Preliminary examination of gray and white matter structure and longitudinal structural changes in frontal systems associated with future suicide attempts in adolescents and young adults with mood disorders
Open accessAbstract
Background Mood disorders are major risk factors for suicidal behavior. While cross-sectional studies implicate frontal systems, data to aid prediction of suicide-related behavior in mood disorders are limited. Longitudinal research on neuroanatomical mechanisms underlying suicide risk may assist in developing targeted interventions. Therefore, we conducted a preliminary study investigating baseline gray and white matter structure and longitudinal structural changes associated with future suicide attempts.Methods High-resolution structural magnetic resonance imaging, diffusion tensor imaging, and suicide-related behavioral assessment data for 46 adolescents and young adults with mood disorders [baseline age mean = 18 years; 61% female] were collected at baseline and at follow-up (interval mean = 3 years). Differences in baseline and longitudinal changes in gray matter volume and white matter fractional anisotropy in frontal systems that distinguished the participants who made future attempts from those who did not were investigated.Results Seventeen (37%) of participants attempted suicide within the follow-up period. Future attempters (those attempting suicide between their baseline and follow-up assessment), compared to those who did not, showed lower baseline ventral and rostral prefrontal gray matter volume and dorsomedial frontal, anterior limb of the internal capsule, and dorsal cingulum fractional anisotropy, as well as greater decreases over time in ventral and dorsal frontal fractional anisotropy (p < 0.005, uncorrected).Limitations Sample size was modest.Conclusions Results suggest abnormalities of gray and white matter in frontal systems and differences in developmental changes of frontal white matter may increase risk of suicide-related behavior in youths with mood disorders. Findings provide potential new leads for early intervention and prevention strategies.
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In a prospective study, reduced ventral and rostral prefrontal gray matter volume at baseline distinguished adolescents and young adults with mood disorders who later attempted suicide.
“In a prospective study, reduced ventral and rostral prefrontal GMV at baseline differentiates adolescents and young adults with mood disorders who later attempt suicide (56).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [56]
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Self-citationImpulsivity in adolescent bipolar disorder
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Self-citationEffects of ANK3 variation on gray and white matter in bipolar disorder
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Self-citationFactor structure of the Barratt impulsiveness scale
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- Authors
- Lippard, E. T. C., Johnston, J. A. Y., Spencer, L., Quatrano, S., Fan, S., Sankar, A., Weathers, J., Pittman, B., Oquendo, M. A., & Blumberg, H. P.
- Affiliations
- Yale University (US)
- Corresponding author
- Lippard, Elizabeth T. Cox
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 245
- Pages
- 1139-1148
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC6487887
- OpenAlex
- W2902713880
- Cited by
- 44
- References
- 103
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 2
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NIH) (RC1MH088366 (HPB), R01MH070902 (HPB), R01MH069747 (HPB), T32MH014276 (ETCL), T32DA022975 (ETCL), K01MH086621 (FW), UL1TR000142)
- National Center for Advancing Translational Science (HPB)
- American Foundation for Suicide Prevention
- International Bipolar Foundation
- Brain and Behavior Research Foundation
- MQ Brighter Futures Program
- For the Love of Travis
- Women's Health Research at Yale
- John and Hope Furth Endowment
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- suicide attempts, mood disorders, adolescents, young adults, frontal lobe, gray matter volume, white matter, fractional anisotropy, ventral prefrontal cortex, dorsomedial frontal cortex, anterior limb of the internal capsule, suicide risk prediction, suicide prevention
- MeSH terms
- Adolescent, Bipolar Disorder, Cross-Sectional Studies, Major Depressive Disorder, Female, Frontal Lobe, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Suicide, Attempted, Anisotropy, Prefrontal Cortex, Mood Disorders, Internal Capsule, Young Adult, Diffusion Tensor Imaging, Suicidal Ideation, White Matter, Gray Matter
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