Cited by 71Fatty Acid Research and HealthLipoproteins and Cardiovascular HealthLipid metabolism and disorders

Effects of prescription omega-3-acid ethyl esters on lipoprotein particle concentrations, apolipoproteins AI and CIII, and lipoprotein-associated phospholipase A2 mass in statin-treated subjects with hypertriglyceridemia

Davidson, Michael H., Maki, Kevin C., Bays, Harold, Carter, Roderick, Ballantyne, Christie M.·2009·Journal of Clinical Lipidology

Abstract

Background Prescription omega-3-acid ethyl esters (P-OM3) often are used for hypertriglyceridemic patients receiving statin therapy who have residual increases in atherogenic lipoprotein lipid levels. To date, limited information has been published regarding the effects of omega-3 fatty acid consumption on lipoprotein particle concentrations. Objective We evaluated the effects of adding P-OM3 4g/d to an ongoing regimen of simvastatin 40mg/d on lipoprotein particles (P) in subjects with hypertriglyceridemia. Methods Data were analyzed from the multicenter, randomized, double-blind, placebo-controlled Combination of Prescription Omega-3s with Simvastatin (COMBOS) study. After an 8-week simvastatin lead-in, 254 subjects received P-OM3 (n=122) or placebo (n=132) for an additional 8 weeks. Nuclear magnetic resonance spectroscopy was used to assess lipoprotein concentrations and sizes. Remnant-like particle cholesterol, apolipoprotein (Apo) CIII, Apo AI, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) levels also were measured. Results Compared with placebo, P-OM3 reduced mean very-low-density lipoprotein (VLDL-P) size and increased low-density lipoprotein particle (LDL-P) size (P Conclusions P-OM3 induces changes in sizes, concentrations, and compositions of lipoproteins that may have relevance for the atherothrombotic process.

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Crossref · 10.1016/j.jacl.2009.08.001

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Authors
Davidson, M. H., Maki, K. C., Bays, H., Carter, R., & Ballantyne, C. M.
Affiliations
  • University of Chicago (US)
  • Louisville Metabolic and Atherosclerosis Research Center (US)
  • Baylor College of Medicine (US)
Corresponding author
Davidson, Michael H.
Venue
Journal of Clinical Lipidology
Publisher
Elsevier BV
Published
2009-10
Volume
3
Issue
5
Pages
332-340
ISSN
  • 1876-4789 (ISSN-L)
  • 1933-2874
OpenAlex
W2066530607
Cited by
71
References
43
Citations by year
2026: 2 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 9 · 2015: 13 · 2014: 4 · 2013: 8 · 2012: 5
FWCI
5.15
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of clinical lipidology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
hypertriglyceridemia, simvastatin, statin therapy, lipoprotein particle size, remnant-like particle cholesterol, apolipoprotein C-III, apolipoprotein A-I, lipoprotein-associated phospholipase A2, VLDL, intermediate density lipoprotein, HDL particle size

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