Elevated IL-6 levels in patients with atypical depression but not in patients with typical depression

Rudolf, Sebastian; Greggersen, Wiebke; Kahl, Kai Gustav; Hüppe, Michael; Schweiger, Ulrich

doi:10.1016/j.psychres.2014.02.016

Cited by 71Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

Elevated IL-6 levels in patients with atypical depression but not in patients with typical depression

Rudolf, Sebastian, Greggersen, Wiebke, Kahl, Kai Gustav, Hüppe, Michael, Schweiger, Ulrich·2014·Psychiatry Research

DOI 10.1016/j.psychres.2014.02.016

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Abstract

Elevated levels of the proinflammatory cytokine Interleukin-6 (IL-6) are among the most consistent findings in patients with major depressive disorder (MDD). Additionally, some evidence suggests that elevated cytokine levels in patients with major depression are responsible for the development of metabolic syndrome in patients suffering from MDD. Therefore, the aim of the study was to examine the concentrations of IL-6 in specific subtypes of MDD and to investigate their relationship to metabolic factors. Twenty-four patients with typical (24) and atypical (eight) major depression according to DSM-IV criteria were studied and compared to 24 normal controls. Blood samples were collected during a stepwise glucose-clamp procedure, and IL-6 concentrations were measured by high sensitivity ELISA. IL-6 levels were elevated in patients suffering from atypical depression but not in patients with typical depression, compared to normal controls. IL-6 correlated significantly with HbA1c, insulin, waist girth, BMI, number of alcoholic drinks per week and C-reactive protein. Our data indicate that high concentrations of IL-6 during the glucose clamp may be limited to the atypical subgroup of patients with MDD.

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Authors: Rudolf, S., Greggersen, W., Kahl, K. G., Hüppe, M., & Schweiger, U.
Affiliations: University of Lübeck (DE)
Medizinische Hochschule Hannover (DE)
Corresponding author: Rudolf, Sebastian
ORCID: Rudolf, Sebastian
Kahl, Kai Gustav
Schweiger, Ulrich
Venue: Psychiatry Research
Publisher: Elsevier BV
Published: 2014-06
Volume: 217
Issue: 1-2
Pages: 34-38
ISSN: 0165-1781 (ISSN-L)
DOI: 10.1016/j.psychres.2014.02.016
OpenAlex: W2094591316
Cited by: 71
References: 55
Citations by year: 2026: 3 · 2025: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 9 · 2015: 4 · 2014: 4
FWCI: 2.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: interleukin-6, atypical depression, major depressive disorder, inflammatory cytokines, metabolic syndrome, glucose clamp, insulin, C-reactive protein, HbA1c, waist circumference, body mass index, alcohol consumption
MeSH terms: Adult, Alcohol Drinking, C-Reactive Protein, Major Depressive Disorder, Female, Glycated Hemoglobin, Humans, Male, Glucose Clamp Technique, Interleukin-6, Body Mass Index, Case-Control Studies, Metabolic Syndrome

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Elevated IL-6 levels in patients with atypical depression but not in patients with typical depression

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