Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease
Open accessAbstract
INTRODUCTION: Neuroimaging biomarkers are important for early diagnosis of Alzheimer's disease, and comparing multimodality neuroimaging to autopsy data is essential. METHODS: F-fluorodeoxyglucose PET (FDG-PET), and MRI. Correlations between neuroimaging biomarkers and neuropathologic schemes were assessed. RESULTS: PiB-PET showed strong correlations with Thal amyloid phase and Consortium to Establish a Registry for Alzheimer's Disease score and categorized 44% of Thal phase 1 participants as positive. FDG-PET and MRI correlated modestly with Braak tangle stage in Alzheimer's type pathology. A subset of participants with "none" or "sparse" neuritic plaque scores had elevated PiB-PET signal due to diffuse amyloid plaque. Participants with findings characterized as "suspected non-Alzheimer's pathophysiology" represented 15% of the group. DISCUSSION: PiB-PET is associated with Alzheimer's disease, neuritic plaques, and diffuse plaques. FDG-PET and MRI have modest correlation with neuropathologic schemes. Participants with findings characterized as suspected non-Alzheimer's pathophysiology most commonly had primary age-related tauopathy.
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Antemortem AD neuropathologic diagnosis can be made with reasonable validity using CSF or PET biomarkers as surrogate markers for cerebral Aβ and tau deposition.
“Antemortem AD neuropathologic diagnoses can now be made with reasonable validity using cerebrospinal fluid (CSF) or positron emission tomography (PET) imaging biomarkers as surrogate markers for cerebral Aβ and tau deposition”
From Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) · cites this paper as Lowe et al., 2019
Antemortem AD diagnosis relies heavily on the presence of Aβ and tau, either measured in spinal fluid or imaged using positron emission tomography.
“Antemortem diagnosis also relies heavily on the presence of Aβ and tau, either as measured in the spinal fluid or imaged using positron emission tomography (PET) [7–10].”
From Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau (2021) · cites this paper as [8]
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Sink-index: a network-based EEG marker for frontotemporal dementia and Alzheimer’s disease
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Characterizing Amyloid Pathogenic Spread in Alzheimer’s Disease Through A Network Diffusion Model
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Multi-Class Classification of Alzheimer’s Disease Using Frontal Cortex Non-invasive fNIRS
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Clinical investigation cases studies and critical thinking problem approaches
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Abnormal amyloid PET usually represents intermediate/high Alzheimer's disease neuropathologic change
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[18F]FDG PET outperforms MRI for detecting early tau-related neurodegeneration
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Molecular Neuroimaging Approaches to Primary Age-Related Tauopathy
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Molecular Neuroimaging in Alzheimer’s Disease
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- Authors
- Lowe, V. J., Lundt, E. S., Albertson, S. M., Przybelski, S. A., Senjem, M. L., Parisi, J. E., Kantarci, K., Boeve, B., Jones, D. T., Knopman, D., Jack, C. R., Dickson, D. W., Petersen, R. C., & Murray, M. E.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Lowe, Val J.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2019-06-04
- Volume
- 15
- Issue
- 7
- Pages
- 927-939
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC6662599
- OpenAlex
- W2948883552
- Cited by
- 90
- References
- 60
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 18 · 2023: 5 · 2022: 8 · 2021: 15 · 2020: 15 · 2019: 1
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (P50 AG016574, R01 NS89757, R01 NS089544, R01 DC10367, R01-AG054449, U01 AG006786, R21 NS094489)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, neuroimaging biomarkers
- MeSH terms
- Neuropathology, Aged, Aged, 80 and over, Alzheimer Disease, Aniline Compounds, Autopsy, Brain, Female, Fluorine Radioisotopes, Humans, Magnetic Resonance Imaging, Male, Prospective Studies, Thiazoles, Neurofibrillary Tangles, Neurodegenerative Diseases, Positron-Emission Tomography, Plaque, Amyloid, Neuroimaging
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