Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications.

Nishikawa, Takeshi; Araki, Eiichi

doi:10.1089/ars.2006.1458

Cited by 391Mitochondrial Function and PathologyNitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications.

Nishikawa, Takeshi, Araki, Eiichi·2007·Antioxidants & Redox Signaling

DOI 10.1089/ars.2006.1458

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Abstract

In this review, the impacts of mitochondrial reactive oxygen species (ROS) on diabetes and its complications are described. In endothelial cells, high-glucose treatment increases mitochondrial ROS and normalization of the ROS production by inhibitors of mitochondrial metabolism, or by overexpression of UCP-1 or MnSOD, prevents glucose-induced activation of PKC, formation of AGE, and accumulation of sorbitol, all of which are believed to be the main molecular mechanisms of diabetic complications. Glomerular hyperfiltration, one of the characteristics of early diabetic nephropathy, may be caused by mitochondrial ROS through activation of COX-2 gene transcription, followed by PGE2 overproduction. In pancreatic beta cells, hyperglycemia also increases mitochondrial ROS, which suppresses the first phase of glucose-induced insulin secretion, at least in part, through the suppression of GAPDH activity. In liver cells, similar to that in hyperglycemia, TNF-alpha increases mitochondrial ROS, which in turn activates apoptosis signal-regulating kinase 1 (ASK1) and c-jun NH2-terminal kinases (JNK), increases serine phosphorylation of IRS-1, and decreases insulin-stimulated tyrosine phosphorylation of IRS-1, leading to insulin resistance. These results suggest the importance of mitochondrial ROS in the pathogenesis of diabetes mellitus and its complications through modification of various cellular events in many tissues, including vessels, kidney, pancreatic beta cells, and liver.

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Chronically increased ROS production can induce β-cell death and result in gradual onset of diabetes.
“Chronically increased ROS production could also induce ␤-cell death and result in gradual onset of diabetes (249 -253).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [252]

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Authors: Nishikawa, T., & Araki, E.
Affiliations: Kumamoto University (JP)
ORCID: Nishikawa, Takeshi
Araki, Eiichi
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2007-03
Volume: 9
Issue: 3
Pages: 343-353
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2006.1458
OpenAlex: W2036467841
Cited by: 391
References: 116
Citations by year: 2026: 12 · 2025: 7 · 2024: 20 · 2023: 9 · 2022: 21 · 2021: 21 · 2020: 29 · 2019: 22 · 2018: 24 · 2017: 19 · 2016: 18 · 2015: 23 · 2014: 24 · 2013: 23 · 2012: 26
FWCI: 1.62
Type: journal article
Language: en
Open access: closed
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
Funders: Takeda Science Foundation
Japan Society for the Promotion of Science
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: mitochondrial reactive oxygen species, diabetes mellitus, diabetes complications, diabetic nephropathy, glomerular hyperfiltration, cyclooxygenase-2, prostaglandin E2, pancreatic beta cells, insulin secretion, glyceraldehyde-3-phosphate dehydrogenase, endothelial cells, advanced glycation end products, sorbitol, insulin resistance, IRS-1 serine phosphorylation, ASK1, JNK, TNF-α, UCP1, manganese superoxide dismutase, protein kinase C
MeSH terms: Blood Glucose, Diabetes Mellitus, Type 2, Electron Transport, Humans, Insulin Resistance, Islets of Langerhans, Mitochondria, Multienzyme Complexes, Protein Serine-Threonine Kinases, Reactive Oxygen Species, AMP-Activated Protein Kinases

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Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications.

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