Cited by 784Inflammasome and immune disordersFatty Acid Research and HealthImmune Response and Inflammation

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

Open access

Yan, Yiqing, Jiang, Wei, Spinetti, Thibaud, Tardivel, Aubry, Castillo, Rosa, Bourquin, Carole, Guarda, Greta, Tian, Zhigang, Tschopp, Jurg, Zhou, Rongbin·2013·Immunity

DOI 10.1016/j.immuni.2013.05.015

Open this paper in CoChat — free account Open PDF

Abstract

Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and metabolic disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2013.05.015

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Self-citation
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Self-citation
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708
Self-citation
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436
Self-citation
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428
Inflammasomes in health and disease
Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230
The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells
Endres, S., Ghorbani, R., Kelley, V. E., Georgilis, K., Lonnemann, G., van der Meer, J. W. M., Cannon, J. G., Rogers, T. S., Klempner, M. S., Weber, P. C., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902023200501 · Cited by 1,911
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Wen, H., Gris, D., Lei, Y., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P.-Y. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,698

Flagged first, then by citations

Show all 48 references

Sorted by citations

Items 101–200 of 783

Lipid Replacement Therapy: A natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function
Nicolson, G. L., & Ash, M. E. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.11.010 · Cited by 117
Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases
Seok, J. K., Kang, H. C., Cho, Y., Lee, H. S., & Lee, J. Y. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01307-9 · Cited by 122
Immunomodulatory Effects of Dopamine in Inflammatory Diseases
Feng, Y., & Lü, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.663102 · Cited by 113
Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons
Wellhauser, L., & Belsham, D. D. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-60 · Cited by 108
An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology
Ratsimandresy, R. A., Dorfleutner, A., & Stehlik, C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00440 · Cited by 114
G protein-coupled receptors as targets for anti-diabetic therapeutics
Oh, D. Y., & Olefsky, J. M. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.4 · Cited by 110
Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation
Yabal, M., Calleja, D. J., Simpson, D. S., & Lawlor, K. E. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.mr0318-124r · Cited by 110
Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders
Wani, K., AlHarthi, H., Alghamdi, A. A., Sabico, S., & Al‐Daghri, N. M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020511 · Cited by 118
Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
Huang, Y., Wang, H., Hao, Y., Lin, H., Dong, M., Ye, J., Song, L., Wang, Y., Li, Q., Shan, B., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0510-3 · Cited by 110
Self-citation
The Potential Influence of the Bacterial Microbiome on the Development and Progression of ADHD
Bull-Larsen, S., & Mohajeri, M. H. (2019) · Nutrients · doi:10.3390/nu11112805 · Cited by 111
The lipid basis of cell death and autophagy
Lin, Z., Long, F., Kang, R., Klionsky, D. J., Yang, M., & Tang, D. (2023) · Autophagy · doi:10.1080/15548627.2023.2259732 · Cited by 107
Chia Flour Supplementation Reduces Blood Pressure in Hypertensive Subjects
Toscano, L. T., da Silva, C. S. O., Toscano, L. T., de Almeida, A. E. M., da Cruz Santos, A., & Silva, A. S. (2014) · Plant Foods for Human Nutrition · doi:10.1007/s11130-014-0452-7 · Cited by 104
Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury
Lin, C., Chao, H., Li, Z., Xu, X., Liu, Y., Bao, Z., Hou, L., Liu, Y., Wang, X., You, Y., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.01.005 · Cited by 103
The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool?
Katsimbri, P., Korakas, E., Kountouri, A., Ikonomidis, I., Tsougos, E., Vlachos, D., Papadavid, E., Raptis, A. E., & Lambadiari, V. (2021) · Antioxidants · doi:10.3390/antiox10020157 · Cited by 114
Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis
López-Armada, M. J., Fernández-Rodríguez, J. A., & Blanco, F. J. (2022) · Antioxidants · doi:10.3390/antiox11061151 · Cited by 118
Modulation of host defence against bacterial and viral infections by omega-3 polyunsaturated fatty acids
Husson, M.-O., Ley, D., Portal, C., Aumar, M., Hueso, T., Desseyn, J., & Gottrand, F. (2016) · Journal of Infection · doi:10.1016/j.jinf.2016.10.001 · Cited by 105
α‐Linolenic acid‐derived metabolites from gut lactic acid bacteria induce differentiation of anti‐inflammatory M2 macrophages through G protein‐coupled receptor 40
Ohue‐Kitano, R., Watanabe‐Yasuoka, Y., Goto, T., Kitamura, N., Park, S., Kishino, S., Kimura, I., Kasubuchi, M., Takahashi, H., Li, Y., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700273r · Cited by 105
Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages
Im, D. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.094 · Cited by 104
Lipids, inflammasomes, metabolism, and disease
Anand, P. (2020) · Immunological Reviews · doi:10.1111/imr.12891 · Cited by 108
A past and present overview of macrophage metabolism and functional outcomes
Curi, R., Mendes, R. D. S., Crispin, L. A. D. C., Norata, G. D., Sampaio, S. C., & Newsholme, P. (2017) · Clinical Science · doi:10.1042/cs20170220 · Cited by 103
The effect of diet on hypertensive pathology: is there a link via gut microbiota-driven immunometabolism?
Jama, H. A., Beale, A. L., Shihata, W., & Marques, F. Z. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz091 · Cited by 105
From Gut Microbiota through Low-Grade Inflammation to Obesity: Key Players and Potential Targets
Vetrani, C., Nisio, A. D., Paschou, S. Α., Barrea, L., Muscogiuri, G., Graziadio, C., Savastano, S., & Colao, A. (2022) · Nutrients · doi:10.3390/nu14102103 · Cited by 108
Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation
Fonseca, W., Lucey, S., Jang, S., Fujimura, K. E., Rasky, A. J., Ting, H.-A., Petersen, J. H., Johnson, C. C., Boushey, H. A., Zoratti, E. M., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.13 · Cited by 102
The NLRP3 inflammasome - interleukin 1 pathway as a therapeutic target in gout
Szekanecz, Z., Szamosi, S., Kovács, G. E., Kocsis, E., & Benkő, S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.01.031 · Cited by 101
Omega-3 Fatty Acids and Other FFA4 Agonists Inhibit Growth Factor Signaling in Human Prostate Cancer Cells
Liu, Z., Hopkins, M. M., Zhang, Z., Quisenberry, C. B., Fix, L. C., Galvan, B. M., & Meier, K. E. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.218974 · Cited by 100
Effects of maternal n-3 fatty acid supplementation on placental cytokines, pro-resolving lipid mediators and their precursors
Keelan, J. A., Mas, E., D’Vaz, N., Dunstan, J. A., Li, S., Barden, A. E., Mark, P. J., Waddell, B. J., Prescott, S. L., & Mori, T. A. (2014) · Reproduction · doi:10.1530/rep-14-0549 · Cited by 100
Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement
Zhou, H., Feng, L., Xu, F., Sun, Y., Ma, Y., Zhang, X., Liu, H., Xu, G., Wu, X., Shen, Y., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.003 · Cited by 101
Omega-3 fatty acids and adipose tissue biology
Kuda, O., Rossmeisl, M., & Kopecký, J. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.01.004 · Cited by 103
Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1
Wu, J., Luo, Y., Jiang, Q. Y., Li, S., Huang, W., Li, X., Liu, D., Hu, Y., Wang, P., Lü, X., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104348 · Cited by 100
Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes
Kim, Y., Wang, W., Okla, M., Kang, I., Moreau, R. F., & Chung, S. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m062828 · Cited by 100
Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes
Fenton, J. I., Hord, N. G., Ghosh, S., & Gurzell, E. A. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.09.011 · Cited by 99
Omega-3 fatty acids and protein metabolism
Girolamo, F. G. D., Situlin, R., Mazzucco, S., Valentini, R., Toigo, G., & Biolo, G. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000032 · Cited by 102
Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy
Shen, L., Yang, Y., Ou, T., Key, C.-C. C., Tong, S. H., Sequeira, R. C., Nelson, J. M., Nie, Y., Wang, Z., Boudyguina, E. Y., et al. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m075879 · Cited by 98
Inflammasomes and type 2 diabetes: An updated systematic review
Sepehri, Z., Kiani, Z., Afshari, M., Kohan, F., Dalvand, A., & Ghavami, S. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.10.010 · Cited by 99
Interventions to promote cardiometabolic health and slow cardiovascular ageing
Fontana, L. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0026-8 · Cited by 96
Gut microbiome, metabolome, and allergic diseases
Hirata, S., & Kunisawa, J. (2017) · Allergology International · doi:10.1016/j.alit.2017.06.008 · Cited by 95
Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship
Briken, V., Ahlbrand, S. E., & Shah, S. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00062 · Cited by 92
Healing Rate and Autoimmune Safety of Full-Thickness Wounds Treated With Fish Skin Acellular Dermal Matrix Versus Porcine Small-Intestine Submucosa
Baldursson, B. T., Kjartansson, H., Konrádsdóttir, F., Gudnason, P., Sigurjonsson, G. F., & Lund, S. H. (2015) · The International Journal of Lower Extremity Wounds · doi:10.1177/1534734615573661 · Cited by 94
Nutrition Regulates Innate Immunity in Health and Disease
Nobs, S. P., Zmora, N., & Elinav, E. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-120919-094440 · Cited by 93
Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid
Hachem, M., Géloën, A., Van, A. L., Fourmaux, B., Fénart, L., Gosselet, F., Silva, P. D., Breton, G., Lagarde, M., Picq, M., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9228-9 · Cited by 89
Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity
Yang, S., Xia, C., Li, S., Du, L., Zhang, L., & Zhou, R. (2014) · Redox Biology · doi:10.1016/j.redox.2014.04.001 · Cited by 88
Self-citation
Supercritical fluid extraction of raspberry seed oil: Experiments and modelling
Pavlić, B., Pezo, L. L., Marić, B. D., Tukuljac, L. P., Zeković, Z. P., Bodroža‐Solarov, M., & Teslić, N. (2019) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2019.104687 · Cited by 88
Frontline Science: Specialized proresolving lipid mediators inhibit the priming and activation of the macrophage NLRP3 inflammasome
Lopategi, A., Flores-Costa, R., Rius, B., López-Vicario, C., Alcaraz-Quiles, J., Titos, E., & Clària, J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3hi0517-206rr · Cited by 87
Immunologic impact of the intestine in metabolic disease
Winer, D. A., Winer, S., Dranse, H. J., & Lam, T. K. T. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88879 · Cited by 95
Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation
Wang, D., Gao, Q., Wang, T., Kan, Z., Li, X., Hu, L., Peng, C., Qian, F., Wang, Y., & Granato, D. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108628 · Cited by 87
Mediterranean diet and cognitive function: From methodology to mechanisms of action
Siervo, M., Shannon, O. M., Llewellyn, D. J., Stephan, B. C. M., & Fontana, L. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.09.018 · Cited by 91
Identification of putative regulatory regions and transcription factors associated with intramuscular fat content traits
César, A. S. M., Regitano, L. C. D. A., Reecy, J. M., Poleti, M., de Oliveira, P. S. N., de Oliveira, G. B., Moreira, G. C. M., Mudadu, M. A., Tizioto, P. C., Koltes, J. E., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-4871-y · Cited by 87
What makes gouty inflammation so variable?
Terkeltaub, R. A. (2017) · BMC Medicine · doi:10.1186/s12916-017-0922-5 · Cited by 86
Impairment of systemic DHA synthesis affects macrophage plasticity and polarization: implications for DHA supplementation during inflammation
Talamonti, E., Pauter, A. M., Asadi, A., Fischer, A. W., Chiurchiù, V., & Jacobsson, A. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2498-9 · Cited by 78
Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer
Miki, Y., Kidoguchi, Y., Sato, M., Taketomi, Y., Taya, C., Muramatsu, K., Gelb, M. H., Yamamoto, K., & Murakami, M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.734624 · Cited by 80
Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate
Ortega, Á., Berná, G., Rojas, A., Martín, F., & Soria, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061188 · Cited by 87
The role of IL-1 in gout: from bench to bedside
So, A. K.-L., Dumusc, A., & Nasi, S. (2017) · Rheumatology · doi:10.1093/rheumatology/kex449 · Cited by 81
Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children
Stratakis, N., Conti, D. V., Borràs, E., Sabidó, E., Roumeliotaki, T., Papadopoulou, E., Agier, L., Basagaña, X., Bustamante, M., Casas, M., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.1007 · Cited by 81
Negative regulation of the inflammasome: keeping inflammation under control
Pedraza‐Alva, G., Pérez‐Martínez, L., Valdez‐Hernández, L., Meza‐Sosa, K. F., & Ando‐Kuri, M. (2015) · Immunological Reviews · doi:10.1111/imr.12294 · Cited by 76
Lipid regulation of NLRP3 inflammasome activity through organelle stress
Liang, J. J., Fraser, I. D. C., & Bryant, C. E. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.07.005 · Cited by 79
Pyroptosis in diabetes and diabetic nephropathy
Zhaohui, C., Huang, D., Tang, C., Lu, Y., Huang, S., Peng, C., & Hu, X. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.04.011 · Cited by 78
Dietary Fat, Sugar Consumption, and Cardiorespiratory Fitness in Patients With Heart Failure With Preserved Ejection Fraction
Carbone, S., Canada, J. M., Buckley, L. F., Trankle, C. R., Billingsley, H., Dixon, D. L., Mauro, A. G., Dessie, S., Kadariya, D., Mezzaroma, E., et al. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.06.009 · Cited by 77
NLRP3 Activation Was Regulated by DNA Methylation Modification during Mycobacterium tuberculosis Infection
Wei, M., Wang, L., Wu, T., Xi, J., Han, Y.-Z., Yang, X., Zhang, D., Fang, Q., & Tang, B. (2016) · BioMed Research International · doi:10.1155/2016/4323281 · Cited by 76
Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders
Gong, T., Wang, X., Yang, Y., Yan, Y., Yu, C., Zhou, R., & Jiang, W. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600145 · Cited by 78
Self-citation
A review on gout: Looking back and looking ahead
Tao, H., Mo, Y., Liu, W., & Wang, H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109977 · Cited by 77
The 17,18-epoxyeicosatetraenoic acid–G protein–coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques
Nagatake, T., Shiogama, Y., Inoue, A., Kikuta, J., Honda, T., Tiwari, P., Kishi, T., Yanagisawa, A., Isobe, Y., Matsumoto, N., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.053 · Cited by 76
Marine-Derived Omega-3 Polyunsaturated Fatty Acids and Heart Failure: Current Understanding for Basic to Clinical Relevance
Sakamoto, A., Saotome, M., Iguchi, K., & Maekawa, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164025 · Cited by 73
Atopic dermatitis: Pathophysiology, microbiota, and metabolome – A comprehensive review
Mohammad, S., Karim, M. R., Iqbal, S., Lee, J. H., Mathiyalagan, R., Kim, Y. J., Yang, D. U., & Yang, D. (2024) · Microbiological Research · doi:10.1016/j.micres.2023.127595 · Cited by 83
Omega-3 Fatty Acids and Adipose Tissue: Inflammation and Browning
Kalupahana, N. S., Goonapienuwala, B. L., & Moustaid-Moussa, N. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122319-034142 · Cited by 72
Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3
Fang, Y., Jiang, Q., Li, S., Zhu, H. Y., Xu, R. H., Song, N., Ding, X. L., Liu, J., Chen, M., Song, M., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-020-00704-9 · Cited by 74
Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity
Camell, C. D., Nguyen, K., Jurczak, M. J., Christian, B. E., Shulman, G. I., Shadel, G. S., & Dixit, V. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.680199 · Cited by 73
The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases
Jiang, H., Gong, T., & Zhou, R. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.11.003 · Cited by 71
Self-citation
Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues
Nicolson, G. L., & Ash, M. E. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.013 · Cited by 75
Free Fatty Acid Receptors as Mediators and Therapeutic Targets in Liver Disease
Secor, J. D., Fligor, S. C., Tsikis, S. T., Yu, L. J., & Puder, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.656441 · Cited by 73
Mechanisms of Spontaneous Resolution of Acute Gouty Inflammation
Steiger, S., & Harper, J. L. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-013-0392-5 · Cited by 73
Innate recognition of microbial-derived signals in immunity and inflammation
Zhang, Y., & Liang, C. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-0325-6 · Cited by 69
Nutrient sensing, signal transduction and immune responses
Walls, J. F., Sinclair, L. V., & Finlay, D. K. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.09.001 · Cited by 69
Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation
Mo, Z., Tang, C., Li, H., Lei, J., Zhu, L., Kou, L., Li, H., Luo, S., Li, C., Chen, W., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117133 · Cited by 66
Regulation and repurposing of nutrient sensing and autophagy in innate immunity
Sanchez‐Garrido, J., & Shenoy, A. R. (2020) · Autophagy · doi:10.1080/15548627.2020.1783119 · Cited by 67
Modulation of immunity by the secreted phospholipase A2 family
Murakami, M., Sato, H., & Taketomi, Y. (2023) · Immunological Reviews · doi:10.1111/imr.13205 · Cited by 66
Potential roles of GPR120 and its agonists in the management of diabetes
Leung, P. S., & Zhang, D. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s53892 · Cited by 67
Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns
Pavillard, L. E., Marín‐Aguilar, F., Bullón, P., & Cordero, M. D. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.018 · Cited by 67
Metabolic regulation of inflammasomes in inflammation
Yang, Q., Liu, R., Yu, Q., Bi, Y., & Liu, G. (2019) · Immunology · doi:10.1111/imm.13056 · Cited by 68
Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs/NF-kB and pyroptosis pathways
Jiang, Z.-F., Zeng, Z., He, H., Li, M., Lan, Y., Hui, J., Bie, P., Chen, Y., Liu, H., Fan, H., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04648-9 · Cited by 67
The NLRP3 Inflammasome: An Important Driver of Neuroinflammation in Hemorrhagic Stroke
Shao-jun, Y., Shao, G., Chen, J., & Gong, J. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0526-9 · Cited by 68
Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT
Sato, H., Taketomi, Y., Miki, Y., Murase, R., Yamamoto, K., & Murakami, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107579 · Cited by 65
Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease
Wang, M., Zhang, X., Ma, L., Feng, R., Yan, C., Su, H., He, C., Kang, J. X., Liu, B., & Wan, J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.026 · Cited by 65
Impact of Morphology on Iron Oxide Nanoparticles-Induced Inflammasome Activation in Macrophages
Liu, L., Sha, R., Yang, L., Zhao, X., Zhu, Y., Gao, J., Zhang, Y., & Wen, L. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b17474 · Cited by 65
Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice
Ren, Z.-P., Chen, L., Wang, Y., Wei, X., Zeng, S., Zheng, Y., Gao, C., & Liu, H. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800637 · Cited by 66
Triglyceride-lowering and anti-inflammatory mechanisms of omega-3 polyunsaturated fatty acids for atherosclerotic cardiovascular risk reduction
Liu, Q. K. (2021) · Journal of clinical lipidology · doi:10.1016/j.jacl.2021.05.007 · Cited by 65
Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury in mice by inhibiting NLRP3 inflammasome activation
Wang, D., Zhang, M., Wang, T., Cai, M., Qian, F., Sun, Y., & Wang, Y. (2019) · Food & Function · doi:10.1039/c9fo00572b · Cited by 64
Epigallocatechin-3-gallate prevents inflammation and diabetes -Induced glucose tolerance through inhibition of NLRP3 inflammasome activation
Zhang, C., Li, X., Hu, X., Xu, Q., Zhang, Y., Liu, H., Diao, Y., Zhang, X., Li, L., Yu, J., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107412 · Cited by 64
Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease
Casali, B. T., Corona, A. W., Mariani, M. M., Karlo, J. C., Ghosal, K., & Landreth, G. E. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1000-15.2015 · Cited by 63
Science behind the cardio-metabolic benefits of omega-3 polyunsaturated fatty acids: biochemical effects vs . clinical outcomes
Thota, R. N., Ferguson, J. J. A., Abbott, K. A., Dias, C. B., & Garg, M. L. (2018) · Food & Function · doi:10.1039/c8fo00348c · Cited by 60
Nutritional aspects of metabolic inflammation in relation to health—insights from transcriptomic biomarkers in PBMC of fatty acids and polyphenols
Afman, L. A., Milenković, D., & Roche, H. M. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300559 · Cited by 61
GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics
Tang, T., Gong, T., Jiang, W., & Zhou, R. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.07.002 · Cited by 64
Self-citation
Dietary Docosahexaenoic Acid Prevents Silica-Induced Development of Pulmonary Ectopic Germinal Centers and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse
Bates, M. A., Akbari, P., Gilley, K. N., Wagner, J. G., Li, N., Kopec, A. K., Wierenga, K. A., Jackson‐Humbles, D. N., Brandenberger, C., Holian, A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02002 · Cited by 60
Fish oil ameliorates trimethylamine N-oxide-exacerbated glucose intolerance in high-fat diet-fed mice
Gao, X., Xu, J., Jiang, C., Zhang, Y., Xue, Y., Li, Z., Wang, J., Xue, C., & Wang, Y. (2015) · Food & Function · doi:10.1039/c5fo00007f · Cited by 60
NLRP3 inflammasome in colitis and colitis-associated colorectal cancer
Perera, A. P., Sajnani, K., Dickinson, J. L., Eri, R. D., & Körner, H. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9783-2 · Cited by 61
α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes
Du, R., Zhou, Y., Xia, M., Lu, M., Ding, J., & Hu, G. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1302-6 · Cited by 61
Scavenger receptor-targeted plaque delivery of microRNA-coated nanoparticles for alleviating atherosclerosis
Bai, Q., Xiao, Y., Hong, H., Cao, X., Zhang, L., Han, R., Lee, L. K. C., Xue, E. Y., Tian, X. Y., & Choi, C. H. J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201443119 · Cited by 59
Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation
Sui, Y. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i8.2533 · Cited by 59
Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation
Yu, X., Zhao, Q., Zhang, X., Zhang, H., Liu, Y., Wu, X., Li, M., Li, X., Zhang, J., Ruan, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18619 · Cited by 60
FFA4 (GPR120) as a fatty acid sensor involved in appetite control, insulin sensitivity and inflammation regulation
Im, D. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.09.001 · Cited by 62
Western lifestyle and immunopathology of multiple sclerosis
Matveeva, O., Bogie, J. F. J., Hendriks, J. J. A., Linker, R. A., Haghikia, A., & Kleinewietfeld, M. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13583 · Cited by 65

Authors: Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., & Zhou, R.
Affiliations: University of Science and Technology of China (CN)
University of Fribourg (CH)
University of Lausanne (CH)
Corresponding author: Tian, Zhigang
Zhou, Rongbin
ORCID: Yan, Yiqing
Jiang, Wei
Spinetti, Thibaud
Tardivel, Aubry
Bourquin, Carole
Guarda, Greta
Tian, Zhigang
Zhou, Rongbin
Venue: Immunity
Publisher: Elsevier BV
Published: 2013-06
Volume: 38
Issue: 6
Pages: 1154-1163
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2013.05.015
OpenAlex: W1998522372
Cited by: 784
References: 48
Citations by year: 2026: 53 · 2025: 65 · 2024: 55 · 2023: 68 · 2022: 51 · 2021: 77 · 2020: 51 · 2019: 63 · 2018: 70 · 2017: 63 · 2016: 57 · 2015: 57 · 2014: 36 · 2013: 17
FWCI: 24.95
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 391 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Open Access CRIS of the University of Bern
Funders: National Natural Science Foundation of China (81222040, 31200659, 81273318, 91029303)
Ministry of Education of the People's Republic of China (20123402110010, 20123402120001)
University of Science and Technology of China
Chinese Academy of Sciences
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Louis-Jeantet Foundation
Fundamental Research Funds for the Central Universities
Program for New Century Excellent Talents in University
Seventh Framework Programme
National Key Research and Development Program of China (2013CB944904)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: omega-3 fatty acids, NLRP3 inflammasome, caspase-1 activation, IL-1β secretion, macrophages, GPR120, GPR40, β-arrestin2, eicosapentaenoic acid, docosahexaenoic acid, type 2 diabetes, metabolic disorders, inflammation, gout, autoinflammatory disease, high-fat diet
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, beta-Arrestins, beta-Arrestin 2, Animals, Carrier Proteins, Cells, Cultured, Diabetes Mellitus, Type 2, Docosahexaenoic Acids, Enzyme Activation, Inflammation, Macrophages, Mice, Inbred C57BL, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Mice, Knockout, Arrestins, Caspase 1, Receptors, G-Protein-Coupled, Mice, Interleukin-1beta, Inflammasomes, Diet, High-Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks