Cited by 6

Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment

Abhishek, A., Fuller, A., Nakafero, G., Zhang, W., Dumbleton, J., Hawkey, C. J., Coupland, C. A. C., Terkeltaub, R. A., & Doherty, M. (2022) · Rheumatology Advances in Practice · doi:10.1093/rap/rkac086 · Cited by 7

Dietary docosahexaenoic acid supplementation inhibits acute pulmonary transcriptional and autoantibody responses to a single crystalline silica exposure in lupus-prone mice

Chauhan, P., Benninghoff, A. D., Favor, O. K., Wagner, J. G., Lewandowski, R. P., Rajasinghe, L. D., Li, Q., Harkema, J. R., & Pestka, J. J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1275265 · Cited by 6

Negative relationship between eicosapentaenoic acid and inflammatory biomarkers in patients with acute myocardial infarction

Masson, D., Leleu, D., Farnier, M., Chague, F., Rampon, C., Bichât, F., Demeule, C., Maza, M., de Barros, J.-P. P., Cottin, Y., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae007 · Cited by 6

LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments

Tang, W., Luan, Y., Yuan, Q., Li, A., Chen, S., Menacherry, S. D., Young, L. H., & Wu, D. (2024) · Nature Communications · doi:10.1038/s41467-024-47262-z · Cited by 6

Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program

Gilley, K. N., Fenton, J. I., Zick, S. M., Li, K., Wang, L., Marder, W., McCune, W. J., Jain, R., Herndon-Fenton, S. J., Hassett, A. L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1459297 · Cited by 5

Maternal dietary DHA and EPA supplementation ameliorates adverse cardiac outcomes in THC-exposed rat offspring

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GPR120 internalization: a key mechanism for EPA in antidepressant action

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