Cited by 784Inflammasome and immune disordersFatty Acid Research and HealthImmune Response and Inflammation

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Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

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Yan, Yiqing, Jiang, Wei, Spinetti, Thibaud, Tardivel, Aubry, Castillo, Rosa, Bourquin, Carole, Guarda, Greta, Tian, Zhigang, Tschopp, Jurg, Zhou, Rongbin·2013·Immunity

DOI 10.1016/j.immuni.2013.05.015

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Abstract

Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and metabolic disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.

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Authors: Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., & Zhou, R.
Affiliations: University of Science and Technology of China (CN)
University of Fribourg (CH)
University of Lausanne (CH)
Corresponding author: Tian, Zhigang
Zhou, Rongbin
ORCID: Yan, Yiqing
Jiang, Wei
Spinetti, Thibaud
Tardivel, Aubry
Bourquin, Carole
Guarda, Greta
Tian, Zhigang
Zhou, Rongbin
Venue: Immunity
Publisher: Elsevier BV
Published: 2013-06
Volume: 38
Issue: 6
Pages: 1154-1163
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2013.05.015
OpenAlex: W1998522372
Cited by: 784
References: 48
Citations by year: 2026: 53 · 2025: 65 · 2024: 55 · 2023: 68 · 2022: 51 · 2021: 77 · 2020: 51 · 2019: 63 · 2018: 70 · 2017: 63 · 2016: 57 · 2015: 57 · 2014: 36 · 2013: 17
FWCI: 24.95
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 391 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Open Access CRIS of the University of Bern
Funders: National Natural Science Foundation of China (81222040, 31200659, 81273318, 91029303)
Ministry of Education of the People's Republic of China (20123402110010, 20123402120001)
University of Science and Technology of China
Chinese Academy of Sciences
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Louis-Jeantet Foundation
Fundamental Research Funds for the Central Universities
Program for New Century Excellent Talents in University
Seventh Framework Programme
National Key Research and Development Program of China (2013CB944904)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: omega-3 fatty acids, NLRP3 inflammasome, caspase-1 activation, IL-1β secretion, macrophages, GPR120, GPR40, β-arrestin2, eicosapentaenoic acid, docosahexaenoic acid, type 2 diabetes, metabolic disorders, inflammation, gout, autoinflammatory disease, high-fat diet
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, beta-Arrestins, beta-Arrestin 2, Animals, Carrier Proteins, Cells, Cultured, Diabetes Mellitus, Type 2, Docosahexaenoic Acids, Enzyme Activation, Inflammation, Macrophages, Mice, Inbred C57BL, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Mice, Knockout, Arrestins, Caspase 1, Receptors, G-Protein-Coupled, Mice, Interleukin-1beta, Inflammasomes, Diet, High-Fat

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Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

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