Cultured Representatives of Two Major Phylogroups of Human Colonic Faecalibacterium prausnitzii Can Utilize Pectin, Uronic Acids, and Host-Derived Substrates for Growth
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Faecalibacterium prausnitzii is one of the most abundant commensal bacteria in the healthy human large intestine, but information on genetic diversity and substrate utilization is limited. Here, we examine the phylogeny, phenotypic characteristics, and influence of gut environmental factors on growth of F. prausnitzii strains isolated from healthy subjects. Phylogenetic analysis based on the 16S rRNA sequences indicated that the cultured strains were representative of F. prausnitzii sequences detected by direct analysis of fecal DNA and separated the available isolates into two phylogroups. Most F. prausnitzii strains tested grew well under anaerobic conditions on apple pectin. Furthermore,F. prausnitzii strains competed successfully in coculture with two other abundant pectin-utilizing species,Bacteroides thetaiotaomicron and Eubacterium eligens, with apple pectin as substrate, suggesting that this species makes a contribution to pectin fermentation in the colon. Many F. prausnitzii isolates were able to utilize uronic acids for growth, an ability previously thought to be confined to Bacteroides spp. among human colonic anaerobes. Most strains grew on N-acetylglucosamine, demonstrating an ability to utilize host-derived substrates. All strains tested were bile sensitive, showing at least 80% growth inhibition in the presence of 0.5 μg/ml bile salts, while inhibition at mildly acidic pH was strain dependent. These attributes help to explain the abundance of F. prausnitzii in the colonic community but also suggest factors in the gut environment that may limit its distribution.
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Butyrate is a key energy source for intestinal epithelial cells and contributes to barrier integrity, T-cell regulation, pathogen resistance, inflammatory response, and metabolic homeostasis.
“Butyrate is a key energy source for intestinal epithelial cells and contributes to barrier integrity, T-cell regulation, pathogen resistance, inflammatory response, and metabolic homeostasis. 36,37”
From Comparative Genomic Insights into Pangenome Diversity and Functional Adaptation of Akkermansia and Faecalibacterium as Gut-Associated Next-Generation Probiotics: A Systematic Review (2026) · cites this paper as [36]
The paper’s introductory discussion (page not supplied) describes butyrate as the preferred energy source for colonocytes and says its effects on inflammation benefit intestinal health. It does not address barrier integrity, T-cell regulation, pathogen resistance, or metabolic homeostasis. (LLM, conf=0.89)
Experimental — accuracy not yet measuredCultured representatives of major Faecalibacterium prausnitzii phylogroups have been shown to use pectin, uronic acids, and host-derived substrates, supporting their role as anaerobic fermenters in the intestinal ecosystem.
“In contrast, cultured representatives of major Faecalibacterium prausnitzii phylogroups have been shown to use pectin, uronic acids, and host-derived substrates, supporting their role as anaerobic fermenters in the intestinal ecosystem. 36”
Interaction between bile acids and gut microbiota can reduce relative abundance of Faecalibacterium spp.
“This interaction can impact the composition of the gut microbiota including reductions in the relative abundance of Faecalibacterium spp. [233].”
From The athletic gut microbiota (2020) · cites this paper as [233]
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New Insights into the Diversity of the Genus Faecalibacterium
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- Authors
- Lopez-Siles, M., Khan, T. M., Duncan, S. H., Harmsen, H. J. M., Garcia-Gil, L. J., & Flint, H. J.
- Affiliations
- Grup de Microbiologia Clínica i Malalties Infeccioses, Departament de Biologia, Facultat de Ciències, Universitat de Girona, Girona, Spain
- University Medical Center Groningen (NL)
- University of Aberdeen (GB)
- Universitat de Girona (ES)
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2012-01-15
- Volume
- 78
- Issue
- 2
- Pages
- 420-428
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC3255724
- OpenAlex
- W2027222165
- Cited by
- 433
- References
- 62
- Citations by year
- 2026: 18 · 2025: 35 · 2024: 34 · 2023: 37 · 2022: 40 · 2021: 35 · 2020: 43 · 2019: 42 · 2018: 32 · 2017: 27 · 2016: 17 · 2015: 24 · 2014: 21 · 2013: 20 · 2012: 7
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Repositori UJI (Universitat Jaume I) (acceptedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, public-domain)
- Funders
- European Commission
- Generalitat de Catalunya
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- Faecalibacterium prausnitzii, phylogenetic groups, uronic acid, N-acetylglucosamine, anaerobic growth, Bacteroides thetaiotaomicron, Eubacterium eligens, colonic microbiota, 16S rRNA phylogeny, pH tolerance
- MeSH terms
- Acetylglucosamine, Anti-Bacterial Agents, Bile, DNA, Bacterial, DNA, Ribosomal, Gram-Positive Bacteria, Humans, Hydrogen-Ion Concentration, Intestine, Large, Microbial Sensitivity Tests, Molecular Sequence Data, Pectins, Phylogeny, RNA, Ribosomal, 16S, Uronic Acids, Genetic Variation, Cluster Analysis, Sequence Analysis, DNA, Malus
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