The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide
Abstract
Background Brain-derived neurotrophic factor (BDNF) mediates neural plasticity, mood, different behaviours, and stress response. A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies. The study evaluated the association between BDNF Val66Met variants and suicide, committed with violent or non-violent methods, in victims with or without stressful childhood experience.Methods BDNF Val66Met polymorphism was genotyped on 560DNA samples from 359 suicide victims and 201 control subjects collected on autopsy from unrelated Caucasian subjects and subdivided according to gender, method of suicide, and influence of childhood adversity.Results A similar frequency of BDNF Val66Met variants was found between all included suicide victims and the control groups, and also between the male groups. The frequency of the combined Met/Met and Met/Val genotypes and the homozygous Val/Val genotype was significantly different between the female suicide victims and female controls, between the female suicide victims who used violent suicide methods and female controls, and between all included suicide victims with or without stressful life events. The combined Met/Met and Met/Val genotypes contributed to this significance.Limitation A small group of suicide victims with available data on childhood adversity was studied.Conclusions The combined Met/Met and Met/Val genotypes of the BDNF Val66Met variant could be the risk factor for violent suicide in female subjects and for suicide in victims exposed to childhood trauma. These results confirm a major role of BDNF in increased vulnerability to suicide.
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The BDNF gene Met allele increases risk for suicidal behavior, particularly in depressed individuals and those exposed to early-life stress, where it may act by loss of ACC volume and altered decision-making or depression circuitry.
“The BDNF gene Met allele, a part of BDNF functional polymorphism (rs6265), increases the risk for suicidal behavior (183, 184), particularly in depressed individuals (185) and in those exposed to early-life stress (186, 187), where it may do so by loss of ACC volume (188) and altered decision-making or depression circuitry.”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [186]
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- Authors
- Pregelj, P., Nedic, G., Paska, A. V., Zupanc, T., Nikolac, M., Balažic, J., Tomori, M., Komel, R., Seler, D. M., & Pivac, N.
- Affiliations
- University Psychiatric Hospital (SI)
- University of Ljubljana (SI)
- Ruđer Bošković Institute (HR)
- Corresponding author
- Pivac, Nela
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 128
- Issue
- 3
- Pages
- 287-290
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2058147190
- Cited by
- 88
- References
- 21
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 6 · 2015: 10 · 2014: 3 · 2013: 12 · 2012: 11
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of the Ruđer Bošković Institute (Ruđer Bošković Institute) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, suicide, violent suicide methods, childhood adversity, life events, sex differences, genetic risk factors, suicide vulnerability
- MeSH terms
- Alleles, Child, Child Abuse, Female, Genotype, Humans, Life Change Events, Male, Middle Aged, Risk Factors, Suicide, Violence, Brain-Derived Neurotrophic Factor, Polymorphism, Single Nucleotide, Genetic Association Studies
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