Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,475

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

Long, Q.-X., Tang, X.-J., Shi, Q.-L., Li, Q., Deng, H.-J., Yuan, J., Hu, J.-L., Xu, W., Zhang, Y., Lv, F.-J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0965-6 · Cited by 2,686

IL-6 as a keystone cytokine in health and disease

Hunter, C. A., & Jones, S. A. (2015) · Nature Immunology · doi:10.1038/ni.3153 · Cited by 2,511

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

Johnston, R. J., Poholek, A. C., DiToro, D., Yusuf, I., Eto, D., Barnett, B., Dent, A. L., Craft, J., & Crotty, S. (2009) · Science · doi:10.1126/science.1175870 · Cited by 1,626

T follicular helper cell biology: a decade of discovery and diseases

Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591

The generation of antibody-secreting plasma cells

Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M., & Corcoran, L. M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3795 · Cited by 1,565

Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

Mackay, F., Woodcock, S. A., Lawton, P., Ambrose, C. M., Baetscher, M., Schneider, P., Tschopp, J., & Browning, J. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.11.1697 · Cited by 1,479

IL-12 family cytokines: immunological playmakers

Vignali, D. A. A., & Kuchroo, V. K. (2012) · Nature Immunology · doi:10.1038/ni.2366 · Cited by 1,331

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

Victora, G. D., Schwickert, T. A., Fooksman, D., Kamphorst, A. O., Meyer‐Hermann, M., Dustin, M. L., & Nussenzweig, M. C. (2010) · Cell · doi:10.1016/j.cell.2010.10.032 · Cited by 1,264

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection

Wang, Z., Muecksch, F., Schaefer-Babajew, D., Finkin, S., Viant, C., Gaebler, C., Hoffmann, H. H., Barnes, C. O., Cipolla, M., Ramos, V., et al. (2021) · Nature · doi:10.1038/s41586-021-03696-9 · Cited by 721

Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities

Laumont, C. M., Banville, A. C., Gilardi, M., Hollern, D. P., & Nelson, B. H. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00466-1 · Cited by 565

Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination

Röltgen, K., Nielsen, S. C. A., Silva, O., Younes, S. F., Zaslavsky, M., Costales, C., Yang, F., Wirz, O. F., Solis, D., Hoh, R. A., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.018 · Cited by 475

Germinal centre-driven maturation of B cell response to mRNA vaccination

Kim, W., Zhou, J. Q., Horvath, S. C., Schmitz, A. J., Sturtz, A. J., Lei, T., Liu, Z., Kalaidina, E., Thapa, M., Alsoussi, W. B., et al. (2022) · Nature · doi:10.1038/s41586-022-04527-1 · Cited by 362

Designing spatial and temporal control of vaccine responses

Roth, G. A., Picece, V. C. T. M., Ou, B. S., Luo, W., Pulendran, B., & Appel, E. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00372-2 · Cited by 334

Tertiary lymphoid structures in anticancer immunity

Teillaud, J., Houel, A., Panouillot, M., Riffard, C., & Dieu‐Nosjean, M. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00728-0 · Cited by 322

B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity

Laumont, C. M., & Nelson, B. H. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.017 · Cited by 269

Dysregulated naive B cells and de novo autoreactivity in severe COVID-19

Woodruff, M. C., Ramonell, R. P., Haddad, N. S., Anam, F. A., Rudolph, M. E., Walker, T. A., Truong, A. D., Dixit, A. N., Han, J. E., Cabrera-Mora, M., et al. (2022) · Nature · doi:10.1038/s41586-022-05273-0 · Cited by 226

Systemic Lupus Erythematosus Pathogenesis: Interferon and Beyond

Caielli, S., Wan, Z., & Pascual, V. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-042422 · Cited by 229

The humoral response and antibodies against SARS-CoV-2 infection

Qi, H., Liu, B., Wang, X., & Zhang, L. (2022) · Nature Immunology · doi:10.1038/s41590-022-01248-5 · Cited by 195

Epstein–Barr virus as a potentiator of autoimmune diseases

Robinson, W. H., Younis, S., Love, Z. Z., Steinman, L., & Lanz, T. V. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01167-9 · Cited by 148

Antibody-mediated neutralization of SARS-CoV-2

Gruell, H., Vanshylla, K., Weber, T., Barnes, C. O., Kreer, C., & Klein, F. (2022) · Immunity · doi:10.1016/j.immuni.2022.05.005 · Cited by 150

Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins

Wang, Z., Muecksch, F., Cho, A., Gaebler, C., Hoffmann, H.-H., Ramos, V., Zong, S., Cipolla, M., Johnson, B., Schmidt, F., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.04.003 · Cited by 145

Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines

Lee, J., Woodruff, M. C., Kim, E. H., & Nam, J. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00999-x · Cited by 141

Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice

Nickerson, K. M., Smita, S., Hoehn, K. B., Marinov, A. D., Thomas, K., Kos, J. T., Yang, Y., Bastacky, S., Watson, C. T., Kleinstein, S. H., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221346 · Cited by 138

Myasthenia gravis: the changing treatment landscape in the era of molecular therapies

Iorio, R. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-023-00916-w · Cited by 140

Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity

Wu, M., Song, G.-P., Li, J., Song, Z.-Q., Zhao, B., Liang, L., Li, W., Hu, H., Tu, H.-Q., Li, S., et al. (2024) · Cell · doi:10.1016/j.cell.2024.04.027 · Cited by 110

Phylogenetic analysis of migration, differentiation, and class switching in B cells

Hoehn, K. B., Pybus, O. G., & Kleinstein, S. H. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009885 · Cited by 105

A shift in lung macrophage composition is associated with COVID-19 severity and recovery

Chen, S. T., Park, M. D., Valle, D. M. D., Buckup, M., Tabachnikova, A., Thompson, R. C., Simons, N. W., Mouskas, K., Lee, B. H., Geanon, D., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn5168 · Cited by 106

B-cell depletion in autoimmune diseases

Schett, G. A., Nagy, G., Krönke, G., & Mielenz, D. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2024-225727 · Cited by 113

T peripheral helper cells in autoimmune diseases*

Marks, K. E., & Rao, D. A. (2022) · Immunological Reviews · doi:10.1111/imr.13069 · Cited by 104

Role of CD4+ T Cells in the Control of Viral Infections: Recent Advances and Open Questions

Kervevan, J., & Chakrabarti, L. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020523 · Cited by 108

B-cell and antibody responses to SARS-CoV-2: infection, vaccination, and hybrid immunity

Lapuente, D., Winkler, T., & Tenbusch, M. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01095-w · Cited by 101

From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis

Scherer, H. U., van der Woude, D., & Toes, R. E. M. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00786-4 · Cited by 85

Distinct metabolic requirements regulate B cell activation and germinal center responses

Sharma, R., Smolkin, R. M., Chowdhury, P., Fernandez, K. C., Kim, Y., Cols, M., Alread, W., Yen, W.-F., Hu, W., Wang, Z.-M., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01540-y · Cited by 90

Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies

Porsch, F., Mallat, Z., & Binder, C. J. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab285 · Cited by 88

IL-10 revisited in systemic lupus erythematosus

Biswas, S., Bieber, K., & Manz, R. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.970906 · Cited by 81

Clonal replacement sustains long-lived germinal centers primed by respiratory viruses

de Carvalho, R. A., Ersching, J., Barbulescu, A., Hobbs, A., Castro, T. B. R., Mesin, L., Jacobsen, J. T., Phillips, B. K., Hoffmann, H.-H., Parsa, R., et al. (2022) · Cell · doi:10.1016/j.cell.2022.11.031 · Cited by 85

Antibody modulation of B cell responses—Incorporating positive and negative feedback

Cyster, J. G., & Wilson, P. C. (2024) · Immunity · doi:10.1016/j.immuni.2024.06.009 · Cited by 78

Functions of double‐negative B cells in autoimmune diseases, infections, and cancers

Chung, M. K. Y., Gong, L., Kwong, D. L., Lee, V. H., Lee, A. W., Guan, X., Kam, N., & Dai, W. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202217341 · Cited by 73

Molecular mechanisms controlling age‐associated B cells in autoimmunity*

Phalke, S., Rivera‐Correa, J., Jenkins, D., Flores-Castro, D., Γιαννοπούλου, Ε., & Pernis, A. B. (2022) · Immunological Reviews · doi:10.1111/imr.13068 · Cited by 79

CD19 Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus

Taubmann, J., Müller, F., Mutlu, M. Y., Völkl, S., Aigner, M., Bözec, A., Mackensen, A., Grieshaber‐Bouyer, R., & Schett, G. A. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42784 · Cited by 75

Lactate’s impact on immune cells in sepsis: unraveling the complex interplay

Zhang, T., Chen, L., Kueth, G., Shao, E., Wang, X., Ha, T., Williams, D. L., Li, C., Fan, M., & Yang, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1483400 · Cited by 75

The durability of vaccine-induced protection: an overview

Vashishtha, V. M., & Kumar, P. (2024) · Expert Review of Vaccines · doi:10.1080/14760584.2024.2331065 · Cited by 70

Marginal zone B cells mediate a CD4 T-cell–dependent extrafollicular antibody response following RBC transfusion in mice

Zerra, P. E., Patel, S. R., Jajosky, R. P., Arthur, C. M., McCoy, J. W., Allen, J. W. L., Chonat, S., Fasano, R. M., Roback, J. D., Josephson, C. D., et al. (2021) · Blood · doi:10.1182/blood.2020009376 · Cited by 68

Short- and Long-Lived Autoantibody-Secreting Cells in Autoimmune Neurological Disorders

Zografou, C., Vakrakou, A. G., & Stathopoulos, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686466 · Cited by 67

New insights into the ontogeny, diversity, maturation and survival of long-lived plasma cells

Fooksman, D., Jing, Z., & Park, R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00991-0 · Cited by 70

A close-up on the expanding landscape of CD21–/low B cells in humans

Gjertsson, I., McGrath, S., Grimstad, K., Jonsson, C. A., Camponeschi, A., Thorarinsdottir, K., & Mårtensson, I. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac103 · Cited by 71

IL-12 induces a B cell-intrinsic IL-12/IFNγ feed-forward loop promoting extrafollicular B cell responses

Elsner, R. A., Smita, S., & Shlomchik, M. J. (2024) · Nature Immunology · doi:10.1038/s41590-024-01858-1 · Cited by 65

Unconstrained generation of synthetic antibody–antigen structures to guide machine learning methodology for antibody specificity prediction

Robert, P. A., Akbar, R., Frank, R., Pavlović, M., Widrich, M., Snapkov, I., Slabodkin, A., Chernigovskaya, M., Scheffer, L., Smorodina, E., et al. (2022) · Nature Computational Science · doi:10.1038/s43588-022-00372-4 · Cited by 69

Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

Biram, A., Liu, J., Hezroni, H., Davidzohn, N., Schmiedel, D., Khatib-Massalha, E., Haddad, M., Grenov, A., Lebon, S., Salame, T., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.01.013 · Cited by 60

Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis

Yin, Y., Yang, X., Wu, S., Ding, X., Zhu, H., Long, X., Wang, Y., Zhai, S., Chen, Y., Che, N., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01287-y · Cited by 62

Defining and using immune archetypes to classify and treat cancer

Combes, A. J., Samad, B., & Krummel, M. F. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00578-2 · Cited by 61

How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions

Chen, J., Deng, J. C., & Goldstein, D. R. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.09.008 · Cited by 61

Skin immune-mesenchymal interplay within tertiary lymphoid structures promotes autoimmune pathogenesis in hidradenitis suppurativa

Yu, W., Barrett, J. N. P., Tong, J., Lin, M., Marohn, M., Devlin, J. C., Herrera, A. M., Remark, J., Levine, J. P., Liu, P., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.11.010 · Cited by 60

Predictive Markers of Immunogenicity and Efficacy for Human Vaccines

Tilbeurgh, M. V., Lemdani, K., Beignon, A., Chapon, C., Tchitchek, N., Cheraitia, L., López, E. M., Pascal, Q., Grand, R. L., Maisonnasse, P., et al. (2021) · Vaccines · doi:10.3390/vaccines9060579 · Cited by 61

Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2

Zurbuchen, Y., Michler, J., Taeschler, P., Adamo, S., Cervia, C., Raeber, M. E., Acar, İ. E., Nilsson, J., Warnatz, K., Soyka, M., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01497-y · Cited by 53

Resident Memory B Cells in Barrier Tissues

Lee, C. M., & Oh, J. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.953088 · Cited by 55

Innate and Adaptive Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms

Brown, B., Ojha, V., Fricke, I., Al-Sheboul, S. A., Imarogbe, C., Gravier, T., Green, M., Peterson, L., Koutsaroff, I. P., Demir, A. N., et al. (2023) · Vaccines · doi:10.3390/vaccines11020408 · Cited by 55

CD27 on human memory B cells–more than just a surface marker

Grimsholm, O. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac114 · Cited by 53

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

Barišić, D., Chin, C. R., Meydan, C., Teater, M. R., Tsialta, I., Mlynarczyk, C., Chadburn, A., Wang, X., Sarkozy, M., Xia, M., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.02.010 · Cited by 55

B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity

Oļeiņika, K., Šlisere, B., Catalán, D., & Rosser, E. C. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac079 · Cited by 54

The extrafollicular B cell response is a hallmark of childhood idiopathic nephrotic syndrome

Al-Aubodah, T.-A., Aoudjit, L., Pascale, G., Perinpanayagam, M. A., Langlais, D., Bitzan, M. M., Samuel, S. M., Piccirillo, C. A., & Takano, T. (2023) · Nature Communications · doi:10.1038/s41467-023-43504-8 · Cited by 47

Anti-complement 5 antibody ameliorates antibody-mediated rejection after liver transplantation in rats

Tajima, T., Hata, K., Kusakabe, J., Miyauchi, H., Badshah, J. S., Kageyama, S., Zhao, X., Kim, S.-K., Tsuruyama, T., Kirchner, V. A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1186653 · Cited by 48

CAR T-cell therapy for systemic lupus erythematosus: current status and future perspectives

Zhou, J., Lei, B., Shi, F., Luo, X., Wu, K., Xu, Y., Zhang, Y., Liu, R., Wang, H., Zhou, J., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1476859 · Cited by 48

Humoral immunity in hepatitis B virus infection: Rehabilitating the B in HBV

Vanwolleghem, T., Adomati, T., Hees, S. V., & Janssen, H. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100398 · Cited by 48

YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation

Grenov, A., Hezroni, H., Lasman, L., Hanna, J. H., & Shulman, Z. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110778 · Cited by 45

B cell heterogeneity, plasticity, and functional diversity in cancer microenvironments

Yuan, W., Huang, C.-X., Xiao, C., Chen, D., Shan, H., He, H., & Kuang, D. (2021) · Oncogene · doi:10.1038/s41388-021-01918-y · Cited by 46

Early human B cell signatures of the primary antibody response to mRNA vaccination

Kardava, L., Rachmaninoff, N., Lau, W. W., Buckner, C. M., Trihemasava, K., de Assis, F. L., Wang, W., Zhang, X., Wang, Y., Chiang, C.-I., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204607119 · Cited by 43

Features of B Cell Responses Relevant to Allergic Disease

Allen, C. D. C. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100988 · Cited by 49

The Role of B Cells in Adult and Paediatric Liver Injury

Patel, A. M., Liu, Y. S., Davies, S. P., Brown, R. M., Kelly, D. A., Scheel‐Toellner, D., Reynolds, G. M., & Stamataki, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729143 · Cited by 44

T follicular helper cells in cancer, tertiary lymphoid structures, and beyond

Cui, C., Craft, J. E., & Joshi, N. S. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101797 · Cited by 42

Multimodal repertoire analysis unveils B cell biology in immune-mediated diseases

Ota, M., Nakano, M., Nagafuchi, Y., Kobayashi, S., Hatano, H., Yoshida, R., Akutsu, Y., Itamiya, T., Ban, N., Tsuchida, Y., et al. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224421 · Cited by 40

Toward curing neurological autoimmune disorders: Biomarkers, immunological mechanisms, and therapeutic targets

Segal‬, Y., Soltys, J. N., Clarkson, B. D. S., Howe, C. L., Irani, S. R., & Pittock, S. J. (2025) · Neuron · doi:10.1016/j.neuron.2024.12.006 · Cited by 40

A roadmap for defining “extrafollicular” B cell responses

Eisenbarth, S. C., Batista, F. D., Cyster, J. G., Elsner, R. A., Kelsoe, G. H., Lund, F. E., Pillai, S. S., Sanz, I., Shlomchik, M. J., Toellner, K., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.08.007 · Cited by 46

Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19

Hoehn, K. B., Ramanathan, P., Unterman, A., Sumida, T. S., Asashima, H., Hafler, D. A., Kaminski, N., Cruz, C. S. D., Sealfon, S. C., Bukreyev, A. A., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100135 · Cited by 40

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency

Oda, H., Manthiram, K., Chavan, P. P., Rieser, E., Veli, Ö., Kaya, Ö., Rauch, C. T., Nakabo, S., Kuehn, H. S., Swart, M., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01817-w · Cited by 41

Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19

Schultheiß, C., Paschold, L., Willscher, E., Simnica, D., Wöstemeier, A., Muscate, F., Wass, M., Eisenmann, S., Dutzmann, J., Keyßer, G., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103325 · Cited by 37

The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus

Voss, L. F., Howarth, A. J., Wittenborn, T. R., Hummelgaard, S., Juul‐Madsen, K., Kastberg, K. S., Pedersen, M. K., Jensen, L., Papanastasiou, A. D., Vorup‐Jensen, T., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1021370 · Cited by 38

Tertiary lymphoid structures as local perpetuators of organ-specific immune injury: implication for lupus nephritis

Wang, M., Rajkumar, S., Lai, Y., Liu, X., He, J., Ishikawa, T., Nallapothula, D., & Singh, R. R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1204777 · Cited by 39

PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus

Tchen, J., Simon, Q., Chapart, L., Thaminy, M. K., Vibhushan, S., Saveanu, L., Lamri, Y., Saidoune, F., Pacreau, E., Pellefigues, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47691-w · Cited by 40

Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis

Faliti, C. E., Mesina, M., Choi, J., Bélanger, S., Marshall, M., Tipton, C. M., Hicks, S. L., Chappa, P., Cardenas, M. A., Abdel-Hakeem, M. S., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.11.006 · Cited by 36

TGFβ links EBV to multisystem inflammatory syndrome in children

Goetzke, C. C., Massoud, M., Frischbutter, S., Guerra, G. M., Ferreira‐Gomes, M., Heinrich, F., von Stuckrad, A. S. L., Wisniewski, S., Licha, J. R., Bondareva, M. A., et al. (2025) · Nature · doi:10.1038/s41586-025-08697-6 · Cited by 40

Peripheral Helper T Cell Responses in Human Diseases

Yoshitomi, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.946786 · Cited by 35

B cells in autoimmune hepatitis: bystanders or central players?

Schultheiß, C., Steinmann, S., Lohse, A. W., & Binder, M. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00937-5 · Cited by 35

B cell‐intrinsic changes with age do not impact antibody‐secreting cell formation but delay B cell participation in the germinal centre reaction

Lee, J. L., Fra-Bidó, S., Burton, A. R., Innocentin, S., Hill, D. L., & Linterman, M. A. (2022) · Aging Cell · doi:10.1111/acel.13692 · Cited by 34

Alternative B Cell Differentiation During Infection and Inflammation

Courey‐Ghaouzi, A., Kleberg, L., & Sundling, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.908034 · Cited by 33

Time-restricted eating reveals a “younger” immune system and reshapes the intestinal microbiome in human

Chen, Y., Li, X., Yang, M., Chen, J., He, Z., Zhou, S., Ruan, P., Wang, Y., Tang, C., Pan, W., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103422 · Cited by 38

Pharmacologically Inferred Glycolysis and Glutaminolysis Requirement of B Cells in Lupus-Prone Mice

Choi, S., Li, W., Zhang, X., Kanda, N., Zeumer-Spataro, L., Teng, X., & Morel, L. M. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100356 · Cited by 32

Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites

Wu, R., Wang, D., Cheng, L., Su, R. J., Li, B., Fan, C., Gao, C., & Wang, C. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03260-y · Cited by 35

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Rogers, K. J., Vijay, R., & Butler, N. S. (2021) · Microbes and Infection · doi:10.1016/j.micinf.2021.104807 · Cited by 32

GABA signaling enforces intestinal germinal center B cell differentiation

Liao, Y., Fan, L., Bin, P., Zhu, C., Chen, Q., Cai, Y., Duan, J., Cai, Q., Han, W., Ding, S., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215921119 · Cited by 32

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Lamontagne, F., Khatri, V., St‐Louis, P., Bourgault, S., & Archambault, D. (2022) · Vaccines · doi:10.3390/vaccines10111920 · Cited by 34

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Tang, Y., Zhang, Y., Li, X., Xu, R., Ji, Y., Liu, J., Liu, J., Zhuang, Q., & Zhang, H. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1237 · Cited by 33

Production and use of antigen tetramers to study antigen-specific B cells

Phelps, A., Pazos‐Castro, D., Urselli, F., Grydziuszko, E., Mann-Delany, O., Fang, A., Walker, T. D., Guruge, R. T., Tomé‐Amat, J., Díaz‐Perales, A., et al. (2024) · Nature Protocols · doi:10.1038/s41596-023-00930-8 · Cited by 32

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Motta, R. V., & Culver, E. L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1272084 · Cited by 29

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Gossez, M., Vigneron, C., Vandermoeten, A., Lepage, M., Courcol, L., Coudereau, R., Païdassi, H., Jallades, L., Lopez, J., Kandara, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57706-9 · Cited by 34

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Bugya, Z., Prechl, J., Szénási, T., Nemes, É., Bácsi, A., & Koncz, G. (2021) · Vaccines · doi:10.3390/vaccines9020174 · Cited by 30

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Yuuki, H., Itamiya, T., Nagafuchi, Y., Ota, M., & Fujio, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1326823 · Cited by 29

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Bonaud, A., Lemos, J. P., Espéli, M., & Balabanian, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.658535 · Cited by 32

Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow

Ferreira‐Gomes, M., Chen, Y., Durek, P., Rincón-Arévalo, H., Heinrich, F., Bauer, L., Szelinski, F., Guerra, G. M., Stefanski, A., Niedobitek, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48570-0 · Cited by 29

Double Negative (DN) B cells: A connecting bridge between rheumatic diseases and COVID-19?

Sachinidis, A., & Garyfallos, A. (2021) · Mediterranean Journal of Rheumatology · doi:10.31138/mjr.32.3.192 · Cited by 29

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Schmiedel, D., Hezroni, H., Hamburg, A., & Shulman, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705848 · Cited by 24

Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells

Staniek, J., Kalina, T., Andrieux, G., Boerries, M., Janowska, I., Fuentes, M., Díez, P., Bakardjieva, M., Stančíková, J., Raabe, J., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adj5948 · Cited by 23

The peculiar features, diversity and impact of citrulline-reactive autoantibodies

Raposo, B., Klareskog, L., Robinson, W. H., Malmström, V., & Grönwall, C. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01124-6 · Cited by 23

Dysfunctional CD11c − CD21 − extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer

Ruffin, A. T., Casey, A. N., Kunning, S. R., MacFawn, I., Liu, Z., Arora, C., Rohatgi, A., Kemp, F., Lampenfeld, C., Somasundaram, A., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adh1315 · Cited by 24

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Li, L., Zhang, D., & Cao, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1320689 · Cited by 24

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Faliti, C. E., Van, T. T. P., Anam, F. A., Cheedarla, N., Williams, M. E., Mishra, A. K., Usman, S. Y., Woodruff, M. C., Kraker, G., Runnstrom, M. C., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-02010-9 · Cited by 23

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Wishnie, A. J., Chwat-Edelstein, T., Attaway, M., & Vuong, B. Q. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.703918 · Cited by 23

SARS-CoV-2 Spike S1-specific IgG kinetic profiles following mRNA or vector-based vaccination in the general Dutch population show distinct kinetics

van den Hoogen, L. L., Verheul, M. K., Vos, E. R. A., van Hagen, C. C. E., van Boven, M., Wong, D., Wijmenga‐Monsuur, A. J., Smits, G. P., Kuijer, M., van Rooijen, D. M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10020-6 · Cited by 21

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Baumgarth, N. (2025) · Immunological Reviews · doi:10.1111/imr.70066 · Cited by 11

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Nakagawa, R., Malinova, D., & Díaz‐Muñoz, M. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1354411

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Shlomchik, M. J., & Weisel, F. J. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01125.x · Cited by 37

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Kurosaki, T. (2023) · International Immunology · doi:10.1093/intimm/dxad040

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Elsner, R. A., & Shlomchik, M. J. (2025) · Immunological Reviews · doi:10.1111/imr.70027 · Cited by 16