Manganese superoxide dismutase gene expression and cognitive functions in recurrent depressive disorder
Abstract
Background: Recent studies have revealed that recurrent depressive disorders (rDD) are linked with dysregulation of the immune system. Previous studies have found that manganese superoxide dismutase (MnSOD, SOD2) may be a key inflammatory enzyme involved in this disorder. The purpose of this study was to determine the mRNA and protein levels of MnSOD in patients with rDD and to define the relationship between serum MnSOD levels and cognitive performance. Methods: The study comprised 236 subjects, which included patients with rDD (n = 131) and healthy subjects (n = 105, healthy control group, HC). Assessment of cognitive function was based on performance on the Trail Making test (TMT), the Stroop test, the Verbal Fluency test (VFT) and the Auditory Verbal Learning test (AVLT). Results: MnSOD gene expression at mRNA and protein level was significantly lower in rDD patients than in the HC group (p < 0.01). In the rDD and HC groups separately, there were no statistically significant associations between mRNA and protein expression levels of the MnSOD and psychological tests. In the total study group (n = 236), there was a statistically significant correlation between both MnSOD gene levels and the following tests (p < 0.01): the TMT parts A and B (negative correlation), the Stroop test parts RCNb (reading color names in black) and NCWd (naming color of word - different; negative correlation), the VFT (positive correlation) and the AVLT (positive correlation). Conclusions: Our study provides evidence that the MnSOD enzyme-coding gene and MnSOD expression are important for the regulation of cognitive functioning.
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Higher oxidative stress, lower antioxidants, and more oxidative stress-related DNA/RNA damage are linked to clinical markers of major depressive disorder progression such as greater chronicity, more episodes, and treatment resistance.
“greater oxidative stress, lower antioxidant, and greater oxidative stress-related DNA/RNA damage have been linked to clinical markers of MDD illness progression, including greater chronicity, more MDEs, and treatment resistance (98,108–113).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [113]
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- Authors
- Talarowska, M., Orzechowska, A., Szemraj, J., Su, K.-P., Maes, M., & Gałecki, P.
- Affiliations
- Medical University of Lodz (PL)
- China Medical University Hospital (TW)
- Deakin University (AU)
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 70
- Issue
- 1
- Pages
- 23-28
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W1576524074
- Cited by
- 28
- References
- 39
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 3
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- manganese superoxide dismutase, recurrent depression, gene expression, cognitive function, inflammation, immune dysregulation, executive function, verbal fluency, auditory verbal learning, Stroop task, Trail Making Test, oxidative stress
- MeSH terms
- Acoustic Stimulation, Adult, Association, Cognition Disorders, Depressive Disorder, Enzyme-Linked Immunosorbent Assay, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, RNA, Messenger, Spectrophotometry, Superoxide Dismutase, Verbal Learning
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