Association of Polymorphism (Val66Met) of Brain-Derived Neurotrophic Factor with Suicide Attempts in Depressed Patients
Abstract
Introduction: Recent post-mortem studies of suicide victims have implicated brain-derived neurotrophic factor (BDNF) in suicide. Therefore, it was decided to examine the possible role of a gene in the regulation of BDNF activity in relation to suicidal behaviour among depressed patients. Method: A series of 170 depressed patients were evaluated for their history of suicide attempts and genotyped for the BDNF Val66Met polymorphism (SNP ID: rs6265). Depressed patients who had (n = 97) or had not (n = 73) attempted suicide were compared. Results: Depressed patients who carried the BDNF Val66Met polymorphism variant (GA + AA) appeared to show a significantly increased risk of suicidal behaviour. The risk of a suicide attempt was also significantly higher among those reporting higher levels of childhood emotional, physical and sexual abuse. Secondary analyses suggested that depression severity was a significant risk factor only in the wild-type BDNF genotype, and that the risk of suicide attempts was more predictable within the wild-type group. Conclusion: These preliminary data suggest that BDNF may play a role in the suicidal behaviour of depressed patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The BDNF gene Met allele increases risk for suicidal behavior, particularly in depressed individuals and those exposed to early-life stress, where it may act by loss of ACC volume and altered decision-making or depression circuitry.
“The BDNF gene Met allele, a part of BDNF functional polymorphism (rs6265), increases the risk for suicidal behavior (183, 184), particularly in depressed individuals (185) and in those exposed to early-life stress (186, 187), where it may do so by loss of ACC volume (188) and altered decision-making or depression circuitry.”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [185]
Cites
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007) · Behavior Research Methods · doi:10.3758/bf03193146 · Cited by 65,971 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
Initial reliability and validity of a new retrospective measure of child abuse and neglect
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.8.1132 · Cited by 3,577 · see citing works
Davenport, Y. B., Adland, M. L., Gold, P. W., & Goodwin, F. K. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92810-1 · Cited by 2,925 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Toward a clinical model of suicidal behavior in psychiatric patients
Mann, J. J., Waternaux, C., Haas, G. L., & Malone, K. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.181 · Cited by 1,791 · cited 1× · see citing works
“The generally accepted model of suicide risk is the stress-diathesis risk factor model [”
BackgroundValidity of the Childhood Trauma Questionnaire in an Adolescent Psychiatric Population
BERNSTEIN, D. P., AHLUVALIA, T., POGGE, D., & HANDELSMAN, L. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199703000-00012 · Cited by 1,574 · see citing works
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works
FERGUSSON, D. M., WOODWARD, L. J., & HORWOOD, L. J. (2000) · Psychological Medicine · doi:10.1017/s003329179900135x · Cited by 832 · see citing works
Kaufman, J., Yang, B.-Z., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., Krystal, J. H., & Gelernter, J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.026 · Cited by 692 · see citing works
FERGUSSON, D. M., HORWOOD, L. J., & WOODWARD, L. J. (2000) · Psychological Medicine · doi:10.1017/s0033291799002111 · Cited by 655 · see citing works
Karege, F., Vaudan, G., Schwald, M., Perroud, N., & La Harpe, R. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.020 · Cited by 600 · see citing works
BDNF in schizophrenia, depression and corresponding animal models
Angelucci, F., Brené, S., & Mathé, A. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001637 · Cited by 548 · see citing works
IDENTIFICATION OF SUICIDE RISK FACTORS USING EPIDEMIOLOGIC STUDIES
Mościcki, E. K. (1997) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70327-0 · Cited by 507 · see citing works
Clinical relevance of the neurotrophins and their receptors
Allen, S. J., & Dawbarn, D. (2006) · Clinical Science · doi:10.1042/cs20050161 · Cited by 316 · see citing works
Low plasma BDNF is associated with suicidal behavior in major depression
Kim, Y.-K., Lee, H.-P., Won, S.-D., Park, E.-Y., Lee, H.-Y., Lee, B.-H., Lee, S.-W., Yoon, D., Han, C., Kim, D.-J., et al. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.024 · Cited by 300 · see citing works
Oquendo, M. A., Currier, D., & Mann, J. J. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00829.x · Cited by 297 · see citing works
Neurotransmitters and Suicidal Behavior
Åsberg, M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52359.x · Cited by 286 · see citing works
Memories of Childhood Neglect and Abuse: Corroboration in a Series of Sisters
Bifulco, A. T., Brown, G. W., Lillie, A., & Jarvis, J. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01520.x · Cited by 251 · see citing works
Jiang, X., Xu, K., Hoberman, J., Tian, F., Marko, A. J., Waheed, J. F., Harris, C. R., Marini, A. M., Enoch, M.-A., & Lipsky, R. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300703 · Cited by 244 · see citing works
Hong, C., Huo, S.-J., Yen, F.-C., Tung, C.-L., Pan, G.-M., & Tsai, S. (2003) · Neuropsychobiology · doi:10.1159/000074636 · Cited by 218 · see citing works
Interaction between Childhood Trauma and Serotonin Transporter Gene Variation in Suicide
Roy, A., Hu, X., Janal, M. N., & Goldman, D. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301331 · Cited by 190 · see citing works
Self-citationRYBAKOWSKI, J. K., Borkowska, A., Czerski, P. M., Skibińska, M., & Hauser, J. (2003) · Bipolar Disorders · doi:10.1046/j.1399-5618.2003.00071.x · Cited by 174 · see citing works
A Review of Prospective Studies of Biologic Predictors of Suicidal Behavior in Mood Disorders
Mann, J. J., & Currier, D. (2006) · Archives of Suicide Research · doi:10.1080/13811110600993124 · Cited by 166 · see citing works
Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology
Kauer‐Sant’Anna, M., Tramontina, J., Andreazza, A. C., Ceresér, K. M. M., da Costa, S. C., Santin, A. M. P., Yatham, L. N., & Kapczinski, F. P. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00478.x · Cited by 148 · see citing works
Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder
Green, E., Raybould, R., MacGregor, S., Hyde, S., Young, A. H., O’Donovan, M. C., Owen, M. J., Kirov, G., Jones, L. A., Jones, I. R., et al. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.009969 · Cited by 135 · see citing works
Interaction between BDNF Val66Met and childhood trauma on adult’s violent suicide attempt
Perroud, N. A., Courtet, P., Vincze, I., Jaussent, I., Jollant, F., Bellivier, F., Leboyer, M., Baud, P., Burési, C., & Malafosse, A. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00354.x · Cited by 121 · see citing works
Suicide Brain Is Associated with Decreased Expression of Neurotrophins
Dwivedi, Y., Mondal, A. C., Rizavi, H. S., & Conley, R. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.014 · Cited by 120 · see citing works
Roy, A. (2002) · Psychological Medicine · doi:10.1017/s0033291702006566 · Cited by 117 · see citing works
Self-citationChildhood trauma and suicide attempts in patients with unipolar depression
Sarchiapone, M., Carli, V., Cuomo, C., & Roy, A. (2007) · Depression and Anxiety · doi:10.1002/da.20243 · Cited by 100 · see citing works
Self-citationRYBAKOWSKI, J. K., Borkowska, A., Skibińska, M., & Hauser, J. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001765 · Cited by 99 · see citing works
BDNF variant linked to anxiety‐related behaviors
Hashimoto, K. (2007) · BioEssays · doi:10.1002/bies.20534 · Cited by 88 · see citing works
Itoh, K., Hashimoto, K., Kumakiri, C., Shimizu, E., & Iyo, M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20078 · Cited by 85 · see citing works
Deveci, A., Aydemir, O., Taşkin, O., Taneli, F., & Esen-Danacı, A. (2007) · Neuropsychobiology · doi:10.1159/000111539 · Cited by 80 · see citing works
Roy, A. (2004) · Acta Psychiatrica Scandinavica · doi:10.1046/j.0001-690x.2003.00234.x · Cited by 75 · see citing works
Self-citationFamily, twin, adoption, and molecular genetic studies of juvenile bipolar disorder
Althoff, R. R., Faraone, S. V., Rettew, D. C., Morley, C. P., & Hudziak, J. J. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00268.x · Cited by 73 · see citing works
Reduced overflow of BDNF from the brain is linked with suicide risk in depressive illness
Dawood, T., Anderson, J., Barton, D., Lambert, E., Esler, M., Hotchkin, E., Haikerwal, D., Dan, K., & Lambert, G. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002059 · Cited by 69 · see citing works
Roy, A., & Janal, M. N. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00647.x · Cited by 60 · see citing works
Self-citationHashimoto, T., & Lewis, D. A. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.534 · Cited by 33 · see citing works
Grünblatt, E., Hupp, E., Bambula, M., Zehetmayer, S., Jungwirth, S., Tragl, K. H., Fischer, P. A., & Riederer, P. F. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.05.008 · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Hashimoto, K. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02113.x · Cited by 388 · see citing works
Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects
Keller, S., Sarchiapone, M., Zarrilli, F., Videtič, A., Ferraro, A., Carli, V., Sacchetti, S., Lembo, F., Angiolillo, A., Jovanovic, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.9 · Cited by 379 · see citing works
Self-citationBrain-derived neurotrophic factor: role in depression and suicide
Dwivedi, Y. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s5700 · Cited by 355 · see citing works
A brain-centric model of suicidal behavior
Mann, J. J., & Rizk, M. M. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20081224 · Cited by 214 · see citing works
Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine
Deyama, S., & Duman, R. S. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172837 · Cited by 186 · see citing works
Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide
Youssef, M. M., Underwood, M. D., Huang, Y.-Y., Hsiung, S.-C., Liu, Y., Simpson, N. R., Bakalian, M. J., Rosoklija, G. B., Dwork, A. J., Arango, V., et al. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy008 · Cited by 183 · see citing works
BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity
Bath, K. G., Jing, D. Q., Dincheva, I., Neeb, C. C., Pattwell, S. S., Chao, M. V., Lee, F. S., & Ninan, I. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.318 · Cited by 169 · see citing works
Neuropathology of suicide: Recent findings and future directions
Lutz, P.-E., Mechawar, N., & Turecki, G. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.141 · Cited by 158 · see citing works
Serotonergic genes and suicide: A systematic review
Antypa, N., Serretti, A., & Rujescu, D. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.03.013 · Cited by 150 · see citing works
Duclot, F., & Kabbaj, M. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107086 · Cited by 103 · see citing works
Lotrich, F. E., Albusaysi, S., & Ferrell, R. E. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.263 · Cited by 92 · see citing works
The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide
Pregelj, P., Nedic, G., Paska, A. V., Zupanc, T., Nikolac, M., Balažic, J., Tomori, M., Komel, R., Seler, D. M., & Pivac, N. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.07.001 · Cited by 88 · see citing works
Schenkel, L. C., Segal, J., Becker, J. A., Manfro, G. G., Bianchin, M. M., & Leistner-Segal, S. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.04.023 · Cited by 53 · see citing works
An overview of the neurobiology of suicidal behaviors as one meta-system
Sokolowski, M., Wasserman, J., & Wasserman, D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.101 · Cited by 50 · see citing works
Kahl, K. G., Stapel, B., & Frieling, H. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.09.004 · Cited by 47 · see citing works
Sanchez, M. M., Das, D., Taylor, J. L., Noda, A., Yesavage, J. A., & Salehi, A. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.47 · Cited by 45 · see citing works
BDNF promoter methylation and genetic variation in late-life depression
Januar, V, Ancelin, M.-L., Ritchie, K., Saffery, R., & Ryan, J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.114 · Cited by 139 · see citing works
- Authors
- Sarchiapone, M., Carli, V., Roy, A., Iacoviello, L., Cuomo, C., Latella, M. C., di Giannantonio, M., Janiri, L., de Gaetano, M., & Janal, M. N.
- Affiliations
- University of Molise (IT)
- Istituto Neurologico Mediterraneo (IT)
- Università Cattolica del Sacro Cuore (IT)
- Rutgers, The State University of New Jersey (US)
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2008
- Volume
- 57
- Issue
- 3
- Pages
- 139-145
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W2050774254
- Cited by
- 115
- References
- 42
- Citations by year
- 2025: 4 · 2024: 4 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 8 · 2013: 12 · 2012: 11
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, suicide attempts, depression, genetic susceptibility to suicide, childhood abuse, depression severity, gene-environment interaction
- MeSH terms
- Adult, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Suicide, Attempted, Chi-Square Distribution, Logistic Models, Brain-Derived Neurotrophic Factor, Amino Acid Substitution, Polymorphism, Single Nucleotide, Adult Survivors of Child Abuse
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
