Blunted reward responsiveness in remitted depression

Pechtel, Pia; Dutra, Sunny J.; Goetz, Elena L.; Pizzagalli, Diego A.

doi:10.1016/j.jpsychires.2013.08.011

Cited by 192Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Blunted reward responsiveness in remitted depression

Open access

Pechtel, Pia, Dutra, Sunny J., Goetz, Elena L., Pizzagalli, Diego A.·2013·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2013.08.011PMC PMC3978009

Open this paper in CoChat — free account

Abstract

Major depressive disorder has been associated with blunted responsiveness to rewards, but inconsistencies exist whether such abnormalities persist after complete remission. To address this issue, across two independent studies, 47 adults with remitted major depressive disorder (rMDD) and 37 healthy controls completed a Probabilistic Reward Task, which used a differential reinforcement schedule of social or monetary feedback to examine reward responsiveness (i.e., ability to modulate behavior as a function of reinforcement history). Relative to controls, adults with rMDD showed blunted reward responsiveness. Importantly, a history of depression predicted reduced reward learning above and beyond residual depressive (including anhedonic) symptoms and perceived stress. Findings indicate that blunted reward responsiveness endures even when adults are in remission and might be a trait-related abnormality in MDD. More research is warranted to investigate if blunted reward responsiveness may predict future depressive episodes and whether targeting reward-related deficits may prevent the re-occurrence of the disorder.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jpsychires.2013.08.011

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Blunted reward learning has been observed in both individuals with current and remitted MDD.
“Second, blunted reward learning—defined as a diminished ability to modulate behavior as a function of rewards—has been observed in both individuals with current and remitted MDD (Goldstein and Klein, 2014; Pechtel et al, 2013; Pizzagalli, 2014).”
From Neural Correlates of Three Promising Endophenotypes of Depression: Evidence from the EMBARC Study (2016) · cites this paper as Pechtel et al, 2013

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807 · see citing works
Research domain criteria (RDoC): toward a new classification framework for research on mental disorders
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067 · see citing works
Detection Theory: A User's Guide
Macmillan, N. A., & Creelman, C. D. (1991) · Cited by 5,415 · see citing works
Detection theory: A user's guide
Lories, G. (1993) · Behavioural Processes · doi:10.1016/0376-6357(93)90083-4 · Cited by 2,927 · see citing works
A scale for the assessment of hedonic tone the Snaith-Hamilton pleasure scale
Snaith, R. P., Hamilton, M., Morley, S., Humayan, A., Hargreaves, D., & Trigwell, P. (1995) · British Journal of Psychiatry · doi:10.1192/bjp.167.1.99 · Cited by 1,778 · see citing works
Randomized trial of behavioral activation, cognitive therapy, and antidepressant medication in the acute treatment of adults with major depression.
Dimidjian, S., Hollon, S. D., Dobson, K. S., Schmaling, K. B., Kohlenberg, R. J., Addis, M. E., Gallop, R., McGlinchey, J. B., Markley, D. K., Gollan, J. K., et al. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.4.658 · Cited by 1,607 · cited 2× · see citing works
“Specifically , a large randomized-control trial found that, in severely depressed patients, BAT was as effective as antidepressant medication and initially more effective than cognitive therapy (Dimidjian et al., 2006).”
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
Testing a tripartite model: I. Evaluating the convergent and discriminant validity of anxiety and depression symptom scales.
Watson, D., Weber, K., Assenheimer, J. S., Clark, L. A., Strauss, M. E., & McCormick, R. A. (1995) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.104.1.3 · Cited by 1,423 · see citing works
Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232 · see citing works
Self-citation
Handbook of depression
Gotlib, I. H., & Hammen, C. L. (2002) · Cited by 980 · see citing works
Corrections for extreme proportions and their biasing effects on estimated values ofd′
Hautus, M. J. (1995) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03203619 · Cited by 941 · see citing works
Developing constructs for psychopathology research: Research domain criteria
Sanislow, C. A., Pine, D. S., Quinn, K. J., Kozak, M. J., Garvey, M. A., Heinssen, R. K., Wang, P. S.-E., & Cuthbert, B. N. (2010) · Journal of Abnormal Psychology · doi:10.1037/a0020909 · Cited by 793 · see citing works
Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task
Pizzagalli, D. A., Iosifescu, D., Hallett, L. A., Ratner, K. G., & Fava, M. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.001 · Cited by 780 · see citing works
Self-citation
Toward an objective characterization of an anhedonic phenotype: A signal-detection approach
Pizzagalli, D. A., Jahn, A. L., & O’Shea, J. P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.026 · Cited by 738 · see citing works
Self-citation
Altered Striatal Activation Predicting Real-World Positive Affect in Adolescent Major Depressive Disorder
Forbes, E. E., Hariri, A. R., Martin, S. L., Silk, J. S., Moyles, D. L., Fisher, P. M., Brown, S. M., Ryan, N. D., Birmaher, B., Axelson, D. A., et al. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07081336 · Cited by 582 · see citing works
Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects
Epstein, J., Pan, H., Kocsis, J. H., Yang, Y., Butler, T., Chusid, J., Hochberg, H., Murrough, J., Strohmayer, E., Stern, E., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.10.1784 · Cited by 464 · see citing works
Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depression
McMakin, D. L., Olino, T. M., Porta, G., Dietz, L. J., Emslie, G., Clarke, G., Wagner, K. D., Asarnow, J. R., Ryan, N. D., Birmaher, B., et al. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.01.011 · Cited by 448 · see citing works
Reduced Reward Learning Predicts Outcome in Major Depressive Disorder
Vrieze, E., Pizzagalli, D. A., Demyttenaere, K., Hompes, T., Sienaert, P. A., de Boer, P., Schmidt, M. E., & Claes, S. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.014 · Cited by 443 · see citing works
Self-citation
Epidemiology of depression
Angst, J. (1992) · Psychopharmacology · doi:10.1007/bf02246240 · Cited by 411 · see citing works
The assessment of anhedonia in clinical and non-clinical populations: further validation of the Snaith-Hamilton Pleasure Scale (SHAPS)
Franken, I. H. A., Rassin, E., & Muris, P. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.08.020 · Cited by 373 · see citing works
Neural Processing of Reward and Loss in Girls at Risk for Major Depression
Gotlib, I. H., Hamilton, J. P., Cooney, R. E., Singh, M. K., Henry, M. L., & Joormann, J. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.13 · Cited by 328 · see citing works
The effects of psychotherapy on neural responses to rewards in major depression
Dichter, G. S., Felder, J. N., Petty, C., Bizzell, J., Ernst, M., & Smoski, M. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.021 · Cited by 278 · see citing works
Determinants of poor 1-year outcome of DSM-III-R major depression in the general population: results of the Netherlands mental health survey and incidence study (NEMESIS)
Spijker, J., Bijl, R. V., De Graaf, R., & Nolen, W. A. (2001) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2001.103002122.x · Cited by 254 · see citing works
Neural representation of reward in recovered depressed patients
McCabe, C., Cowen, P. J., & Harmer, C. J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1573-9 · Cited by 248 · see citing works
Handbook of depression, 2nd ed.
Gotlib, I. H., & Hammen, C. L. (2009) · Cited by 233 · see citing works
Single dose of a dopamine agonist impairs reinforcement learning in humans: Behavioral evidence from a laboratory-based measure of reward responsiveness
Pizzagalli, D. A., Evins, A. E., Schetter, E. C., Frank, M. J., Pajtas, P. E., Santesso, D. L., & Culhane, M. (2008) · Psychopharmacology · doi:10.1007/s00213-007-0957-y · Cited by 219 · see citing works
Self-citation
Reward fails to alter response bias in depression.
Henriques, J. B., Glowacki, J. M., & Davidson, R. J. (1994) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.103.3.460 · Cited by 215 · see citing works
Sensitivity to Reward Frequency in Boys With Attention Deficit Hyperactivity Disorder
Tripp, G., & Alsop, B. (1999) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp280309 · Cited by 183 · see citing works
Behavioral activation system deficits predict the six-month course of depression
McFarland, B. R., Shankman, S. A., Tenke, C. E., Bruder, G. E., & Klein, D. N. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.01.012 · Cited by 174 · see citing works
Reward fails to alter response bias in depression.
Henriques, J. B., Glowacki, J. M., & Davidson, R. J. (1994) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.103.3.460 · Cited by 172 · see citing works
Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes
Dichter, G. S., Kozink, R. V., McClernon, F. J., & Smoski, M. J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.09.048 · Cited by 170 · see citing works
Affective symptoms associated with the onset of major depression in the community: findings from the US National Institute of Mental Health Epidemiologic Catchment Area Program
Dryman, A., & Eaton, W. W. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb01410.x · Cited by 169 · cited 1× · see citing works
“In addition, anhedonia and/or reduced reward responsiveness have been found to precede the onset of depression (Dryman and Eaton, 1991), shows temporal stability (Oquendo et al., 2004), and predicts a variety of clinically important variables, including poor outcome in naturalistic studies (Spijker…”
Increased perceived stress is associated with blunted hedonic capacity: Potential implications for depression research
Pizzagalli, D. A., Bogdan, R., Ratner, K. G., & Jahn, A. L. (2007) · Behaviour Research and Therapy · doi:10.1016/j.brat.2007.07.013 · Cited by 159 · see citing works
Self-citation
Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression
Schaefer, H. S., Putnam, K. M., Benca, R. M., & Davidson, R. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.024 · Cited by 158 · see citing works
Emotional reactivity in depression: diminished responsiveness to anticipated reward but not to anticipated punishment or to nonreward or avoidance
McFarland, B. R., & Klein, D. N. (2009) · Depression and Anxiety · doi:10.1002/da.20513 · Cited by 157 · see citing works
Neural Processing of Reward and Punishment in Young People at Increased Familial Risk of Depression
McCabe, C., Woffindale, C., Harmer, C. J., & Cowen, P. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.034 · Cited by 152 · see citing works
Neural markers of symptomatic improvement during antidepressant therapy in severe depression: subgenual cingulate and visual cortical responses to sad, but not happy, facial stimuli are correlated with changes in symptom score
Keedwell, P., Drapier, D., Surguladze, S., Giampietro, V, Brammer, M., & Phillips, M. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108093589 · Cited by 149 · see citing works
Individual differences in reinforcement learning: Behavioral, electrophysiological, and neuroimaging correlates
Santesso, D. L., Dillon, D. G., Birk, J. L., Holmes, A. J., Davis, E., Bogdan, R., & Pizzagalli, D. A. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.05.032 · Cited by 135 · see citing works
Self-citation
The interaction of reinforcement sensitivity and life events in the prediction of anhedonic depression and mixed anxiety-depression symptoms
Hundt, N. E., Nelson‐Gray, R. O., Kimbrel, N. A., Mitchell, J. T., & Kwapil, T. R. (2007) · Personality and Individual Differences · doi:10.1016/j.paid.2007.02.021 · Cited by 102 · see citing works
Symptom-Based Predictors of a 10-Year Chronic Course of Treated Depression
Moos, R. H., & Cronkite, R. C. (1999) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199906000-00005 · Cited by 89 · see citing works
Reduced hedonic capacity in euthymic bipolar subjects: a trait-like feature
Di Nicola, M., De Risio, L., Battaglia, C., Camardese, G., Tedeschi, D., Mazza, M., Martinotti, G., Pozzi, G., Niolu, C., Di Giannantonio, M., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.004 · Cited by 87 · see citing works
Instability of Symptoms in Recurrent Major Depression: A Prospective Study
Oquendo, M. A., Barrera, A., Ellis, S. P., Li, S., Burke, A. K., Grunebaum, M., Endicott, J., & Mann, J. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.255 · Cited by 84 · see citing works
Measuring extrastriatal dopamine release during a reward learning task
Vrieze, E., Ceccarini, J., Pizzagalli, D. A., Bormans, G. M., Vandenbulcke, M., Demyttenaere, K., Laere, K. V., & Claes, S. J. (2011) · Human Brain Mapping · doi:10.1002/hbm.21456 · Cited by 63 · see citing works
Self-citation

Flagged first, then by citations

Research works printed but not linked: 1

First M Spitzer R Gibbon M Williams J Structured Clinical Interview for DSM-IV-TR Axis I Disorders researchversion non-patient edition (SCID-I/NP) 2002 New York Biometrics Research New York State Psychiatric Institute

Sorted by citations

Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model
Pizzagalli, D. A. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185606 · Cited by 1,155 · see citing works
Self-citation
Reward processing dysfunction in major depression, bipolar disorder and schizophrenia
Whitton, A. E., Treadway, M. T., & Pizzagalli, D. A. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000122 · Cited by 740 · see citing works
Self-citation
Assessing anhedonia in depression: potentials and pitfalls
Rizvi, S. J., Pizzagalli, D. A., Sproule, B. A., & Kennedy, S. H. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.004 · Cited by 571 · see citing works
Self-citation
Dysfunctional reward processing in depression
Admon, R., & Pizzagalli, D. A. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2014.12.011 · Cited by 343 · see citing works
Self-citation
Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain
Thomsen, K. R., Whybrow, P. C., & Kringelbach, M. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00049 · Cited by 235 · see citing works
Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia
Barch, D. M., Pagliaccio, D., & Luking, K. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_376 · Cited by 218 · see citing works
Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder
Savitz, J. B., Drevets, W. C., Wurfel, B. E., Ford, B. N., Bellgowan, P. S. F., Victor, T. A., Bodurka, J., Teague, T. K., & Dantzer, R. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.007 · Cited by 207 · see citing works
Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression
Borsini, A., Wallis, A. S. J., Zunszain, P., Pariante, C. M., & Kempton, M. J. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00804-6 · Cited by 207 · see citing works
Anhedonia in depression: biological mechanisms and computational models
Cooper, J. A., Arulpragasam, A. R., & Treadway, M. T. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.024 · Cited by 188 · see citing works
Measuring anhedonia: impaired ability to pursue, experience, and learn about reward
Thomsen, K. R. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01409 · Cited by 156 · see citing works
A review of selected candidate endophenotypes for depression
Goldstein, B. L., & Klein, D. N. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.06.003 · Cited by 128 · see citing works
Translational assessment of reward and motivational deficits in psychiatric disorders
Der-Avakian, A., Barnes, S. A., Markou, A., & Pizzagalli, D. A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5004 · Cited by 122 · see citing works
Self-citation
Blunted Neural Responses to Reward in Remitted Major Depression: A High-Density Event-Related Potential Study
Whitton, A. E., Kakani, P., Foti, D., Veer, A. V., Haile, A., Crowley, D. J., & Pizzagalli, D. A. (2015) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.09.007 · Cited by 127 · see citing works
Self-citation
Why dysfunctional expectations in depression persist – Results from two experimental studies investigating cognitive immunization
Κube, T., Rief, W., Gollwitzer, M., Gärtner, T., & Glombiewski, J. A. (2018) · Psychological Medicine · doi:10.1017/s0033291718002106 · Cited by 117 · see citing works
Effort-cost decision-making in psychosis and depression: could a similar behavioral deficit arise from disparate psychological and neural mechanisms?
Culbreth, A. J., Moran, E. K., & Barch, D. M. (2017) · Psychological Medicine · doi:10.1017/s0033291717002525 · Cited by 111 · see citing works
Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS)
Pizzagalli, D. A., Smoski, M. J., Ang, Y., Whitton, A. E., Sanacora, G., Mathew, S. J., Nürnberger, J. I., Lisanby, S. H., Iosifescu, D. V., Murrough, J. W., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0738-4 · Cited by 104 · see citing works
Self-citation
Neural Correlates of Three Promising Endophenotypes of Depression: Evidence from the EMBARC Study
Webb, C. A., Dillon, D. G., Pechtel, P., Goer, F. K., Murray, L., Huys, Q. J., Fava, M., McGrath, P. J., Weissman, M., Parsey, R., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.165 · Cited by 103 · see citing works
Self-citation
Neuroclinical Framework for the Role of Stress in Addiction
Kwako, L. E., & Koob, G. F. (2017) · Chronic Stress · doi:10.1177/2470547017698140 · Cited by 99 · see citing works
Neural substrates of trait impulsivity, anhedonia, and irritability: Mechanisms of heterotypic comorbidity between externalizing disorders and unipolar depression
Zisner, A. R., & Beauchaine, T. P. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000754 · Cited by 92 · see citing works
The habenula in psychiatric disorders: More than three decades of translational investigation
Fakhoury, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.010 · Cited by 90 · see citing works
Great Expectations: A Critical Review of and Suggestions for the Study of Reward Processing as a Cause and Predictor of Depression
Nielson, D. M., Keren, H., O’Callaghan, G., Jackson, S. M., Douka, I., Vidal‐Ribas, P., Pornpattananangkul, N., Camp, C., Gorham, L. S., Wei, C. Y., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.012 · Cited by 87 · see citing works
New directions in behavioral activation: Using findings from basic science and translational neuroscience to inform the exploration of potential mechanisms of change
Forbes, C. N. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101860 · Cited by 88 · see citing works
Blunted Reward Processing in Remitted Melancholic Depression
Weinberg, A., & Shankman, S. A. (2016) · Clinical Psychological Science · doi:10.1177/2167702616633158 · Cited by 84 · see citing works
Neurobiology of hedonic tone: the relationship between treatment-resistant depression, attention-deficit hyperactivity disorder, and substance abuse
Katzman, M., & Sternat, T. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s111818 · Cited by 83 · see citing works
Brain Reward System Dysfunction in Adolescence: Current, Cumulative, and Developmental Periods of Depression
Rappaport, B. I., Kandala, S., Luby, J. L., & Barch, D. M. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19030281 · Cited by 83 · see citing works
Anhedonia in melancholic and non-melancholic depressive disorders
Fletcher, K., Parker, G. B., Paterson, A., D, M. F. M., Iosifescu, D. V., & Pizzagalli, D. A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.05.028 · Cited by 81 · see citing works
Self-citation
Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder
Ding, Y., Chen, X., Chen, Z., Li, L., Li, X., Castellanos, F. X., Bai, T., Bo, Q., Cao, J., Chang, Z., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01995-x · Cited by 81 · see citing works
Differentiating the abnormalities of social and monetary reward processing associated with depressive symptoms
Zhang, D., Shen, J., Bi, R., Zhang, Y., Zhou, F., Feng, C., & Gu, R. (2020) · Psychological Medicine · doi:10.1017/s0033291720003967 · Cited by 80 · see citing works
Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression
Admon, R., Holsen, L. M., Aizley, H. G., Remington, A., Whitfield, S., Goldstein, J. M., & Pizzagalli, D. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.019 · Cited by 76 · see citing works
Self-citation
Anhedonia is associated with blunted reward sensitivity in first-degree relatives of patients with major depression
Liu, W., Roiser, J. P., Wang, L.-Z., Zhu, Y.-H., Huang, J., Neumann, D. L., Shum, D., Cheung, E. F. C., & Chan, R. C. K. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.10.050 · Cited by 78 · see citing works
L‐type Ca2+ channels in mood, cognition and addiction: integrating human and rodent studies with a focus on behavioural endophenotypes
Kabir, Z. D., Lee, A. S., & Rajadhyaksha, A. M. (2016) · The Journal of Physiology · doi:10.1113/jp270673 · Cited by 75 · see citing works
From movement to motivation: a proposed framework to understand the antidepressant effect of exercise
Hird, E. J., Slanina-Davies, A., Lewis, G., Hamer, M., & Roiser, J. P. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02922-y · Cited by 79 · see citing works
Anhedonia in chronic pain and prescription opioid misuse
Garland, E. L., Trøstheim, M., Eikemo, M., Ernst, G., & Leknes, S. (2019) · Psychological Medicine · doi:10.1017/s0033291719002010 · Cited by 72 · see citing works
Antidepressant effects of ketamine on depression-related phenotypes and dopamine dysfunction in rodent models of stress
Rincón‐Cortés, M., & Grace, A. A. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112367 · Cited by 71 · see citing works
Learning and Choice in Mood Disorders: Searching for the Computational Parameters of Anhedonia
Robinson, O. J., & Chase, H. W. (2017) · Computational Psychiatry · doi:10.1162/cpsy_a_00009 · Cited by 66 · see citing works
Reward systems and cognitions in Major Depressive Disorder
Cléry-Melin, M.-L., Jollant, F., & Gorwood, P. A. P. M. (2018) · CNS Spectrums · doi:10.1017/s1092852918001335 · Cited by 68 · see citing works
Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats
Der‐Avakian, A., D’Souza, M. S., Potter, D. N., Chartoff, E. H., Carlezon, W. A., Pizzagalli, D. A., & Markou, A. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4584-y · Cited by 67 · see citing works
Self-citation
Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers
Peechatka, A. L., Whitton, A. E., Farmer, S. L., Pizzagalli, D. A., & Janes, A. C. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.07.015 · Cited by 67 · see citing works
Self-citation
Understanding psychiatric disorder by capturing ecologically relevant features of learning and decision-making
Scholl, J., & Klein-Flügge, M. C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.050 · Cited by 62 · see citing works
Momentary subjective well-being depends on learning and not reward
Blain, B., & Rutledge, R. B. (2020) · eLife · doi:10.7554/elife.57977 · Cited by 61 · see citing works
Corticostriatal pathways contribute to the natural time course of positive mood
Admon, R., & Pizzagalli, D. A. (2015) · Nature Communications · doi:10.1038/ncomms10065 · Cited by 57 · see citing works
Self-citation
“Don't [ruminate], be happy”: A cognitive perspective linking depression and anhedonia
Rutherford, A. V., McDougle, S. D., & Joormann, J. (2023) · Clinical Psychology Review · doi:10.1016/j.cpr.2023.102255 · Cited by 57 · see citing works
Domain-specific hedonic deficits towards social affective but not monetary incentives in social anhedonia
Xie, W.-Z., Yan, C., Ying, X.-Y., Zhu, S.-Y., Shi, H.-S., Wang, Y., Cheung, E. F. C., & Chan, R. C. K. (2014) · Scientific Reports · doi:10.1038/srep04056 · Cited by 54 · see citing works
Neural Responsiveness to Reward as an Index of Depressive Symptom Change Following Cognitive-Behavioral Therapy and SSRI Treatment
Burkhouse, K. L., Gorka, S. M., Klumpp, H., Kennedy, A. E., Karich, S. R., Francis, J., Ajilore, O., Craske, M. G., Langenecker, S. A., Shankman, S. A., et al. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.17m11836 · Cited by 55 · see citing works
Disrupted reward and cognitive control networks contribute to anhedonia in depression
Gong, L., He, C., Zhang, H., Zhang, H., Zhang, Z., & Xie, C. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.05.010 · Cited by 53 · see citing works
The Electrical Aftermath: Brain Signals of Posttraumatic Stress Disorder Filtered Through a Clinical Lens
Butt, M., Espinal, E., Aupperle, R. L., Nikulina, V., & Stewart, J. L. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00368 · Cited by 52 · see citing works
Inflammation and dimensions of reward processing following exposure to the influenza vaccine
Boyle, C. C., Kuhlman, K. R., Dooley, L. N., Haydon, M. D., Robles, T. F., Ang, Y., Pizzagalli, D. A., & Bower, J. E. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.11.024 · Cited by 52 · see citing works
Self-citation
Reward processing as a common diathesis for chronic pain and depression.
Rizvi, S., Gandhi, W., & Salomons, T. (2021) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.033 · Cited by 44 · see citing works
A transnosographic approach of negative symptoms pathophysiology in schizophrenia and depressive disorders
Guessoum, S. B., Strat, Y. L., Dubertret, C., & Mallet, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109862 · Cited by 45 · see citing works
The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression
Tozzi, L., Staveland, B. R., Holt-Gosselin, B., Chesnut, M., Chang, S. E., Choi, D., Shiner, M., Wu, H., Lerma‐Usabiaga, G., Sporns, O., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116715 · Cited by 47 · see citing works
Social reinforcement learning as a predictor of real-life experiences in individuals with high and low depressive symptomatology
Frey, A.-L., Frank, M. J., & McCabe, C. (2019) · Psychological Medicine · doi:10.1017/s0033291719003222 · Cited by 44 · see citing works
Attentional bias scores in patients with depression and effects of age: a controlled, eye-tracking study
Lu, S., Xu, J., Li, M., Xue, J., Lu, X., Feng, L., Fu, B., Wang, G., Zhong, N., & Hu, B. (2017) · Journal of International Medical Research · doi:10.1177/0300060517708920 · Cited by 40 · see citing works
Depression and Approach Motivation: Differential Relations to Monetary, Social, and Food Reward
Fussner, L. M., Mancini, K. J., & Luebbe, A. M. (2017) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-017-9620-z · Cited by 38 · see citing works
Multiple Facets of Value-Based Decision Making in Major Depressive Disorder
Mukherjee, D., Lee, S., Kazinka, R., Satterthwaite, T. D., & Kable, J. W. (2020) · Scientific Reports · doi:10.1038/s41598-020-60230-z · Cited by 42 · see citing works
Blunted cardiovascular reactivity in dysphoria during reward and punishment anticipation
Franzén, J., & Brinkmann, K. (2014) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2014.11.007 · Cited by 40 · see citing works
Executive function deficits associated with current and past major depressive symptoms
Bredemeier, K., Warren, S. L., Berenbaum, H., Miller, G. A., & Heller, W. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.03.070 · Cited by 38 · see citing works
Translational Assessments of Reward and Anhedonia: A Tribute to Athina Markou
Der-Avakian, A., & Pizzagalli, D. A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.008 · Cited by 36 · see citing works
Self-citation
The Potential of KCNQ Potassium Channel Openers as Novel Antidepressants
Costi, S., Han, M., & Murrough, J. W. (2022) · CNS Drugs · doi:10.1007/s40263-021-00885-y · Cited by 36 · see citing works
NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses
Hughes, B. W., Siemsen, B. M., Tsvetkov, E., Berto, S., Kumar, J., Cornbrooks, R. G., Akiki, R. M., Cho, J. Y., Carter, J. S., Snyder, K. K., et al. (2023) · eLife · doi:10.7554/elife.75631 · Cited by 34 · see citing works
Impaired social learning predicts reduced real-life motivation in individuals with depression: A computational fMRI study
Frey, A.-L., & McCabe, C. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.049 · Cited by 35 · see citing works
I don’t care about others’ approval: Dysphoric individuals show reduced effort mobilization for obtaining a social reward
Brinkmann, K., Franzén, J., Rossier, C., & Gendolla, G. H. E. (2014) · Motivation and Emotion · doi:10.1007/s11031-014-9437-y · Cited by 37 · see citing works
Probabilistic Reinforcement Learning and Anhedonia
Kangas, B. D., Der‐Avakian, A., & Pizzagalli, D. A. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_349 · Cited by 34 · see citing works
Self-citation
Mental Imagery Training Increases Wanting of Rewards and Reward Sensitivity and Reduces Depressive Symptoms
Linke, J. O., & Wessa, M. (2017) · Behavior Therapy · doi:10.1016/j.beth.2017.04.002 · Cited by 32 · see citing works
Chronic non-discriminatory social defeat stress reduces effort-related motivated behaviors in male and female mice
Dieterich, A., Liu, T. T., & Samuels, B. A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01250-9 · Cited by 33 · see citing works
Emotional and cognitive dysregulation in schizophrenia and depression: understanding common and distinct behavioral and neural mechanisms
Anticevic, A., Schleifer, C., & Cho, Y. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.4/aanticevic · Cited by 34 · see citing works
Reward Responsiveness Varies by Smoking Status in Women with a History of Major Depressive Disorder
Janes, A. C., Pedrelli, P., Whitton, A. E., Pechtel, P., Douglas, S., Martinson, M. A., Huz, I., D, M. F. M., Pizzagalli, D. A., & Evins, A. E. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.43 · Cited by 32 · see citing works
Self-citation
The impact bias in self and others: Affective and empathic forecasting in individuals with social anxiety
Arditte Hall, K. A., Joormann, J., Siemer, M., & Timpano, K. R. (2018) · Behaviour Research and Therapy · doi:10.1016/j.brat.2018.05.001 · Cited by 30 · see citing works
Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study
Mocking, R. J. T., Figueroa, C. A., Rive, M. M., Geugies, H., Servaas, M. N., Assies, J., Koeter, M. W. J., Vaz, F. M., Wichers, M., van Straalen, J. P., et al. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-009510 · Cited by 31 · see citing works
Altered reward network responses to social touch in major depression
Mielacher, C., Scheele, D., Kiebs, M., Schmitt, L., Dellert, T., Philipsen, A., Lamm, C., & Hurlemann, R. (2023) · Psychological Medicine · doi:10.1017/s0033291723001617 · Cited by 30 · see citing works
Past-year relational victimization is associated with a blunted neural response to rewards in emerging adults
Ethridge, P., Sandre, A., Dirks, M. A., & Weinberg, A. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy091 · Cited by 29 · see citing works
An Integrated Sleep and Reward Processing Model of Major Depressive Disorder
Boland, E. M., Goldschmied, J., Wakschal, E. S., Nusslock, R., & Gehrman, P. (2020) · Behavior Therapy · doi:10.1016/j.beth.2019.12.005 · Cited by 29 · see citing works
CACNA1C risk variant affects reward responsiveness in healthy individuals
Lancaster, T. M., Heerey, E. A., Mantripragada, K. K., & Linden, D. E. J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.100 · Cited by 28 · see citing works
Diagnostic and dimensional evaluation of implicit reward learning in social anxiety disorder and major depression
Reilly, E. E., Whitton, A. E., Pizzagalli, D. A., Rutherford, A. V., Stein, M. B., Paulus, M. P., & Taylor, C. T. (2020) · Depression and Anxiety · doi:10.1002/da.23081 · Cited by 28 · see citing works
Self-citation
Affective traits and history of depression are related to ventral striatum connectivity
DelDonno, S. R., Jenkins, L. M., Crane, N. A., Nusslock, R., Ryan, K. A., Shankman, S. A., Phan, K. L., & Langenecker, S. A. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.06.014 · Cited by 28 · see citing works
Cortisol reactivity to stress predicts behavioral responsivity to reward moderation by sex, depression, and anhedonia
Cunningham, S., Mazurka, R., Wynne‐Edwards, K. E., Milev, R. V., Pizzagalli, D. A., Kennedy, S. H., & Harkness, K. L. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.126 · Cited by 27 · see citing works
Self-citation
Challenging the negative learning bias hypothesis of depression: reversal learning in a naturalistic psychiatric sample
Brolsma, S. C. A., Vrijsen, J. N., Vassena, E., Kandroodi, M. R., Bergman, M. A., van Eijndhoven, P., Collard, R. M., den Ouden, H. E. M., Schene, A. H., & Cools, R. (2020) · Psychological Medicine · doi:10.1017/s0033291720001956 · Cited by 27 · see citing works
What can animal models tell us about depressive disorders?
Hoffman, K. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-08-100099-1.00002-9 · Cited by 26 · see citing works
Divergent associations between ghrelin and neural responsivity to palatable food in hyperphagic and hypophagic depression
Cerit, H., Christensen, K. A., Moondra, P., Klibanski, A., Goldstein, J. M., & Holsen, L. M. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.088 · Cited by 25 · see citing works
Depression genetic risk score is associated with anhedonia-related markers across units of analysis
Guffanti, G., Kumar, P., Admon, R., Treadway, M. T., Hall, M., Mehta, M., Douglas, S., Arulpragasam, A. R., & Pizzagalli, D. A. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0566-7 · Cited by 25 · see citing works
Self-citation
Activation of Basolateral Amygdala to Nucleus Accumbens Projection Neurons Attenuates Chronic Corticosterone-Induced Behavioral Deficits in Male Mice
Dieterich, A., Floeder, J. R., Stech, K., Lee, J., Srivastava, P., Barker, D. J., & Samuels, B. A. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.643272 · Cited by 24 · see citing works
Blunted cardiovascular reactivity during social reward anticipation in subclinical depression
Brinkmann, K., & Franzén, J. (2017) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.01.010 · Cited by 24 · see citing works
Motives for Nonsuicidal Self-Injury in Individuals with Lifetime Depressive Disorders and Posttraumatic Stress Disorder
Forbes, C. N., Tull, M. T., Richmond, J. R., Chapman, A. L., Dixon–Gordon, K. L., & Gratz, K. L. (2019) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-019-09739-w · Cited by 24 · see citing works
Patterns of premenstrual syndrome and depression symptoms in Chinese female university students: Results of a latent profile analysis
Hou, L., & Zhou, R. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.06.017 · Cited by 25 · see citing works
Sensitivity to intrinsic rewards is domain general and related to mental health
Blain, B., Pinhorn, I., & Sharot, T. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00116-x · Cited by 24 · see citing works
Blunted neural effects of perceived control on reward feedback in major depressive disorder
Chang, Y., Wang, Y., Mei, S., Yi, W., & Zheng, Y. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.06.071 · Cited by 22 · see citing works
Positive Affectivity Is Dampened in Youths With Histories of Major Depression and Their Never-Depressed Adolescent Siblings
Kovács, M., Bylsma, L. M., Yaroslavsky, I., Rottenberg, J. A., George, C. J., Kiss, E., Halas, K., Benák, I., Baji, I., Vetró, Á., et al. (2015) · Clinical Psychological Science · doi:10.1177/2167702615607182 · Cited by 22 · see citing works
Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress
Wilkinson, M. P., Slaney, C., Mellor, J. R., & Robinson, E. S. J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260444 · Cited by 22 · see citing works
Erwartungsfokussierte psychotherapeutische Interventionen bei Personen mit depressiver Symptomatik
Κube, T., Glombiewski, J. A., & Rief, W. (2019) · Verhaltenstherapie · doi:10.1159/000496944 · Cited by 22 · see citing works
Striatal reactivity to reward under threat-of-shock and working memory load in adults at increased familial risk for major depression: A preliminary study
Gaillard, C., Guillod, M., Ernst, M., Federspiel, A., Schoebi, D., Recabarren, R. E., Ouyang, X., Mueller‐Pfeiffer, C., Horsch, A., Homan, P., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102193 · Cited by 23 · see citing works
Longitudinal associations between perceived stress and anhedonia during psychotherapy
Phillips, R., Walsh, E. C., Jensen, T. M., Nagy, G. A., Kinard, J. L., Cernasov, P., Smoski, M. J., & Dichter, G. S. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.011 · Cited by 24 · see citing works
Comparison of conventional and rapid-acting antidepressants in a rodent probabilistic reversal learning task
Wilkinson, M. P., Grogan, J. P., Mellor, J. R., & Robinson, E. S. J. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820907177 · Cited by 20 · see citing works
Dissociable mechanisms underpinning effort-cost decision-making across the psychosis spectrum
Whitton, A. E., Merchant, J. T., & Lewandowski, K. E. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.09.014 · Cited by 20 · see citing works
Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission From Depression
Kotoula, V., Stringaris, A. K., Mackes, N. K., Mazibuko, N., Hawkins, P. C. T., Furey, M., Curran, H. V., & Mehta, M. A. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.05.009 · Cited by 19 · see citing works
Striatal Dopamine Binding in Anhedonia: A Simultaneous [ 11 C]Raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging Investigation
Phillips, R., Walsh, E. C., Zürcher, N. R., Lalush, D. S., Kinard, J. L., Tseng, C.-E. J., Cernasov, P., Kan, D., Cummings, K. K., Kelley, L., et al. (2022) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2023.111660 · Cited by 19 · see citing works
Self-citation
Transdiagnostic inflexible learning dynamics explain deficits in depression and schizophrenia
Kirschner, H., Nassar, M. R., Fischer, A. G., Frodl, T., Meyer-Lotz, G., Froböse, S., Seidenbecher, S., Klein, T. A., & Ullsperger, M. (2023) · Brain · doi:10.1093/brain/awad362 · Cited by 20 · see citing works
Circadian rhythms of melatonin and its relationship with anhedonia in patients with mood disorders: a cross-sectional study
Li, X., Yu, J., Jiang, S., Fang, L., Li, Y., Ma, S., Kong, H., Qin, X., & Zhu, D. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05606-5 · Cited by 20 · see citing works
Affective personality predictors of disrupted reward learning and pursuit in major depressive disorder
DelDonno, S. R., Weldon, A. L., Crane, N. A., Passarotti, A. M., Pruitt, P. J., Gabriel, L. B., Yau, W., Meyers, K. K., Hsu, D. T., Taylor, S. F., et al. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.08.011 · Cited by 18 · see citing works
Kappa Opioid Receptors in the Pathology and Treatment of Major Depressive Disorder
Browne, C. A., Wulf, H. A., & Lucki, I. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2020_432 · Cited by 18 · see citing works
Reduced Reward Responsiveness in Women With Moderate - to - Severe Premenstrual Syndrome: Evidence From a Probabilistic Reward Task
Hou, L., Chang, L., Chen, L., & Zhou, R. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00028 · Cited by 16 · see citing works
Reduced Hedonic Capacity/Approach Motivation Relates to Blunted Responsivity to Gain and Loss Feedback in Children
Luking, K. R., Neiman, J. S., Luby, J. L., & Barch, D. M. (2015) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2015.1012721 · Cited by 17 · see citing works

Blunted Reward Processing in Remitted Melancholic Depression
Weinberg, A., & Shankman, S. A. (2016) · Clinical Psychological Science · doi:10.1177/2167702616633158 · Cited by 84 · see citing works
Pupillary response in reward processing in adults with major depressive disorder in remission
Guath, M., Willfors, C., Avdic, H. B., Nordgren, A., & Kleberg, J. (2022) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617722000224 · Cited by 11 · see citing works
Lifetime history of major depressive disorder is associated with decreased reward learning: Evidence from a novel online version of the probabilistic reward task
Esfand, S. M., Null, K. E., Duda, J. M., de Leeuw, J. R., & Pizzagalli, D. A. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.133 · Cited by 10 · see citing works
Self-citation
Reduced Reward Learning Predicts Outcome in Major Depressive Disorder
Vrieze, E., Pizzagalli, D. A., Demyttenaere, K., Hompes, T., Sienaert, P. A., de Boer, P., Schmidt, M. E., & Claes, S. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.014 · Cited by 443 · see citing works
Self-citation
Reward Sensitivity and Response to Treatment in Major Depression
Vrieze, E., Pizzagalli, D. A., Demyttenaere, K., & Claes, S. J. (2009) · European Psychiatry · doi:10.1016/s0924-9338(09)70920-4 · Cited by 1 · see citing works
Self-citation

Authors: Pechtel, P., Dutra, S. J., Goetz, E. L., & Pizzagalli, D. A.
Affiliations: Harvard University (US)
Yale University (US)
Corresponding author: Pechtel, Pia
Pizzagalli, Diego A.
ORCID: Pechtel, Pia
Dutra, Sunny J.
Pizzagalli, Diego A.
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2013-12
Volume: 47
Issue: 12
Pages: 1864-1869
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2013.08.011
PMC: PMC3978009
OpenAlex: W2142577246
Cited by: 192
References: 42
Citations by year: 2026: 14 · 2025: 13 · 2024: 6 · 2023: 15 · 2022: 17 · 2021: 17 · 2020: 25 · 2019: 13 · 2018: 15 · 2017: 16 · 2016: 11 · 2015: 22 · 2014: 8
FWCI: 7.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Harvard University
Deutsche Forschungsgemeinschaft
National Institute of Mental Health (R01MH101521, R01MH095809, R01MH068376, R21MH078979, R01 MH68376)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: remitted depression, reward learning, probabilistic reward task, differential reinforcement, anhedonia, residual depressive symptoms, perceived stress
MeSH terms: Adult, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Learning Disabilities, Male, Neuropsychological Tests, Probability, Psychiatric Status Rating Scales, Reaction Time, Regression Analysis, Reward, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Blunted reward responsiveness in remitted depression

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks