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Human microglia maturation is underpinned by specific gene regulatory networks

Han, Claudia Z., Li, Rick Z., Hansen, Emily, Trescott, Samantha, Fixsen, Bethany R., Nguyen, Celina T., Mora, Cristina M., Spann, Nathanael J., Bennett, Hunter R., Poirion, Olivier, Buchanan, Justin, Warden, Anna S., Xia, Bing, Schlachetzki, Johannes C.M., Pasillas, Martina P., Preissl, Sebastian, Wang, Allen, O’Connor, Carolyn, Shriram, Shreya, Kim, Roy, Schafer, Danielle, Ramirez, Gabriela, Challacombe, Jean, Anavim, Samuel A., Johnson, Avalon, Gupta, Mihir, Glass, Ian A., Levy, Michael L., Haim, Sharona Ben, Gonda, David D., Laurent, Louise, Hughes, Jennifer F., Page, David C., Blurton-Jones, Mathew, Glass, Christopher K., Coufal, Nicole G.·2023·Immunity
DOI 10.1016/j.immuni.2023.07.016
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  • HNOs that incorporate microglia promote maturation and provide unique advantages as in vitro neuroimmune models.

    “Despite the limitations of organoid-based models, HNOs that incorporate microglia promote maturation97 and provide unique advantages as in vitro neuroimmune models98–103, which are increasingly becoming utilized.”

    From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [99]

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Metadata

Authors
Han, C. Z., Li, R. Z., Hansen, E., Trescott, S., Fixsen, B. R., Nguyen, C. T., Mora, C. M., Spann, N. J., Bennett, H. R., Poirion, O., Buchanan, J., Warden, A. S., Xia, B., Schlachetzki, J. C. M., Pasillas, M. P., Preissl, S., Wang, A., O’Connor, C., Shriram, S., Kim, R., Schafer, D., Ramirez, G., Challacombe, J., Anavim, S. A., Johnson, A., Gupta, M., Glass, I. A., Levy, M. L., Haim, S. B., Gonda, D. D., Laurent, L., Hughes, J. F., Page, D. C., Blurton-Jones, M., Glass, C. K., & Coufal, N. G.
ORCID
Glass, Christopher K.
Venue
Immunity
Publisher
Elsevier BV
Published
2023-09
Volume
56
Issue
9
Pages
2152-2171.e13
ISSN
1074-7613
DOI
10.1016/j.immuni.2023.07.016
Cited by
84
References
44
Language
en
Licence
Funders
  • California Institute for Regenerative Medicine (SIG S10-OD023689, EDUC2-08388)
  • Cancer Research Institute
  • National Institute of Mental Health (K99 MH129983)
  • National Institute of Neurological Disorders and Stroke (R01 NS124637, NS126452, R01 NS096170)
  • Simons Foundation Autism Research Initiative (R01 NS124637, K08 NS109200)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (WO/2018/160496, 5R24HD000836)
  • School of Medicine, University of California, San Diego (S10 OD026929)
  • University of California, San Diego
  • Cure Alzheimer's Fund
  • Alzheimer's Association (ADSF-21-829655-C)
  • Doris Duke Charitable Foundation
  • The Chan Zuckerberg Initiative
  • National Institutes of Health (S10 OD026929)
  • National Cancer Institute (P30 014195, SIG S10-OD023689)
  • National Institute on Drug Abuse
  • JPB Foundation (KR29574)
  • Hartwell Foundation

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