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Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis
Open accessAbstract
BACKGROUND: Atopic dermatitis (AD) is a serious global epidemic associated with a modern lifestyle. OBJECTIVE: Although aberrant interactions between gut microbes and the intestinal immune system have been implicated in this skin disease, the nature of the microbiome dysfunction underlying the disease remains unclear. METHODS: The gut microbiome from 132 subjects, including 90 patients with AD, was analyzed by using 16S rRNA gene and metagenome sequence analyses. Reference genomes from the Human Microbiome Project and the KEGG Orthology database were used for metagenome analyses. Short-chain fatty acids in fecal samples were compared by using gas chromatographic-mass spectrometric analyses. RESULTS: We show that enrichment of a subspecies of the major gut species Faecalibacterium prausnitzii is strongly associated with AD. In addition, the AD microbiome was enriched in genes encoding the use of various nutrients that could be released from damaged gut epithelium, reflecting a bloom of auxotrophic bacteria. Fecal samples from patients with AD showed decreased levels of butyrate and propionate, which have anti-inflammatory effects. This is likely a consequence of an intraspecies compositional change in F prausnitzii that reduces the number of high butyrate and propionate producers, including those related to the strain A2-165, a lack of which has been implicated in patients with Crohn disease. CONCLUSIONS: The data suggest that feedback interactions between dysbiosis in F prausnitzii and dysregulation of gut epithelial inflammation might underlie the chronic progression of AD by resulting in impairment of the gut epithelial barrier, which ultimately leads to aberrant TH2-type immune responses to allergens in the skin.
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“Gut dysbiosis has been observed in conditions such as atopic dermatitis [82].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [82]
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Background
Metadata
- Authors
- Song, H., Yoo, Y., Hwang, J., Na, Y.-C., & Kim, H. S.
- Affiliations
- Korea University (KR)
- Korea Basic Science Institute (KR)
- Corresponding author
- Kim, Heenam Stanley
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 137
- Issue
- 3
- Pages
- 852-860
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W1822404940
- Cited by
- 416
- References
- 61
- Citations by year
- 2026: 27 · 2025: 40 · 2024: 64 · 2023: 57 · 2022: 43 · 2021: 55 · 2020: 28 · 2019: 28 · 2018: 39 · 2017: 18 · 2016: 16
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- atopic dermatitis, Faecalibacterium prausnitzii, gut dysbiosis, short-chain fatty acids, butyrate, propionate, intestinal epithelial barrier, Th2 immune response, Crohn's disease, intestinal immune regulation
- MeSH terms
- Eubacteriales, Gastrointestinal Microbiome, Dermatitis, Atopic, Feces, Female, Humans, Male, Models, Biological, Phylogeny, RNA, Ribosomal, 16S, Cluster Analysis, Sequence Analysis, DNA, Computational Biology, Metagenome, Metagenomics, Dysbiosis
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