Artificial Intelligence in Cardiovascular Care—Part 2: Applications
Open accessAbstract
Recent artificial intelligence (AI) advancements in cardiovascular care offer potential enhancements in effective diagnosis, treatment, and outcomes. More than 600 U.S. Food and Drug Administration-approved clinical AI algorithms now exist, with 10% focusing on cardiovascular applications, highlighting the growing opportunities for AI to augment care. This review discusses the latest advancements in the field of AI, with a particular focus on the utilization of multimodal inputs and the field of generative AI. Further discussions in this review involve an approach to understanding the larger context in which AI-augmented care may exist, and include a discussion of the need for rigorous evaluation, appropriate infrastructure for deployment, ethics and equity assessments, regulatory oversight, and viable business cases for deployment. Embracing this rapidly evolving technology while setting an appropriately high evaluation benchmark with careful and patient-centered implementation will be crucial for cardiology to leverage AI to enhance patient care and the provider experience.
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The US FDA has a new digital health innovation plan that proposes a pragmatic risk-based approach to regulate software and wearable medical devices through precertification programs.
“Currently, the US Food and Drug Administration has a new digital health innovation plan that proposes a pragmatic risk-based approach to regulate software and wearable medical devices through precertification programs that aim to assess and determine appropriate product development.52”
From Unlocking Tomorrow’s Health Care: Expanding the Clinical Scope of Wearables by Applying Artificial Intelligence (2024) · cites this paper as [52]
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Artificial Intelligence in the Management of Heart Failure
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Artificial Intelligence for Cardiovascular Care in Action
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Digital Therapeutics in Cardiovascular Healthcare: A Narrative Review
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Artificial Intelligence-Enabled Electrocardiography in Practice: A State-of-the-Art Review
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Self-citationMultimodal Generative AI in Diagnostics: Bridging Medical Imaging and Clinical ReasoningPreprint
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Current and future use of artificial intelligence in valvular heart disease imaging
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Self-citationMachine Learning in Postcardiotomy Shock: Implications for Temporary Mechanical Circulatory Support
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Artificial intelligence: a promising tool for the clinical cardiologist
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Ethical Challenges and Current Opportunities of Artificial Intelligence in Cardiology
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The role of artificial intelligence in early detection and risk prediction of ischemic heart disease
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Contemporary Multi-modality Imaging of Prosthetic Aortic Valves
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Artificial Intelligence in Predicting Sudden Cardiac Death
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Guiding the AI Revolution in Cardiovascular Medicine
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AI-driven Innovations in Cardiology: A Comprehensive Review of Effectiveness and Challenges
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AI-ECG Detection of Structural Heart Disease in the Community Setting
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Cardiology and Humanism in the Age of Artificial Intelligence: A Challenge to Become More Human
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Artificial Intelligence-Assisted PCI
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Embracing Artificial Intelligence in Cardiovascular Disease Fellowship
Derector, E., & Ricketti, D. A. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.101709
(2025) · International Journal of Integrative Cardiology · doi:10.47275/2690-862x-152
Advances in Artificial Intelligence-Assisted Diagnosis (AI) in Ultrasound
Jianglei, X., Xinyu, L., Xuan, Z. Y., Qian, Z., Xue, S., Yanling, Z., & Liu, C. (2025) · International Journal of Biomedical Science and Engineering · doi:10.11648/j.ijbse.20251303.13
Novel Artificial Intelligence Applications in Heart Transplantation
Richter, I., Raikhelkar, J., Clerkin, K. J., DeFilippis, E. M., Estrin, D. L., Lotan, D., ELAD, B., Sayer, G. T., & Uriel, N. (2025) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.11.012
Artificial Intelligence in heart and brain ultrasound: the least you need to know
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Comparative performance of large language models on cardiovascular certification simulation exam
Nachnani, E., Goel, K., & Sullivan, A. E. (2026) · American Heart Journal · doi:10.1016/j.ahj.2026.107353
Gao, M., Luo, Y., & Guo, R. (2026) · Nano Research · doi:10.26599/nr.2026.94908440
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Artificial intelligence in early heart failure detection: from algorithms to bedside integration
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Harnessing RAG in Heart Failure Risk
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AI–driven models for early detection and prevention of cardiovascular diseases
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CardioFusionNet: A Multimodal Deep Learning Framework for Enhanced Coronary Artery Disease Diagnosis
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AI-Driven Ultrasound: Automation, Image Interpretation and Decision Support
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ПОРІВНЯЛЬНИЙ АНАЛІЗ МЕТРИК ЗВ'ЯЗНОСТІ КОМПОНЕНТІВ МІКРОСЕРВІСНИХ СИСТЕМ
Лахай, В., & Seniv, M. (2026) · doi:10.64828/conf-122-2026-9
ЗНАЧЕННЯ MODIC-ЗМІН У ВИБОРІ МЕТОДУ ХІРУРГІЧНОГО ЛІКУВАННЯ ГРИЖ ПОПЕРЕКОВОГО ВІДДІЛУ ХРЕБТА
Слинько, Є., & Chamata, R. (2026) · doi:10.64828/conf-122-2026-4
КЛІНІКО-РЕНТГЕНОЛОГІЧНЕ ОБҐРУНТУВАННЯ ЗАСТОСУВАННЯ КЕЙДЖІВ ПРИ ГРИЖАХ ПОПЕРЕКОВОГО ВІДДІЛУ ХРЕБТА
Слинько, Є., & Chamata, R. (2026) · doi:10.64828/conf-122-2026-3
Бондаренко, В. В., Khudyakova, S. N., & Кондратюк, Н. В. (2026) · doi:10.64828/conf-122-2026-6
МЕХАНІЗМ АВТОНОМНОЇ ПОСАДКИ ДРОНА НА ГІЛКУ ЯК ПРИКЛАД БІОНІЧНОГО ІНЖЕНЕРНОГО РІШЕННЯ
Івасина, О., Михайлюк, В., Солодуха, Є., & ФОМЕНКО, А. (2026) · doi:10.64828/conf-122-2026-1
АФІКСАЛЬНИЙ СПОСІБ ТВОРЕННЯ ОКАЗІОНАЛІЗМІВ У ТЕКСТАХ РЕКЛАМИ ДЛЯ ДІТЕЙ
Кравченко, Л., & Лавринчук, Ю. (2026) · doi:10.64828/conf-122-2026-10
НОВИЙ ХЕМОСЕНСОР ДЛЯ ЧУТЛИВОГО ТА СЕЛЕКТИВНОГО ВИЗНАЧЕННЯ ПАЛАДІЮ ТА СРІБЛА У ЇХ СУМІШАХ
Khudyakova, S. N., Smagin, I., & Кондратюк, Н. В. (2026) · doi:10.64828/conf-122-2026-8
Батрун, І. (2026) · doi:10.64828/conf-122-2026-7
ПІСЛЯОПЕРАЦІЙНА ДИНАМІКА БОЛЬОВОГО СИНДРОМУ ПІСЛЯ ДЕКОМПРЕСИВНИХ ТА СТАБІЛІЗУЮЧИХ ВТРУЧАНЬ
Слинько, Є., & Chamata, R. (2026) · doi:10.64828/conf-122-2026-5
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Achieving Equity in Generative Artificial Intelligence in Cardiovascular Medicine
Kulkarni, A., & Visweswaran, S. (2026) · JACC Advances · doi:10.1016/j.jacadv.2026.102967
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Artificial intelligence, preventive cardiology and making time for what matters: a fellow’s voice
Lopes, R. A. (2026) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2026.101754
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ARTIFICIAL INTELLIGENCE IN THE DIAGNOSIS, TREATMENT AND PROGNOSIS OF CARDIOVASCULAR DISEASES
Soboleva, M. A., Kargaev, O. G., Chekurishvili, M. A., Tedeeva, M. V., Gopantsov, I. V., Zakaryan, N. G., Babayan, A. A., Tsogoeva, D. A., Tsagaraev, A. B., Yuzbasheva, V. E., et al. (2026) · Complex Issues of Cardiovascular Diseases · doi:10.17802/2306-1278-2026-15-4-225-241
Large language models as integrative intelligence for multimodal cardiovascular decision support
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Pharmacist-Led Medication Titration for Cardiometabolic Disease: Evidence, Equity, and Scale
Yarlagadda, S., & Blood, A. J. (2026) · Current Cardiology Reports · doi:10.1007/s11886-026-02432-x
Angina with Non-obstructive Coronary Arteries: Diagnostic Evaluation and Endotype-guided Management
Reddy, T. K., Sejo, C. S., Garber, R., Kassab, J. T., Gangavelli, A., Donisan, T., Vasilakis, G. M., & Raphael, C. E. (2026) · US Cardiology Review · doi:10.15420/usc.2026.02
- Authors
- Jain, S. S., Elias, P., Poterucha, T., Randazzo, M., Lopez Jimenez, F., Khera, R., Perez, M., Ouyang, D., Pirruccello, J., Salerno, M., Einstein, A. J., Avram, R., Tison, G. H., Nadkarni, G., Natarajan, V., Pierson, E., Beecy, A., Kumaraiah, D., Haggerty, C., Avari Silva, J. N., & Maddox, T. M.
- Affiliations
- Stanford Medicine (US)
- Columbia University Irving Medical Center (US)
- University of Chicago Medical Center (US)
- Yale University (US)
- Cedars-Sinai Medical Center (US)
- University of California, San Francisco (US)
- Montreal Heart Institute (CA)
- Icahn School of Medicine at Mount Sinai (US)
- Google (United States) (US)
- Cornell Tech (US)
- NewYork–Presbyterian Hospital (US)
- Washington University in St. Louis (US)
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2024-06
- Volume
- 83
- Issue
- 24
- Pages
- 2487-2496
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC12215878
- OpenAlex
- W4394061293
- Cited by
- 74
- References
- 76
- Citations by year
- 2026: 27 · 2025: 35 · 2024: 12
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, other-oa)
- Funders
- National Institutes of Health (1s10od026880-01, 1s10od030463-01)
- National Heart, Lung, and Blood Institute (UG3HL165065, K08HL159346)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
- Physical Sciences › Computer Science › Artificial Intelligence › Artificial Intelligence Applications
- Keywords
- artificial intelligence in cardiology, cardiovascular care, multimodal data, generative AI, AI evaluation, regulatory oversight, diagnosis and treatment
- MeSH terms
- Artificial Intelligence, Cardiology, Cardiovascular Diseases, Humans
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