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Cited by 41Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesFrailty in Older Adults

TAVR in Older Adults

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Damluji, Abdulla A., Bernacki, Gwen, Afilalo, Jonathan, Lyubarova, Radmila, Orkaby, Ariela R., Kwak, Min Ji, Hummel, Scott, Kirkpatrick, James N. +7 more·2024·JACC: Advances
DOI 10.1016/j.jacadv.2024.100877PMC PMC11062620
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Abstract

Calcific aortic stenosis can be considered a model for geriatric cardiovascular conditions due to a confluence of factors. The remarkable technological development of transcatheter aortic valve replacement was studied initially on older adult populations with prohibitive or high-risk for surgical valve replacement. Through these trials, the cardiovascular community has recognized that stratification of these chronologically older adults can be improved incrementally by invoking the concept of frailty and other geriatric risks. Given the complexity of the aging process, stratification by chronological age should only be the initial step but is no longer sufficient to optimally quantify cardiovascular and noncardiovascular risk. In this review, we employ a geriatric cardiology lens to focus on the diagnosis and the comprehensive management of aortic stenosis in older adults to enhance shared decision-making with patients and their families and optimize patient-centered outcomes. Finally, we highlight knowledge gaps that are critical for future areas of study.

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  • Aging and chronic diseases such as cardiovascular disease are two principal risk factors for the wasting continuum, and these conditions adversely influence outcomes for older adults with cardiovascular disease at greater risk of disability and mortality.

    “Aging and chronic diseases such as CVD are 2 principal risk factors for the wasting continuum, and these conditions adversely influence outcomes for older adults with CVD at greater risk of disability and mortality.91,92”

    From Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association (2026) · cites this paper as [91]

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Authors
Damluji, A. A., Bernacki, G., Afilalo, J., Lyubarova, R., Orkaby, A. R., Kwak, M. J., Hummel, S., Kirkpatrick, J. N., Maurer, M. S., Wenger, N., Rich, M. W., Kim, D. H., Wang, R. Y., Forman, D. E., & Krishnaswami, A.
Affiliations
  • Inova Health System (US)
  • University of Washington (US)
  • McGill University (CA)
  • Albany Medical College (US)
  • Brigham and Women's Hospital (US)
  • The University of Texas Health Science Center at Houston (US)
  • University of Michigan (US)
  • Columbia University Irving Medical Center (US)
  • Emory University (US)
  • Washington University in St. Louis (US)
  • Harvard University (US)
  • Santa Clara Valley Medical Center (US)
  • University of Pittsburgh (US)
  • Kaiser Permanente San Jose Medical Center (US)
Corresponding author
Damluji, Abdulla A.
ORCID
Venue
JACC: Advances
Publisher
Elsevier BV
Published
2024-04
Volume
3
Issue
4
Pages
100877
ISSN
2772-963X (ISSN-L)
DOI
10.1016/j.jacadv.2024.100877
PMC
PMC11062620
OpenAlex
W4394569714
Cited by
41
References
7
Citations by year
2026: 14 · 2025: 21 · 2024: 6
FWCI
12.33
Type
journal article
Language
en
Open access
Licence
Locations
  • JACC Advances (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Digital Commons-TMC (Texas Medical Center) (submittedVersion)
Funders
NHLBI
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords
transcatheter aortic valve implantation, calcific aortic stenosis, older adults, frailty, geriatric cardiology, risk stratification, shared decision-making, patient-centered outcomes

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