Neural substrates of suicide and suicidal behaviour: From a neuroimaging perspective
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In this article, we have reviewed neuroimaging studies on the neural circuitry associated with suicidal behaviour in order to identify the neural substrates of suicidal behaviour. The Medline and ScienceDirect databases were comprehensively and systematically searched and articles published from 1990 through 2017 were reviewed. Reviewed brain-imaging modalities included structural magnetic resonance imaging, diffusion tensor imaging, positron-emission tomography, single-photon emission computed tomography, resting-state functional Imaging, and functional magnetic resonance imaging. Although subject characteristics and imaging methods vary across studies, convergent findings involving the structure and function of frontostriatal network and fronto-limbic structures, and the serotonergic system were identified. These neuroimaging studies of suicide behaviour have provided crucial information on the neural circuitry associated with suicide risk. Future studies examining neural changes associated with before and after pharmacologic and behavioural interventions would be instrumental in suicide risk reduction.
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Prior reviews have identified brain regions implicated in suicidal and non-suicidal behaviors.
“Several prior reviews have highlighted brain regions implicated in suicidal (32, 45–49) and non-suicidal behaviors (39, 50).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [45]
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- Authors
- Balcioglu, Y. H., & Kose, S.
- Affiliations
- Neurology, and Neurosurgery, Forensic Psychiatry Unit, Bakirkoy Prof. Mazhar Osman Training and Research Hospital for Psychiatry, Istanbul, Turkey
- Department of Psychology, Hasan Kalyoncu University, Gaziantep, Turkey
- Venue
- Psychiatry and Clinical Psychopharmacology
- Publisher
- Taylor & Francis
- Published
- 2018-01-03
- Volume
- 28
- Issue
- 3
- Pages
- 314-328
- ISSN
- 2475-0573 (ISSN-L)
- 2475-0581
- OpenAlex
- W2781678342
- Cited by
- 50
- References
- 115
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 11 · 2020: 7 · 2019: 5 · 2018: 3
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Psychiatry and Clinical Psychopharmacology (publishedVersion, cc-by)
- Psychiatry and Clinical Psychopharmacology (publishedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Hasan Kalyoncu University Institutional Repository (Hasan Kalyoncu University) (submittedVersion, cc-by-nc-nd)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- suicide, suicidal behavior, neural correlates, neural circuits, fronto-striatal network, serotonergic system, suicide risk, suicide risk reduction
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