Cited by 147Ionic liquids properties and applicationsPhytochemicals and Antioxidant ActivitiesAgricultural and Biological Research

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Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

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Vieira, Vanessa, Prieto, Miguel A., Barros, Lillian, Coutinho, João A.P., Ferreira, Isabel C.F.R., Ferreira, Olga·2018·Industrial Crops and Products

DOI 10.1016/j.indcrop.2018.02.029

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Abstract

The extraction of phenolic compounds from walnut leaves (Juglans regia L.) was optimized using heat-assisted extraction and deep eutectic solvents based on choline chloride and carboxylic acids. A preliminary solvent screening was performed using a selected group of carboxylic acids as hydrogen bond donors, showing that the highest extraction yield of phenolic compounds was obtained using choline chloride mixtures with butyric or phenylpropionic acid at a mole ratio 1:2, with 20% of water (w/w). The extraction conditions (time, temperature and water proportion) were then optimized by an experimental design, assisted by response surface methodology. To evaluate the response, the three most abundant compounds identified by HPLC (neochlorogenic acid, quercetin 3-O-glucoside and quercetin O-pentoside) were quantified. Additionally, the solid/liquid ratio effect at the optimal conditions, in dose-response format, was studied in view of its upscale, not showing any significant decrease until 140 g/L. The results here presented provide valuable information towards the design of a process in a pre-industrial form for the extraction of phenolic compounds from J. regia leaves using deep eutectic solvents.

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Authors: Vieira, V., Prieto, M. A., Barros, L., Coutinho, J. A. P., Ferreira, I. C. F. R., & Ferreira, O.
Affiliations: Universidade Politécnica de Bragança (PT)
Laboratório Associado CICECO – Instituto de Materiais de Aveiro (PT)
Corresponding author: Ferreira, Isabel C.F.R.
Ferreira, Olga
ORCID: Vieira, Vanessa
Prieto, Miguel A.
Barros, Lillian
Coutinho, João A.P.
Ferreira, Isabel C.F.R.
Ferreira, Olga
Venue: Industrial Crops and Products
Publisher: Elsevier BV
Published: 2018-05
Volume: 115
Pages: 261-271
ISSN: 0926-6690 (ISSN-L)
DOI: 10.1016/j.indcrop.2018.02.029
OpenAlex: W2789362899
Cited by: 147
References: 42
Citations by year: 2026: 8 · 2025: 19 · 2024: 19 · 2023: 20 · 2022: 25 · 2021: 18 · 2020: 19 · 2019: 15 · 2018: 4
FWCI: 3.35
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Industrial Crops and Products (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Investigo Institutional repository of UVigo (Universidade de Vigo) (submittedVersion)
Topics: Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Ionic liquids properties and applications
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
Keywords: phenolic compounds, Juglans regia, walnut leaves, deep eutectic solvents, choline chloride, carboxylic acids, heat-assisted extraction, solvent screening, extraction optimization, neochlorogenic acid, quercetin glycosides, solid-to-liquid ratio, green extraction

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Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

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