The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.
Open accessAbstract
The extraction of phenolic compounds from walnut leaves (Juglans regia L.) was optimized using heat-assisted extraction and deep eutectic solvents based on choline chloride and carboxylic acids. A preliminary solvent screening was performed using a selected group of carboxylic acids as hydrogen bond donors, showing that the highest extraction yield of phenolic compounds was obtained using choline chloride mixtures with butyric or phenylpropionic acid at a mole ratio 1:2, with 20% of water (w/w). The extraction conditions (time, temperature and water proportion) were then optimized by an experimental design, assisted by response surface methodology. To evaluate the response, the three most abundant compounds identified by HPLC (neochlorogenic acid, quercetin 3-O-glucoside and quercetin O-pentoside) were quantified. Additionally, the solid/liquid ratio effect at the optimal conditions, in dose-response format, was studied in view of its upscale, not showing any significant decrease until 140 g/L. The results here presented provide valuable information towards the design of a process in a pre-industrial form for the extraction of phenolic compounds from J. regia leaves using deep eutectic solvents.
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“Different researches have demonstrated seaweed antioxidant capacity in vitro, attributed to the presence of new antioxidant compounds like carotenoids, certain polysaccharides, and polyphenols, which show scavenger activity, being able to neutralize those reactive oxygen species through their own oxidation, since their affinity to those oxidative compounds is very high [56,68,80,81,82,83,84,85].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [85]
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Novel Bioactive Compounds From Marine Sources as a Tool for Functional Food Development
Ghosh, S., Sarkar, T., Pati, S., Kari, Z. A., Edinur, H. A., & Chakraborty, R. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.832957 · Cited by 287
The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value
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Alam, M. A., Muhammad, G., Khan, M. N., Mofijur, M., Lv, Y., Xiong, W., & Xu, J. (2021) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2021.127445 · Cited by 269
Metadata
- Authors
- Vieira, V., Prieto, M. A., Barros, L., Coutinho, J. A. P., Ferreira, I. C. F. R., & Ferreira, O.
- Affiliations
- Universidade Politécnica de Bragança (PT)
- Laboratório Associado CICECO – Instituto de Materiais de Aveiro (PT)
- Corresponding author
- Ferreira, Isabel C.F.R.
- Ferreira, Olga
- ORCID
- Venue
- Industrial Crops and Products
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 115
- Pages
- 261-271
- ISSN
- 0926-6690 (ISSN-L)
- OpenAlex
- W2789362899
- Cited by
- 147
- References
- 42
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 19 · 2023: 20 · 2022: 25 · 2021: 18 · 2020: 19 · 2019: 15 · 2018: 4
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Industrial Crops and Products (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Investigo Institutional repository of UVigo (Universidade de Vigo) (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Ionic liquids properties and applications
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
- Keywords
- phenolic compounds, Juglans regia, walnut leaves, deep eutectic solvents, choline chloride, carboxylic acids, heat-assisted extraction, solvent screening, extraction optimization, neochlorogenic acid, quercetin glycosides, solid-to-liquid ratio, green extraction
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