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Macrophages in Tissue Repair, Regeneration, and Fibrosis
Open accessAbstract
Inflammatory monocytes and resident tissue macrophages are key regulators of tissue repair, regeneration, and fibrosis. Following tissue injury, monocytes and macrophages undergo marked phenotypic and functional changes to play critical roles during the initiation, maintenance, and resolution phases of tissue repair. Disturbances in macrophage function can lead to aberrant repair, with uncontrolled inflammatory mediator and growth factor production, deficient generation of anti-inflammatory macrophages, or failed communication between macrophages and epithelial cells, endothelial cells, fibroblasts, and stem or tissue progenitor cells all contributing to a state of persistent injury, which may lead to the development of pathological fibrosis. In this review, we discuss the mechanisms that instruct macrophages to adopt pro-inflammatory, pro-wound healing, pro-fibrotic, anti-inflammatory, anti-fibrotic, pro-resolving, and tissue regenerating phenotypes following injury, and highlight how some of these mechanisms and macrophage activation states could be exploited therapeutically.
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“M1 and M2 macrophages also play coordinating roles in the wound healing process by secreting cytokines, such as IL-6, transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α), and IL-8, to mobilize peripheral or systemic monocytes and lymphocytes to gather around the wound surface (Snyder et al., 2016;Wynn and Vannella, 2016).”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
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“M1 macrophages secrete numerous proteolytic enzymes to degrade extracellular matrix (ECM), including collagens, elastin, and fibronectin.”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
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“M2 macrophages secrete ECM cross-linking enzymes, such as glutaminyl transferase and osteopontin, which promote ECM and cell adhesion”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
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“suggesting that both macrophages play important roles in collagen deposition (Wynn and Vannella, 2016;Hesketh et al., 2017;Liu et al., 2021).”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
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“Beyond biochemical cues, the biomechanical properties of the fibrotic microenvironment-notably increased matrix stiffness, fluid shear stress, and intercellular tension-are now recognized as active instructors of macrophage polarization (6,74,75).”
From The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives (2025) · cites this paper as [74]
In the citing paper
“pro-fibrotic macrophages commonly coordinate scar formation via a range of interactions with fibroblasts, the major cellular source of pathological extracellular matrix deposition during fibrosis18,27,74–78.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [76]
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“M1 macrophages suppress, and M2 macrophages promote, fibroproliferation and uncontrolled repair (17).”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [17]
In the citing paper
“M1 macrophages suppress, and M2 macrophages promote, fibroproliferation and uncontrolled repair (17).”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [17]
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1 retracted
Stutchfield, B. M., Antoine, D. J., MacKinnon, A. C., Gow, D., Bain, C. C., Hawley, C. A., Hughes, M. J., Francis, B., Wojtacha, D., Man, T. Y., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.053 · Cited by 176
RetractedExploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Self-citationMacrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269
Self-citationMacrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Self-citationCellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
Self-citationCirculating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
Self-citationThe regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,293
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765
Self-citationSelective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649
Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585
Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
Wynn, T. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31487 · Cited by 1,487
Self-citationJenkins, S. J., Rückerl, D., Cook, P. C., Jackson-Jones, L. H., Finkelman, F. D., van Rooijen, N., MacDonald, A. S., & Allen, J. E. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,404
Macrophages: master regulators of inflammation and fibrosis
Wynn, T., & Barron, L. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255354 · Cited by 1,392
Self-citationNeutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
Warnatsch, A., Ιωάννου, Μ., Wang, Q., & Papayannopoulos, V. (2015) · Science · doi:10.1126/science.aaa8064 · Cited by 1,309
Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping
Rappolee, D. A., Mark, D., Banda, M. J., & Werb, Z. (1988) · Science · doi:10.1126/science.3041594 · Cited by 1,105
Galli, S. J., Borregaard, N., & Wynn, T. A. (2011) · Nature Immunology · doi:10.1038/ni.2109 · Cited by 1,055
Self-citationRamachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119964109 · Cited by 1,001
Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves
Cattin, A.-L., Burden, J. J., Emmenis, L. V., Mackenzie, F. E., Hoving, J. J., Calavia, N. G., Guo, Y., McLaughlin, M., Rosenberg, L. H., Quereda, V., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.021 · Cited by 975
Berse, B., Brown, L. F., Water, L. V. D., Dvorak, H. F., & Senger, D. R. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.2.211 · Cited by 897
Macrophages are required for neonatal heart regeneration
Aurora, A. B., Porrello, E. R., Tan, W. H., Mahmoud, A. I., Hill, J. A., Bassel‐Duby, R., Sadek, H. A., & Olson, E. N. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72181 · Cited by 840
Macrophages are required for adult salamander limb regeneration
Godwin, J. W., Pinto, A. R., & Rosenthal, N. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300290110 · Cited by 829
Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration
Heredia, J. E., Mukundan, L., Chen, F. M., Mueller, A. A., Deo, R. C., Locksley, R. M., Rando, T. A., & Chawla, A. (2013) · Cell · doi:10.1016/j.cell.2013.02.053 · Cited by 818
Lavine, K. J., Epelman, S., Uchida, K., Weber, K. J., Nichols, C. G., Schilling, J. D., Ornitz, D. M., Randolph, G. J., & Mann, D. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406508111 · Cited by 818
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000371 · Cited by 816
Self-citationPonomarev, E. D., Veremeyko, T., Barteneva, N., Krichevsky, A. M., & Weiner, H. L. (2011) · Nature Medicine · doi:10.1038/nm.2266 · Cited by 787
Hume, D. A., & MacDonald, K. P. A. (2011) · Blood · doi:10.1182/blood-2011-09-379214 · Cited by 776
Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration
Das, A., Sinha, M., Datta, S., Abas, M., Chaffee, S. M., Sen, C. K., & Roy, S. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.06.001 · Cited by 770
Boulter, L., Govaere, O., Bird, T. G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R. A., Seo, S. S., Spee, B., Van Rooijen, N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2667 · Cited by 747
Lemos, D. R., Babaeijandaghi, F., Low, M., Chang, C.-K., Lee, S. T., Fiore, D., Zhang, R.-H., Natarajan, A., Nedospasov, S. A., & Rossi, F. M. V. (2015) · Nature Medicine · doi:10.1038/nm.3869 · Cited by 740
Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology · doi:10.1038/ni.2865 · Cited by 727
A significant part of macrophage-derived growth factor consists of at least two forms of PDGF
Shimokado, K., Raines, E. W., Madtes, D. K., Barrett, T. B., Benditt, E. P., & Ross, R. (1985) · Cell · doi:10.1016/0092-8674(85)90033-9 · Cited by 715
Macrophages and cancer: from mechanisms to therapeutic implications
Ostuni, R., Kratochvill, F., Murray, P. J., & Natoli, G. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.004 · Cited by 709
Shechter, R., Miller, O., Yovel, G., Rosenzweig, N., London, A., Ruckh, J., Kim, K.-W., Klein, E., Kalchenko, V., Bendel, P., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.012 · Cited by 683
Jay, T. R., Miller, C. M., Cheng, P. J., Graham, L. C., Bemiller, S., Broihier, M. L., Xu, G., Margevicius, D., Karlo, J. C., Sousa, G. L., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142322 · Cited by 682
Kroner, A., Greenhalgh, A. D., Zarruk, J. G., Passos dos Santos, R., Gaestel, M., & David, S. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.027 · Cited by 655
JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
Han, M. S., Jung, D. Y., Morel, C., Lakhani, S. A., Kim, J. K., Flavell, R. A., & Davis, R. J. (2012) · Science · doi:10.1126/science.1227568 · Cited by 646
Host Responses in Tissue Repair and Fibrosis
Duffield, J. S., Lupher, M., Thannickal, V. J., & Wynn, T. A. (2012) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-163930 · Cited by 644
Self-citationShaping Gene Expression in Activated and Resting Primary Macrophages by IL-10
Lang, R., Patel, D. H., Morris, J. J., Rutschman, R., & Murray, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2253 · Cited by 621
Pradere, J.-P., Kluwe, J., De Minicis, S., Jiao, J.-J., Gwak, G.-Y., Dapito, D. H., Jang, M.-K., Guenther, N. D., Mederacke, I., Friedman, R., et al. (2013) · Hepatology · doi:10.1002/hep.26429 · Cited by 613
Baeck, C., Wehr, A., Karlmark, K. R., Heymann, F., Vucur, M., Gassler, N., Huss, S., Klussmann, S., Eulberg, D., Luedde, T., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-300304 · Cited by 609
Shouval, D. S., Biswas, A., Goettel, J. A., McCann, K. J., Conaway, E. A., Redhu, N. S., Mascanfroni, I. D., Adham, Z. A., Lavoie, S., Ibourk, M., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.011 · Cited by 581
Zigmond, E., Bernshtein, B., Friedlander, G., Walker, C., Yona, S., Kim, K.-W., Brenner, O. J., Krauthgamer, R., Varol, C., Müller, W., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.012 · Cited by 578
Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis
Henderson, N. C., Mackinnon, A. C., Farnworth, S. L., Kipari, T., Haslett, C., Iredale, J. P., Liu, F.-T., Hughes, J., & Sethi, T. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070726 · Cited by 562
Cho, D. I., Kim, M. R., Jeong, H. Y., Jeong, H. C., Jeong, M. H., Yoon, S. H., Kim, Y. S., & Ahn, Y. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.135 · Cited by 553
Scavenger receptors in innate immunity
Peiser, L., Mukhopadhyay, S., & Gordon, S. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00307-7 · Cited by 536
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Willenborg, S., Lucas, T., van Loo, G., Knipper, J. A., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A., Ferrara, N., et al. (2012) · Blood · doi:10.1182/blood-2012-01-403386 · Cited by 534
MacDonald, K. P. A., Palmer, J. S., Cronau, S. L., Seppanen, E. J., Olver, S. D., Raffelt, N. C., Kuns, R. D., Pettit, A. R., Clouston, A. D., Wainwright, B. J., et al. (2010) · Blood · doi:10.1182/blood-2010-02-266296 · Cited by 520
Khalil, N., Bereznay, O., Sporn, M., & Greenberg, A. H. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.3.727 · Cited by 505
Said, E. A., Dupuy, F. P., Trautmann, L., Zhang, Y., Shi, Y., Far, M. E., Hill, B. J., Noto, A., Ancuța, P., Peretz, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2106 · Cited by 490
Nardo, D. D., Labzin, L. I., Kono, H., Seki, R., Schmidt, S. V., Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F. A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2784 · Cited by 477
IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration
Deng, B., Wehling-Henricks, M., Villalta, S. A., Wang, Y., & Tidball, J. G. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103180 · Cited by 472
Blériot, C., Dupuis, T., Jouvion, G., Eberl, G., Disson, O., & Lecuit, M. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.020 · Cited by 471
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis
Gibbons, M. A., MacKinnon, A. C., Ramachandran, P., Dhaliwal, K., Duffin, R., Phythian-Adams, A. T., van Rooijen, N., Haslett, C., Howie, S. E., Simpson, A. J., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1719oc · Cited by 466
Mounier, R., Théret, M., Arnold, L., Cuvellier, S., Bultot, L., Göransson, O., Sanz, N., Ferry, A., Sakamoto, K., Foretz, M., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.017 · Cited by 464
Dal-Secco, D., Wang, J., Zeng, Z., Kołaczkowska, E., Wong, C. H. Y., Petri, B., Ransohoff, R. M., Charo, I. F., Jenne, C. N., & Kubes, P. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141539 · Cited by 464
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity
Westphalen, K., Gusarova, G. A., Islam, M. N., Subramanian, M., Cohen, T. S., Prince, A. S., & Bhattacharya, J. (2014) · Nature · doi:10.1038/nature12902 · Cited by 463
Saclier, M., Yacoub‐Youssef, H., Mackey, A. L., Arnold, L., Ardjoune, H., Magnan, M., Sailhan, F., Chelly, J., Pavlath, G. K., Mounier, R., et al. (2012) · Stem Cells · doi:10.1002/stem.1288 · Cited by 446
Xu, H., Zhu, J., Smith, S. M., Foldi, J., Zhao, B., Chung, A. Y., Outtz, H. H., Kitajewski, J., Shi, C., Weber, S., et al. (2012) · Nature Immunology · doi:10.1038/ni.2304 · Cited by 442
Lech, M., & Anders, H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.12.001 · Cited by 441
Chen, F., Liu, Z., Wu, W., Rozo, C. T., Bowdridge, S. A. A., Millman, A., van Rooijen, N., Urban, J. F., Wynn, T. A., & Gause, W. C. (2012) · Nature Medicine · doi:10.1038/nm.2628 · Cited by 440
Self-citationNegash, A. A., Ramos, H. J., Crochet, N., Lau, D., Doehle, B., Papić, N., Delker, D. A., Jo, J., Bertoletti, A., Hagedorn, C. H., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003330 · Cited by 424
Jenkins, S. J., Rückerl, D., Thomas, G. D., Hewitson, J. P., Duncan, S., Brombacher, F., Maizels, R. M., Hume, D. A., & Allen, J. E. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121999 · Cited by 411
Recurrent turnover of senescent cells during regeneration of a complex structure
Yun, M. H., Davaapil, H., & Brockes, J. P. (2015) · eLife · doi:10.7554/elife.05505 · Cited by 385
Gundra, U. M., Girgis, N. M., Ruckerl, D., Jenkins, S., Ward, L. N., Kurtz, Z. D., Wiens, K. E., Tang, M. S., Basu-Roy, U., Mansukhani, A., et al. (2014) · Blood · doi:10.1182/blood-2013-08-520619 · Cited by 371
Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair
Harel-Adar, T., Ben-Mordechai, T., Amsalem, Y., Feinberg, M. S., Leor, J., & Cohen, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015623108 · Cited by 371
IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-β Independent
Kaviratne, M., Hesse, M., Leusink, M., Cheever, A. W., Davies, S. J., McKerrow, J. H., Wakefield, L. M., Letterio, J. J., & Wynn, T. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.4020 · Cited by 370
Self-citationTGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P
Murray, L. A., Chen, Q., Kramer, M. S., Hesson, D. P., Argentieri, R. L., Peng, X., Gulati, M., Homer, R. J., Russell, T., van Rooijen, N., et al. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.10.013 · Cited by 362
Thomas, J. A., Pope, C., Wojtacha, D., Robson, A. J., Gordon-Walker, T. T., Hartland, S., Ramachandran, P., Van Deemter, M., Hume, D. A., Iredale, J. P., et al. (2011) · Hepatology · doi:10.1002/hep.24315 · Cited by 346
The IL-21 receptor augments Th2 effector function and alternative macrophage activation
Pesce, J. T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27727 · Cited by 344
Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance
Soroosh, P., Doherty, T. A., Duan, W., Mehta, A. K., Choi, H., Adams, Y. F., Mikulski, Z., Khorram, N., Rosenthal, P., Broide, D. H., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121849 · Cited by 340
Tonkin, J. N., Temmerman, L., Sampson, R. D., Gallego-Colón, E., Barberi, L., Bilbao, D., Schneider, M. D., Musarò, A., & Rosenthal, N. A. (2015) · Molecular Therapy · doi:10.1038/mt.2015.66 · Cited by 330
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair
Knipper, J. A., Willenborg, S., Brinckmann, J., Bloch, W., Maaß, T., Wagener, R., Krieg, T. M., Sutherland, T. E., Munitz, A., Rothenberg, M. E., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.005 · Cited by 326
CSF-1 signaling mediates recovery from acute kidney injury
Zhang, M.-Z., Yao, B., Yang, S., Li, J., Wang, S., Fan, X., Yin, H., Wong, K., Miyazawa, T., Chen, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60363 · Cited by 319
M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7
Xiao, X., Gaffar, I. M., Guo, P., Wiersch, J. C., Fischbach, S., Peirish, L., Song, Z., El‐Gohary, Y., Prasadan, K. L., Shiota, C., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321347111 · Cited by 312
Pulmonary macrophage transplantation therapy
Suzuki, T., Arumugam, P. I., Sakagami, T., Lachmann, N., Chalk, C., Sallese, A., Abe, S., Trapnell, C., Carey, B. C., Moritz, T., et al. (2014) · Nature · doi:10.1038/nature13807 · Cited by 304
TNF Counterbalances the Emergence of M2 Tumor Macrophages
Kratochvill, F., Neale, G. A. M., Haverkamp, J. M., de Velde, L.-A. V., Smith, A. M., Kawauchi, D., McEvoy, J. D., Roussel, M. F., Dyer, M. A., Qualls, J. E., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.033 · Cited by 291
Mitchell, S., Thomas, G., Harvey, K., Cottell, D., Reville, K., Berlasconi, G., Petasis, N. A., Erwig, L., Rees, A. J., Savill, J., et al. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000032417.73640.72 · Cited by 287
IL-10/TGF-β–Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis
Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V. W., Zheng, G., Tan, T. K., Ince, J., Alexander, S. I., et al. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060592 · Cited by 287
Eosinophils secrete IL-4 to facilitate liver regeneration
Goh, Y. P. S., Henderson, N. C., Heredia, J. E., Eagle, A. R., Odegaard, J. I., Lehwald, N., Nguyen, K. D., Sheppard, D., Mukundan, L., Locksley, R. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304046110 · Cited by 286
Antoniades, C. G., Quaglia, A., Taams, L. S., Mitry, R. R., Hussain, M. J., Abeles, R. D., Possamai, L. A., Bruce, M., McPhail, M. J. W., Starling, C., et al. (2012) · Hepatology · doi:10.1002/hep.25657 · Cited by 281
CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis
Ehling, J., Bartneck, M., Wei, X., Gremse, F., Fech, V., Möckel, D., Baeck, C., Hittatiya, K., Eulberg, D., Luedde, T., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306294 · Cited by 273
Baeck, C., Wei, X., Bartneck, M., Fech, V., Heymann, F., Gassler, N., Hittatiya, K., Eulberg, D., Luedde, T., Trautwein, C., et al. (2014) · Hepatology · doi:10.1002/hep.26783 · Cited by 270
Macrophage Subpopulations Are Essential for Infarct Repair With and Without Stem Cell Therapy
Ben-Mordechai, T., Holbová, R., Landa‐Rouben, N., Harel-Adar, T., Feinberg, M. S., Elrahman, I. A., Blum, G., Epstein, F. H., Silman, Z., Cohen, S., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.057 · Cited by 268
Su, S., Zhao, Q., He, C., Huang, D., Liu, J., Chen, F., Chen, J., Liao, J.-Y., Cui, X., Zeng, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms9523 · Cited by 257
Macrophages modulate the viability and growth of human mesenchymal stem cells
Freytes, D. O., Kang, J. W., Marcos‐Campos, I., & Vunjak‐Novakovic, G. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24357 · Cited by 255
Local Arginase 1 Activity Is Required for Cutaneous Wound Healing
Campbell, L., Saville, C. R., Murray, P. J., Cruickshank, S. M., & Hardman, M. J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.164 · Cited by 254
CSF-1–dependant donor-derived macrophages mediate chronic graft-versus-host disease
Alexander, K. A., Flynn, R. P., Lineburg, K. E., Kuns, R. D., Teal, B. E., Olver, S. D., Lor, M., Raffelt, N. C., Koyama, M., Leveque, L., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75935 · Cited by 254
Utay, N. S., Mentink‐Kane, M. M., Cheever, A. W., & Wynn, T. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3655 · Cited by 249
Self-citationOrgan-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations
Chen, C., Wang, L., Plikus, M. V., Jiang, T. X., Murray, P. J., Ramos, R., Guerrero‐Juarez, C. F., Hughes, M. W., Lee, O. K., Shi, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.02.016 · Cited by 245
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
Xu, J., Chi, F., Guo, T., Punj, V., Lee, W. N. P., French, S. W., & Tsukamoto, H. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76468 · Cited by 241
Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction
Korf‐Klingebiel, M., Reboll, M. R., Klede, S., Brod, T., Pich, A., Polten, F., Napp, L. C., Bauersachs, J. K., Ganser, A., Brinkmann, E., et al. (2015) · Nature Medicine · doi:10.1038/nm.3778 · Cited by 227
Evans, T. A., Barkauskas, D. S., Myers, J., Hare, E. G., You, J., Ransohoff, R. M., Huang, A. Y.-C., & Silver, J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.013 · Cited by 217
London, A., Itskovich, E., Benhar, I., Kalchenko, V., Mack, M., Jung, S., & Schwartz, M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101202 · Cited by 217
Bourdonnay, E., Zasłona, Z., Penke, L. R. K., Speth, J. M., Schneider, D. J., Przybranowski, S. A., Swanson, J. A., Mancuso, P., Freeman, C. M., Curtis, J. L., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141675 · Cited by 208
Macrophage activation and skeletal muscle healing following traumatic injury
Novak, M. L., Weinheimer-Haus, E. M., & Koh, T. J. (2013) · The Journal of Pathology · doi:10.1002/path.4301 · Cited by 208
Dalmas, E., Toubal, A., Alzaid, F., Blazek, K., Eames, H. L., Lebozec, K., Pini, M., Hainault, I., Montastier, E., Denis, R. G. P., et al. (2015) · Nature Medicine · doi:10.1038/nm.3829 · Cited by 205
Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice
Mitchell, C., Couton, D., Couty, J., Anson, M., Crain‐Denoyelle, A., Bizet, V., Rénia, L., Pol, S., Mallet, V. O., & Gilgenkrantz, H. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080632 · Cited by 193
Pellicoro, A., Aucott, R. L., Ramachandran, P., Robson, A. J., Fallowfield, J. A., Snowdon, V., Hartland, S. N., Vernon, M. A., Duffield, J. S., Benyon, C. R., et al. (2011) · Hepatology · doi:10.1002/hep.25567 · Cited by 191
Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart
Lörchner, H., Pöling, J., Gajawada, P., Hou, Y., Polyakova, V., Sawa Kostin, D., Adrian-Segarra, J. M., Boettger, T., Wietelmann, A., Warnecke, H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3816 · Cited by 186
Heymann, F., Hammerich, L., Storch, D., Bartneck, M., Huss, S., Rüsseler, V., Gaßler, N., Lira, S. A., Luedde, T., Trautwein, C., et al. (2011) · Hepatology · doi:10.1002/hep.24764 · Cited by 181
Madala, S. K., Pesce, J. T., Ramalingam, T. R., Wilson, M. S., Minnicozzi, S. C., Cheever, A. W., Thompson, R. W., Mentink‐Kane, M. M., & Wynn, T. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903008 · Cited by 166
Self-citationBusch, S. A., Hamilton, J. A., Horn, K. P., Cuascut, F. X., Cutrone, R., Lehman, N., Deans, R., Ting, A. E., Mays, R. W., & Silver, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3566-10.2011 · Cited by 145
Ueno, M., Maeno, T., Nomura, M., Aoyagi, K., Matsui, H., Hara, K., Tanaka, T., Iso, T., Suga, T., & Kurabayashi, M. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00146.2010 · Cited by 145
Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease
Chen, L., Zhou, X., Fan, L. X., Yao, Y., Swenson-Fields, K. I., Gadjeva, M. G., Wallace, D. P., Peters, D. J. M., Yu, A. S. L., Grantham, J. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80467 · Cited by 139
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis
Borthwick, L. A., Barron, L., Hart, K. M., Vannella, K. M., Thompson, R. W., Oland, S., Cheever, A., Sciurba, J., Ramalingam, T. R., Fisher, A. J., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2015.34 · Cited by 138
Self-citationYuk, J., Kim, T. S., Kim, S. Y., Lee, H., Han, J., Dufour, C. R., Kim, J. K., Jin, H. S., Yang, C., Park, K.-S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.003 · Cited by 136
Resolution of Liver Fibrosis: Basic Mechanisms and Clinical Relevance
Ramachandran, P., Iredale, J., & Fallowfield, J. (2015) · Seminars in Liver Disease · doi:10.1055/s-0035-1550057 · Cited by 129
Chen, G., Chen, H., Wang, C., Peng, Y., Sun, L., Liu, H., & Liu, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033626 · Cited by 129
Shaked, I., Hanna, R. N., Shaked, H., Chodaczek, G., Nowyhed, H. N., Tweet, G., Tacke, R., Basat, A. B., Mikulski, Z., Togher, S., et al. (2015) · Nature Immunology · doi:10.1038/ni.3321 · Cited by 128
Perdiguero, E. G., Klapproth, K., Schulz, C., Busch, K., Bruijn, M. F. T. R. D., Rodewald, H.-R., & Geissmann, F. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.022 · Cited by 122
Boehler, R. M., Kuo, R., Shin, S., Goodman, A. G., Pilecki, M. A., Leonard, J. N., & Shea, L. D. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.25175 · Cited by 117
Hesse, M., Cheever, A. W., Jankovic, D. L., & Wynn, T. A. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64607-x · Cited by 117
Self-citationVannella, K. M., Barron, L., Borthwick, L. A., Kindrachuk, K. N., Narasimhan, P. B., Hart, K. M., Thompson, R. W., White, S., Cheever, A. W., Ramalingam, T. R., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004372 · Cited by 112
Self-citationMurray, P. J., Rathmell, J. C., & Pearce, E. J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.014 · Cited by 99
Chujo, S., Shirasaki, F., Kondo‐Miyazaki, M., Ikawa, Y., & Takehara, K. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21750 · Cited by 84
Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus
Zheng, D., Wang, Y., Cao, Q., Lee, V. W., Zheng, G., Sun, Y., Tan, T. K., Wang, Y., Alexander, S. I., & Harris, D. C. H. (2011) · Nephron Experimental Nephrology · doi:10.1159/000321034 · Cited by 82
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Cao, Q., Wang, C., Dong, Z., Wang, Y., Lee, V. W., Wang, Y. M., Zheng, G., Tan, T. K., Yu, D., Alexander, S. I., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010070693 · Cited by 82
Wehr, A., Baeck, C., Ulmer, T. F., Gaßler, N., Hittatiya, K., Luedde, T., Neumann, U. P., Trautwein, C., & Tacke, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112327 · Cited by 79
Ueno, M., Maeno, T., Nishimura, S., Ogata, F., Masubuchi, H., Hara, K., Yamaguchi, K., Aoki, F., Suga, T., Nagai, R., et al. (2015) · Nature Communications · doi:10.1038/ncomms7332 · Cited by 71
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Hos, D., Bucher, F., Regenfuß, B., Dreisow, M.-L., Bock, F., Heindl, L. M., Eming, S. A., & Cursiefen, C. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.012 · Cited by 70
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Muñoz‐Cánoves, P., & Serrano, A. L. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.07.005 · Cited by 67
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Kluth, D. (2007) · Kidney International · doi:10.1038/sj.ki.5002332 · Cited by 28
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Knuever, J., Willenborg, S., Ding, X.-L., Akyüz, M., Partridge, L., Niessen, C., Brüning, J., & Eming, S. (2015) · Journal of Immunology · doi:10.4049/jimmunol.1501237 · Cited by 28
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Metadata
- Authors
- Wynn, T. A., & Vannella, K. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Wynn, Thomas A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 44
- Issue
- 3
- Pages
- 450-462
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4794754
- OpenAlex
- W2301044272
- Semantic Scholar
- 3e7cc72db53c49f88a543c99b71749931fb6c7b0
- Cited by
- 4,481
- References
- 129
- Citations by year
- 2026: 673 · 2025: 638 · 2024: 564 · 2023: 511 · 2022: 504 · 2021: 475 · 2020: 399 · 2019: 299 · 2018: 228 · 2017: 136 · 2016: 35
- FWCI
- 29.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (Z01AI001019, Z01AI000829)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- macrophages, tissue repair, tissue regeneration, fibrosis, inflammatory monocytes, macrophage polarization, wound healing, inflammation resolution, macrophage-targeted therapy
- MeSH terms
- Animals, Cell Communication, Cell Differentiation, Fibrosis, Humans, Macrophage Activation, Macrophages, Phenotype, Regeneration, Wound Healing
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