The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Cited by (1,068)

Items 1,001–1,068 of 1,068

1. QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis
   Lee, Jeesan, Villarreal, Oscar David, Chen, Xiaoru, Zandee, Stéphanie, Young, Yoon Kow, Torok, Cynthia, Lamarche-Vane, Nathalie, Prat, Alexandre, Rivest, Serge, Gosselin, David et al. · 2020 · Cell Reports
2. Delivery Platforms for CRISPR/Cas9 Genome Editing of Glial Cells in the Central Nervous System
   Vasco Meneghini, Marco Peviani, Marco Luciani, Giada Zambonini, Angela Gritti · 2021 · Frontiers in Genome Editing
3. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference
   Kloske, Courtney M., Belloy, Michael E., Blue, Elizabeth E., Bowman, Gregory R., Carrillo, Maria C., Chen, Xiaoying, Chiba‐Falek, Ornit, Davis, Albert A., Paolo, Gilbert Di, Garretti, Francesca et al. · 2024 · Alzheimer's & Dementia
4. APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses
   Friday, Cassi M., Stephens, Isaiah O., Smith, Cathryn T., Lee, Sangderk, Satish, Diksha, Devanney, Nicholas A., Cohen, Sarah, Morganti, Josh M., Gordon, Scott M., Johnson, Lance A. · 2025 · Neurobiology of Disease
5. Alzheimer’s Disease (AD) Therapeutics—2: Beyond Amyloid—Re-Defining AD and Its Causality to Discover Effective Therapeutics
   Mullane, Kevin, Williams, Michael · 2018 · Biochemical Pharmacology
6. Loss of microglial EED impairs synapse density, learning, and memory
   Wang, Ying-Ying, Deng, Yu-Sen, Dai, Shang-Kun, Mi, Ting-Wei, Li, Rui-Yang, Liu, Pei-Pei, Liu, Cong, He, Bao-Dong, He, Xuan-Cheng, Du, Hong-Zhen et al. · 2022 · Molecular Psychiatry
7. The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
   Naguib, Sarah, Lopez-Lee, Chloe, Torres, Eileen Ruth, Lee, Se-In, Zhu, Jingjie, Zhu, Daphne, Ye, Pearly, Norman, Kendra, Zhao, Mingrui, Wong, Man Ying et al. · 2025 · Immunity
8. APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
   Preman, Pranav, Moechars, Daan, Fertan, Emre, Wolfs, Leen, Serneels, Lutgarde, Shah, Disha, Lamote, Jochen, Poovathingal, Suresh, Snellinx, An, Mancuso, Renzo et al. · 2024 · EMBO Molecular Medicine
9. Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits
   Beckers, Lien, Geric, Ivana, Stroobants, Stijn, Beel, Sander, Van Damme, Philip, D’Hooge, Rudi, Baes, Myriam · 2019 · Journal of Neuroinflammation
10. Lymphoid gene expression supports neuroprotective microglia function
    Ayata, Pinar, Crowley, Jessica M., Challman, Matthew F., Sahasrabuddhe, Vinaya, Gratuze, Maud, Werneburg, Sebastian, Ribeiro, Diogo, Hays, Emma C., Durán-Laforet, Violeta, Faust, Travis E. et al. · 2025 · Nature
11. Galectin-3 in Microglia-Mediated Neuroinflammation: Implications for Central Nervous System Diseases
    Tian, Yu-Ke, Ye, Da-Wei, Ge, Meng-Meng, Chen, Nan, Zhou, Ya-Qun, Yang, Hui · 2022 · Current Neuropharmacology
12. APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
    Tran, Kristine M., Kwang, Nellie E., Butler, Claire A., Gomez-Arboledas, Angela, Kawauchi, Shimako, Mar, Cassandra, Chao, Donna, Barahona, Rocio A., Da Cunha, Celia, Tsourmas, Kate I. et al. · 2025 · Molecular Neurodegeneration
13. Opposing Roles of apolipoprotein E in aging and neurodegeneration
    Hudry, Eloise, Klickstein, Jacob, Cannavo, Claudia, Jackson, Rosemary, Muzikansky, Alona, Gandhi, Sheetal, Urick, David, Sargent, Taylie, Wrobleski, Lauren, Roe, Allyson D et al. · 2019 · Life Science Alliance
14. THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency
    Vautheny, Audrey, Duwat, Charlotte, Aurégan, Gwennaëlle, Joséphine, Charlène, Hérard, Anne-Sophie, Jan, Caroline, Mitja, Julien, Gipchtein, Pauline, Gaillard, Marie-Claude, Buée, Luc et al. · 2021 · Neurobiology of Disease
15. Versatile nanomaterials for Alzheimer’s disease: Pathogenesis inspired disease-modifying therapy
    Xi, Yilong, Chen, Yun, Jin, Yi, Han, Guochen, Song, Mingjie, Song, Tingting, Shi, Yang, Tao, Ling, Huang, Zewei, Zhou, Jianping et al. · 2022 · Journal of Controlled Release
16. Senescence in aging and disorders of the central nervous system
    Swenson, Barbara L., Meyer, Charlton F., Bussian, Tyler J., Baker, Darren J. · 2019 · Translational Medicine of Aging
17. APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
    Naguib, Sarah, Lopez-Lee, Chloe, Torres, Eileen Ruth, Lee, Se-In, Zhu, Jingjie, Zhu, Daphne, Ye, Pearly, Norman, Kendra, Zhao, Mingrui, Wong, Man Ying et al. · 2024
18. Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice
    Hemonnot-Girard, Anne-Laure, Meersseman, Cédric, Pastore, Manuela, Garcia, Valentin, Linck, Nathalie, Rey, Catherine, Chebbi, Amine, Jeanneteau, Freddy, Ginsberg, Stephen D., Lachuer, Joël et al. · 2022 · Journal of Neuroinflammation
19. Stage-specific roles of clonally expanded CD8+ T cells in regulating amyloid pathology in Alzheimer’s disease models
    Ohyagi, Masaki, Ito, Minako, Iizuka-Koga, Mana, Mise-Omata, Setsuko, Yoshimura, Akihiko · 2025 · Nature Communications
20. Protective ApoE variants support neuronal function by effluxing oxidized phospholipids
    Ralhan, Isha, Do, Alison D., Bae, Ju-Young, Feringa, Femke M., Cai, Wendy, Chang, Jinlan, Chik, Kennedi, Lee, Nathanael Y.J., Gerry, Christopher J., van der Kant, Rik et al. · 2026 · Neuron
21. Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids
    Chen, Xianwei, Sun, Guoqiang, Feng, Lizhao, Tian, E, Shi, Yanhong · 2025 · Communications Biology
22. Restoring microglial and astroglial homeostasis using DNA immunization in a down Syndrome mouse model.
    Illouz, Tomer, Madar, Ravit, Biragyn, Arya, Okun, Eitan · 2019 · Brain, Behavior, and Immunity
23. Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis
    Illouz, Tomer, Nicola, Raneen, Ben-Shushan, Linoy, Madar, Ravit, Biragyn, Arya, Okun, Eitan · 2021 · Communications Biology
24. A microglia clonal inflammatory disorder in Alzheimer’s disease
    Vicario, Rocio, Fragkogianni, Stamatina, Weber, Leslie, Lazarov, Tomi, Hu, Yang, Hayashi, Samantha Y, Craddock, Barbara, Socci, Nicholas D, Alberdi, Araitz, Baako, Ann et al. · 2025 · eLife
25. Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimer’s disease brains
    Gamache, Julia, Gingerich, Daniel, Shwab, E. Keats, Barrera, Julio, Garrett, Melanie E., Hume, Cordelia, Crawford, Gregory E., Ashley-Koch, Allison E., Chiba-Falek, Ornit · 2023 · Cell & Bioscience
26. The transcriptional and phenotypic characteristics that define alveolar macrophage subsets in acute hypoxemic respiratory failure
    Morrell, Eric D., Holton, Sarah E., Lawrance, Matthew, Orlov, Marika, Franklin, Zoie, Mitchem, Mallorie A., DeBerg, Hannah, Gersuk, Vivian H., Garay, Ashley, Barnes, Elizabeth et al. · 2023 · Nature Communications
27. Current insights into apolipoprotein E and the immune response in Alzheimer's disease
    Lin, Peter Bor‐Chian, Holtzman, David M. · 2024 · Immunological Reviews
28. Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation
    Tawbeh, Ali, Raas, Quentin, Tahri-Joutey, Mounia, Keime, Céline, Kaiser, Romain, Trompier, Doriane, Nasser, Boubker, Bellanger, Emma, Dessard, Marie, Hamon, Yannick et al. · 2023 · Frontiers in Molecular Neuroscience
29. Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Ibanez, Kristen R., McFarland, Karen N., Phillips, Jennifer, Allen, Mariet, Lessard, Christian B., Zobel, Lillian, De La Cruz, Elsa Gonzalez, Shah, Shivani, Vo, Quan, Wang, Xue et al. · 2022 · Alzheimer's Research & Therapy
30. Primary cilia-mediated regulation of microglial secretion in Alzheimer’s disease
    Yeo, Seungeun, Jang, Jaemyung, Jung, Hyun Jin, Lee, Hyeyoung, Choe, Youngshik · 2023 · Frontiers in Molecular Biosciences
31. PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology
    Messenger, Evan J., Baar, Sydney A., Bedford, Logan M., Tsai, Andy P., Lin, Peter Bor‐Chian, Ferguson, Chloe A., Xu, Guixiang, Wallace, Abigail, Landreth, Gary E., Lamb, Bruce T. et al. · 2025 · Alzheimer's & Dementia
32. HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV
    Cheng, Yan, Jung, Jaekeun, Guo, Liyang, Shuboni-Mulligan, Dorela D., Chen, Jian-Fu, Hu, Wenhui, Guo, Ming-Lei · 2025 · Brain, Behavior, and Immunity
33. Peroxisomal defects in microglial cells induce a disease-associated microglial signature
    Raas, Quentin, Tawbeh, Ali, Tahri-Joutey, Mounia, Gondcaille, Catherine, Keime, Céline, Kaiser, Romain, Trompier, Doriane, Nasser, Boubker, Leoni, Valerio, Bellanger, Emma et al. · 2023 · Frontiers in Molecular Neuroscience
34. Immunological signatures in frontotemporal lobar degeneration
    Sirkis, Daniel W., Bonham, Luke W., Karch, Celeste M., Yokoyama, Jennifer S. · 2019 · Current Opinion in Neurology
35. The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
    Takalo, Mari, Jeskanen, Heli, Rolova, Taisia, Kervinen, Inka, Hellén, Marianna, Heikkinen, Sami, Koivisto, Hennariikka, Jokivarsi, Kimmo, Müller, Stephan A., Koivumäki, Esa-Mikko et al. · 2025 · Journal of Neuroinflammation
36. Therapeutic Idol reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice
    Gao, Jie, Littman, Russell, Diamante, Graciel, Xiao, Xu, Ahn, In Sook, Yang, Xia, Cole, Tracy A., Tontonoz, Peter · 2020 · Molecular and Cellular Biology
37. Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype
    Pankiewicz, Joanna E., Lizińczyk, Anita M., Franco, Leor A., Diaz, Jenny R., Martá-Ariza, Mitchell, Sadowski, Martin J. · 2021 · Acta Neuropathologica Communications
38. TREM2 and microglial immunity in Alzheimer’s disease: mechanisms, genetics, and therapeutic opportunities
    Wang, Tianqing, Liu, Xinru, Wang, Xifeng, Hua, Fuzhou, Yan, Lei · 2026 · Frontiers in Immunology
39. Loss of Homeostatic Microglia Signature in Prion Diseases
    Wang, Yue, Hartmann, Kristin, Thies, Edda, Mohammadi, Behnam, Altmeppen, Hermann, Sepulveda-Falla, Diego, Glatzel, Markus, Krasemann, Susanne · 2022 · Cells
40. Deficient brain GABA metabolism leads to widespread impairments of astrocyte and oligodendrocyte function
    Andersen, Jens V., Marian, Oana C., Qvist, Filippa L., Westi, Emil W., Aldana, Blanca I., Schousboe, Arne, Don, Anthony S., Skotte, Niels H., Wellendorph, Petrine · 2024 · Glia
41. APOE ε 4 is also required in TREM 2 R47H variant carriers for Alzheimer's disease to develop
    Murray, C. E., King, A., Troakes, C., Hodges, A., Lashley, T. · 2019 · Neuropathology and Applied Neurobiology
42. Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
    Risgaard, Ryan D., Hanthanan Arachchilage, Kalpana, Knaack, Sara A., Hosseini, Masoumeh, Chen, Rachel J., Kumarage, Pubudu, Schmidt, Danielle K., Huang, Xiang, Sheng, Jie, Wang, Carlos J. et al. · 2026 · Science
43. Distinct microglia profile in Creutzfeldt-Jakob disease and Alzheimer’s disease is independent of disease kinetics
    Krbot, Katarina, Hermann, Peter, Skorić, Magdalena Krbot, Zerr, Inga, Sepulveda‐Falla, Diego, Goebel, Stefan, Matschke, Jakob, Krasemann, Susanne, Glatzel, Markus · 2018 · Neuropathology
44. TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration
    Zhu, Keying, Liu, Yun, Min, Jin-Hong, Joshua, Vijay, Lin, Jianing, Li, Yue, Kreutzmann, Judith C., Guo, Yuxi, Xia, Wenlong, Mohammadi, Elyas et al. · 2026 · Nature Neuroscience
45. Systemic Metabolism and Mitochondria in the Mechanism of Alzheimer’s Disease: Finding Potential Therapeutic Targets
    Song, Meiying, Fan, Xiang · 2023 · International Journal of Molecular Sciences
46. Do Alzheimer's Disease Risk Gene Products Actually Act in Microglia?
    Hashioka, Sadayuki, Inoue, Ken, Takeshita, Haruo, Inagaki, Masatoshi · 2020 · Frontiers in Aging Neuroscience
47. Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform
    Strickland, Michael R., Wang, Zhen, Golden, Lesley R., Wang, Hu, Lu, Ping, Ren, Yingxue, Tabor, G. Travis, Zhao, Na, Ulrich, Jason D., Han, Xianlin et al. · 2026 · Journal of Lipid Research
48. Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1α
    Grubman, Alexandra, Choo, Xin Yi, Chew, Gabriel, Ouyang, John F., Sun, Guizhi, Croft, Nathan P., Rossello, Fernando J., Simmons, Rebecca, Buckberry, Sam, Landin, Dulce Vargas et al. · 2019
49. Soluble CSF1R promotes microglial activation and amyloid clearance in Alzheimer’s disease
    Zhang, Lianshuai, Chen, Kai, Zeng, Ruicheng, Bu, Guojun, Chen, Xiao-Fen · 2025 · Journal of Neuroinflammation
50. Roles of Microglia in Synaptogenesis, Synaptic Pruning, and Synaptic Plasticity in Physiological Conditions and Central Nervous System Disorders
    Xie, Meizhen, Wang, Tian, Feng, Jiachun, Ma, Di, Feng, Liangshu, Hao, Yulei · 2025 · Current Neuropharmacology
51. Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases
    Etebar, Fazeleh, Harkin, Damien G., White, Anthony R., Dando, Samantha J. · 2024 · Frontiers in Cellular Neuroscience
52. TREM2-dependent senescent microglia conserved in aging and Alzheimer’s disease
    Rachmian, N, Medina, S., Cherqui, U., Akiva, H., Deitch, D, Edilbi, D, Croese, T., Salame, TM., Peralta Ramos, JM., Cahalon, L. et al. · 2023
53. Microglial states revisited: from homeostasis to disease
    Eggen, Bart J. L., Kooistra, Susanne M. · 2026 · Nature Reviews Neuroscience
54. Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease
    Kitani, Akihiro, Matsui, Yusuke, for the Alzheimer’s Disease Neuroimaging Initiative · 2025 · Alzheimer's Research & Therapy
55. microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients
    Penning, Amber, Snoeck, Sarah, Ormaechea, Olmo Ruiz, Ayyildiz, Dilara, Polzer, Oliver, Buitrago-Arango, Martin, Capobianco, Raffaella, de Winter, Fred, Balusu, Sriram, Verhaagen, Joost et al. · 2026 · Acta Neuropathologica Communications
56. Cell signaling pathways discovery from multi-modal data
    He, Changhan, Simpson, Claire, Cossentino, Ian, Zhang, Bin, Tkachev, Sasha, Eddins, Devon J., Kosters, Astrid, Yang, Junkai, Sheth, Shivani, Levy, Tyler et al. · 2025
57. INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia
    Terzioglu, Gizem, Karp, Emma S., Heuer, Sarah E., Chadarevian, Jean Paul, Ahsan, Fasih M., Haage, Verena C., Davtyan, Hayk, Fogo, Garrett M., Curle, Annabel J., Ashour, Nancy et al. · 2025
58. Network analysis identifies strain-dependent response to tau and tau seeding-associated genes
    Acri, Dominic J., You, Yanwen, Tate, Mason D., Karahan, Hande, Martinez, Pablo, McCord, Brianne, Sharify, A. Daniel, John, Sutha, Kim, Byungwook, Dabin, Luke C. et al. · 2023 · Journal of Experimental Medicine
59. Targeting macrophages in liver fibrosis
    González del Barrio, Lydia, Ipsen, David H., Pfister, Dominik R., Hancz, Dora, Scott, Charlotte L. · 2026 · Frontiers in Immunology
60. ApoE expression across the CNS: Who, What, Where, When, and How (much)?
    Nolt, Georgia L., Lucido, Chloe C., Smith, Lily M., Johnson, Lance A. · 2026 · Molecular Neurodegeneration Advances
61. Protective PLCG2 variants associate with a delayed onset of Alzheimer’s disease among heterozygous APOE ε4 carriers
    Jeskanen, Heli, Heikkinen, Sami, Kervinen, Inka, Lehtisalo, Jenni, Ngandu, Tiia, Willman, Roosa-Maria, Rosa, Jessica, Hoffmann, Dorit, FinnGen, Leinonen, Ville et al. · 2026 · Alzheimer's Research & Therapy
62. SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain
    Huang, Huijie, Shi, Christina Huan, Yang, Wenqi, Piña-Crespo, Juan C., Bhatnagar, Jay, Curatolo, Julian, Murad, Rabi, Shah, Palak, Campos, Alex, Houser, Alexandra et al. · 2026 · Science Advances
63. Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis?
    Chmiel, James, Gawełczyk, Wiktor, Soczyńska, Julia, Leszek, Jerzy · 2026 · Cells
64. PLCγ2 deficiency compromises systemic immune tolerance and erodes myelin homeostasis while enhancing oxidative metabolism in the mouse brain
    Gutierrez-Kuri, Eduardo, Marie Garcia-Rogers, Juliet Lynn, Perez, Jaid, Smith, Sabrina, Kenwood, Matthew R., Archuleta, Kahealani S., Xiao, Yangming, Campos, Gabriela, Barannikov, Savannah, Wang, Hu et al. · 2026
65. Is there a role for B cells in Alzheimer's disease?
    Charavner, Eva-Loren, Fillatreau, Simon, El Behi, Mohamed · 2026 · Cellular Immunology
66. Older adult APOE4 mice exhibit modest immunometabolic adaptation following microglial APOE2 replacement
    Nolt, Georgia L., MacLean, Steven M., Golden, Lesley R., Thorpe, Shealee P., Stephens, Isaiah O., Funnell, Jessica L., Brock, Chesney R., Lucido, Chloe C., Smith, Lily, Hernandez, Gabriela et al. · 2027 · Neurobiology of Aging
67. ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders
    Strickland, Michael R., Holtzman, David M. · 2026 · Molecular Neurodegeneration
68. Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis
    Walsh, Adeline E., Davis, Benjamin A., Samuels, Joshua D., Mills, William A., Thanos, Jessica M., Johnson, Alexis M., Moore, Katelyn A., Puchalski, Michael A., Steacy, Eric J., Wendell, Benjamin W. et al. · 2026 · Journal of Experimental Medicine