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Macrophages in Tissue Repair, Regeneration, and Fibrosis
Open accessAbstract
Inflammatory monocytes and resident tissue macrophages are key regulators of tissue repair, regeneration, and fibrosis. Following tissue injury, monocytes and macrophages undergo marked phenotypic and functional changes to play critical roles during the initiation, maintenance, and resolution phases of tissue repair. Disturbances in macrophage function can lead to aberrant repair, with uncontrolled inflammatory mediator and growth factor production, deficient generation of anti-inflammatory macrophages, or failed communication between macrophages and epithelial cells, endothelial cells, fibroblasts, and stem or tissue progenitor cells all contributing to a state of persistent injury, which may lead to the development of pathological fibrosis. In this review, we discuss the mechanisms that instruct macrophages to adopt pro-inflammatory, pro-wound healing, pro-fibrotic, anti-inflammatory, anti-fibrotic, pro-resolving, and tissue regenerating phenotypes following injury, and highlight how some of these mechanisms and macrophage activation states could be exploited therapeutically.
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“M1 and M2 macrophages also play coordinating roles in the wound healing process by secreting cytokines, such as IL-6, transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α), and IL-8, to mobilize peripheral or systemic monocytes and lymphocytes to gather around the wound surface (Snyder et al., 2016;Wynn and Vannella, 2016).”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
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“M1 macrophages secrete numerous proteolytic enzymes to degrade extracellular matrix (ECM), including collagens, elastin, and fibronectin.”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
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“M2 macrophages secrete ECM cross-linking enzymes, such as glutaminyl transferase and osteopontin, which promote ECM and cell adhesion”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
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“suggesting that both macrophages play important roles in collagen deposition (Wynn and Vannella, 2016;Hesketh et al., 2017;Liu et al., 2021).”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
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“Beyond biochemical cues, the biomechanical properties of the fibrotic microenvironment-notably increased matrix stiffness, fluid shear stress, and intercellular tension-are now recognized as active instructors of macrophage polarization (6,74,75).”
From The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives (2025) · cites this paper as [74]
In the citing paper
“pro-fibrotic macrophages commonly coordinate scar formation via a range of interactions with fibroblasts, the major cellular source of pathological extracellular matrix deposition during fibrosis18,27,74–78.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [76]
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“M1 macrophages suppress, and M2 macrophages promote, fibroproliferation and uncontrolled repair (17).”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [17]
In the citing paper
“M1 macrophages suppress, and M2 macrophages promote, fibroproliferation and uncontrolled repair (17).”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [17]
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Cites
1 retracted
Stutchfield, B. M., Antoine, D. J., MacKinnon, A. C., Gow, D., Bain, C. C., Hawley, C. A., Hughes, M. J., Francis, B., Wojtacha, D., Man, T. Y., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.053 · Cited by 176
RetractedExploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Self-citationMacrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269
Self-citationMacrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Self-citationCellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
Self-citationCirculating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
Self-citationThe regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,293
Flagged first, then by citations
Cited by
Sorted by citations
Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981
Macrophages in immunoregulation and therapeutics
Chen, S., Saeed, A. F. U. H., Liu, Q., Jiang, Q., Xu, H., Xiao, G. G., Rao, L., & Duo, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01452-1 · Cited by 2,477
Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868
Self-citationInflammation and metabolism in tissue repair and regeneration
Eming, S. A., Wynn, T. A., & Martin, P. (2017) · Science · doi:10.1126/science.aam7928 · Cited by 1,369
Self-citationTransforming growth factor–β in tissue fibrosis
Frangogiannis, N. G. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190103 · Cited by 1,354
The Neutrophil’s Role During Health and Disease
Liew, P. X., & Kubes, P. (2019) · Physiological Reviews · doi:10.1152/physrev.00012.2018 · Cited by 1,237
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C.-I., Anekalla, K. R., Joshi, N., Williams, K. J. N., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162152 · Cited by 1,133
Type 2 immunity in tissue repair and fibrosis
Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055
Self-citationBui, T. M., Wiesolek, H. L., & Sumagin, R. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mr0220-549r · Cited by 1,002
Phagocytosis: An Immunobiologic Process
Gordon, S. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.026 · Cited by 902
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Na, Y. R., Stakenborg, M., Seok, S. H., & Matteoli, G. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0172-4 · Cited by 900
M2b macrophage polarization and its roles in diseases
Wang, L., Zhang, S.-X., Wu, H., Rong, X., & Guo, J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru1018-378rr · Cited by 919
Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities
Frangogiannis, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.07.001 · Cited by 880
Liu, L., Wei, Q., Lin, Q., Fang, J., Wang, H., Kwok, H., Tang, H., Nishiura, K., Peng, J., Tan, Z., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123158 · Cited by 830
Design of biodegradable, implantable devices towards clinical translation
Li, C., Guo, C., Fitzpatrick, V., Ibrahim, A. G. A., Zwierstra, M. J., Hanna, P. C., Lechtig, A., Nazarian, A., Lin, S. J., & Kaplan, D. L. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0150-z · Cited by 828
Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J. R., Bearden, A. R., Lavine, K. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.014 · Cited by 828
Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift
Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.010 · Cited by 799
Iddir, M., Alex Brito, O., Dingeo, G., Sosa, S., Samouda, H., Frano, M. R. L., & Bohn, T. (2020) · Nutrients · doi:10.3390/nu12061562 · Cited by 825
Zhao, J., Li, X., Hu, J., Chen, F., Qiao, S., Sun, X., Gao, L., Xie, J., & Xu, B. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz040 · Cited by 779
Promoting tissue regeneration by modulating the immune system
Julier, Z., Park, A. J., Briquez, P. S., & Martino, M. M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.056 · Cited by 766
Macrophages in inflammation, repair and regeneration
Oishi, Y., & Manabe, I. (2018) · International Immunology · doi:10.1093/intimm/dxy054 · Cited by 770
Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing
Kharaziha, M., Baidya, A., & Annabi, N. (2021) · Advanced Materials · doi:10.1002/adma.202100176 · Cited by 735
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Mariani, E., Lisignoli, G., Borzì, R. M., & Pulsatelli, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030636 · Cited by 706
Skin Acute Wound Healing: A Comprehensive Review
Cañedo‐Dorantes, L., & Cañedo-Ayala, M. (2019) · International Journal of Inflammation · doi:10.1155/2019/3706315 · Cited by 742
Mechanisms of Organ Injury and Repair by Macrophages
Vannella, K. M., & Wynn, T. A. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034356 · Cited by 656
Self-citationShared and distinct mechanisms of fibrosis
Distler, J. H. W., Györfi, A., Ramanujam, M., Whitfield, M. L., Königshoff, M., & Lafyatis, R. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0322-7 · Cited by 674
Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Di, X., Gao, X., Peng, L., Ai, J., Jin, X., Qi, S., Li, H., Wang, K., & Luo, D. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01501-9 · Cited by 715
Tissue macrophages: heterogeneity and functions
Gordon, S., & Plüddemann, A. (2017) · BMC Biology · doi:10.1186/s12915-017-0392-4 · Cited by 628
Role of Vitamin A in the Immune System
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090258 · Cited by 597
Macrophages as a therapeutic target to promote diabetic wound healing
Sharifiaghdam, M., Shaabani, E., Majidi, R. F., Smedt, S. C. D., Braeckmans, K., & Fraire, J. C. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.07.016 · Cited by 606
Jiang, Y., Trotsyuk, A. A., Niu, S., Henn, D., Chen, K., Shih, C., Larson, M. R., Mermin-Bunnell, A. M., Mittal, S., Lai, J., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01528-3 · Cited by 616
Peiseler, M., Schwabe, R., Hampe, J., Kubes, P., Heikenwälder, M., & Tacke, F. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.06.012 · Cited by 564
Sicco, C. L., Reverberi, D., Balbi, C., Ulivi, V., Principi, E., Pascucci, L., Becherini, P., Bosco, M. C., Varesio, L., Franzin, C., et al. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0363 · Cited by 579
An acute immune response underlies the benefit of cardiac stem cell therapy
Vagnozzi, R. J., Maillet, M., Sargent, M. A., Khalil, H., Johansen, A. K. Z., Schwanekamp, J. A., York, A. J., Huang, V. H., Nahrendorf, M., Sadayappan, S., et al. (2019) · Nature · doi:10.1038/s41586-019-1802-2 · Cited by 557
Myc Cooperates with Ras by Programming Inflammation and Immune Suppression
Kortlever, R. M., Sodir, N. M., Wilson, C. H., Burkhart, D. L., Pellegrinet, L., Brown Swigart, L., Littlewood, T. D., & Evan, G. I. (2017) · Cell · doi:10.1016/j.cell.2017.11.013 · Cited by 553
Physiology and diseases of tissue-resident macrophages
Lazarov, T., Juarez-Carreño, S., Cox, N., & Geissmann, F. (2023) · Nature · doi:10.1038/s41586-023-06002-x · Cited by 571
Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
Dehkordi, A. N., Mirahmadi, F., Chehelgerdi, M., & Dehkordi, S. R. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1212-2 · Cited by 561
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
Wendisch, D., Dietrich, O., Mari, T., von Stillfried, S., Ibarra, I. L., Mittermaier, M., Mache, C., Chua, R. L., Knoll, R., Timm, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.033 · Cited by 528
Yurdagul, A., Subramanian, M., Wang, X., Crown, S. B., Ilkayeva, O. R., Darville, L., Kolluru, G. K., Rymond, C. C., Gerlach, B. D., Zheng, Z., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.001 · Cited by 525
Abandoning M1/M2 for a Network Model of Macrophage Function
Nahrendorf, M., & Swirski, F. K. (2016) · Circulation Research · doi:10.1161/circresaha.116.309194 · Cited by 525
Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair
Shook, B. A., Wasko, R. R., Rivera-Gonzalez, G. C., Salazar-Gatzimas, E., López-Giráldez, F., Dash, B. C., Muñoz-Rojas, A. R., Aultman, K. D., Zwick, R. K., Lei, V., et al. (2018) · Science · doi:10.1126/science.aar2971 · Cited by 519
The extracellular matrix and the immune system: A mutually dependent relationship
Sutherland, T. E., Dyer, D. P., & Allen, J. E. (2023) · Science · doi:10.1126/science.abp8964 · Cited by 519
Macrophages and the maintenance of homeostasis
Mosser, D. M., Hamidzadeh, K., & Gonçalves, R. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00541-3 · Cited by 526
Establishment and Maintenance of the Macrophage Niche
Guilliams, M., Thierry, G. R., Bonnardel, J., & Bajenoff, M. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.015 · Cited by 512
Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?
Parisi, L., Gini, E., Baci, D., Tremolati, M., Fanuli, M., Bassani, B., Farronato, G., Bruno, A., & Mortara, L. (2018) · Journal of Immunology Research · doi:10.1155/2018/8917804 · Cited by 508
Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application
Wang, M., Yuan, Q., & Xie, L. (2018) · Stem Cells International · doi:10.1155/2018/3057624 · Cited by 506
Tissue-specific contribution of macrophages to wound healing
Minutti, C. M., Knipper, J. A., Allen, J. E., & Zaiss, D. M. W. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.08.006 · Cited by 488
Single cell transcriptomic landscape of diabetic foot ulcers
Theocharidis, G., Thomas, B. E., Sarkar, D., Mumme, H., Pilcher, W., Dwivedi, B., Sandoval-Schaefer, T., Sîrbulescu, R. F., Kafanas, A., Mezghani, I., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27801-8 · Cited by 493
Irizarry-Caro, R. A., McDaniel, M. M., Overcast, G. R., Jain, V. G., Troutman, T. D., & Pasare, C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009778117 · Cited by 472
TGF-β1 – A truly transforming growth factor in fibrosis and immunity
Lodyga, M., & Hinz, B. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.010 · Cited by 467
Astrocytes and microglia: In sickness and in health
Vainchtein, I. D., & Molofsky, A. V. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.01.003 · Cited by 450
Macrophages in Lung Injury, Repair, and Fibrosis
Cheng, P., Li, S., & Chen, H. (2021) · Cells · doi:10.3390/cells10020436 · Cited by 457
Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing
Chen, G., Yu, Y., Wu, X., Wang, G., Ren, J., & Zhao, Y. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201801386 · Cited by 437
The Formation and Function of Granulomas
Pagán, A. J., & Ramakrishnan, L. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100022 · Cited by 450
Tu, Z., Chen, M., Wang, M., Shao, Z., Jiang, X., Wang, K., Yao, Z., Yang, S., Zhang, X., Gao, W., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100924 · Cited by 430
Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease
Prame Kumar, K., Nicholls, A. J., & Wong, C. H. Y. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2753-2 · Cited by 417
Role of Inflammation and the Immune System in the Progression of Osteoarthritis
Woodell‐May, J., & Sommerfeld, S. D. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24457 · Cited by 416
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I. I., et al. (2017) · Aging · doi:10.18632/aging.101268 · Cited by 407
Tailoring Materials for Modulation of Macrophage Fate
Li, J., Jiang, X., Li, H., Gelinsky, M., & Gu, Z. (2021) · Advanced Materials · doi:10.1002/adma.202004172 · Cited by 406
Fetal monocytes and the origins of tissue-resident macrophages
Hoeffel, G., & Ginhoux, F. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.001 · Cited by 431
CGRP sensory neurons promote tissue healing via neutrophils and macrophages
Lu, Y., Nayer, B., Singh, S. K., Alshoubaki, Y. K., Yuan, E., Park, A. J., Maruyama, K., Akira, S., & Martino, M. M. (2024) · Nature · doi:10.1038/s41586-024-07237-y · Cited by 437
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Biological responses to physicochemical properties of biomaterial surface
Rahmati, M., Silva, E. A., Reseland, J. E., Heyward, C. A., & Haugen, H. J. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00103a · Cited by 409
Macrophage Polarization and Osteoporosis: A Review
Muñoz, J., Akhavan, N. S., Mullins, A. P., & Arjmandi, B. H. (2020) · Nutrients · doi:10.3390/nu12102999 · Cited by 391
Type 2 immunity in allergic diseases
Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Ardıçlı, S., Li, M., D’Avino, P., Beha, C., Babayev, H., Zhao, B., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01261-2 · Cited by 453
Macrophages in Renal Injury and Repair
Huen, S. C., & Cantley, L. G. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034219 · Cited by 384
Li, L., Yu, R., Cai, T., Chen, Z., Lan, M., Zou, T., Wang, B., Wang, Q., Zhao, Y., & Cai, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106939 · Cited by 397
The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics
Prakash, J., & Shaked, Y. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0002 · Cited by 416
Agarwal, H., Nakara, A., & Shanmugam, V. K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.116 · Cited by 391
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
Zhang, L., Wang, Y., Wu, G., Xiong, W., Gu, W., & Wang, C. (2018) · Respiratory Research · doi:10.1186/s12931-018-0864-2 · Cited by 379
Cui, H., Xie, N., Banerjee, S., Ge, J., Jiang, D., Dey, T., Matthews, Q. L., Liu, R.-M., & Liu, G. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0360oc · Cited by 373
Martin, K. E., & Garcı́a, A. J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.038 · Cited by 384
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371
Macrophage polarization and meta-inflammation
Li, C., Xu, M. M., Wang, K., Adler, A. J., Vella, A. T., & Zhou, B. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.004 · Cited by 376
Macrophage plasticity: signaling pathways, tissue repair, and regeneration
Yan, L., Wang, J., Cai, X., Liou, Y., Shen, H., Hao, J., Huang, C., Luo, G., & He, W. (2024) · MedComm · doi:10.1002/mco2.658 · Cited by 406
Chronic wounds: Current status, available strategies and emerging therapeutic solutions
Las Heras, K., Igartua, M., Santos-Vizcaino, E., & Hernandez, R. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.039 · Cited by 370
Macrophage biology in the peripheral nervous system after injury
Zigmond, R. E., & Echevarría, F. D. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.001 · Cited by 383
Silvin, A., Uderhardt, S., Piot, C., Da Mesquita, S., Yang, K., Geirsdottir, L., Mulder, K., Eyal, D., Liu, Z., Bridlance, C., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.07.004 · Cited by 368
Bochenek, M. A., Veiseh, O., Vegas, A. J., McGarrigle, J. J., Qi, M., Marchese, E., Omami, M., Doloff, J. C., Mendoza-Elias, J., Nourmohammadzadeh, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0275-1 · Cited by 367
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Ma, W., Gao, F., Gu, K., & Chen, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01140 · Cited by 368
Macrophage polarization and metabolism in atherosclerosis
Hou, P., Fang, J., Liu, Z., Shi, Y., Agostini, M., Bernassola, F., Bove, P., Candi, E., Rovella, V., Sica, G. S., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06206-z · Cited by 388
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Sawaya, A. P., Stone, R. C., Brooks, S. R., Pastar, I., Jozic, I., Hasneen, K., O’Neill, K. E., Mehdizadeh, S., Head, C. R., Štrbo, N., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18276-0 · Cited by 370
Advances of hydrogel dressings in diabetic wounds
Wang, H., Xu, Z., Meng, Z., Liu, G., & Wu, J. (2020) · Biomaterials Science · doi:10.1039/d0bm01747g · Cited by 359
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Fabre, T., Barron, A. M. S., Christensen, S. M., Asano, S., Bound, K., Lech, M. P., Wadsworth, M. H., Chen, X., Wang, C., Wang, J., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.add8945 · Cited by 355
Self-citationHe, L., Jhong, J.-H., Chen, Q., Huang, K.-Y., Strittmatter, K., Kreuzer, J., DeRan, M., Wu, X., Lee, T.-Y., Slavov, N., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109955 · Cited by 354
Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 358
Scarless wound healing programmed by core-shell microneedles
Zhang, Y., Yang, Y., Yang, Y., Zhao, S., You, J., Wang, J., Cai, J., Wang, J., Wang, J., Zhang, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39129-6 · Cited by 360
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Li, N., & Hua, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2473-5 · Cited by 338
Hoeft, K., Schaefer, G. J. L., Kim, H., Schumacher, D., Bleckwehl, T., Long, Q., Klinkhammer, B. M., Peisker, F., Koch, L., Nagai, J. S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112131 · Cited by 327
Key players in the immune response to biomaterial scaffolds for regenerative medicine
Chung, L., Maestas, D. R., Housseau, F., & Elisseeff, J. H. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.006 · Cited by 333
YAP-mediated mechanotransduction tunes the macrophage inflammatory response
Meli, V. S., Atcha, H., Veerasubramanian, P. K., Nagalla, R. R., Luu, T. U., Chen, E. Y., Guerrero-Juarez, C. F., Yamaga, K., Pandori, W., Hsieh, J. Y., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb8471 · Cited by 329
Saleh, B., Dhaliwal, H. K., Lara, R. P., Sani, E. S., Abdi, R., Amiji, M. M., & Annabi, N. (2019) · Small · doi:10.1002/smll.201902232 · Cited by 326
Interaction of tumor-associated macrophages and cancer chemotherapy
Larionova, I., Cherdyntseva, N., Liu, T., Patysheva, M., Rakina, M., & Kzhyshkowska, J. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1596004 · Cited by 322
Lei, F., Cui, N., Zhou, C., Chodosh, J., Vavvas, D. G., & Paschalis, E. I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922788117 · Cited by 322
The interaction of innate immune and adaptive immune system
Wang, R., Lan, C., Benlagha, K., Câmara, N. O. S., Miller, H. E., Kubo, M., Heegaard, S., Lee, P. P. W., Yang, L., Forsman, H. F., et al. (2024) · MedComm · doi:10.1002/mco2.714 · Cited by 395
Zou, J., Yang, W., Cui, W., Li, C., Ma, C., Ji, X., Hong, J., Qu, Z., Chen, J., Liu, A., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01778-6 · Cited by 325
Resolution of inflammation in bone regeneration: From understandings to therapeutic applications
Newman, H., Shih, Y.-R. V., & Varghese, S. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121114 · Cited by 318
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Desai, O., Winkler, J., Minasyan, M., & Herzog, E. L. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00043 · Cited by 314
Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis
Rodríguez-Morales, P., & Franklin, R. A. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.10.004 · Cited by 341
Metadata
- Authors
- Wynn, T. A., & Vannella, K. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Wynn, Thomas A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 44
- Issue
- 3
- Pages
- 450-462
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4794754
- OpenAlex
- W2301044272
- Semantic Scholar
- 3e7cc72db53c49f88a543c99b71749931fb6c7b0
- Cited by
- 4,481
- References
- 129
- Citations by year
- 2026: 673 · 2025: 638 · 2024: 564 · 2023: 511 · 2022: 504 · 2021: 475 · 2020: 399 · 2019: 299 · 2018: 228 · 2017: 136 · 2016: 35
- FWCI
- 29.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (Z01AI001019, Z01AI000829)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- macrophages, tissue repair, tissue regeneration, fibrosis, inflammatory monocytes, macrophage polarization, wound healing, inflammation resolution, macrophage-targeted therapy
- MeSH terms
- Animals, Cell Communication, Cell Differentiation, Fibrosis, Humans, Macrophage Activation, Macrophages, Phenotype, Regeneration, Wound Healing
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